Q9HRM6 - HALSA - GREMLIN Contacts

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Q9HRM6 - Aspartate aminotransferase

UniProt:	Q9HRM6	Sequences: MNFSTRVTSVEPSATLAVSTLASELEADGVDVVDLSVGEPDFDTPESIVDAGKAAMDAGHTGYAPSNGVPELRDAIAEKLQGDGLDYEAGNVIVTPGAKQALYETFQAVVDEGDEVALLDPAWVSYEAMAKLAGGELNRVDLAPHDFQLEPALDDLADAVSDDTELLVVNSPSNPTGAVYSRAAMEGVRDLAVDHDITVISDEIYQRVNYGPAHVSLAGLDGMFERTVTINGFSKAYSMTGWRLGYLAGPEALVDQAGKVQSHSVSSAANFIQRAGVEAIRHTDDAIDEMVAAFESRRDLLVDLFAEHGTDVSTPDGAFYLMLPVADDDQAWCQDALKDAHVATVPGSAFGAPGYARLSYAASTDRLEAAVDRLAAEGYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (343)
Sequences:	43669 (30226)
Seq/√Len:	1632.0

ECOLI - ALAC YBDL ALAA AVTA YJIR MALY YDCR HIS8
BACSU - AAT1 MTNE AAT2 YUGH PATA AAT3 CBL YDFD YISV YCXD YDEF HIS8 YHDI YDEL GABR
HALSA - Q9HRM6 Q9HQK2 Q9HRX4 Q9HQW2 HIS8 Q9HPL0
SULSO - AAT Y104 Q97YX5 Q97TY7 HIS8 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_T	101_A	3.019	1.00
53_K	57_D	3.011	1.00
157_A	194_D	2.987	1.00
115_E	136_E	2.927	1.00
295_E	299_D	2.777	1.00
340_A	376_A	2.769	1.00
114_D	165_E	2.747	1.00
182_R	186_E	2.740	1.00
311_D	324_P	2.739	1.00
75_A	281_R	2.635	1.00
335_D	339_D	2.610	1.00
296_S	364_T	2.590	1.00
369_A	373_R	2.563	1.00
300_L	368_E	2.560	1.00
110_V	135_G	2.481	1.00
46_E	50_D	2.392	1.00
249_G	254_V	2.352	1.00
81_Q	86_D	2.326	1.00
71_E	277_V	2.236	1.00
103_Y	107_Q	2.209	1.00
244_L	276_G	2.133	1.00
181_S	184_A	2.120	1.00
328_D	331_A	2.109	1.00
186_E	190_D	2.084	1.00
304_L	371_V	2.059	1.00
82_G	284_D	2.012	1.00
369_A	372_D	1.993	1.00
50_D	54_A	1.957	1.00
154_D	187_G	1.914	1.00
130_A	135_G	1.873	1.00
115_E	138_N	1.862	1.00
304_L	307_E	1.856	1.00
74_D	78_E	1.855	1.00
143_A	184_A	1.842	1.00
303_D	307_E	1.818	1.00
78_E	281_R	1.814	1.00
196_D	226_R	1.788	1.00
302_V	306_A	1.769	1.00
157_A	187_G	1.768	1.00
74_D	89_A	1.757	1.00
155_D	159_A	1.756	1.00
192_A	199_V	1.736	1.00
152_A	155_D	1.734	1.00
35_L	370_A	1.731	1.00
299_D	303_D	1.721	1.00
105_T	228_V	1.719	1.00
306_A	312_V	1.715	1.00
304_L	372_D	1.692	1.00
204_I	232_G	1.685	1.00
166_L	200_I	1.680	1.00
300_L	304_L	1.672	1.00
200_I	230_I	1.665	1.00
115_E	164_T	1.664	1.00
363_S	366_R	1.662	1.00
77_A	89_A	1.658	1.00
302_V	314_T	1.654	1.00
115_E	161_S	1.635	1.00
120_D	139_R	1.618	1.00
105_T	200_I	1.618	1.00
70_P	74_D	1.617	1.00
91_N	251_E	1.610	1.00
98_A	230_I	1.597	1.00
54_A	278_E	1.566	1.00
115_E	163_D	1.555	1.00
155_D	158_D	1.548	1.00
301_L	321_L	1.548	1.00
187_G	190_D	1.543	1.00
75_A	78_E	1.522	1.00
106_F	130_A	1.520	1.00
127_E	131_K	1.520	1.00
87_Y	248_A	1.518	1.00
304_L	375_A	1.517	1.00
116_V	130_A	1.515	1.00
344_T	356_A	1.501	1.00
76_I	246_Y	1.477	1.00
300_L	364_T	1.454	1.00
49_V	53_K	1.453	1.00
80_L	248_A	1.444	1.00
190_D	194_D	1.439	1.00
247_L	257_A	1.432	1.00
71_E	281_R	1.423	1.00
288_D	292_A	1.421	1.00
329_D	348_S	1.413	1.00
322_M	347_G	1.410	1.00
183_A	186_E	1.408	1.00
269_A	272_I	1.406	1.00
340_A	373_R	1.402	1.00
90_G	251_E	1.401	1.00
153_L	191_L	1.394	1.00
192_A	197_I	1.382	1.00
157_A	195_H	1.380	1.00
302_V	321_L	1.379	1.00
331_A	335_D	1.378	1.00
120_D	141_D	1.374	1.00
233_F	276_G	1.333	1.00
160_V	191_L	1.329	1.00
93_I	254_V	1.317	1.00
52_G	56_M	1.314	1.00
161_S	164_T	1.312	1.00
75_A	277_V	1.309	1.00
306_A	314_T	1.297	1.00
307_E	375_A	1.295	1.00
293_A	296_S	1.291	1.00
368_E	372_D	1.290	1.00
191_L	195_H	1.288	1.00
153_L	187_G	1.283	1.00
331_A	334_Q	1.282	1.00
117_A	164_T	1.281	1.00
301_L	371_V	1.279	1.00
228_V	249_G	1.278	1.00
372_D	376_A	1.270	1.00
141_D	155_D	1.268	1.00
76_I	94_V	1.263	1.00
302_V	312_V	1.258	1.00
323_L	358_L	1.258	1.00
106_F	168_V	1.255	1.00
288_D	291_V	1.255	1.00
49_V	57_D	1.255	1.00
293_A	364_T	1.240	1.00
184_A	187_G	1.231	1.00
50_D	53_K	1.229	1.00
100_Q	261_Q	1.228	1.00
78_E	82_G	1.227	1.00
118_L	137_L	1.226	1.00
324_P	355_Y	1.221	1.00
52_G	275_A	1.220	1.00
69_V	274_R	1.219	1.00
190_D	193_V	1.217	1.00
67_N	258_G	1.213	1.00
51_A	278_E	1.211	1.00
127_E	139_R	1.206	1.00
80_L	246_Y	1.196	1.00
191_L	197_I	1.195	1.00
364_T	368_E	1.186	1.00
143_A	146_D	1.183	1.00
292_A	295_E	1.182	1.00
106_F	110_V	1.176	1.00
182_R	215_V	1.170	1.00
67_N	73_R	1.168	1.00
298_R	302_V	1.166	1.00
231_N	246_Y	1.156	1.00
256_Q	259_K	1.154	1.00
76_I	92_V	1.145	1.00
30_V	341_H	1.143	1.00
261_Q	265_V	1.139	1.00
73_R	77_A	1.136	1.00
117_A	140_V	1.136	1.00
277_V	281_R	1.128	1.00
189_R	223_M	1.128	1.00
366_R	369_A	1.128	1.00
182_R	220_L	1.127	1.00
158_D	162_D	1.122	1.00
108_A	260_V	1.115	1.00
143_A	152_A	1.113	1.00
96_P	100_Q	1.112	1.00
293_A	297_R	1.111	1.00
110_V	116_V	1.108	1.00
71_E	274_R	1.107	1.00
157_A	191_L	1.107	1.00
304_L	368_E	1.104	1.00
157_A	161_S	1.101	1.00
278_E	281_R	1.099	1.00
336_A	374_L	1.097	1.00
333_C	344_T	1.096	1.00
292_A	296_S	1.096	1.00
54_A	58_A	1.091	1.00
225_E	250_P	1.089	1.00
111_D	114_D	1.087	1.00
183_A	187_G	1.079	1.00
255_D	259_K	1.077	1.00
107_Q	133_A	1.076	1.00
182_R	219_G	1.072	1.00
88_E	91_N	1.070	1.00
101_A	247_L	1.069	1.00
228_V	247_L	1.068	1.00
211_G	316_D	1.063	1.00
70_P	89_A	1.063	1.00
109_V	166_L	1.062	1.00
112_E	134_G	1.062	1.00
284_D	288_D	1.061	1.00
88_E	251_E	1.059	1.00
297_R	300_L	1.055	1.00
216_S	219_G	1.049	1.00
47_S	282_H	1.045	1.00
167_L	197_I	1.044	1.00
46_E	49_V	1.042	1.00
79_K	284_D	1.035	1.00
77_A	92_V	1.030	1.00
130_A	137_L	1.023	1.00
77_A	88_E	1.021	1.00
198_T	228_V	1.018	1.00
70_P	73_R	1.016	1.00
122_A	170_N	1.013	1.00
49_V	56_M	1.013	1.00
104_E	261_Q	1.008	1.00
330_Q	348_S	1.008	1.00
298_R	360_Y	1.002	1.00
51_A	54_A	0.997	1.00
71_E	74_D	0.997	1.00
109_V	198_T	0.995	1.00
217_L	220_L	0.993	1.00
91_N	254_V	0.990	1.00
336_A	344_T	0.978	1.00
72_L	94_V	0.978	1.00
101_A	230_I	0.975	1.00
198_T	226_R	0.968	1.00
116_V	166_L	0.965	1.00
186_E	220_L	0.961	1.00
193_V	224_F	0.959	1.00
193_V	225_E	0.957	1.00
151_P	184_A	0.955	1.00
189_R	199_V	0.954	1.00
140_V	159_A	0.947	1.00
93_I	257_A	0.946	1.00
299_D	314_T	0.946	1.00
96_P	269_A	0.943	1.00
332_W	356_A	0.941	1.00
92_V	248_A	0.940	1.00
108_A	257_A	0.939	1.00
186_E	223_M	0.938	1.00
189_R	227_T	0.933	1.00
278_E	282_H	0.928	1.00
154_D	158_D	0.918	1.00
303_D	306_A	0.917	1.00
335_D	340_A	0.913	1.00
160_V	197_I	0.912	1.00
126_Y	168_V	0.912	1.00
31_D	341_H	0.910	1.00
205_Y	320_Y	0.896	1.00
300_L	303_D	0.896	1.00
310_T	325_V	0.895	1.00
303_D	368_E	0.891	1.00
105_T	257_A	0.889	1.00
98_A	204_I	0.880	1.00
289_E	292_A	0.875	1.00
230_I	247_L	0.875	1.00
160_V	164_T	0.873	1.00
222_G	225_E	0.870	1.00
91_N	224_F	0.870	1.00
40_P	294_F	0.867	1.00
42_F	293_A	0.865	1.00
198_T	253_L	0.865	1.00
131_K	137_L	0.865	1.00
199_V	217_L	0.861	1.00
330_Q	334_Q	0.858	1.00
51_A	55_A	0.856	1.00
217_L	227_T	0.856	1.00
161_S	195_H	0.855	1.00
153_L	188_V	0.851	1.00
301_L	367_L	0.851	1.00
99_K	125_S	0.850	1.00
218_A	229_T	0.848	1.00
117_A	167_L	0.848	1.00
342_V	374_L	0.848	1.00
79_K	207_R	0.847	1.00
54_A	57_D	0.847	1.00
251_E	255_D	0.847	1.00
254_V	258_G	0.846	1.00
289_E	293_A	0.844	1.00
143_A	155_D	0.843	1.00
301_L	304_L	0.842	1.00
154_D	157_A	0.839	1.00
98_A	232_G	0.834	1.00
182_R	213_A	0.834	1.00
310_T	323_L	0.832	1.00
285_D	289_E	0.831	1.00
298_R	315_P	0.831	1.00
164_T	197_I	0.829	1.00
117_A	159_A	0.829	1.00
358_L	370_A	0.828	1.00
50_D	57_D	0.828	1.00
79_K	237_Y	0.828	1.00
334_Q	339_D	0.817	1.00
311_D	326_A	0.815	1.00
69_V	277_V	0.814	1.00
344_T	358_L	0.813	1.00
153_L	157_A	0.813	1.00
203_E	229_T	0.811	1.00
210_Y	295_E	0.807	1.00
274_R	277_V	0.803	1.00
153_L	184_A	0.800	1.00
97_G	243_R	0.796	1.00
99_K	123_W	0.796	1.00
193_V	226_R	0.795	1.00
365_D	368_E	0.794	1.00
47_S	50_D	0.791	1.00
35_L	367_L	0.791	1.00
100_Q	265_V	0.791	1.00
244_L	268_A	0.790	1.00
78_E	81_Q	0.789	1.00
95_T	247_L	0.787	1.00
209_N	212_P	0.786	1.00
119_L	140_V	0.786	1.00
296_S	299_D	0.786	1.00
47_S	278_E	0.785	1.00
110_V	166_L	0.785	1.00
249_G	257_A	0.778	1.00
116_V	135_G	0.777	1.00
207_R	236_A	0.771	1.00
72_L	76_I	0.768	1.00
110_V	114_D	0.767	1.00
31_D	369_A	0.762	1.00
209_N	214_H	0.760	1.00
285_D	288_D	0.757	1.00
325_V	356_A	0.755	1.00
244_L	272_I	0.755	1.00
286_A	290_M	0.751	1.00
119_L	151_P	0.750	1.00
193_V	222_G	0.750	1.00
228_V	253_L	0.748	1.00
301_L	360_Y	0.748	1.00
261_Q	268_A	0.747	1.00
233_F	246_Y	0.746	1.00
117_A	156_L	0.745	1.00
106_F	166_L	0.744	1.00
79_K	83_D	0.744	1.00
138_N	161_S	0.742	1.00
214_H	218_A	0.741	1.00
300_L	371_V	0.738	1.00
225_E	252_A	0.735	1.00
330_Q	346_P	0.734	1.00
69_V	273_Q	0.730	1.00
68_G	73_R	0.729	1.00
223_M	227_T	0.726	1.00
100_Q	104_E	0.725	1.00
142_L	173_S	0.725	1.00
52_G	271_F	0.724	1.00
329_D	346_P	0.721	1.00
119_L	173_S	0.721	1.00
193_V	223_M	0.718	1.00
34_D	39_E	0.718	1.00
43_D	49_V	0.711	1.00
53_K	56_M	0.709	1.00
138_N	164_T	0.707	1.00
329_D	333_C	0.707	1.00
93_I	247_L	0.704	1.00
342_V	373_R	0.704	1.00
290_M	294_F	0.699	1.00
118_L	130_A	0.699	1.00
332_W	336_A	0.695	1.00
333_C	346_P	0.689	1.00
215_V	220_L	0.688	1.00
173_S	176_T	0.687	1.00
156_L	167_L	0.681	1.00
174_N	205_Y	0.680	1.00
299_D	302_V	0.679	1.00
60_H	274_R	0.678	1.00
77_A	87_Y	0.677	1.00
286_A	289_E	0.676	1.00
152_A	184_A	0.675	1.00
160_V	195_H	0.672	1.00
223_M	226_R	0.668	1.00
45_P	48_I	0.668	1.00
75_A	280_I	0.668	1.00
44_T	47_S	0.667	1.00
115_E	165_E	0.666	1.00
113_G	136_E	0.665	1.00
203_E	216_S	0.662	1.00
126_Y	130_A	0.661	1.00
342_V	370_A	0.660	1.00
55_A	275_A	0.660	1.00
104_E	257_A	0.660	1.00
156_L	191_L	0.658	1.00
347_G	355_Y	0.658	1.00
128_A	131_K	0.658	1.00
144_P	311_D	0.656	1.00
367_L	370_A	0.654	1.00
328_D	332_W	0.654	1.00
168_V	200_I	0.653	1.00
333_C	356_A	0.653	1.00
102_L	129_M	0.653	1.00
31_D	366_R	0.652	1.00
105_T	230_I	0.652	1.00
224_F	227_T	0.650	1.00
120_D	351_G	0.649	1.00
167_L	192_A	0.649	1.00
237_Y	284_D	0.647	1.00
73_R	89_A	0.645	1.00
236_A	287_I	0.645	1.00
85_L	218_A	0.645	1.00
29_G	341_H	0.643	1.00
296_S	300_L	0.640	1.00
146_D	155_D	0.636	1.00
307_E	368_E	0.634	1.00
304_L	308_H	0.633	1.00
347_G	350_F	0.633	1.00
322_M	355_Y	0.631	1.00
323_L	355_Y	0.631	1.00
329_D	332_W	0.631	1.00
169_V	185_M	0.630	1.00
94_V	244_L	0.627	1.00
211_G	295_E	0.624	1.00
287_I	291_V	0.623	1.00
301_L	358_L	0.619	1.00
106_F	135_G	0.618	1.00
140_V	155_D	0.617	1.00
103_Y	133_A	0.616	1.00
83_D	206_Q	0.609	1.00
38_G	205_Y	0.609	1.00
201_S	229_T	0.609	1.00
372_D	375_A	0.608	1.00
104_E	260_V	0.607	1.00
99_K	266_S	0.606	1.00
300_L	367_L	0.605	1.00
107_Q	260_V	0.604	1.00
41_D	297_R	0.603	1.00
44_T	49_V	0.600	1.00
171_S	203_E	0.600	1.00
144_P	324_P	0.598	1.00
48_I	239_M	0.596	1.00
214_H	219_G	0.596	1.00
211_G	298_R	0.595	1.00
362_A	366_R	0.595	1.00
47_S	286_A	0.594	1.00
118_L	127_E	0.592	1.00
172_P	317_G	0.591	1.00
55_A	58_A	0.590	1.00
208_V	291_V	0.587	1.00
106_F	133_A	0.586	1.00
138_N	159_A	0.585	1.00
312_V	321_L	0.585	1.00
210_Y	360_Y	0.584	1.00
298_R	314_T	0.583	1.00
151_P	156_L	0.583	1.00
44_T	286_A	0.581	1.00
164_T	167_L	0.580	1.00
80_L	229_T	0.579	1.00
249_G	253_L	0.577	1.00
178_A	316_D	0.576	1.00
44_T	48_I	0.576	1.00
103_Y	129_M	0.576	1.00
145_H	184_A	0.574	1.00
118_L	139_R	0.572	1.00
33_V	369_A	0.572	1.00
199_V	223_M	0.572	1.00
87_Y	91_N	0.572	1.00
48_I	279_A	0.571	1.00
305_F	323_L	0.570	1.00
180_Y	184_A	0.570	1.00
291_V	295_E	0.570	1.00
93_I	258_G	0.569	1.00
252_A	255_D	0.568	1.00
201_S	217_L	0.566	1.00
146_D	184_A	0.564	1.00
295_E	298_R	0.563	1.00
275_A	278_E	0.561	1.00
79_K	206_Q	0.560	1.00
215_V	219_G	0.558	1.00
210_Y	298_R	0.557	1.00
180_Y	185_M	0.556	1.00
94_V	273_Q	0.555	1.00
337_L	343_A	0.554	1.00
297_R	364_T	0.553	1.00
250_P	253_L	0.553	1.00
192_A	196_D	0.553	1.00
51_A	275_A	0.550	1.00
258_G	261_Q	0.550	1.00
73_R	258_G	0.549	1.00
58_A	278_E	0.549	1.00
333_C	336_A	0.548	1.00
274_R	278_E	0.545	1.00
93_I	249_G	0.545	1.00
158_D	161_S	0.543	1.00
106_F	129_M	0.542	1.00
111_D	165_E	0.542	1.00
255_D	258_G	0.542	1.00
369_A	376_A	0.539	1.00
141_D	159_A	0.539	1.00
270_N	274_R	0.536	1.00
373_R	376_A	0.534	1.00
324_P	354_G	0.534	1.00
114_D	163_D	0.533	1.00
216_S	229_T	0.533	1.00
306_A	311_D	0.532	1.00
297_R	363_S	0.531	1.00
29_G	32_V	0.531	1.00
329_D	354_G	0.531	1.00
96_P	268_A	0.530	1.00
333_C	337_L	0.529	1.00
171_S	179_V	0.529	1.00
74_D	281_R	0.529	1.00
74_D	77_A	0.528	1.00
64_A	69_V	0.528	1.00
311_D	327_D	0.527	1.00
348_S	353_P	0.526	1.00
329_D	356_A	0.525	1.00
322_M	357_R	0.525	1.00
214_H	220_L	0.524	1.00
233_F	280_I	0.524	1.00
141_D	152_A	0.522	1.00
81_Q	84_G	0.521	1.00
239_M	279_A	0.521	1.00
174_N	357_R	0.520	1.00
81_Q	85_L	0.518	1.00
185_M	217_L	0.517	1.00
206_Q	231_N	0.517	1.00
38_G	320_Y	0.516	1.00
234_S	243_R	0.516	1.00
82_G	281_R	0.515	1.00
105_T	166_L	0.515	1.00
52_G	55_A	0.512	1.00
34_D	37_V	0.512	1.00
185_M	201_S	0.512	1.00
72_L	276_G	0.511	1.00
328_D	348_S	0.510	1.00
47_S	285_D	0.509	1.00
326_A	354_G	0.506	1.00
103_Y	264_S	0.505	1.00
33_V	373_R	0.505	1.00
216_S	220_L	0.505	1.00
69_V	270_N	0.503	1.00
151_P	167_L	0.502	1.00
213_A	217_L	0.501	1.00
64_A	267_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1b5pA	2	0.9842	100	0.268	Contact Map
1j32A	2	0.9974	100	0.269	Contact Map
2x5dA	3	0.9632	100	0.274	Contact Map
1gd9A	2	0.9842	100	0.276	Contact Map
3dydA	2	0.9526	100	0.278	Contact Map
1xi9A	4	0.9921	100	0.279	Contact Map
3h14A	2	0.95	100	0.28	Contact Map
2o0rA	2	0.9816	100	0.281	Contact Map
1o4sA	2	0.9895	100	0.281	Contact Map
3jtxA	2	0.9816	100	0.285	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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