GREMLIN Database
Q9HRM2 - Phosphoribosylaminoimidazole carboxylase catalytic subunit
UniProt: Q9HRM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (156)
Sequences: 1678 (849)
Seq/√Len: 68.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_G84_Y3.1001.00
34_D186_V2.9181.00
50_L158_A2.4421.00
89_A173_R2.4401.00
159_Q176_Q2.3831.00
70_W187_S2.3431.00
108_P133_V2.3401.00
52_F158_A2.2461.00
40_M123_V2.1901.00
161_L168_L2.1731.00
26_D94_D2.1661.00
130_V134_I2.1551.00
145_V156_A2.1031.00
29_V44_H2.0691.00
138_T151_Y2.0141.00
162_A168_L1.9941.00
68_E91_R1.9881.00
79_T86_R1.9601.00
30_I111_T1.9491.00
28_G93_L1.9331.00
40_M99_G1.8871.00
89_A169_A1.8761.00
48_T67_F1.8691.00
82_D114_L1.7461.00
80_L184_A1.7071.00
126_Q148_G1.7061.00
94_D164_D1.6981.00
44_H69_S1.6941.00
181_E185_D1.6740.99
158_A168_L1.6710.99
83_A87_T1.6710.99
188_A192_S1.6630.99
72_V81_M1.6550.99
77_T183_V1.6000.99
121_V145_V1.5970.99
87_T90_A1.5940.99
130_V147_A1.5690.99
50_L171_R1.5560.99
41_A45_D1.5550.99
167_T171_R1.5240.99
89_A117_P1.5230.99
41_A193_Q1.5040.99
70_W80_L1.4900.99
117_P169_A1.4810.99
170_D174_D1.4570.98
174_D178_A1.4280.98
42_G45_D1.4190.98
160_F163_T1.4060.98
70_W191_H1.3920.98
27_V95_V1.3610.98
51_G66_T1.3600.98
187_S191_H1.3460.97
46_A154_G1.3150.97
49_D178_A1.3110.97
51_G171_R1.3060.97
134_I147_A1.2890.97
26_D66_T1.2820.97
172_L176_Q1.2730.96
121_V143_T1.2700.96
44_H67_F1.2690.96
81_M111_T1.2490.96
46_A50_L1.2460.96
102_G128_K1.2280.96
155_L158_A1.2210.95
146_D149_K1.2020.95
175_L179_R1.1990.95
177_A181_E1.1700.94
117_P173_R1.1360.93
80_L187_S1.1310.93
138_T149_K1.1230.93
84_Y93_L1.0950.92
81_M110_M1.0840.92
117_P172_L1.0830.92
180_Q184_A1.0690.91
185_D188_A1.0620.91
85_A96_I1.0470.90
102_G129_S1.0420.90
79_T83_A1.0340.90
182_G186_V1.0300.89
185_D189_R1.0240.89
155_L176_Q1.0160.89
96_I118_I1.0020.88
40_M150_S0.9940.88
178_A182_G0.9940.88
39_V148_G0.9910.88
77_T80_L0.9780.87
42_G151_Y0.9650.86
72_V110_M0.9630.86
80_L183_V0.9540.85
46_A49_D0.9440.85
34_D189_R0.9360.84
177_A180_Q0.9330.84
46_A155_L0.9290.84
173_R177_A0.9270.84
122_G133_V0.9190.83
99_G123_V0.9110.83
151_Y175_L0.9020.82
94_D165_D0.9000.82
183_V187_S0.8970.82
79_T180_Q0.8860.81
44_H48_T0.8850.81
150_S154_G0.8770.80
178_A181_E0.8760.80
85_A88_A0.8700.80
94_D163_T0.8590.79
81_M85_A0.8450.78
94_D169_A0.8290.76
25_P66_T0.8280.76
30_I77_T0.8230.76
68_E93_L0.8210.76
37_L69_S0.8200.76
85_A111_T0.8190.76
95_V161_L0.8130.75
78_P113_S0.8100.75
25_P94_D0.8030.74
68_E84_Y0.8010.74
179_R182_G0.7970.74
39_V42_G0.7830.72
86_R114_L0.7800.72
39_V125_V0.7740.71
87_T91_R0.7720.71
129_S132_S0.7670.71
146_D159_Q0.7660.71
30_I96_I0.7630.70
45_D48_T0.7590.70
46_A151_Y0.7590.70
29_V69_S0.7520.69
38_D41_A0.7510.69
37_L71_V0.7450.68
98_A133_V0.7430.68
176_Q179_R0.7380.68
154_G158_A0.7370.68
138_T146_D0.7350.67
28_G68_E0.7330.67
89_A162_A0.7290.67
43_A99_G0.7270.67
99_G154_G0.7240.66
127_E146_D0.7230.66
102_G138_T0.7150.65
45_D49_D0.7150.65
158_A161_L0.7110.65
168_L172_L0.7100.65
49_D151_Y0.7090.65
88_A96_I0.7050.64
50_L175_L0.7040.64
131_P140_A0.6930.63
80_L191_H0.6930.63
158_A172_L0.6890.62
131_P150_S0.6870.62
169_A173_R0.6860.62
167_T170_D0.6770.61
127_E131_P0.6760.61
95_V160_F0.6720.60
52_F168_L0.6720.60
79_T82_D0.6710.60
189_R193_Q0.6700.60
181_E184_A0.6690.60
90_A170_D0.6610.59
98_A108_P0.6580.59
140_A176_Q0.6550.58
186_V189_R0.6500.58
72_V80_L0.6490.58
28_G96_I0.6460.57
94_D161_L0.6450.57
165_D170_D0.6390.57
162_A169_A0.6380.56
31_M40_M0.6370.56
28_G91_R0.6300.56
49_D171_R0.6290.55
37_L44_H0.6280.55
42_G150_S0.6270.55
110_M113_S0.6240.55
182_G185_D0.6240.55
81_M108_P0.6220.55
39_V126_Q0.6190.54
143_T156_A0.6140.54
46_A175_L0.6130.54
85_A114_L0.6100.53
189_R192_S0.6100.53
41_A48_T0.6060.53
102_G110_M0.6020.52
170_D173_R0.5920.51
72_V132_S0.5920.51
82_D86_R0.5910.51
26_D165_D0.5890.51
108_P122_G0.5860.50
72_V102_G0.5810.50
93_L118_I0.5790.49
162_A176_Q0.5790.49
166_P169_A0.5760.49
102_G127_E0.5700.48
158_A171_R0.5660.48
37_L193_Q0.5610.47
71_V125_V0.5610.47
77_T187_S0.5580.47
81_M133_V0.5580.47
30_I84_Y0.5550.47
30_I81_M0.5540.46
83_A177_A0.5540.46
114_L146_D0.5510.46
140_A172_L0.5490.46
81_M129_S0.5400.45
110_M132_S0.5400.45
82_D132_S0.5370.44
113_S123_V0.5360.44
126_Q149_K0.5350.44
102_G108_P0.5340.44
99_G125_V0.5330.44
111_T115_A0.5320.44
71_V193_Q0.5310.44
34_D145_V0.5310.44
30_I72_V0.5310.44
110_M133_V0.5290.44
102_G125_V0.5240.43
111_T114_L0.5190.42
40_M128_K0.5180.42
51_G167_T0.5180.42
93_L96_I0.5140.42
166_P170_D0.5120.42
138_T154_G0.5110.41
89_A170_D0.5100.41
84_Y96_I0.5090.41
85_A118_I0.5090.41
151_Y182_G0.5080.41
71_V186_V0.5050.41
66_T86_R0.5050.41
121_V157_A0.5040.41
128_K148_G0.5030.40
131_P193_Q0.5020.40
24_T177_A0.5010.40
151_Y179_R0.5010.40
66_T171_R0.5010.40
79_T114_L0.5010.40
46_A71_V0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o4vA 5 0.803 100 0.318 Contact Map
3lp6A 5 0.8227 100 0.329 Contact Map
3trhA 5 0.7734 100 0.338 Contact Map
3orsA 5 0.7537 100 0.344 Contact Map
4ja0A 6 0.8522 100 0.346 Contact Map
4grdA 5 0.7882 100 0.348 Contact Map
1u11A 6 0.7635 100 0.35 Contact Map
2h31A 6 0.8768 100 0.351 Contact Map
3oowA 5 0.7586 100 0.351 Contact Map
4ay3A 2 0.7537 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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