GREMLIN Database
Q9HRM8 - Citrate (Pro-3S)-lyase
UniProt: Q9HRM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (269)
Sequences: 3794 (2526)
Seq/√Len: 154.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_R279_D4.4541.00
222_A249_D4.3291.00
238_A247_I4.3231.00
212_H220_A4.2271.00
36_G73_V3.7871.00
89_C114_S3.7711.00
260_W264_V3.2231.00
65_R68_D3.1391.00
222_A226_R2.9611.00
154_N157_E2.8011.00
149_A177_D2.7981.00
191_Y195_R2.7601.00
159_A167_L2.7111.00
216_E242_A2.5111.00
30_S248_N2.4821.00
70_R102_D2.4611.00
92_V99_A2.2611.00
265_L295_M2.2031.00
221_V247_I2.2031.00
224_D236_K2.2011.00
144_A164_T2.1631.00
285_A289_A2.1611.00
89_C116_V2.1591.00
215_I277_R2.1481.00
153_L195_R2.1151.00
263_R278_V2.0811.00
169_F174_L2.0701.00
254_T257_D2.0621.00
28_R87_E2.0311.00
245_D249_D2.0301.00
117_V129_V2.0271.00
289_A292_E2.0091.00
71_R75_D1.9451.00
174_L178_I1.9291.00
264_V278_V1.8791.00
121_T150_A1.8761.00
255_E259_A1.8721.00
55_F73_V1.8651.00
37_D65_R1.8481.00
229_A257_D1.8391.00
101_D104_D1.8091.00
225_A250_A1.7971.00
209_D236_K1.7191.00
122_D125_D1.7101.00
127_A161_A1.6831.00
153_L202_A1.6301.00
37_D62_A1.6281.00
258_T294_I1.6201.00
259_A263_R1.6091.00
278_V283_I1.6031.00
262_T299_R1.5941.00
124_D127_A1.5771.00
171_A210_T1.5671.00
155_A199_A1.5451.00
31_V52_V1.5451.00
141_P165_D1.5231.00
172_E213_T1.4881.00
67_G101_D1.4821.00
95_V99_A1.4661.00
214_A217_D1.4651.00
219_S222_A1.4651.00
33_F237_L1.4641.00
39_P72_A1.4551.00
168_V237_L1.4481.00
31_V208_I1.4311.00
94_P97_S1.4311.00
38_Q41_L1.4171.00
137_D140_S1.4161.00
126_V144_A1.4101.00
221_V246_P1.3931.00
293_R297_R1.3651.00
262_T266_D1.3611.00
120_V158_I1.3591.00
200_A207_A1.3581.00
222_A250_A1.3451.00
181_T230_D1.3381.00
68_D72_A1.3091.00
29_R248_N1.3071.00
156_H195_R1.2751.00
90_V106_V1.2661.00
225_A236_K1.2631.00
133_L142_V1.2611.00
228_A251_Y1.2601.00
196_V207_A1.2591.00
146_V155_A1.2581.00
216_E277_R1.2511.00
49_G86_C1.2311.00
74_S105_A1.2261.00
190_L194_E1.2171.00
152_V192_A1.2151.00
260_W294_I1.2071.00
100_G132_L1.2071.00
31_V54_V1.2061.00
150_A154_N1.1951.00
218_P222_A1.1941.00
288_I292_E1.1901.00
130_D162_G1.1901.00
176_A289_A1.1821.00
153_L156_H1.1751.00
156_H202_A1.1621.00
146_V152_V1.1601.00
143_L168_V1.1511.00
116_V168_V1.1381.00
144_A158_I1.1321.00
207_A234_D1.1321.00
75_D79_A1.1281.00
100_G104_D1.1141.00
292_E296_R1.1100.99
59_D119_K1.1040.99
193_R209_D1.0960.99
172_E286_P1.0860.99
285_A292_E1.0830.99
52_V89_C1.0770.99
151_G155_A1.0600.99
258_T295_M1.0450.99
123_A157_E1.0410.99
42_M55_F1.0400.99
67_G71_R1.0360.99
46_P76_L1.0330.99
115_V133_L1.0210.99
212_H224_D1.0180.99
190_L231_L1.0140.99
246_P250_A1.0100.99
181_T257_D1.0080.99
208_I237_L1.0060.99
217_D220_A1.0050.99
42_M76_L0.9950.99
201_S234_D0.9850.99
191_Y194_E0.9840.99
260_W279_D0.9830.99
213_T282_M0.9810.99
218_P242_A0.9760.99
260_W281_E0.9730.99
179_G293_R0.9690.99
221_V225_A0.9690.99
150_A160_A0.9650.99
155_A159_A0.9610.99
74_S78_T0.9550.98
103_V129_V0.9530.98
172_E287_L0.9390.98
223_A227_F0.9340.98
156_H160_A0.9340.98
99_A129_V0.9300.98
68_D71_R0.9280.98
258_T298_A0.9240.98
43_R46_P0.9220.98
219_S223_A0.9210.98
174_L198_L0.9150.98
73_V90_V0.9130.98
44_K47_T0.9080.98
256_A259_A0.9050.98
269_A292_E0.8980.98
124_D128_T0.8960.98
221_V243_Q0.8940.98
130_D163_P0.8930.98
225_A251_Y0.8860.97
222_A246_P0.8850.97
190_L227_F0.8850.97
125_D128_T0.8760.97
197_V233_F0.8750.97
275_V284_D0.8750.97
191_Y198_L0.8580.97
61_V69_A0.8560.97
123_A154_N0.8550.97
33_F211_V0.8540.97
108_S112_F0.8520.97
253_P258_T0.8510.97
292_E299_R0.8500.97
175_S189_V0.8490.97
39_P42_M0.8480.97
123_A127_A0.8460.97
147_E173_D0.8430.97
175_S180_A0.8420.97
187_T227_F0.8370.96
183_T188_E0.8300.96
146_V158_I0.8300.96
143_L166_A0.8280.96
48_T244_V0.8270.96
122_D154_N0.8260.96
107_L133_L0.8240.96
152_V198_L0.8240.96
166_A200_A0.8230.96
103_V136_H0.8220.96
214_A281_E0.8220.96
195_R198_L0.8190.96
122_D158_I0.7990.95
212_H236_K0.7970.95
172_E282_M0.7970.95
165_D206_D0.7960.95
43_R79_A0.7940.95
209_D228_A0.7930.95
80_A83_D0.7930.95
117_V126_V0.7920.95
258_T262_T0.7890.95
96_G125_D0.7890.95
286_P290_Q0.7880.95
91_R95_V0.7850.95
28_R52_V0.7840.95
160_A203_A0.7820.95
104_D132_L0.7800.95
169_F192_A0.7780.95
34_S53_V0.7770.95
149_A202_A0.7750.95
168_V235_G0.7740.95
143_L208_I0.7700.94
152_V174_L0.7660.94
150_A202_A0.7660.94
62_A65_R0.7610.94
167_L200_A0.7590.94
187_T190_L0.7540.94
194_E197_V0.7530.94
72_A75_D0.7520.94
296_R299_R0.7500.94
58_E119_K0.7490.94
126_V129_V0.7490.94
40_S43_R0.7480.93
262_T295_M0.7470.93
218_P246_P0.7430.93
212_H243_Q0.7370.93
277_R280_G0.7340.93
66_K93_N0.7340.93
225_A247_I0.7300.93
177_D201_S0.7290.93
146_V196_V0.7260.92
28_R206_D0.7250.92
174_L192_A0.7250.92
42_M72_A0.7250.92
273_A276_F0.7240.92
107_L137_D0.7240.92
49_G245_D0.7210.92
149_A178_I0.7200.92
284_D287_L0.7190.92
92_V129_V0.7190.92
117_V120_V0.7170.92
39_P43_R0.7150.92
172_E284_D0.7140.92
121_T151_G0.7140.92
215_I242_A0.7100.92
209_D224_D0.7080.91
28_R31_V0.7050.91
208_I235_G0.7050.91
81_D113_D0.7040.91
259_A262_T0.7040.91
58_E147_E0.7030.91
207_A284_D0.7020.91
128_T131_S0.7000.91
92_V117_V0.6990.91
266_D270_D0.6980.91
185_E230_D0.6960.91
123_A161_A0.6950.91
31_V89_C0.6950.91
290_Q294_I0.6910.90
45_A55_F0.6830.90
169_F196_V0.6820.90
148_S177_D0.6810.90
146_V151_G0.6810.90
29_R51_D0.6780.90
33_F171_A0.6780.90
244_V248_N0.6780.90
276_F285_A0.6750.89
61_V66_K0.6730.89
229_A250_A0.6720.89
103_V115_V0.6720.89
54_V116_V0.6660.89
266_D269_A0.6630.89
70_R93_N0.6630.89
206_D234_D0.6620.89
90_V105_A0.6590.88
29_R252_T0.6590.88
275_V282_M0.6580.88
295_M299_R0.6570.88
152_V155_A0.6550.88
215_I239_I0.6510.88
96_G99_A0.6480.87
182_R290_Q0.6440.87
157_E160_A0.6420.87
147_E170_G0.6420.87
106_V112_F0.6420.87
43_R47_T0.6410.87
31_V143_L0.6400.87
35_P240_H0.6400.87
175_S182_R0.6390.87
166_A207_A0.6380.87
40_S48_T0.6350.86
276_F283_I0.6350.86
226_R230_D0.6310.86
265_L292_E0.6280.86
104_D136_H0.6250.86
50_A244_V0.6230.85
210_T237_L0.6230.85
259_A266_D0.6220.85
58_E173_D0.6220.85
127_A131_S0.6210.85
100_G128_T0.6190.85
264_V279_D0.6150.85
33_F54_V0.6150.85
121_T125_D0.6140.85
77_L88_V0.6140.85
129_V142_V0.6130.84
260_W278_V0.6130.84
166_A208_I0.6110.84
115_V142_V0.6090.84
73_V112_F0.6080.84
155_A195_R0.6070.84
268_A288_I0.6070.84
260_W263_R0.6030.83
133_L140_S0.6030.83
42_M45_A0.6020.83
194_E231_L0.5990.83
105_A108_S0.5980.83
150_A203_A0.5970.83
121_T148_S0.5960.83
153_L191_Y0.5950.83
225_A229_A0.5880.82
239_I282_M0.5870.82
197_V207_A0.5860.82
34_S41_L0.5850.82
154_N158_I0.5840.81
31_V235_G0.5820.81
77_L90_V0.5800.81
83_D86_C0.5800.81
38_Q42_M0.5760.81
49_G244_V0.5760.81
286_P289_A0.5760.81
214_A220_A0.5760.81
169_F193_R0.5760.81
64_A67_G0.5750.80
90_V112_F0.5750.80
193_R233_F0.5720.80
181_T229_A0.5720.80
102_D106_V0.5710.80
74_S108_S0.5700.80
106_V115_V0.5670.80
217_D223_A0.5670.80
240_H282_M0.5660.79
182_R188_E0.5630.79
249_D252_T0.5630.79
92_V100_G0.5620.79
59_D173_D0.5610.79
170_G173_D0.5580.78
66_K70_R0.5570.78
130_D142_V0.5540.78
212_H221_V0.5530.78
77_L110_G0.5520.78
116_V145_L0.5510.78
159_A199_A0.5470.77
274_G284_D0.5470.77
116_V143_L0.5460.77
151_G154_N0.5440.77
114_S166_A0.5430.77
128_T132_L0.5420.76
42_M82_F0.5400.76
30_S238_A0.5400.76
96_G100_G0.5390.76
189_V233_F0.5380.76
117_V142_V0.5380.76
211_V224_D0.5360.76
145_L237_L0.5350.76
33_F116_V0.5350.76
225_A228_A0.5330.75
65_R72_A0.5330.75
46_P80_A0.5330.75
67_G98_G0.5320.75
78_T82_F0.5320.75
211_V287_L0.5310.75
99_A132_L0.5280.75
199_A203_A0.5270.74
103_V108_S0.5250.74
101_D105_A0.5250.74
36_G42_M0.5240.74
112_F140_S0.5240.74
119_K148_S0.5230.74
82_F87_E0.5230.74
293_R296_R0.5220.74
172_E176_A0.5210.74
89_C143_L0.5210.74
30_S50_A0.5210.74
166_A172_E0.5200.73
108_S140_S0.5200.73
104_D107_L0.5170.73
265_L268_A0.5170.73
255_E262_T0.5150.73
257_D260_W0.5140.73
180_A197_V0.5140.73
36_G74_S0.5130.73
226_R250_A0.5110.72
95_V125_D0.5100.72
195_R199_A0.5090.72
133_L137_D0.5080.72
143_L165_D0.5080.72
276_F288_I0.5080.72
131_S270_D0.5080.72
267_A278_V0.5070.72
70_R97_S0.5070.72
62_A275_V0.5060.71
218_P243_Q0.5050.71
265_L288_I0.5040.71
229_A297_R0.5040.71
34_S146_V0.5040.71
260_W290_Q0.5030.71
94_P99_A0.5020.71
167_L205_V0.5020.71
64_A272_D0.5010.71
152_V196_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sgjA 3 0.7459 100 0.28 Contact Map
4l80A 5 0.9901 100 0.282 Contact Map
1u5hA 3 0.7162 100 0.291 Contact Map
3qqwA 3 0.8515 100 0.294 Contact Map
4l9zA 5 0.9373 100 0.297 Contact Map
4roqA 5 0.9472 100 0.297 Contact Map
3oyzA 5 0.9109 100 0.302 Contact Map
3qllA 3 0.6997 100 0.304 Contact Map
3r4iA 5 0.9142 100 0.309 Contact Map
3cuxA 1 0.9604 100 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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