GREMLIN Database
Q9HRM3 - N5-carboxyaminoimidazole ribonucleotide synthase
UniProt: Q9HRM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (350)
Sequences: 23036 (12805)
Seq/√Len: 684.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_E145_V3.6911.00
104_A163_E3.2761.00
115_R149_R3.1811.00
144_S147_D3.1811.00
110_D113_D2.9541.00
216_G220_D2.8671.00
238_V241_R2.8041.00
38_D41_G2.6651.00
123_A145_V2.6521.00
341_G346_L2.6271.00
343_D346_L2.5191.00
219_A223_D2.5111.00
106_R120_E2.4941.00
217_V220_D2.4051.00
272_R277_L2.3981.00
97_D224_A2.2561.00
66_D70_A2.2091.00
66_D83_R2.2091.00
143_D147_D2.1901.00
213_D241_R2.1351.00
95_L221_V2.1261.00
212_E216_G2.0701.00
117_A120_E2.0211.00
8_P268_E2.0191.00
47_A71_H2.0171.00
177_R182_T1.9911.00
207_S210_V1.9871.00
61_P86_Q1.9721.00
90_V93_R1.9601.00
208_P212_E1.9591.00
67_A71_H1.9421.00
93_R97_D1.9381.00
141_P164_L1.9381.00
19_T33_R1.9261.00
263_R283_T1.9051.00
6_A13_V1.8981.00
117_A121_L1.8891.00
145_V149_R1.8871.00
268_E272_R1.8821.00
263_R285_R1.8731.00
83_R90_V1.8631.00
342_G346_L1.8561.00
32_I45_L1.7991.00
5_A268_E1.7731.00
202_V261_G1.7691.00
43_R47_A1.7581.00
7_S29_T1.7521.00
143_D166_D1.7461.00
111_A115_R1.7411.00
217_V242_V1.7411.00
78_S81_T1.7201.00
115_R145_V1.7101.00
176_A269_Q1.6911.00
43_R71_H1.6831.00
213_D216_G1.6811.00
111_A149_R1.6781.00
322_W325_K1.6761.00
89_L93_R1.6721.00
210_V213_D1.6451.00
52_L73_V1.6441.00
93_R96_A1.6411.00
12_D30_D1.6371.00
41_G44_E1.6361.00
84_T94_A1.6321.00
39_P67_A1.6301.00
89_L107_A1.6171.00
92_N162_E1.6081.00
109_D113_D1.5881.00
94_A224_A1.5811.00
220_D223_D1.5801.00
98_A224_A1.5761.00
291_A351_A1.5731.00
84_T90_V1.5571.00
212_E215_T1.5571.00
40_D67_A1.5451.00
106_R117_A1.5381.00
125_L161_A1.5371.00
96_A104_A1.5171.00
304_A307_A1.4971.00
116_A120_E1.4891.00
176_A230_V1.4761.00
94_A97_D1.4721.00
39_P43_R1.4691.00
25_S31_H1.4681.00
210_V237_A1.4671.00
115_R119_E1.4501.00
130_R158_G1.4491.00
178_G181_E1.4461.00
171_L237_A1.4461.00
87_D130_R1.4371.00
325_K328_L1.4271.00
118_F123_A1.4201.00
94_A98_A1.4181.00
260_E338_T1.4111.00
9_L272_R1.4071.00
215_T219_A1.3971.00
163_E243_L1.3851.00
260_E340_S1.3811.00
111_A152_F1.3801.00
80_E84_T1.3751.00
95_L244_V1.3681.00
315_D318_V1.3671.00
69_E78_S1.3611.00
345_R349_A1.3601.00
165_V245_N1.3501.00
116_A119_E1.3361.00
175_A222_L1.3361.00
176_A273_A1.3261.00
93_R105_F1.3251.00
44_E47_A1.3151.00
213_D217_V1.3111.00
101_P241_R1.2951.00
118_F125_L1.2881.00
317_G350_R1.2811.00
112_A116_A1.2791.00
69_E79_P1.2711.00
67_A70_A1.2671.00
68_A73_V1.2671.00
123_A144_S1.2661.00
108_V117_A1.2651.00
91_Q95_L1.2601.00
321_H324_G1.2561.00
173_V214_A1.2481.00
68_A75_V1.2471.00
109_D158_G1.2441.00
11_V275_L1.2381.00
206_T210_V1.2351.00
175_A218_A1.2241.00
92_N102_V1.2231.00
113_D116_A1.2201.00
294_I332_R1.2181.00
89_L130_R1.2181.00
341_G350_R1.2131.00
352_A356_V1.2131.00
96_A102_V1.2081.00
291_A336_H1.1911.00
175_A231_F1.1841.00
85_I247_I1.1831.00
126_M141_P1.1801.00
324_G327_Q1.1771.00
348_R352_A1.1771.00
182_T219_A1.1741.00
208_P211_R1.1701.00
346_L350_R1.1611.00
211_R215_T1.1591.00
112_A115_R1.1441.00
74_A275_L1.1441.00
101_P217_V1.1391.00
237_A242_V1.1381.00
107_A158_G1.1321.00
175_A233_V1.1311.00
104_A121_L1.1301.00
126_M164_L1.1281.00
184_T215_T1.1271.00
46_A73_V1.1111.00
64_L68_A1.1091.00
140_A151_E1.1081.00
287_P342_G1.1071.00
78_S228_R1.1011.00
166_D239_D1.0931.00
350_R353_R1.0881.00
63_V66_D1.0861.00
169_R189_E1.0841.00
209_A213_D1.0841.00
341_G347_A1.0801.00
264_T269_Q1.0671.00
207_S240_G1.0621.00
96_A105_F1.0621.00
114_L148_A1.0591.00
339_V351_A1.0551.00
269_Q272_R1.0531.00
146_A150_A1.0491.00
353_R356_V1.0451.00
123_A148_A1.0431.00
17_D22_C1.0421.00
337_V354_D1.0361.00
222_L225_L1.0351.00
259_I338_T1.0311.00
349_A353_R1.0291.00
5_A8_P1.0271.00
104_A120_E1.0271.00
218_A233_V1.0251.00
45_L49_A1.0241.00
222_L231_F1.0211.00
272_R275_L1.0181.00
193_E198_R1.0161.00
40_D44_E1.0121.00
119_E149_R1.0101.00
233_V247_I1.0051.00
121_L125_L1.0031.00
9_L268_E1.0021.00
285_R340_S1.0001.00
147_D150_A0.9961.00
118_F148_A0.9901.00
6_A271_I0.9861.00
319_A322_W0.9861.00
15_V28_A0.9831.00
177_R223_D0.9831.00
186_P202_V0.9811.00
80_E83_R0.9791.00
52_L68_A0.9761.00
108_V114_L0.9711.00
114_L152_F0.9701.00
66_D79_P0.9691.00
186_P211_R0.9661.00
189_E205_R0.9631.00
218_A235_L0.9631.00
318_V354_D0.9611.00
58_L62_D0.9511.00
173_V218_A0.9501.00
251_P266_Q0.9501.00
271_I275_L0.9471.00
294_I355_A0.9451.00
181_E223_D0.9441.00
177_R222_L0.9431.00
166_D238_V0.9411.00
216_G219_A0.9371.00
125_L142_V0.9341.00
309_V324_G0.9331.00
324_G328_L0.9321.00
6_A11_V0.9301.00
43_R70_A0.9271.00
339_V354_D0.9251.00
85_I225_L0.9221.00
19_T22_C0.9191.00
180_A223_D0.9181.00
17_D31_H0.9181.00
46_A52_L0.9131.00
43_R67_A0.9121.00
65_A68_A0.9121.00
165_V243_L0.9101.00
221_V224_A0.9081.00
15_V26_Q0.9041.00
220_D224_A0.9011.00
142_V151_E0.8991.00
127_L151_E0.8971.00
173_V215_T0.8961.00
127_L159_F0.8951.00
100_I244_V0.8941.00
12_D29_T0.8931.00
7_S13_V0.8911.00
126_M139_N0.8901.00
318_V339_V0.8771.00
87_D131_T0.8771.00
236_F245_N0.8711.00
179_D278_P0.8701.00
14_I30_D0.8641.00
113_D117_A0.8631.00
152_F159_F0.8601.00
58_L61_P0.8601.00
81_T226_D0.8571.00
146_A149_R0.8571.00
16_L34_A0.8511.00
63_V67_A0.8501.00
89_L158_G0.8481.00
65_A69_E0.8431.00
192_H197_L0.8431.00
319_A323_Y0.8411.00
66_D80_E0.8361.00
165_V238_V0.8321.00
308_G311_A0.8291.00
176_A185_F0.8271.00
127_L142_V0.8261.00
69_E228_R0.8221.00
53_T270_C0.8201.00
213_D242_V0.8161.00
131_T156_L0.8151.00
182_T223_D0.8151.00
339_V347_A0.8111.00
78_S226_D0.8101.00
214_A242_V0.8101.00
221_V225_L0.8041.00
65_A75_V0.8021.00
57_E60_D0.8011.00
96_A106_R0.7991.00
209_A212_E0.7981.00
34_A45_L0.7901.00
221_V247_I0.7901.00
154_G157_G0.7891.00
289_V347_A0.7891.00
303_P306_I0.7811.00
5_A9_L0.7811.00
346_L349_A0.7811.00
173_V187_V0.7751.00
42_V68_A0.7741.00
14_I32_I0.7741.00
94_A225_L0.7721.00
65_A83_R0.7701.00
35_D38_D0.7691.00
321_H325_K0.7661.00
118_F122_G0.7641.00
68_A71_H0.7581.00
261_G288_T0.7581.00
314_R318_V0.7571.00
270_C274_V0.7541.00
191_L199_E0.7521.00
106_R113_D0.7511.00
163_E241_R0.7511.00
313_F347_A0.7491.00
228_R273_A0.7481.00
101_P243_L0.7461.00
182_T222_L0.7461.00
169_R237_A0.7451.00
87_D90_V0.7431.00
345_R348_R0.7411.00
315_D350_R0.7411.00
89_L160_V0.7391.00
142_V148_A0.7371.00
246_E250_R0.7351.00
76_H271_I0.7341.00
87_D158_G0.7331.00
217_V235_L0.7321.00
175_A184_T0.7291.00
127_L161_A0.7291.00
184_T219_A0.7241.00
174_I230_V0.7241.00
66_D69_E0.7231.00
117_A161_A0.7211.00
22_C25_S0.7211.00
198_R294_I0.7211.00
289_V348_R0.7191.00
206_T211_R0.7191.00
187_V204_A0.7191.00
287_P340_S0.7141.00
88_K128_K0.7121.00
193_E196_I0.7121.00
179_D228_R0.7111.00
199_E291_A0.7111.00
64_L67_A0.7101.00
181_E278_P0.7101.00
183_A282_T0.7071.00
93_R107_A0.7071.00
63_V68_A0.7061.00
177_R228_R0.7051.00
320_L324_G0.7051.00
259_I265_S0.7011.00
173_V235_L0.7011.00
121_L163_E0.7011.00
171_L214_A0.6991.00
90_V94_A0.6981.00
34_A41_G0.6961.00
192_H196_I0.6951.00
306_I309_V0.6931.00
201_V344_D0.6921.00
63_V83_R0.6911.00
351_A355_A0.6891.00
178_G279_L0.6871.00
127_L152_F0.6851.00
311_A314_R0.6841.00
9_L271_I0.6831.00
187_V211_R0.6831.00
111_A148_A0.6821.00
188_A204_A0.6781.00
293_L296_D0.6771.00
171_L235_L0.6761.00
269_Q280_G0.6761.00
28_A31_H0.6691.00
114_L161_A0.6691.00
214_A217_V0.6691.00
46_A68_A0.6681.00
302_H305_T0.6641.00
173_V184_T0.6631.00
110_D152_F0.6631.00
174_I232_G0.6621.00
47_A70_A0.6581.00
79_P83_R0.6581.00
227_G231_F0.6571.00
84_T97_D0.6551.00
185_F262_C0.6541.00
174_I188_A0.6541.00
238_V243_L0.6541.00
240_G243_L0.6491.00
320_L337_V0.6481.00
320_L335_A0.6471.00
39_P62_D0.6451.00
185_F266_Q0.6441.00
41_G45_L0.6441.00
51_V274_V0.6441.00
323_Y328_L0.6441.00
130_R160_V0.6441.00
39_P64_L0.6421.00
11_V50_D0.6411.00
69_E80_E0.6401.00
188_A200_S0.6401.00
111_A114_L0.6351.00
292_N295_G0.6341.00
217_V221_V0.6341.00
262_C284_L0.6331.00
40_D43_R0.6321.00
209_A240_G0.6311.00
347_A351_A0.6311.00
290_M348_R0.6311.00
175_A182_T0.6291.00
189_E204_A0.6291.00
233_V244_V0.6281.00
124_P164_L0.6281.00
27_P31_H0.6251.00
69_E75_V0.6251.00
178_G276_G0.6241.00
115_R118_F0.6231.00
218_A222_L0.6221.00
202_V257_Y0.6221.00
107_A130_R0.6201.00
186_P284_L0.6201.00
46_A49_A0.6191.00
99_G220_D0.6181.00
147_D151_E0.6181.00
199_E202_V0.6181.00
142_V147_D0.6151.00
81_T228_R0.6141.00
257_Y260_E0.6141.00
16_L42_V0.6121.00
181_E280_G0.6121.00
179_D276_G0.6111.00
323_Y327_Q0.6111.00
344_D348_R0.6101.00
312_A322_W0.6091.00
193_E197_L0.6081.00
123_A143_D0.6031.00
105_F162_E0.5981.00
230_V251_P0.5961.00
210_V240_G0.5951.00
80_E226_D0.5951.00
227_G249_P0.5931.00
163_E238_V0.5931.00
204_A211_R0.5921.00
189_E201_V0.5891.00
272_R276_G0.5881.00
296_D307_A0.5881.00
207_S237_A0.5861.00
168_E239_D0.5851.00
288_T344_D0.5841.00
118_F121_L0.5831.00
13_V29_T0.5811.00
171_L206_T0.5801.00
266_Q270_C0.5771.00
192_H195_E0.5771.00
42_V52_L0.5761.00
180_A228_R0.5761.00
186_P261_G0.5761.00
171_L204_A0.5751.00
82_L249_P0.5751.00
95_L100_I0.5731.00
260_E321_H0.5701.00
269_Q282_T0.5691.00
71_H74_A0.5661.00
14_I48_R0.5661.00
303_P307_A0.5661.00
118_F152_F0.5651.00
143_D164_L0.5641.00
43_R73_V0.5621.00
315_D353_R0.5621.00
81_T85_I0.5621.00
95_L247_I0.5621.00
16_L45_L0.5601.00
92_N105_F0.5591.00
307_A310_P0.5581.00
297_P304_A0.5541.00
256_H336_H0.5541.00
312_A320_L0.5541.00
119_E123_A0.5531.00
306_I310_P0.5521.00
306_I311_A0.5491.00
256_H290_M0.5481.00
210_V242_V0.5471.00
343_D347_A0.5471.00
47_A73_V0.5451.00
188_A202_V0.5451.00
74_A228_R0.5451.00
80_E90_V0.5451.00
17_D27_P0.5441.00
187_V206_T0.5421.00
271_I274_V0.5421.00
91_Q244_V0.5421.00
14_I49_A0.5411.00
275_L278_P0.5411.00
220_D225_L0.5411.00
165_V168_E0.5411.00
100_I217_V0.5401.00
270_C273_A0.5391.00
103_P245_N0.5381.00
323_Y326_R0.5371.00
92_N96_A0.5341.00
81_T84_T0.5331.00
186_P258_T0.5301.00
108_V113_D0.5291.00
260_E319_A0.5281.00
172_S188_A0.5261.00
213_D220_D0.5261.00
177_R180_A0.5251.00
141_P195_E0.5241.00
103_P165_V0.5241.00
311_A326_R0.5231.00
20_P33_R0.5231.00
92_N103_P0.5221.00
169_R204_A0.5221.00
30_D33_R0.5200.99
118_F145_V0.5200.99
36_F39_P0.5200.99
106_R121_L0.5190.99
290_M295_G0.5180.99
264_T280_G0.5160.99
349_A352_A0.5150.99
39_P66_D0.5150.99
164_L236_F0.5140.99
88_K139_N0.5140.99
177_R226_D0.5130.99
215_T220_D0.5120.99
122_G145_V0.5100.99
315_D354_D0.5090.99
115_R148_A0.5080.99
257_Y289_V0.5080.99
95_L102_V0.5070.99
50_D74_A0.5070.99
9_L277_L0.5060.99
150_A154_G0.5060.99
201_V204_A0.5050.99
140_A150_A0.5050.99
291_A338_T0.5040.99
112_A149_R0.5030.99
265_S268_E0.5030.99
65_A79_P0.5020.99
127_L148_A0.5000.99
18_P25_S0.5000.99
339_V350_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dwcA 4 0.9725 100 0.279 Contact Map
4dimA 1 0.967 100 0.279 Contact Map
1kjqA 2 0.967 100 0.286 Contact Map
3ax6A 2 0.9396 100 0.294 Contact Map
4mamA 2 0.9451 100 0.297 Contact Map
3aw8A 2 0.9478 100 0.298 Contact Map
4e4tA 2 0.9835 100 0.301 Contact Map
4rcnA 6 0.9231 100 0.302 Contact Map
3votA 1 0.9698 100 0.308 Contact Map
3orqA 2 0.9505 100 0.311 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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