GREMLIN Database
Q9HRM6 - Aspartate aminotransferase
UniProt: Q9HRM6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (343)
Sequences: 43669 (30226)
Seq/√Len: 1632.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_T101_A3.0191.00
53_K57_D3.0111.00
157_A194_D2.9871.00
115_E136_E2.9271.00
295_E299_D2.7771.00
340_A376_A2.7691.00
114_D165_E2.7471.00
182_R186_E2.7401.00
311_D324_P2.7391.00
75_A281_R2.6351.00
335_D339_D2.6101.00
296_S364_T2.5901.00
369_A373_R2.5631.00
300_L368_E2.5601.00
110_V135_G2.4811.00
46_E50_D2.3921.00
249_G254_V2.3521.00
81_Q86_D2.3261.00
71_E277_V2.2361.00
103_Y107_Q2.2091.00
244_L276_G2.1331.00
181_S184_A2.1201.00
328_D331_A2.1091.00
186_E190_D2.0841.00
304_L371_V2.0591.00
82_G284_D2.0121.00
369_A372_D1.9931.00
50_D54_A1.9571.00
154_D187_G1.9141.00
130_A135_G1.8731.00
115_E138_N1.8621.00
304_L307_E1.8561.00
74_D78_E1.8551.00
143_A184_A1.8421.00
303_D307_E1.8181.00
78_E281_R1.8141.00
196_D226_R1.7881.00
302_V306_A1.7691.00
157_A187_G1.7681.00
74_D89_A1.7571.00
155_D159_A1.7561.00
192_A199_V1.7361.00
152_A155_D1.7341.00
35_L370_A1.7311.00
299_D303_D1.7211.00
105_T228_V1.7191.00
306_A312_V1.7151.00
304_L372_D1.6921.00
204_I232_G1.6851.00
166_L200_I1.6801.00
300_L304_L1.6721.00
200_I230_I1.6651.00
115_E164_T1.6641.00
363_S366_R1.6621.00
77_A89_A1.6581.00
302_V314_T1.6541.00
115_E161_S1.6351.00
120_D139_R1.6181.00
105_T200_I1.6181.00
70_P74_D1.6171.00
91_N251_E1.6101.00
98_A230_I1.5971.00
54_A278_E1.5661.00
115_E163_D1.5551.00
155_D158_D1.5481.00
301_L321_L1.5481.00
187_G190_D1.5431.00
75_A78_E1.5221.00
106_F130_A1.5201.00
127_E131_K1.5201.00
87_Y248_A1.5181.00
304_L375_A1.5171.00
116_V130_A1.5151.00
344_T356_A1.5011.00
76_I246_Y1.4771.00
300_L364_T1.4541.00
49_V53_K1.4531.00
80_L248_A1.4441.00
190_D194_D1.4391.00
247_L257_A1.4321.00
71_E281_R1.4231.00
288_D292_A1.4211.00
329_D348_S1.4131.00
322_M347_G1.4101.00
183_A186_E1.4081.00
269_A272_I1.4061.00
340_A373_R1.4021.00
90_G251_E1.4011.00
153_L191_L1.3941.00
192_A197_I1.3821.00
157_A195_H1.3801.00
302_V321_L1.3791.00
331_A335_D1.3781.00
120_D141_D1.3741.00
233_F276_G1.3331.00
160_V191_L1.3291.00
93_I254_V1.3171.00
52_G56_M1.3141.00
161_S164_T1.3121.00
75_A277_V1.3091.00
306_A314_T1.2971.00
307_E375_A1.2951.00
293_A296_S1.2911.00
368_E372_D1.2901.00
191_L195_H1.2881.00
153_L187_G1.2831.00
331_A334_Q1.2821.00
117_A164_T1.2811.00
301_L371_V1.2791.00
228_V249_G1.2781.00
372_D376_A1.2701.00
141_D155_D1.2681.00
76_I94_V1.2631.00
302_V312_V1.2581.00
323_L358_L1.2581.00
106_F168_V1.2551.00
288_D291_V1.2551.00
49_V57_D1.2551.00
293_A364_T1.2401.00
184_A187_G1.2311.00
50_D53_K1.2291.00
100_Q261_Q1.2281.00
78_E82_G1.2271.00
118_L137_L1.2261.00
324_P355_Y1.2211.00
52_G275_A1.2201.00
69_V274_R1.2191.00
190_D193_V1.2171.00
67_N258_G1.2131.00
51_A278_E1.2111.00
127_E139_R1.2061.00
80_L246_Y1.1961.00
191_L197_I1.1951.00
364_T368_E1.1861.00
143_A146_D1.1831.00
292_A295_E1.1821.00
106_F110_V1.1761.00
182_R215_V1.1701.00
67_N73_R1.1681.00
298_R302_V1.1661.00
231_N246_Y1.1561.00
256_Q259_K1.1541.00
76_I92_V1.1451.00
30_V341_H1.1431.00
261_Q265_V1.1391.00
73_R77_A1.1361.00
117_A140_V1.1361.00
277_V281_R1.1281.00
189_R223_M1.1281.00
366_R369_A1.1281.00
182_R220_L1.1271.00
158_D162_D1.1221.00
108_A260_V1.1151.00
143_A152_A1.1131.00
96_P100_Q1.1121.00
293_A297_R1.1111.00
110_V116_V1.1081.00
71_E274_R1.1071.00
157_A191_L1.1071.00
304_L368_E1.1041.00
157_A161_S1.1011.00
278_E281_R1.0991.00
336_A374_L1.0971.00
333_C344_T1.0961.00
292_A296_S1.0961.00
54_A58_A1.0911.00
225_E250_P1.0891.00
111_D114_D1.0871.00
183_A187_G1.0791.00
255_D259_K1.0771.00
107_Q133_A1.0761.00
182_R219_G1.0721.00
88_E91_N1.0701.00
101_A247_L1.0691.00
228_V247_L1.0681.00
211_G316_D1.0631.00
70_P89_A1.0631.00
109_V166_L1.0621.00
112_E134_G1.0621.00
284_D288_D1.0611.00
88_E251_E1.0591.00
297_R300_L1.0551.00
216_S219_G1.0491.00
47_S282_H1.0451.00
167_L197_I1.0441.00
46_E49_V1.0421.00
79_K284_D1.0351.00
77_A92_V1.0301.00
130_A137_L1.0231.00
77_A88_E1.0211.00
198_T228_V1.0181.00
70_P73_R1.0161.00
122_A170_N1.0131.00
49_V56_M1.0131.00
104_E261_Q1.0081.00
330_Q348_S1.0081.00
298_R360_Y1.0021.00
51_A54_A0.9971.00
71_E74_D0.9971.00
109_V198_T0.9951.00
217_L220_L0.9931.00
91_N254_V0.9901.00
336_A344_T0.9781.00
72_L94_V0.9781.00
101_A230_I0.9751.00
198_T226_R0.9681.00
116_V166_L0.9651.00
186_E220_L0.9611.00
193_V224_F0.9591.00
193_V225_E0.9571.00
151_P184_A0.9551.00
189_R199_V0.9541.00
140_V159_A0.9471.00
93_I257_A0.9461.00
299_D314_T0.9461.00
96_P269_A0.9431.00
332_W356_A0.9411.00
92_V248_A0.9401.00
108_A257_A0.9391.00
186_E223_M0.9381.00
189_R227_T0.9331.00
278_E282_H0.9281.00
154_D158_D0.9181.00
303_D306_A0.9171.00
335_D340_A0.9131.00
160_V197_I0.9121.00
126_Y168_V0.9121.00
31_D341_H0.9101.00
205_Y320_Y0.8961.00
300_L303_D0.8961.00
310_T325_V0.8951.00
303_D368_E0.8911.00
105_T257_A0.8891.00
98_A204_I0.8801.00
289_E292_A0.8751.00
230_I247_L0.8751.00
160_V164_T0.8731.00
222_G225_E0.8701.00
91_N224_F0.8701.00
40_P294_F0.8671.00
42_F293_A0.8651.00
198_T253_L0.8651.00
131_K137_L0.8651.00
199_V217_L0.8611.00
330_Q334_Q0.8581.00
51_A55_A0.8561.00
217_L227_T0.8561.00
161_S195_H0.8551.00
153_L188_V0.8511.00
301_L367_L0.8511.00
99_K125_S0.8501.00
218_A229_T0.8481.00
117_A167_L0.8481.00
342_V374_L0.8481.00
79_K207_R0.8471.00
54_A57_D0.8471.00
251_E255_D0.8471.00
254_V258_G0.8461.00
289_E293_A0.8441.00
143_A155_D0.8431.00
301_L304_L0.8421.00
154_D157_A0.8391.00
98_A232_G0.8341.00
182_R213_A0.8341.00
310_T323_L0.8321.00
285_D289_E0.8311.00
298_R315_P0.8311.00
164_T197_I0.8291.00
117_A159_A0.8291.00
358_L370_A0.8281.00
50_D57_D0.8281.00
79_K237_Y0.8281.00
334_Q339_D0.8171.00
311_D326_A0.8151.00
69_V277_V0.8141.00
344_T358_L0.8131.00
153_L157_A0.8131.00
203_E229_T0.8111.00
210_Y295_E0.8071.00
274_R277_V0.8031.00
153_L184_A0.8001.00
97_G243_R0.7961.00
99_K123_W0.7961.00
193_V226_R0.7951.00
365_D368_E0.7941.00
47_S50_D0.7911.00
35_L367_L0.7911.00
100_Q265_V0.7911.00
244_L268_A0.7901.00
78_E81_Q0.7891.00
95_T247_L0.7871.00
209_N212_P0.7861.00
119_L140_V0.7861.00
296_S299_D0.7861.00
47_S278_E0.7851.00
110_V166_L0.7851.00
249_G257_A0.7781.00
116_V135_G0.7771.00
207_R236_A0.7711.00
72_L76_I0.7681.00
110_V114_D0.7671.00
31_D369_A0.7621.00
209_N214_H0.7601.00
285_D288_D0.7571.00
325_V356_A0.7551.00
244_L272_I0.7551.00
286_A290_M0.7511.00
119_L151_P0.7501.00
193_V222_G0.7501.00
228_V253_L0.7481.00
301_L360_Y0.7481.00
261_Q268_A0.7471.00
233_F246_Y0.7461.00
117_A156_L0.7451.00
106_F166_L0.7441.00
79_K83_D0.7441.00
138_N161_S0.7421.00
214_H218_A0.7411.00
300_L371_V0.7381.00
225_E252_A0.7351.00
330_Q346_P0.7341.00
69_V273_Q0.7301.00
68_G73_R0.7291.00
223_M227_T0.7261.00
100_Q104_E0.7251.00
142_L173_S0.7251.00
52_G271_F0.7241.00
329_D346_P0.7211.00
119_L173_S0.7211.00
193_V223_M0.7181.00
34_D39_E0.7181.00
43_D49_V0.7111.00
53_K56_M0.7091.00
138_N164_T0.7071.00
329_D333_C0.7071.00
93_I247_L0.7041.00
342_V373_R0.7041.00
290_M294_F0.6991.00
118_L130_A0.6991.00
332_W336_A0.6951.00
333_C346_P0.6891.00
215_V220_L0.6881.00
173_S176_T0.6871.00
156_L167_L0.6811.00
174_N205_Y0.6801.00
299_D302_V0.6791.00
60_H274_R0.6781.00
77_A87_Y0.6771.00
286_A289_E0.6761.00
152_A184_A0.6751.00
160_V195_H0.6721.00
223_M226_R0.6681.00
45_P48_I0.6681.00
75_A280_I0.6681.00
44_T47_S0.6671.00
115_E165_E0.6661.00
113_G136_E0.6651.00
203_E216_S0.6621.00
126_Y130_A0.6611.00
342_V370_A0.6601.00
55_A275_A0.6601.00
104_E257_A0.6601.00
156_L191_L0.6581.00
347_G355_Y0.6581.00
128_A131_K0.6581.00
144_P311_D0.6561.00
367_L370_A0.6541.00
328_D332_W0.6541.00
168_V200_I0.6531.00
333_C356_A0.6531.00
102_L129_M0.6531.00
31_D366_R0.6521.00
105_T230_I0.6521.00
224_F227_T0.6501.00
120_D351_G0.6491.00
167_L192_A0.6491.00
237_Y284_D0.6471.00
73_R89_A0.6451.00
236_A287_I0.6451.00
85_L218_A0.6451.00
29_G341_H0.6431.00
296_S300_L0.6401.00
146_D155_D0.6361.00
307_E368_E0.6341.00
304_L308_H0.6331.00
347_G350_F0.6331.00
322_M355_Y0.6311.00
323_L355_Y0.6311.00
329_D332_W0.6311.00
169_V185_M0.6301.00
94_V244_L0.6271.00
211_G295_E0.6241.00
287_I291_V0.6231.00
301_L358_L0.6191.00
106_F135_G0.6181.00
140_V155_D0.6171.00
103_Y133_A0.6161.00
83_D206_Q0.6091.00
38_G205_Y0.6091.00
201_S229_T0.6091.00
372_D375_A0.6081.00
104_E260_V0.6071.00
99_K266_S0.6061.00
300_L367_L0.6051.00
107_Q260_V0.6041.00
41_D297_R0.6031.00
44_T49_V0.6001.00
171_S203_E0.6001.00
144_P324_P0.5981.00
48_I239_M0.5961.00
214_H219_G0.5961.00
211_G298_R0.5951.00
362_A366_R0.5951.00
47_S286_A0.5941.00
118_L127_E0.5921.00
172_P317_G0.5911.00
55_A58_A0.5901.00
208_V291_V0.5871.00
106_F133_A0.5861.00
138_N159_A0.5851.00
312_V321_L0.5851.00
210_Y360_Y0.5841.00
298_R314_T0.5831.00
151_P156_L0.5831.00
44_T286_A0.5811.00
164_T167_L0.5801.00
80_L229_T0.5791.00
249_G253_L0.5771.00
178_A316_D0.5761.00
44_T48_I0.5761.00
103_Y129_M0.5761.00
145_H184_A0.5741.00
118_L139_R0.5721.00
33_V369_A0.5721.00
199_V223_M0.5721.00
87_Y91_N0.5721.00
48_I279_A0.5711.00
305_F323_L0.5701.00
180_Y184_A0.5701.00
291_V295_E0.5701.00
93_I258_G0.5691.00
252_A255_D0.5681.00
201_S217_L0.5661.00
146_D184_A0.5641.00
295_E298_R0.5631.00
275_A278_E0.5611.00
79_K206_Q0.5601.00
215_V219_G0.5581.00
210_Y298_R0.5571.00
180_Y185_M0.5561.00
94_V273_Q0.5551.00
337_L343_A0.5541.00
297_R364_T0.5531.00
250_P253_L0.5531.00
192_A196_D0.5531.00
51_A275_A0.5501.00
258_G261_Q0.5501.00
73_R258_G0.5491.00
58_A278_E0.5491.00
333_C336_A0.5481.00
274_R278_E0.5451.00
93_I249_G0.5451.00
158_D161_S0.5431.00
106_F129_M0.5421.00
111_D165_E0.5421.00
255_D258_G0.5421.00
369_A376_A0.5391.00
141_D159_A0.5391.00
270_N274_R0.5361.00
373_R376_A0.5341.00
324_P354_G0.5341.00
114_D163_D0.5331.00
216_S229_T0.5331.00
306_A311_D0.5321.00
297_R363_S0.5311.00
29_G32_V0.5311.00
329_D354_G0.5311.00
96_P268_A0.5301.00
333_C337_L0.5291.00
171_S179_V0.5291.00
74_D281_R0.5291.00
74_D77_A0.5281.00
64_A69_V0.5281.00
311_D327_D0.5271.00
348_S353_P0.5261.00
329_D356_A0.5251.00
322_M357_R0.5251.00
214_H220_L0.5241.00
233_F280_I0.5241.00
141_D152_A0.5221.00
81_Q84_G0.5211.00
239_M279_A0.5211.00
174_N357_R0.5201.00
81_Q85_L0.5181.00
185_M217_L0.5171.00
206_Q231_N0.5171.00
38_G320_Y0.5161.00
234_S243_R0.5161.00
82_G281_R0.5151.00
105_T166_L0.5151.00
52_G55_A0.5121.00
34_D37_V0.5121.00
185_M201_S0.5121.00
72_L276_G0.5111.00
328_D348_S0.5101.00
47_S285_D0.5091.00
326_A354_G0.5061.00
103_Y264_S0.5051.00
33_V373_R0.5051.00
216_S220_L0.5051.00
69_V270_N0.5031.00
151_P167_L0.5021.00
213_A217_L0.5011.00
64_A267_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b5pA 2 0.9842 100 0.268 Contact Map
1j32A 2 0.9974 100 0.269 Contact Map
2x5dA 3 0.9632 100 0.274 Contact Map
1gd9A 2 0.9842 100 0.276 Contact Map
3dydA 2 0.9526 100 0.278 Contact Map
1xi9A 4 0.9921 100 0.279 Contact Map
3h14A 2 0.95 100 0.28 Contact Map
2o0rA 2 0.9816 100 0.281 Contact Map
1o4sA 2 0.9895 100 0.281 Contact Map
3jtxA 2 0.9816 100 0.285 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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