GREMLIN Database
RISB - 6,7-dimethyl-8-ribityllumazine synthase
UniProt: Q9HRM5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (128)
Sequences: 3116 (1529)
Seq/√Len: 135.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_D93_E3.3581.00
61_A126_A3.1461.00
5_G53_L3.1341.00
26_A120_A2.3761.00
8_V20_E2.3211.00
55_R95_D1.9731.00
50_A64_V1.9701.00
14_S113_R1.9171.00
51_D93_E1.8801.00
70_T106_G1.8641.00
24_R28_A1.8521.00
118_K121_A1.8411.00
26_A124_E1.8271.00
27_A32_A1.7981.00
36_D59_I1.7891.00
72_D114_E1.7861.00
82_A85_D1.7831.00
64_V87_L1.7811.00
46_S102_V1.7461.00
10_E128_S1.7351.00
51_D55_R1.7231.00
85_D89_D1.6981.00
20_E37_T1.6551.00
110_A114_E1.6401.00
13_R17_E1.6241.00
14_S109_G1.5131.00
99_T125_S1.5001.00
5_G59_I1.4971.00
48_L91_S1.4681.00
51_D92_L1.4541.00
83_T102_V1.4431.00
52_R95_D1.4421.00
18_R21_A1.4311.00
68_I79_I1.4261.00
4_L130_T1.4181.00
17_E39_H1.3981.00
74_D77_H1.3941.00
38_V53_L1.3631.00
44_Y100_F1.3441.00
7_V50_A1.3311.00
74_D78_V1.2771.00
28_A34_I1.2721.00
54_A94_R1.2631.00
15_V67_A1.2511.00
30_A127_V1.2371.00
106_G111_E1.2121.00
40_V49_A1.1860.99
77_H80_A1.1770.99
76_D80_A1.1610.99
68_I80_A1.1570.99
54_A62_V1.1330.99
7_V46_S1.1300.99
81_S85_D1.1260.99
9_A16_T1.1040.99
54_A96_T1.1010.99
51_D95_D1.0980.99
74_D106_G1.0950.99
99_T122_A1.0950.99
27_A123_V1.0890.99
126_A130_T1.0870.99
27_A63_A1.0870.99
8_V16_T1.0860.99
4_L27_A1.0800.99
50_A62_V1.0760.99
26_A29_D1.0460.99
69_V109_G1.0250.98
83_T100_F1.0100.98
78_V81_S1.0100.98
25_E29_D0.9940.98
56_R59_I0.9900.98
47_P86_T0.9830.98
65_V101_G0.9820.98
20_E39_H0.9710.98
26_A30_A0.9580.98
41_P129_L0.9570.98
54_A90_V0.9470.97
99_T126_A0.9460.97
51_D94_R0.9420.97
12_N67_A0.9410.97
109_G114_E0.9410.97
55_R94_R0.9270.97
101_G122_A0.9270.97
88_T91_S0.9180.97
20_E24_R0.9170.97
21_A25_E0.9160.97
15_V113_R0.8980.97
90_V98_V0.8930.96
109_G113_R0.8880.96
17_E21_A0.8840.96
50_A87_L0.8810.96
8_V39_H0.8790.96
70_T74_D0.8660.96
13_R39_H0.8660.96
108_S111_E0.8650.96
6_L20_E0.8630.96
24_R37_T0.8520.95
84_A100_F0.8500.95
22_A117_E0.8460.95
21_A24_R0.8400.95
4_L32_A0.8380.95
48_L52_R0.8370.95
46_S64_V0.8290.95
4_L126_A0.8270.94
62_V96_T0.8230.94
76_D106_G0.8190.94
112_A115_R0.8140.94
19_M22_A0.8100.94
120_A124_E0.8080.94
47_P88_T0.8070.94
52_R55_R0.8070.94
48_L90_V0.8050.94
86_T90_V0.7750.92
105_P112_A0.7710.92
3_R33_A0.7670.92
12_N16_T0.7660.92
48_L51_D0.7580.92
53_L59_I0.7410.91
49_A129_L0.7370.90
44_Y84_A0.7360.90
4_L61_A0.7250.90
89_D92_L0.7220.89
75_H115_R0.7190.89
24_R34_I0.7190.89
41_P128_S0.7160.89
72_D109_G0.7150.89
48_L92_L0.7060.88
8_V37_T0.6980.88
61_A99_T0.6850.87
3_R58_D0.6840.87
44_Y78_V0.6840.87
16_T67_A0.6810.87
36_D58_D0.6750.86
118_K122_A0.6670.85
54_A57_D0.6670.85
46_S87_L0.6550.84
5_G38_V0.6510.84
6_L23_A0.6500.84
22_A119_G0.6490.84
82_A86_T0.6470.84
4_L123_V0.6470.84
22_A116_V0.6440.83
72_D84_A0.6390.83
55_R93_E0.6380.83
62_V97_P0.6370.83
122_A125_S0.6310.82
48_L129_L0.6270.82
18_R116_V0.6240.81
15_V109_G0.6240.81
25_E120_A0.6210.81
81_S84_A0.6200.81
44_Y79_I0.6150.80
7_V53_L0.6150.80
57_D96_T0.6140.80
73_T115_R0.6140.80
8_V65_V0.6130.80
7_V49_A0.6080.80
86_T92_L0.6070.80
63_A123_V0.6050.79
26_A127_V0.6010.79
4_L63_A0.6000.79
61_A130_T0.6000.79
78_V100_F0.5970.78
10_E17_E0.5960.78
9_A46_S0.5940.78
110_A115_R0.5860.77
46_S83_T0.5840.77
28_A35_T0.5830.77
74_D80_A0.5820.77
3_R57_D0.5750.76
58_D96_T0.5700.75
43_A68_I0.5610.74
7_V62_V0.5610.74
113_R116_V0.5610.74
15_V116_V0.5600.74
5_G62_V0.5600.74
22_A101_G0.5600.74
112_A116_V0.5570.74
99_T129_L0.5540.73
76_D103_S0.5460.72
124_E128_S0.5440.72
70_T77_H0.5440.72
56_R96_T0.5420.72
30_A124_E0.5360.71
63_A99_T0.5340.70
110_A113_R0.5310.70
59_I96_T0.5300.70
9_A40_V0.5250.69
50_A90_V0.5160.68
6_L63_A0.5160.68
127_V130_T0.5120.67
44_Y88_T0.5100.67
9_A105_P0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c2yA 6 0.9925 100 0.087 Contact Map
1kz1A 5 0.9925 100 0.092 Contact Map
1ejbA 3 0.9925 100 0.093 Contact Map
1hqkA 6 0.9925 100 0.093 Contact Map
1rvvA 6 0.9925 100 0.096 Contact Map
3nq4A 6 0.9925 100 0.098 Contact Map
1di0A 5 0.9925 100 0.102 Contact Map
2obxA 4 0.9925 100 0.104 Contact Map
4j07A 3 0.9774 100 0.107 Contact Map
1c41A 6 0.9925 100 0.107 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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