GREMLIN Database
Q9HRM9 - Molybdenum cofactor biosynthesis protein
UniProt: Q9HRM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (133)
Sequences: 6455 (4024)
Seq/√Len: 348.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_E96_F3.0781.00
14_T104_Q3.0101.00
22_T100_T2.5181.00
109_D122_T2.5151.00
14_T106_T2.4681.00
88_D142_E2.4371.00
10_E13_E2.4221.00
108_T124_R2.4161.00
93_A135_E2.3151.00
28_N97_H2.2581.00
21_R27_D2.0841.00
25_E45_A1.9151.00
106_T124_R1.9141.00
63_T95_V1.9001.00
45_A49_S1.8751.00
46_A49_S1.8541.00
16_E104_Q1.8511.00
33_D38_Q1.7201.00
45_A56_R1.7101.00
25_E56_R1.6841.00
130_V137_L1.6791.00
24_S27_D1.6671.00
124_R142_E1.6611.00
64_M89_V1.6441.00
111_R120_V1.6361.00
11_V109_D1.6341.00
23_V66_L1.6141.00
95_V138_V1.5931.00
29_Q33_D1.5511.00
100_T131_N1.5231.00
45_A55_E1.5061.00
99_D132_R1.4981.00
67_A129_A1.4881.00
108_T142_E1.4331.00
62_Y66_L1.4281.00
104_Q130_V1.4201.00
10_E110_K1.4021.00
11_V110_K1.3731.00
110_K121_V1.3331.00
25_E29_Q1.3231.00
70_I103_V1.3021.00
20_R100_T1.2961.00
20_R102_R1.2931.00
87_D122_T1.2801.00
122_T142_E1.2701.00
63_T139_C1.2641.00
67_A103_V1.2621.00
131_N135_E1.2521.00
40_P47_F1.2341.00
46_A50_E1.2331.00
90_E140_E1.2281.00
32_C59_N1.2271.00
23_V62_Y1.2241.00
32_C43_L1.2061.00
124_R140_E1.1971.00
122_T144_T1.1861.00
26_A29_Q1.1811.00
14_T17_H1.1611.00
92_P140_E1.1351.00
95_V101_I1.1191.00
120_V144_T1.1171.00
87_D142_E1.1091.00
17_H104_Q1.1051.00
130_V138_V1.0981.00
96_F99_D1.0961.00
26_A30_E1.0951.00
108_T122_T1.0811.00
42_H60_G1.0691.00
69_G73_P1.0641.00
105_S123_M1.0581.00
30_E33_D1.0391.00
107_V123_M1.0371.00
28_N58_V1.0261.00
30_E34_M1.0141.00
103_V125_V1.0071.00
44_D47_F1.0011.00
113_T118_R0.9831.00
16_E102_R0.9471.00
12_G106_T0.9381.00
26_A33_D0.9361.00
99_D131_N0.9291.00
61_L68_V0.9281.00
102_R130_V0.9211.00
123_M145_V0.9201.00
96_F133_E0.9181.00
61_L86_Y0.8981.00
78_G81_V0.8941.00
99_D133_E0.8931.00
107_V121_V0.8911.00
111_R122_T0.8731.00
61_L64_M0.8591.00
22_T98_G0.8531.00
89_V141_F0.8521.00
38_Q43_L0.8491.00
113_T116_G0.8431.00
9_F121_V0.8421.00
86_Y89_V0.8421.00
47_F51_T0.8401.00
86_Y143_R0.8391.00
102_R134_D0.8371.00
55_E97_H0.8341.00
131_N138_V0.8231.00
35_T59_N0.8131.00
57_I96_F0.8121.00
113_T120_V0.8111.00
29_Q43_L0.8101.00
59_N62_Y0.7811.00
21_R66_L0.7721.00
27_D36_M0.7631.00
67_A139_C0.7481.00
56_R97_H0.7471.00
9_F13_E0.7431.00
21_R62_Y0.7330.99
13_E110_K0.7310.99
37_N59_N0.7310.99
47_F50_E0.7300.99
61_L91_H0.7300.99
137_L140_E0.7280.99
87_D90_E0.7270.99
92_P137_L0.7240.99
40_P51_T0.7230.99
27_D30_E0.7220.99
40_P44_D0.7150.99
105_S125_V0.7140.99
37_N42_H0.7020.99
67_A125_V0.6890.99
49_S54_G0.6860.99
67_A141_F0.6700.99
82_A85_S0.6700.99
68_V72_I0.6680.99
130_V134_D0.6660.99
71_T143_R0.6640.99
39_Q47_F0.6630.99
130_V133_E0.6520.99
61_L65_S0.6520.99
22_T27_D0.6480.99
42_H59_N0.6470.99
49_S55_E0.6460.99
92_P139_C0.6410.99
9_F107_V0.6400.99
52_Q57_I0.6380.99
53_F94_P0.6300.98
110_K119_G0.6290.98
32_C37_N0.6290.98
116_G119_G0.6290.98
64_M91_H0.6270.98
36_M69_G0.6250.98
81_V84_L0.6200.98
119_G125_V0.6200.98
98_G101_I0.6180.98
35_T42_H0.6180.98
74_E105_S0.6170.98
113_T146_L0.6150.98
84_L146_L0.6120.98
61_L143_R0.6110.98
29_Q45_A0.6060.98
85_S90_E0.5980.98
87_D144_T0.5980.98
7_E110_K0.5970.98
64_M139_C0.5950.98
49_S52_Q0.5920.98
118_R146_L0.5890.98
71_T123_M0.5860.98
129_A139_C0.5830.97
85_S144_T0.5830.97
9_F110_K0.5720.97
36_M62_Y0.5690.97
54_G96_F0.5680.97
17_H21_R0.5660.97
11_V108_T0.5640.97
31_F65_S0.5630.97
57_I94_P0.5620.97
51_T54_G0.5540.97
21_R69_G0.5520.97
93_A138_V0.5510.96
32_C38_Q0.5470.96
52_Q55_E0.5470.96
72_I75_T0.5460.96
18_A70_I0.5450.96
27_D34_M0.5440.96
25_E97_H0.5390.96
93_A133_E0.5350.96
93_A131_N0.5340.96
131_N134_D0.5340.96
29_Q38_Q0.5280.96
64_M68_V0.5280.96
101_I131_N0.5250.95
104_Q129_A0.5240.95
100_T132_R0.5220.95
102_R129_A0.5220.95
71_T125_V0.5200.95
85_S89_V0.5180.95
23_V95_V0.5130.95
67_A143_R0.5080.95
41_L47_F0.5070.94
99_D138_V0.5070.94
70_I101_I0.5050.94
29_Q56_R0.5040.94
31_F61_L0.5010.94
24_S29_Q0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q6wA 6 0.9236 100 0.214 Contact Map
2bi0A 3 0.9682 100 0.236 Contact Map
3exzA 2 0.9172 100 0.246 Contact Map
4e3eA 3 0.9299 100 0.253 Contact Map
4ffuA 6 0.9554 100 0.258 Contact Map
4rv2B 2 0.8662 100 0.302 Contact Map
2c2iA 2 0.9172 100 0.303 Contact Map
3ir3A 2 0.8089 100 0.304 Contact Map
4v12A 2 0.8726 100 0.306 Contact Map
3k67A 2 0.8344 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.