Q9HRN2 - HALSA - GREMLIN Contacts

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Q9HRN2 - Uncharacterized protein

UniProt:	Q9HRN2	Sequences: MDSLAIVGAGPAGAAAAYGLREADREITVFEKSRGVCGRAATRRKDGCRYDHGANYVKPGDGPVAELVHALGDDGLVDVTAPVWTFTGDGELSPGRGDDDPKWTWEAGITQLAKRLFAATDATVQTETRVETLARTDDGDWTVATDGGTRHTGFDDVLLTPPAPQTATLLSSTDWADDRRDALRAAAADVSYRSIVTAVLHYPFELDREWYGLVNTDDGHDIGWLSREACKAGHVPDGEEILIVQMAPDWSREHYDHPASKQATVAARAAGVLLDDDRLADPDWTDTQGWRYAIPNDAVAGAPVDAAREAGLHVAGDWVAGDGRVHAAVEAGLAAADHITRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	342 (330)
Sequences:	16019 (12785)
Seq/√Len:	703.8

ECOLI - GLF
BACSU - YOBN PPOX
HALSA - Q9HRN2 Q9HP88 Q9HP54 Q9HPD8 Q9HSE1 Q9HRU3
SULSO - Q97W24 Q97UT6 Q97YW3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_A	154_F	4.253	1.00
3_S	26_E	4.097	1.00
28_T	125_Q	3.768	1.00
36_V	126_T	3.536	1.00
3_S	155_D	3.384	1.00
32_K	129_R	3.336	1.00
132_T	144_A	3.012	1.00
30_F	152_T	2.922	1.00
159_L	166_T	2.882	1.00
16_A	158_L	2.870	1.00
36_V	117_F	2.712	1.00
34_R	127_E	2.696	1.00
5_A	30_F	2.649	1.00
110_T	114_K	2.637	1.00
134_A	144_A	2.565	1.00
129_R	146_D	2.498	1.00
5_A	143_V	2.384	1.00
332_G	336_A	2.380	1.00
5_A	152_T	2.375	1.00
26_E	123_T	2.354	1.00
9_A	36_V	2.341	1.00
4_L	25_R	2.328	1.00
111_Q	114_K	2.300	1.00
258_P	261_K	2.267	1.00
134_A	142_T	2.186	1.00
7_V	159_L	2.150	1.00
19_G	333_L	2.124	1.00
145_T	152_T	2.118	1.00
131_E	146_D	2.114	1.00
160_T	315_A	2.101	1.00
263_A	285_T	2.094	1.00
125_Q	128_T	2.076	1.00
128_T	145_T	2.074	1.00
3_S	28_T	2.057	1.00
271_G	279_L	2.042	1.00
44_R	49_R	2.004	1.00
30_F	125_Q	1.995	1.00
12_A	160_T	1.991	1.00
156_D	313_H	1.976	1.00
11_P	325_V	1.916	1.00
35_G	41_A	1.915	1.00
115_R	118_A	1.873	1.00
15_A	329_V	1.853	1.00
117_F	124_V	1.848	1.00
30_F	154_F	1.824	1.00
19_G	22_E	1.817	1.00
203_P	281_D	1.803	1.00
203_P	283_D	1.793	1.00
144_A	150_R	1.759	1.00
18_Y	119_A	1.759	1.00
7_V	161_P	1.758	1.00
313_H	335_A	1.751	1.00
76_L	106_E	1.729	1.00
19_G	337_D	1.716	1.00
228_E	231_K	1.709	1.00
131_E	144_A	1.702	1.00
42_T	49_R	1.681	1.00
28_T	123_T	1.677	1.00
128_T	147_G	1.671	1.00
125_Q	152_T	1.581	1.00
264_T	268_R	1.576	1.00
142_T	153_G	1.563	1.00
4_L	20_L	1.528	1.00
4_L	156_D	1.525	1.00
226_S	231_K	1.489	1.00
36_V	113_A	1.488	1.00
271_G	277_D	1.453	1.00
213_L	216_T	1.443	1.00
130_V	143_V	1.443	1.00
22_E	70_A	1.437	1.00
69_H	74_D	1.424	1.00
18_Y	22_E	1.416	1.00
30_F	130_V	1.415	1.00
28_T	154_F	1.412	1.00
17_A	29_V	1.409	1.00
315_A	335_A	1.400	1.00
109_I	325_V	1.397	1.00
239_E	283_D	1.395	1.00
202_Y	282_P	1.381	1.00
161_P	166_T	1.378	1.00
158_L	339_I	1.374	1.00
3_S	25_R	1.357	1.00
259_A	289_G	1.354	1.00
40_A	113_A	1.348	1.00
292_Y	296_N	1.292	1.00
260_S	264_T	1.292	1.00
39_R	317_D	1.288	1.00
6_I	17_A	1.284	1.00
63_P	333_L	1.277	1.00
28_T	152_T	1.269	1.00
227_R	231_K	1.265	1.00
36_V	124_V	1.265	1.00
29_V	124_V	1.263	1.00
5_A	28_T	1.259	1.00
65_A	69_H	1.254	1.00
66_E	70_A	1.250	1.00
21_R	122_A	1.246	1.00
145_T	149_T	1.245	1.00
156_D	339_I	1.242	1.00
48_C	201_H	1.242	1.00
162_P	165_Q	1.242	1.00
269_A	272_V	1.235	1.00
21_R	27_I	1.227	1.00
114_K	118_A	1.214	1.00
257_H	261_K	1.207	1.00
111_Q	115_R	1.203	1.00
13_G	160_T	1.193	1.00
140_D	153_G	1.192	1.00
335_A	338_H	1.190	1.00
223_G	226_S	1.185	1.00
282_P	285_T	1.182	1.00
227_R	230_C	1.177	1.00
30_F	128_T	1.172	1.00
203_P	239_E	1.166	1.00
145_T	148_G	1.160	1.00
45_K	286_D	1.159	1.00
66_E	333_L	1.146	1.00
263_A	267_A	1.131	1.00
43_R	52_H	1.130	1.00
78_D	106_E	1.128	1.00
163_A	318_W	1.127	1.00
120_T	124_V	1.126	1.00
198_A	287_T	1.123	1.00
243_I	247_A	1.119	1.00
184_R	188_A	1.119	1.00
154_F	157_V	1.115	1.00
279_L	282_P	1.115	1.00
334_A	338_H	1.107	1.00
75_G	79_V	1.102	1.00
201_H	284_W	1.098	1.00
142_T	150_R	1.095	1.00
333_L	337_D	1.093	1.00
264_T	279_L	1.088	1.00
265_V	268_R	1.084	1.00
9_A	29_V	1.074	1.00
201_H	283_D	1.074	1.00
68_V	73_D	1.073	1.00
16_A	332_G	1.072	1.00
19_G	332_G	1.067	1.00
107_A	111_Q	1.065	1.00
44_R	47_G	1.064	1.00
267_A	271_G	1.061	1.00
12_A	315_A	1.058	1.00
277_D	280_A	1.054	1.00
128_T	152_T	1.048	1.00
136_T	153_G	1.041	1.00
246_M	266_A	1.041	1.00
221_D	224_W	1.038	1.00
44_R	110_T	1.037	1.00
222_I	225_L	1.035	1.00
210_W	214_V	1.032	1.00
19_G	23_A	1.030	1.00
74_D	106_E	1.028	1.00
225_L	231_K	1.028	1.00
18_Y	116_L	1.027	1.00
12_A	331_A	1.027	1.00
226_S	229_A	1.022	1.00
133_L	140_D	1.017	1.00
105_W	112_L	1.014	1.00
221_D	226_S	1.011	1.00
204_F	281_D	1.010	1.00
133_L	157_V	1.004	1.00
181_D	185_A	1.003	1.00
134_A	150_R	1.000	1.00
117_F	126_T	0.997	1.00
261_K	265_V	0.996	1.00
136_T	142_T	0.995	1.00
297_D	300_A	0.992	1.00
224_W	227_R	0.991	1.00
210_W	213_L	0.980	1.00
313_H	338_H	0.980	1.00
18_Y	70_A	0.977	1.00
263_A	287_T	0.972	1.00
115_R	119_A	0.963	1.00
21_R	120_T	0.957	1.00
319_V	334_A	0.955	1.00
125_Q	149_T	0.954	1.00
293_A	296_N	0.954	1.00
135_R	141_W	0.951	1.00
224_W	228_E	0.950	1.00
18_Y	120_T	0.949	1.00
200_L	267_A	0.947	1.00
292_Y	295_P	0.942	1.00
95_G	98_D	0.937	1.00
221_D	227_R	0.937	1.00
12_A	328_A	0.936	1.00
165_Q	168_T	0.932	1.00
185_A	188_A	0.930	1.00
62_G	66_E	0.927	1.00
11_P	40_A	0.923	1.00
221_D	225_L	0.922	1.00
114_K	117_F	0.921	1.00
277_D	281_D	0.919	1.00
295_P	299_V	0.918	1.00
6_I	27_I	0.918	1.00
21_R	123_T	0.914	1.00
67_L	71_L	0.913	1.00
292_Y	298_A	0.912	1.00
142_T	145_T	0.912	1.00
267_A	285_T	0.912	1.00
150_R	153_G	0.908	1.00
64_V	329_V	0.902	1.00
202_Y	267_A	0.902	1.00
30_F	145_T	0.898	1.00
25_R	28_T	0.898	1.00
45_K	284_W	0.897	1.00
268_R	271_G	0.896	1.00
223_G	227_R	0.893	1.00
248_P	251_S	0.891	1.00
316_G	331_A	0.888	1.00
220_H	224_W	0.888	1.00
295_P	298_A	0.884	1.00
94_P	97_G	0.883	1.00
9_A	126_T	0.883	1.00
268_R	272_V	0.882	1.00
212_G	215_N	0.881	1.00
63_P	330_E	0.881	1.00
222_I	227_R	0.877	1.00
261_K	264_T	0.875	1.00
22_E	119_A	0.871	1.00
135_R	311_G	0.871	1.00
283_D	286_D	0.867	1.00
20_L	336_A	0.866	1.00
259_A	263_A	0.866	1.00
250_W	253_E	0.862	1.00
304_V	307_A	0.859	1.00
198_A	202_Y	0.858	1.00
65_A	68_V	0.857	1.00
336_A	339_I	0.856	1.00
141_W	157_V	0.856	1.00
262_Q	287_T	0.851	1.00
149_T	152_T	0.848	1.00
222_I	226_S	0.847	1.00
292_Y	300_A	0.845	1.00
270_A	274_L	0.845	1.00
66_E	69_H	0.840	1.00
205_E	208_R	0.840	1.00
198_A	201_H	0.839	1.00
15_A	19_G	0.837	1.00
293_A	298_A	0.835	1.00
159_L	312_L	0.832	1.00
135_R	309_E	0.831	1.00
305_D	308_R	0.827	1.00
293_A	297_D	0.826	1.00
43_R	286_D	0.819	1.00
252_R	255_Y	0.819	1.00
263_A	266_A	0.819	1.00
269_A	273_L	0.815	1.00
156_D	311_G	0.814	1.00
3_S	153_G	0.811	1.00
211_Y	215_N	0.811	1.00
295_P	300_A	0.810	1.00
3_S	152_T	0.808	1.00
141_W	311_G	0.808	1.00
26_E	155_D	0.801	1.00
268_R	279_L	0.799	1.00
183_L	186_A	0.799	1.00
33_S	41_A	0.798	1.00
292_Y	297_D	0.797	1.00
313_H	339_I	0.793	1.00
200_L	282_P	0.792	1.00
287_T	290_W	0.792	1.00
24_D	27_I	0.791	1.00
63_P	66_E	0.791	1.00
211_Y	216_T	0.788	1.00
46_D	284_W	0.788	1.00
296_N	299_V	0.787	1.00
330_E	334_A	0.784	1.00
136_T	141_W	0.784	1.00
105_W	111_Q	0.783	1.00
68_V	71_L	0.780	1.00
132_T	172_S	0.778	1.00
328_A	332_G	0.776	1.00
265_V	269_A	0.775	1.00
243_I	246_M	0.771	1.00
69_H	72_G	0.770	1.00
131_E	134_A	0.768	1.00
137_D	140_D	0.766	1.00
212_G	216_T	0.766	1.00
309_E	312_L	0.765	1.00
19_G	70_A	0.764	1.00
220_H	223_G	0.764	1.00
45_K	50_Y	0.764	1.00
16_A	335_A	0.761	1.00
28_T	155_D	0.758	1.00
211_Y	214_V	0.757	1.00
296_N	300_A	0.755	1.00
221_D	228_E	0.755	1.00
306_A	338_H	0.754	1.00
223_G	228_E	0.752	1.00
11_P	328_A	0.751	1.00
240_E	243_I	0.749	1.00
240_E	244_V	0.747	1.00
15_A	332_G	0.745	1.00
67_L	70_A	0.739	1.00
294_I	297_D	0.736	1.00
133_L	159_L	0.736	1.00
223_G	231_K	0.735	1.00
226_S	230_C	0.731	1.00
131_E	145_T	0.729	1.00
201_H	239_E	0.729	1.00
130_V	145_T	0.729	1.00
11_P	113_A	0.728	1.00
319_V	331_A	0.725	1.00
244_V	270_A	0.722	1.00
3_S	154_F	0.721	1.00
220_H	227_R	0.719	1.00
6_I	13_G	0.719	1.00
180_R	184_R	0.717	1.00
219_G	223_G	0.715	1.00
21_R	121_D	0.715	1.00
7_V	130_V	0.714	1.00
225_L	229_A	0.713	1.00
108_G	111_Q	0.713	1.00
70_A	73_D	0.710	1.00
185_A	189_D	0.704	1.00
183_L	187_A	0.703	1.00
136_T	140_D	0.702	1.00
294_I	299_V	0.702	1.00
277_D	282_P	0.702	1.00
105_W	108_G	0.698	1.00
161_P	165_Q	0.695	1.00
41_A	288_Q	0.694	1.00
48_C	239_E	0.694	1.00
11_P	329_V	0.693	1.00
231_K	234_H	0.693	1.00
264_T	285_T	0.692	1.00
128_T	149_T	0.689	1.00
61_D	65_A	0.687	1.00
84_W	88_G	0.686	1.00
48_C	236_P	0.685	1.00
25_R	155_D	0.682	1.00
14_A	113_A	0.682	1.00
294_I	298_A	0.681	1.00
251_S	255_Y	0.680	1.00
97_G	100_D	0.679	1.00
140_D	311_G	0.676	1.00
132_T	174_D	0.674	1.00
17_A	122_A	0.673	1.00
93_S	96_R	0.671	1.00
292_Y	299_V	0.668	1.00
40_A	54_A	0.667	1.00
193_R	197_T	0.666	1.00
84_W	94_P	0.666	1.00
239_E	243_I	0.666	1.00
200_L	244_V	0.664	1.00
31_E	126_T	0.664	1.00
220_H	225_L	0.663	1.00
200_L	285_T	0.663	1.00
293_A	299_V	0.663	1.00
133_L	143_V	0.660	1.00
196_V	287_T	0.657	1.00
218_D	223_G	0.657	1.00
104_T	109_I	0.655	1.00
42_T	110_T	0.655	1.00
23_A	337_D	0.653	1.00
302_A	306_A	0.651	1.00
222_I	228_E	0.650	1.00
71_L	74_D	0.647	1.00
251_S	254_H	0.645	1.00
260_S	263_A	0.638	1.00
270_A	278_R	0.634	1.00
90_G	93_S	0.633	1.00
194_S	197_T	0.631	1.00
165_Q	169_L	0.631	1.00
164_P	168_T	0.630	1.00
220_H	231_K	0.629	1.00
267_A	279_L	0.629	1.00
61_D	67_L	0.625	1.00
139_G	310_A	0.624	1.00
39_R	53_G	0.623	1.00
135_R	138_D	0.620	1.00
113_A	117_F	0.619	1.00
25_R	156_D	0.618	1.00
29_V	120_T	0.618	1.00
235_V	238_G	0.617	1.00
131_E	147_G	0.617	1.00
224_W	231_K	0.616	1.00
181_D	184_R	0.616	1.00
141_W	312_L	0.616	1.00
301_G	304_V	0.616	1.00
14_A	120_T	0.616	1.00
82_P	85_T	0.614	1.00
35_G	110_T	0.614	1.00
92_L	95_G	0.614	1.00
225_L	228_E	0.612	1.00
235_V	239_E	0.611	1.00
51_D	56_Y	0.610	1.00
293_A	300_A	0.610	1.00
17_A	120_T	0.610	1.00
220_H	226_S	0.610	1.00
87_T	93_S	0.608	1.00
241_I	245_Q	0.608	1.00
67_L	329_V	0.608	1.00
11_P	15_A	0.606	1.00
41_A	52_H	0.606	1.00
197_T	201_H	0.605	1.00
84_W	87_T	0.604	1.00
76_L	79_V	0.599	1.00
93_S	98_D	0.599	1.00
196_V	289_G	0.599	1.00
228_E	232_A	0.598	1.00
68_V	105_W	0.597	1.00
218_D	222_I	0.596	1.00
335_A	339_I	0.595	1.00
179_R	183_L	0.594	1.00
102_K	105_W	0.591	1.00
65_A	103_W	0.589	1.00
206_L	209_E	0.589	1.00
210_W	215_N	0.588	1.00
278_R	281_D	0.588	1.00
63_P	326_H	0.587	1.00
241_I	247_A	0.586	1.00
179_R	184_R	0.583	1.00
161_P	169_L	0.583	1.00
294_I	300_A	0.581	1.00
14_A	117_F	0.579	1.00
236_P	239_E	0.579	1.00
195_I	198_A	0.578	1.00
197_T	202_Y	0.577	1.00
264_T	267_A	0.575	1.00
71_L	116_L	0.573	1.00
163_A	167_A	0.572	1.00
184_R	187_A	0.572	1.00
221_D	230_C	0.571	1.00
224_W	229_A	0.570	1.00
50_Y	199_V	0.570	1.00
15_A	116_L	0.567	1.00
51_D	109_I	0.567	1.00
183_L	308_R	0.565	1.00
315_A	332_G	0.565	1.00
272_V	275_D	0.561	1.00
64_V	325_V	0.561	1.00
50_Y	241_I	0.555	1.00
163_A	190_V	0.554	1.00
182_A	186_A	0.554	1.00
117_F	120_T	0.553	1.00
195_I	201_H	0.548	1.00
34_R	126_T	0.548	1.00
81_A	84_W	0.547	1.00
42_T	51_D	0.545	1.00
6_I	158_L	0.542	1.00
267_A	282_P	0.541	1.00
262_Q	266_A	0.541	1.00
219_G	227_R	0.540	1.00
210_W	216_T	0.540	1.00
256_D	291_R	0.539	1.00
140_D	155_D	0.539	1.00
83_V	87_T	0.538	1.00
62_G	65_A	0.538	1.00
88_G	91_E	0.537	1.00
157_V	311_G	0.535	1.00
95_G	99_D	0.533	1.00
64_V	68_V	0.533	1.00
54_A	58_K	0.533	1.00
111_Q	118_A	0.532	1.00
180_R	183_L	0.531	1.00
243_I	248_P	0.531	1.00
134_A	141_W	0.530	1.00
66_E	71_L	0.529	1.00
141_W	145_T	0.529	1.00
303_P	307_A	0.529	1.00
218_D	231_K	0.528	1.00
249_D	252_R	0.528	1.00
139_G	142_T	0.526	1.00
40_A	109_I	0.524	1.00
87_T	92_L	0.521	1.00
14_A	29_V	0.521	1.00
147_G	150_R	0.520	1.00
202_Y	206_L	0.518	1.00
158_L	315_A	0.517	1.00
61_D	68_V	0.516	1.00
222_I	230_C	0.516	1.00
282_P	290_W	0.516	1.00
218_D	227_R	0.514	1.00
158_L	313_H	0.514	1.00
135_R	140_D	0.513	0.99
199_V	202_Y	0.512	0.99
308_R	311_G	0.512	0.99
218_D	221_D	0.512	0.99
221_D	269_A	0.511	0.99
190_V	193_R	0.511	0.99
5_A	157_V	0.510	0.99
88_G	93_S	0.509	0.99
244_V	247_A	0.508	0.99
167_A	188_A	0.508	0.99
92_L	98_D	0.508	0.99
35_G	114_K	0.507	0.99
113_A	116_L	0.505	0.99
224_W	230_C	0.505	0.99
223_G	229_A	0.503	0.99
86_F	92_L	0.502	0.99
259_A	262_Q	0.501	0.99
219_G	224_W	0.500	0.99
288_Q	291_R	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i59A	1	0.962	100	0.298	Contact Map
2yg5A	2	0.9649	100	0.309	Contact Map
2ivdA	1	0.9649	100	0.311	Contact Map
1s3eA	2	0.9678	100	0.316	Contact Map
3i6dA	1	0.9561	100	0.331	Contact Map
1b37A	4	0.9766	100	0.342	Contact Map
3lovA	1	0.9474	100	0.346	Contact Map
2vvmA	2	0.9444	100	0.346	Contact Map
1sezA	3	0.9795	100	0.354	Contact Map
3nksA	2	0.9678	100	0.355	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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