GREMLIN Database
Q9HRN2 - Uncharacterized protein
UniProt: Q9HRN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (330)
Sequences: 16019 (12785)
Seq/√Len: 703.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_A154_F4.2531.00
3_S26_E4.0971.00
28_T125_Q3.7681.00
36_V126_T3.5361.00
3_S155_D3.3841.00
32_K129_R3.3361.00
132_T144_A3.0121.00
30_F152_T2.9221.00
159_L166_T2.8821.00
16_A158_L2.8701.00
36_V117_F2.7121.00
34_R127_E2.6961.00
5_A30_F2.6491.00
110_T114_K2.6371.00
134_A144_A2.5651.00
129_R146_D2.4981.00
5_A143_V2.3841.00
332_G336_A2.3801.00
5_A152_T2.3751.00
26_E123_T2.3541.00
9_A36_V2.3411.00
4_L25_R2.3281.00
111_Q114_K2.3001.00
258_P261_K2.2671.00
134_A142_T2.1861.00
7_V159_L2.1501.00
19_G333_L2.1241.00
145_T152_T2.1181.00
131_E146_D2.1141.00
160_T315_A2.1011.00
263_A285_T2.0941.00
125_Q128_T2.0761.00
128_T145_T2.0741.00
3_S28_T2.0571.00
271_G279_L2.0421.00
44_R49_R2.0041.00
30_F125_Q1.9951.00
12_A160_T1.9911.00
156_D313_H1.9761.00
11_P325_V1.9161.00
35_G41_A1.9151.00
115_R118_A1.8731.00
15_A329_V1.8531.00
117_F124_V1.8481.00
30_F154_F1.8241.00
19_G22_E1.8171.00
203_P281_D1.8031.00
203_P283_D1.7931.00
144_A150_R1.7591.00
18_Y119_A1.7591.00
7_V161_P1.7581.00
313_H335_A1.7511.00
76_L106_E1.7291.00
19_G337_D1.7161.00
228_E231_K1.7091.00
131_E144_A1.7021.00
42_T49_R1.6811.00
28_T123_T1.6771.00
128_T147_G1.6711.00
125_Q152_T1.5811.00
264_T268_R1.5761.00
142_T153_G1.5631.00
4_L20_L1.5281.00
4_L156_D1.5251.00
226_S231_K1.4891.00
36_V113_A1.4881.00
271_G277_D1.4531.00
213_L216_T1.4431.00
130_V143_V1.4431.00
22_E70_A1.4371.00
69_H74_D1.4241.00
18_Y22_E1.4161.00
30_F130_V1.4151.00
28_T154_F1.4121.00
17_A29_V1.4091.00
315_A335_A1.4001.00
109_I325_V1.3971.00
239_E283_D1.3951.00
202_Y282_P1.3811.00
161_P166_T1.3781.00
158_L339_I1.3741.00
3_S25_R1.3571.00
259_A289_G1.3541.00
40_A113_A1.3481.00
292_Y296_N1.2921.00
260_S264_T1.2921.00
39_R317_D1.2881.00
6_I17_A1.2841.00
63_P333_L1.2771.00
28_T152_T1.2691.00
227_R231_K1.2651.00
36_V124_V1.2651.00
29_V124_V1.2631.00
5_A28_T1.2591.00
65_A69_H1.2541.00
66_E70_A1.2501.00
21_R122_A1.2461.00
145_T149_T1.2451.00
156_D339_I1.2421.00
48_C201_H1.2421.00
162_P165_Q1.2421.00
269_A272_V1.2351.00
21_R27_I1.2271.00
114_K118_A1.2141.00
257_H261_K1.2071.00
111_Q115_R1.2031.00
13_G160_T1.1931.00
140_D153_G1.1921.00
335_A338_H1.1901.00
223_G226_S1.1851.00
282_P285_T1.1821.00
227_R230_C1.1771.00
30_F128_T1.1721.00
203_P239_E1.1661.00
145_T148_G1.1601.00
45_K286_D1.1591.00
66_E333_L1.1461.00
263_A267_A1.1311.00
43_R52_H1.1301.00
78_D106_E1.1281.00
163_A318_W1.1271.00
120_T124_V1.1261.00
198_A287_T1.1231.00
243_I247_A1.1191.00
184_R188_A1.1191.00
154_F157_V1.1151.00
279_L282_P1.1151.00
334_A338_H1.1071.00
75_G79_V1.1021.00
201_H284_W1.0981.00
142_T150_R1.0951.00
333_L337_D1.0931.00
264_T279_L1.0881.00
265_V268_R1.0841.00
9_A29_V1.0741.00
201_H283_D1.0741.00
68_V73_D1.0731.00
16_A332_G1.0721.00
19_G332_G1.0671.00
107_A111_Q1.0651.00
44_R47_G1.0641.00
267_A271_G1.0611.00
12_A315_A1.0581.00
277_D280_A1.0541.00
128_T152_T1.0481.00
136_T153_G1.0411.00
246_M266_A1.0411.00
221_D224_W1.0381.00
44_R110_T1.0371.00
222_I225_L1.0351.00
210_W214_V1.0321.00
19_G23_A1.0301.00
74_D106_E1.0281.00
225_L231_K1.0281.00
18_Y116_L1.0271.00
12_A331_A1.0271.00
226_S229_A1.0221.00
133_L140_D1.0171.00
105_W112_L1.0141.00
221_D226_S1.0111.00
204_F281_D1.0101.00
133_L157_V1.0041.00
181_D185_A1.0031.00
134_A150_R1.0001.00
117_F126_T0.9971.00
261_K265_V0.9961.00
136_T142_T0.9951.00
297_D300_A0.9921.00
224_W227_R0.9911.00
210_W213_L0.9801.00
313_H338_H0.9801.00
18_Y70_A0.9771.00
263_A287_T0.9721.00
115_R119_A0.9631.00
21_R120_T0.9571.00
319_V334_A0.9551.00
125_Q149_T0.9541.00
293_A296_N0.9541.00
135_R141_W0.9511.00
224_W228_E0.9501.00
18_Y120_T0.9491.00
200_L267_A0.9471.00
292_Y295_P0.9421.00
95_G98_D0.9371.00
221_D227_R0.9371.00
12_A328_A0.9361.00
165_Q168_T0.9321.00
185_A188_A0.9301.00
62_G66_E0.9271.00
11_P40_A0.9231.00
221_D225_L0.9221.00
114_K117_F0.9211.00
277_D281_D0.9191.00
295_P299_V0.9181.00
6_I27_I0.9181.00
21_R123_T0.9141.00
67_L71_L0.9131.00
292_Y298_A0.9121.00
142_T145_T0.9121.00
267_A285_T0.9121.00
150_R153_G0.9081.00
64_V329_V0.9021.00
202_Y267_A0.9021.00
30_F145_T0.8981.00
25_R28_T0.8981.00
45_K284_W0.8971.00
268_R271_G0.8961.00
223_G227_R0.8931.00
248_P251_S0.8911.00
316_G331_A0.8881.00
220_H224_W0.8881.00
295_P298_A0.8841.00
94_P97_G0.8831.00
9_A126_T0.8831.00
268_R272_V0.8821.00
212_G215_N0.8811.00
63_P330_E0.8811.00
222_I227_R0.8771.00
261_K264_T0.8751.00
22_E119_A0.8711.00
135_R311_G0.8711.00
283_D286_D0.8671.00
20_L336_A0.8661.00
259_A263_A0.8661.00
250_W253_E0.8621.00
304_V307_A0.8591.00
198_A202_Y0.8581.00
65_A68_V0.8571.00
336_A339_I0.8561.00
141_W157_V0.8561.00
262_Q287_T0.8511.00
149_T152_T0.8481.00
222_I226_S0.8471.00
292_Y300_A0.8451.00
270_A274_L0.8451.00
66_E69_H0.8401.00
205_E208_R0.8401.00
198_A201_H0.8391.00
15_A19_G0.8371.00
293_A298_A0.8351.00
159_L312_L0.8321.00
135_R309_E0.8311.00
305_D308_R0.8271.00
293_A297_D0.8261.00
43_R286_D0.8191.00
252_R255_Y0.8191.00
263_A266_A0.8191.00
269_A273_L0.8151.00
156_D311_G0.8141.00
3_S153_G0.8111.00
211_Y215_N0.8111.00
295_P300_A0.8101.00
3_S152_T0.8081.00
141_W311_G0.8081.00
26_E155_D0.8011.00
268_R279_L0.7991.00
183_L186_A0.7991.00
33_S41_A0.7981.00
292_Y297_D0.7971.00
313_H339_I0.7931.00
200_L282_P0.7921.00
287_T290_W0.7921.00
24_D27_I0.7911.00
63_P66_E0.7911.00
211_Y216_T0.7881.00
46_D284_W0.7881.00
296_N299_V0.7871.00
330_E334_A0.7841.00
136_T141_W0.7841.00
105_W111_Q0.7831.00
68_V71_L0.7801.00
132_T172_S0.7781.00
328_A332_G0.7761.00
265_V269_A0.7751.00
243_I246_M0.7711.00
69_H72_G0.7701.00
131_E134_A0.7681.00
137_D140_D0.7661.00
212_G216_T0.7661.00
309_E312_L0.7651.00
19_G70_A0.7641.00
220_H223_G0.7641.00
45_K50_Y0.7641.00
16_A335_A0.7611.00
28_T155_D0.7581.00
211_Y214_V0.7571.00
296_N300_A0.7551.00
221_D228_E0.7551.00
306_A338_H0.7541.00
223_G228_E0.7521.00
11_P328_A0.7511.00
240_E243_I0.7491.00
240_E244_V0.7471.00
15_A332_G0.7451.00
67_L70_A0.7391.00
294_I297_D0.7361.00
133_L159_L0.7361.00
223_G231_K0.7351.00
226_S230_C0.7311.00
131_E145_T0.7291.00
201_H239_E0.7291.00
130_V145_T0.7291.00
11_P113_A0.7281.00
319_V331_A0.7251.00
244_V270_A0.7221.00
3_S154_F0.7211.00
220_H227_R0.7191.00
6_I13_G0.7191.00
180_R184_R0.7171.00
219_G223_G0.7151.00
21_R121_D0.7151.00
7_V130_V0.7141.00
225_L229_A0.7131.00
108_G111_Q0.7131.00
70_A73_D0.7101.00
185_A189_D0.7041.00
183_L187_A0.7031.00
136_T140_D0.7021.00
294_I299_V0.7021.00
277_D282_P0.7021.00
105_W108_G0.6981.00
161_P165_Q0.6951.00
41_A288_Q0.6941.00
48_C239_E0.6941.00
11_P329_V0.6931.00
231_K234_H0.6931.00
264_T285_T0.6921.00
128_T149_T0.6891.00
61_D65_A0.6871.00
84_W88_G0.6861.00
48_C236_P0.6851.00
25_R155_D0.6821.00
14_A113_A0.6821.00
294_I298_A0.6811.00
251_S255_Y0.6801.00
97_G100_D0.6791.00
140_D311_G0.6761.00
132_T174_D0.6741.00
17_A122_A0.6731.00
93_S96_R0.6711.00
292_Y299_V0.6681.00
40_A54_A0.6671.00
193_R197_T0.6661.00
84_W94_P0.6661.00
239_E243_I0.6661.00
200_L244_V0.6641.00
31_E126_T0.6641.00
220_H225_L0.6631.00
200_L285_T0.6631.00
293_A299_V0.6631.00
133_L143_V0.6601.00
196_V287_T0.6571.00
218_D223_G0.6571.00
104_T109_I0.6551.00
42_T110_T0.6551.00
23_A337_D0.6531.00
302_A306_A0.6511.00
222_I228_E0.6501.00
71_L74_D0.6471.00
251_S254_H0.6451.00
260_S263_A0.6381.00
270_A278_R0.6341.00
90_G93_S0.6331.00
194_S197_T0.6311.00
165_Q169_L0.6311.00
164_P168_T0.6301.00
220_H231_K0.6291.00
267_A279_L0.6291.00
61_D67_L0.6251.00
139_G310_A0.6241.00
39_R53_G0.6231.00
135_R138_D0.6201.00
113_A117_F0.6191.00
25_R156_D0.6181.00
29_V120_T0.6181.00
235_V238_G0.6171.00
131_E147_G0.6171.00
224_W231_K0.6161.00
181_D184_R0.6161.00
141_W312_L0.6161.00
301_G304_V0.6161.00
14_A120_T0.6161.00
82_P85_T0.6141.00
35_G110_T0.6141.00
92_L95_G0.6141.00
225_L228_E0.6121.00
235_V239_E0.6111.00
51_D56_Y0.6101.00
293_A300_A0.6101.00
17_A120_T0.6101.00
220_H226_S0.6101.00
87_T93_S0.6081.00
241_I245_Q0.6081.00
67_L329_V0.6081.00
11_P15_A0.6061.00
41_A52_H0.6061.00
197_T201_H0.6051.00
84_W87_T0.6041.00
76_L79_V0.5991.00
93_S98_D0.5991.00
196_V289_G0.5991.00
228_E232_A0.5981.00
68_V105_W0.5971.00
218_D222_I0.5961.00
335_A339_I0.5951.00
179_R183_L0.5941.00
102_K105_W0.5911.00
65_A103_W0.5891.00
206_L209_E0.5891.00
210_W215_N0.5881.00
278_R281_D0.5881.00
63_P326_H0.5871.00
241_I247_A0.5861.00
179_R184_R0.5831.00
161_P169_L0.5831.00
294_I300_A0.5811.00
14_A117_F0.5791.00
236_P239_E0.5791.00
195_I198_A0.5781.00
197_T202_Y0.5771.00
264_T267_A0.5751.00
71_L116_L0.5731.00
163_A167_A0.5721.00
184_R187_A0.5721.00
221_D230_C0.5711.00
224_W229_A0.5701.00
50_Y199_V0.5701.00
15_A116_L0.5671.00
51_D109_I0.5671.00
183_L308_R0.5651.00
315_A332_G0.5651.00
272_V275_D0.5611.00
64_V325_V0.5611.00
50_Y241_I0.5551.00
163_A190_V0.5541.00
182_A186_A0.5541.00
117_F120_T0.5531.00
195_I201_H0.5481.00
34_R126_T0.5481.00
81_A84_W0.5471.00
42_T51_D0.5451.00
6_I158_L0.5421.00
267_A282_P0.5411.00
262_Q266_A0.5411.00
219_G227_R0.5401.00
210_W216_T0.5401.00
256_D291_R0.5391.00
140_D155_D0.5391.00
83_V87_T0.5381.00
62_G65_A0.5381.00
88_G91_E0.5371.00
157_V311_G0.5351.00
95_G99_D0.5331.00
64_V68_V0.5331.00
54_A58_K0.5331.00
111_Q118_A0.5321.00
180_R183_L0.5311.00
243_I248_P0.5311.00
134_A141_W0.5301.00
66_E71_L0.5291.00
141_W145_T0.5291.00
303_P307_A0.5291.00
218_D231_K0.5281.00
249_D252_R0.5281.00
139_G142_T0.5261.00
40_A109_I0.5241.00
87_T92_L0.5211.00
14_A29_V0.5211.00
147_G150_R0.5201.00
202_Y206_L0.5181.00
158_L315_A0.5171.00
61_D68_V0.5161.00
222_I230_C0.5161.00
282_P290_W0.5161.00
218_D227_R0.5141.00
158_L313_H0.5141.00
135_R140_D0.5130.99
199_V202_Y0.5120.99
308_R311_G0.5120.99
218_D221_D0.5120.99
221_D269_A0.5110.99
190_V193_R0.5110.99
5_A157_V0.5100.99
88_G93_S0.5090.99
244_V247_A0.5080.99
167_A188_A0.5080.99
92_L98_D0.5080.99
35_G114_K0.5070.99
113_A116_L0.5050.99
224_W230_C0.5050.99
223_G229_A0.5030.99
86_F92_L0.5020.99
259_A262_Q0.5010.99
219_G224_W0.5000.99
288_Q291_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i59A 1 0.962 100 0.298 Contact Map
2yg5A 2 0.9649 100 0.309 Contact Map
2ivdA 1 0.9649 100 0.311 Contact Map
1s3eA 2 0.9678 100 0.316 Contact Map
3i6dA 1 0.9561 100 0.331 Contact Map
1b37A 4 0.9766 100 0.342 Contact Map
3lovA 1 0.9474 100 0.346 Contact Map
2vvmA 2 0.9444 100 0.346 Contact Map
1sezA 3 0.9795 100 0.354 Contact Map
3nksA 2 0.9678 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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