GREMLIN Database
Q9HRM1 - NADH dehydrogenase/oxidoreductase-like protein
UniProt: Q9HRM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 136 (112)
Sequences: 4777 (2307)
Seq/√Len: 218.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_W101_M4.7571.00
100_P115_A4.2581.00
114_W117_R3.7581.00
17_I21_M2.6671.00
25_S29_R2.3461.00
109_V113_A2.3201.00
16_L20_G2.3031.00
33_S38_R2.2711.00
28_I31_S2.2581.00
21_M24_V2.2161.00
26_S31_S2.0801.00
58_Q124_M2.0461.00
98_L102_L2.0301.00
107_I115_A1.9691.00
114_W118_K1.9331.00
36_G39_A1.8491.00
92_I97_V1.8491.00
107_I111_G1.8331.00
12_L16_L1.7351.00
77_F80_T1.7091.00
59_Y62_V1.6841.00
66_F70_D1.6671.00
92_I95_T1.6161.00
19_A23_S1.5781.00
34_E39_A1.5641.00
99_A103_V1.5501.00
99_A102_L1.5201.00
37_K111_G1.5061.00
39_A46_V1.4991.00
15_V19_A1.4631.00
75_L118_K1.4151.00
104_F108_L1.3691.00
39_A45_E1.3251.00
11_A14_S1.3151.00
24_V28_I1.3081.00
39_A47_P1.2791.00
29_R32_V1.2511.00
95_T100_P1.2401.00
95_T99_A1.2331.00
66_F69_F1.2241.00
97_V101_M1.1611.00
76_I101_M1.1481.00
6_A9_M1.1311.00
74_V77_F1.1091.00
73_T115_A1.0901.00
82_I85_D1.0821.00
115_A121_V1.0671.00
12_L15_V1.0311.00
39_A43_S1.0191.00
23_S27_L1.0161.00
102_L105_I1.0041.00
109_V115_A0.9911.00
79_W97_V0.9861.00
71_I74_V0.9861.00
36_G45_E0.9711.00
63_A66_F0.9561.00
116_W123_W0.9541.00
40_T56_N0.9280.99
25_S28_I0.9040.99
95_T98_L0.9010.99
11_A15_V0.8990.99
18_P76_I0.8900.99
8_G19_A0.8800.99
54_Q60_Y0.8790.99
113_A117_R0.8730.99
113_A116_W0.8590.99
58_Q80_T0.8410.99
28_I32_V0.8400.99
84_R112_L0.8390.99
104_F113_A0.8340.99
56_N59_Y0.8220.99
45_E56_N0.8210.99
102_L106_G0.8190.99
56_N60_Y0.8140.99
72_E108_L0.8130.99
50_N63_A0.8060.99
112_L121_V0.8040.99
15_V99_A0.7970.98
23_S26_S0.7940.98
61_M121_V0.7870.98
46_V49_G0.7860.98
25_S31_S0.7800.98
38_R41_Y0.7660.98
97_V100_P0.7520.98
67_L110_V0.7440.98
9_M38_R0.7410.97
8_G18_P0.7350.97
76_I120_V0.7350.97
45_E59_Y0.7250.97
10_L74_V0.7210.97
37_K71_I0.7180.97
16_L93_G0.7180.97
18_P22_L0.7170.97
54_Q64_L0.7160.97
77_F97_V0.7140.97
64_L124_M0.7100.97
62_V115_A0.7050.97
14_S119_G0.6890.96
22_L25_S0.6850.96
106_G109_V0.6830.96
80_T84_R0.6830.96
35_Q117_R0.6820.96
56_N64_L0.6790.96
63_A114_W0.6730.96
53_L65_L0.6700.95
61_M108_L0.6660.95
103_V110_V0.6630.95
73_T112_L0.6590.95
95_T110_V0.6560.95
13_V16_L0.6560.95
65_L115_A0.6520.95
17_I20_G0.6430.94
77_F81_V0.6420.94
103_V107_I0.6410.94
13_V17_I0.6340.94
62_V66_F0.6340.94
43_S62_V0.6310.94
74_V80_T0.6310.94
108_L111_G0.6270.94
51_A55_F0.6190.93
79_W98_L0.6170.93
95_T106_G0.6160.93
9_M23_S0.6120.93
20_G23_S0.6060.92
65_L71_I0.6040.92
43_S54_Q0.6030.92
74_V97_V0.6020.92
116_W122_Q0.5990.92
30_P71_I0.5980.92
93_G117_R0.5950.92
81_V84_R0.5940.92
52_R71_I0.5900.91
10_L18_P0.5900.91
49_G53_L0.5820.91
8_G12_L0.5800.91
76_I103_V0.5750.90
8_G83_Y0.5710.90
19_A33_S0.5700.90
77_F104_F0.5690.90
38_R106_G0.5690.90
58_Q63_A0.5680.90
60_Y123_W0.5630.89
22_L97_V0.5530.89
120_V124_M0.5530.89
41_Y114_W0.5440.88
75_L102_L0.5390.87
6_A10_L0.5340.87
24_V84_R0.5320.87
75_L101_M0.5270.86
10_L17_I0.5270.86
75_L104_F0.5250.86
52_R62_V0.5250.86
45_E71_I0.5150.85
50_N53_L0.5140.85
22_L26_S0.5140.85
15_V18_P0.5140.85
63_A120_V0.5130.85
14_S18_P0.5120.84
67_L70_D0.5110.84
17_I28_I0.5100.84
45_E115_A0.5100.84
9_M12_L0.5100.84
68_V72_E0.5090.84
37_K68_V0.5050.84
45_E52_R0.5040.84
6_A71_I0.5030.83
11_A65_L0.5020.83
73_T124_M0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoA 1 0.6985 100 0.132 Contact Map
4he8A 1 0.6544 100 0.193 Contact Map
4tllB 2 0.2206 16.9 0.934 Contact Map
4djkA 2 0.7868 11.5 0.939 Contact Map
3mk7C 2 0.6912 9 0.942 Contact Map
3aqpA 1 0.7721 7.7 0.943 Contact Map
3wajA 1 0.6765 4.8 0.948 Contact Map
2kv5A 1 0.2426 3.8 0.951 Contact Map
2m20A 2 0.3382 3.7 0.951 Contact Map
4qinA 2 0.9338 3.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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