GREMLIN Database
DHE4 - NADP-specific glutamate dehydrogenase A1
UniProt: Q9HRM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (378)
Sequences: 4809 (2356)
Seq/√Len: 121.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_I234_A4.2981.00
284_T306_D3.8291.00
215_V226_A3.8111.00
214_A287_V3.4391.00
35_E63_G3.0961.00
287_V309_A3.0951.00
259_A263_E3.0861.00
286_D308_D2.9651.00
326_D330_E2.8581.00
253_D256_A2.7931.00
111_D114_E2.7621.00
118_S122_R2.7171.00
197_A313_V2.6481.00
94_T346_V2.5531.00
212_T235_D2.5321.00
199_E202_D2.4651.00
101_Y350_Y2.4391.00
146_V295_L2.4171.00
329_T393_N2.4021.00
203_Y387_E2.3651.00
129_T159_T2.3611.00
196_A341_A2.3281.00
206_R211_A2.3261.00
226_A239_V2.3231.00
199_E376_T2.2641.00
213_V229_I2.2321.00
61_F87_S2.2301.00
385_A389_A2.2241.00
39_E80_R2.2161.00
46_M52_E2.2051.00
193_T315_A2.1911.00
385_A404_Q2.1771.00
149_G152_E2.1351.00
227_K231_D2.1141.00
320_L328_L2.0771.00
301_E323_D2.0421.00
313_V341_A2.0251.00
336_V341_A2.0191.00
43_S126_A2.0071.00
404_Q408_D2.0031.00
199_E380_D1.9661.00
393_N396_T1.9491.00
194_M232_Q1.9231.00
203_Y383_T1.9101.00
72_I156_I1.9091.00
198_R232_Q1.8931.00
283_L290_L1.8871.00
379_F383_T1.8831.00
304_A327_V1.8651.00
300_D303_L1.8581.00
213_V234_A1.8521.00
208_L234_A1.8311.00
200_V311_V1.8251.00
68_Y104_G1.8221.00
65_R98_D1.8201.00
59_S87_S1.8191.00
110_L115_Y1.8181.00
184_G364_E1.8101.00
366_R370_E1.8081.00
96_V340_L1.7521.00
339_I399_Y1.7441.00
154_N176_A1.7341.00
198_R372_E1.7131.00
384_D388_D1.6881.00
392_P400_V1.6801.00
128_A156_I1.6791.00
214_A238_A1.6781.00
203_Y379_F1.6531.00
278_S281_A1.6511.00
178_E408_D1.6471.00
327_V331_R1.6451.00
299_I307_V1.6021.00
132_R164_E1.5921.00
238_A282_L1.5741.00
129_T162_T1.5621.00
37_V84_K1.5021.00
392_P397_A1.5021.00
249_P275_E1.4961.00
195_F372_E1.4911.00
79_T82_E1.4911.00
213_V291_V1.4831.00
322_P325_D1.4781.00
316_A319_P1.4641.00
200_V336_V1.4521.00
61_F91_V1.4271.00
225_A291_V1.4161.00
258_K262_T1.4141.00
380_D384_D1.4121.00
201_F289_L1.4071.00
238_A285_M1.4041.00
221_A315_A1.3841.00
166_T169_P1.3831.00
242_S261_K1.3801.00
159_T162_T1.3781.00
260_F264_T1.3761.00
184_G187_N1.3631.00
201_F208_L1.3561.00
75_H295_L1.3461.00
313_V336_V1.3451.00
33_H55_K1.3421.00
239_V257_V1.3371.00
91_V406_V1.3351.00
45_E118_S1.3341.00
254_T258_K1.3341.00
56_A127_F1.3301.00
356_N361_Q1.3291.00
207_D210_D1.3191.00
63_G68_Y1.3151.00
340_L382_M1.3111.00
203_Y380_D1.3051.00
193_T313_V1.3031.00
301_E327_V1.2961.00
305_H327_V1.2931.00
257_V261_K1.2911.00
126_A159_T1.2901.00
121_E125_R1.2821.00
214_A285_M1.2751.00
197_A289_L1.2731.00
379_F394_L1.2721.00
225_A293_A1.2711.00
213_V289_L1.2611.00
198_R202_D1.2591.00
195_F368_N1.2570.99
290_L307_V1.2490.99
42_L126_A1.2480.99
212_T286_D1.2450.99
150_Q186_V1.2410.99
327_V330_E1.2390.99
132_R163_L1.2330.99
76_P111_D1.2310.99
117_D151_R1.2290.99
40_T131_L1.2260.99
230_A255_R1.2240.99
243_S266_S1.2220.99
92_Y339_I1.2200.99
326_D329_T1.2200.99
38_L134_F1.2190.99
237_V247_H1.2180.99
388_D404_Q1.2180.99
178_E412_G1.2150.99
229_I236_V1.2030.99
37_V80_R1.2000.99
299_I328_L1.2000.99
212_T288_D1.1940.99
92_Y406_V1.1860.99
328_L333_V1.1860.99
237_V287_V1.1830.99
385_A401_V1.1750.99
227_K258_K1.1750.99
115_Y123_I1.1710.99
148_T153_M1.1640.99
97_A347_T1.1630.99
270_Y273_A1.1560.99
325_D395_R1.1560.99
212_T249_P1.1530.99
57_F109_I1.1490.99
389_A400_V1.1470.99
194_M229_I1.1440.99
97_A343_A1.1280.99
59_S80_R1.1260.99
204_L310_D1.1250.99
245_A277_L1.1210.99
245_A279_N1.1200.99
214_A237_V1.1180.99
311_V334_T1.1170.99
365_D369_E1.1140.99
110_L123_I1.1140.99
191_R368_N1.1140.99
55_K109_I1.1070.99
364_E368_N1.1040.99
387_E392_P1.1000.99
256_A270_Y1.0990.99
301_E305_H1.0930.99
191_R228_L1.0880.99
290_L298_A1.0850.99
363_T366_R1.0810.98
408_D411_E1.0810.98
312_V328_L1.0770.98
206_R310_D1.0680.98
193_T197_A1.0590.98
131_L134_F1.0590.98
281_A284_T1.0530.98
213_V236_V1.0530.98
218_Y239_V1.0510.98
197_A291_V1.0450.98
43_S53_T1.0420.98
256_A259_A1.0370.98
363_T373_A1.0370.98
74_Y148_T1.0300.98
224_V227_K1.0250.98
372_E376_T1.0240.98
62_N410_Y1.0200.98
126_A129_T1.0190.98
204_L334_T1.0180.98
133_P165_D1.0170.98
193_T291_V1.0100.98
257_V270_Y1.0060.98
258_K261_K1.0040.98
230_A254_T1.0020.97
225_A229_I1.0000.97
299_I320_L1.0000.97
153_M156_I0.9990.97
179_N412_G0.9970.97
226_A236_V0.9940.97
389_A392_P0.9890.97
200_V313_V0.9860.97
248_N256_A0.9830.97
191_R372_E0.9730.97
75_H146_V0.9730.97
403_V406_V0.9700.97
385_A400_V0.9700.97
307_V312_V0.9680.97
64_D406_V0.9630.97
193_T293_A0.9580.97
259_A262_T0.9560.97
392_P396_T0.9550.97
223_S258_K0.9550.97
204_L311_V0.9520.97
116_S119_E0.9510.97
46_M54_F0.9500.97
65_R95_A0.9470.96
77_G82_E0.9440.96
39_E55_K0.9420.96
276_E279_N0.9420.96
98_D374_I0.9400.96
299_I312_V0.9400.96
230_A236_V0.9400.96
176_A179_N0.9300.96
139_K165_D0.9290.96
37_V59_S0.9280.96
111_D116_S0.9250.96
246_V267_V0.9230.96
377_D381_A0.9230.96
156_I172_I0.9230.96
40_T56_A0.9210.96
37_V83_V0.9100.96
299_I304_A0.9080.96
203_Y384_D0.9030.95
286_D309_A0.9020.95
275_E278_S0.8990.95
280_E284_T0.8990.95
302_D305_H0.8970.95
105_K317_N0.8960.95
74_Y108_I0.8930.95
229_I291_V0.8920.95
196_A382_M0.8910.95
291_V313_V0.8900.95
260_F270_Y0.8880.95
124_T128_A0.8840.95
248_N270_Y0.8820.95
113_E242_S0.8810.95
72_I142_P0.8790.95
197_A311_V0.8780.95
74_Y124_T0.8760.95
346_V349_S0.8720.94
230_A253_D0.8690.94
261_K276_E0.8670.94
245_A284_T0.8640.94
301_E324_A0.8610.94
284_T303_L0.8550.94
198_R208_L0.8500.94
106_G124_T0.8490.94
265_G269_G0.8460.93
117_D121_E0.8400.93
186_V224_V0.8400.93
69_K346_V0.8370.93
237_V285_M0.8290.93
224_V228_L0.8280.93
57_F80_R0.8210.92
334_T394_L0.8120.92
36_R60_Q0.8100.92
369_E373_A0.8070.92
126_A130_E0.8030.92
138_D357_R0.8030.92
212_T237_V0.8010.91
155_W158_D0.8000.91
81_D84_K0.7990.91
309_A333_V0.7990.91
387_E390_G0.7970.91
247_H285_M0.7970.91
125_R159_T0.7960.91
182_S362_W0.7930.91
188_A371_L0.7930.91
305_H331_R0.7900.91
193_T225_A0.7890.91
153_M172_I0.7820.90
246_V257_V0.7820.90
325_D329_T0.7770.90
368_N372_E0.7690.90
349_S352_E0.7690.90
38_L131_L0.7670.90
247_H275_E0.7670.90
264_T269_G0.7660.90
98_D377_D0.7650.89
196_A313_V0.7640.89
244_G267_V0.7630.89
113_E261_K0.7580.89
157_K168_A0.7580.89
299_I338_D0.7560.89
385_A397_A0.7550.89
69_K101_Y0.7540.89
74_Y110_L0.7530.89
260_F269_G0.7530.89
137_E168_A0.7440.88
354_V360_F0.7410.88
39_E57_F0.7400.88
386_H394_L0.7400.88
153_M179_N0.7400.88
128_A172_I0.7370.88
347_T375_I0.7370.88
376_T380_D0.7360.88
402_A406_V0.7350.88
238_A245_A0.7340.87
201_F211_A0.7340.87
196_A336_V0.7330.87
45_E52_E0.7310.87
60_Q139_K0.7310.87
218_Y257_V0.7290.87
307_V328_L0.7280.87
279_N282_L0.7270.87
52_E114_E0.7260.87
245_A285_M0.7240.87
44_V54_F0.7230.87
137_E166_T0.7220.87
278_S282_L0.7220.87
190_G225_A0.7210.87
93_K317_N0.7190.86
189_T345_G0.7180.86
241_D244_G0.7170.86
335_V338_D0.7160.86
228_L368_N0.7150.86
260_F265_G0.7150.86
312_V335_V0.7100.86
126_A162_T0.7100.86
105_K189_T0.7090.86
260_F271_E0.7080.86
252_L257_V0.7080.86
78_V107_G0.7060.85
46_M50_T0.7060.85
355_Q362_W0.7050.85
226_A254_T0.7020.85
42_L123_I0.6990.85
157_K161_E0.6980.85
72_I124_T0.6980.85
174_G349_S0.6960.85
288_D310_D0.6950.84
135_I156_I0.6940.84
89_W318_G0.6900.84
289_L311_V0.6890.84
240_S283_L0.6880.84
401_V405_R0.6840.84
215_V239_V0.6840.84
52_E115_Y0.6820.83
218_Y254_T0.6800.83
301_E325_D0.6790.83
350_Y354_V0.6780.83
291_V315_A0.6770.83
383_T394_L0.6770.83
215_V229_I0.6760.83
193_T341_A0.6750.83
386_H390_G0.6740.83
148_T188_A0.6740.83
395_R399_Y0.6710.82
163_L172_I0.6700.82
72_I127_F0.6690.82
348_V367_V0.6690.82
144_P185_R0.6680.82
165_D168_A0.6670.82
205_D211_A0.6670.82
106_G127_F0.6660.82
264_T267_V0.6660.82
335_V395_R0.6650.82
147_N221_A0.6650.82
214_A282_L0.6620.82
351_F366_R0.6610.81
277_L281_A0.6600.81
226_A257_V0.6600.81
137_E169_P0.6590.81
320_L325_D0.6590.81
347_T374_I0.6580.81
188_A348_V0.6570.81
188_A220_N0.6560.81
60_Q68_Y0.6560.81
383_T387_E0.6520.81
95_A402_A0.6520.81
320_L324_A0.6520.81
87_S91_V0.6510.80
268_S272_G0.6510.80
159_T163_L0.6500.80
229_I289_L0.6490.80
128_A135_I0.6490.80
216_Q298_A0.6480.80
300_D320_L0.6470.80
221_A242_S0.6470.80
202_D376_T0.6470.80
200_V383_T0.6460.80
408_D412_G0.6430.80
312_V333_V0.6420.80
125_R158_D0.6420.80
64_D409_A0.6400.79
315_A341_A0.6390.79
281_A303_L0.6380.79
122_R158_D0.6370.79
173_T349_S0.6350.79
296_E318_G0.6330.79
194_M225_A0.6330.79
84_K87_S0.6300.78
194_M198_R0.6290.78
403_V407_V0.6280.78
143_A173_T0.6280.78
144_P220_N0.6240.78
325_D328_L0.6210.77
241_D261_K0.6200.77
54_F110_L0.6200.77
223_S260_F0.6200.77
280_E302_D0.6190.77
214_A245_A0.6180.77
185_R220_N0.6170.77
129_T161_E0.6170.77
128_A131_L0.6160.77
189_T220_N0.6160.77
93_K105_K0.6150.77
299_I305_H0.6150.77
369_E372_E0.6140.76
325_D335_V0.6130.76
69_K94_T0.6130.76
143_A220_N0.6110.76
275_E279_N0.6110.76
214_A309_A0.6110.76
257_V276_E0.6110.76
386_H389_A0.6090.76
202_D380_D0.6080.76
144_P349_S0.6070.76
125_R128_A0.6060.76
193_T221_A0.6050.75
189_T342_N0.6030.75
255_R258_K0.6020.75
300_D321_T0.6010.75
348_V362_W0.6010.75
245_A282_L0.6010.75
290_L312_V0.6000.75
248_N272_G0.6000.75
304_A328_L0.6000.75
302_D306_D0.5980.75
336_V394_L0.5970.74
190_G315_A0.5960.74
299_I335_V0.5950.74
185_R349_S0.5950.74
212_T247_H0.5950.74
198_R376_T0.5940.74
385_A388_D0.5930.74
64_D410_Y0.5930.74
228_L232_Q0.5920.74
263_E273_A0.5910.74
305_H330_E0.5900.74
389_A404_Q0.5900.74
72_I106_G0.5870.73
283_L298_A0.5860.73
386_H392_P0.5850.73
223_S262_T0.5850.73
83_V87_S0.5840.73
92_Y403_V0.5840.73
173_T346_V0.5830.73
85_A318_G0.5830.73
351_F370_E0.5820.73
248_N273_A0.5820.73
400_V403_V0.5810.72
41_T53_T0.5800.72
100_P354_V0.5760.72
371_L375_I0.5750.72
182_S367_V0.5750.72
128_A159_T0.5740.72
194_M197_A0.5730.71
269_G272_G0.5720.71
200_V334_T0.5710.71
303_L324_A0.5690.71
65_R405_R0.5680.71
141_V353_W0.5670.71
105_K143_A0.5660.71
283_L306_D0.5660.71
124_T156_I0.5650.70
336_V379_F0.5650.70
143_A153_M0.5650.70
257_V260_F0.5620.70
151_R154_N0.5620.70
189_T221_A0.5610.70
197_A315_A0.5610.70
97_A378_A0.5610.70
370_E373_A0.5610.70
124_T152_E0.5590.70
240_S282_L0.5590.70
119_E123_I0.5580.69
144_P348_V0.5560.69
190_G221_A0.5560.69
381_A384_D0.5540.69
320_L335_V0.5540.69
120_L124_T0.5530.69
343_A347_T0.5530.69
33_H41_T0.5530.69
214_A286_D0.5520.69
385_A392_P0.5520.69
106_G142_P0.5510.68
138_D359_R0.5500.68
301_E328_L0.5500.68
138_D166_T0.5480.68
184_G348_V0.5460.68
293_A315_A0.5440.68
187_N224_V0.5440.68
110_L116_S0.5410.67
90_M93_K0.5410.67
56_A72_I0.5400.67
208_L213_V0.5400.67
88_G92_Y0.5390.67
373_A377_D0.5390.67
397_A400_V0.5380.67
321_T324_A0.5370.67
101_Y353_W0.5370.67
194_M228_L0.5360.66
173_T185_R0.5360.66
69_K349_S0.5350.66
225_A315_A0.5340.66
161_E413_S0.5330.66
130_E159_T0.5330.66
174_G352_E0.5320.66
226_A264_T0.5300.66
243_S268_S0.5290.65
195_F198_R0.5290.65
62_N91_V0.5270.65
191_R227_K0.5260.65
144_P153_M0.5220.64
197_A225_A0.5200.64
384_D387_E0.5200.64
221_A342_N0.5200.64
117_D120_L0.5190.64
200_V379_F0.5180.64
127_F255_R0.5180.64
76_P112_P0.5160.63
69_K353_W0.5160.63
182_S348_V0.5150.63
97_A374_I0.5140.63
45_E51_I0.5130.63
196_A379_F0.5130.63
243_S276_E0.5130.63
283_L303_L0.5120.63
354_V358_Q0.5110.63
188_A368_N0.5100.63
177_L183_E0.5100.63
90_M317_N0.5100.63
76_P110_L0.5100.63
245_A278_S0.5090.62
212_T287_V0.5090.62
201_F205_D0.5080.62
188_A351_F0.5080.62
243_S267_V0.5070.62
211_A289_L0.5070.62
238_A277_L0.5070.62
298_A304_A0.5060.62
69_K173_T0.5040.62
96_V381_A0.5040.62
328_L335_V0.5020.61
348_V352_E0.5020.61
282_L285_M0.5020.61
183_E187_N0.5010.61
320_L332_G0.5010.61
35_E413_S0.5000.61
223_S254_T0.5000.61
383_T386_H0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.9808 100 0.066 Contact Map
2tmgA 5 0.976 100 0.071 Contact Map
2yfqA 5 0.9376 100 0.072 Contact Map
3aoeE 3 0.9856 100 0.077 Contact Map
1v9lA 4 0.9856 100 0.08 Contact Map
3aogA 8 0.9952 100 0.083 Contact Map
4fccA 5 0.9952 100 0.086 Contact Map
3k92A 5 0.9904 100 0.09 Contact Map
3r3jA 5 0.9904 100 0.092 Contact Map
2bmaA 5 0.9904 100 0.094 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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