GREMLIN Database
Q9HRM0 - NADH dehydrogenase/oxidoreductase
UniProt: Q9HRM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (191)
Sequences: 363 (106)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_G74_S3.9960.97
165_I178_G3.6500.95
70_I77_M3.2950.91
84_K173_E3.2180.90
80_T176_V3.1890.89
118_R153_K2.7720.81
140_T145_F2.5730.76
50_K53_K2.4540.72
46_F163_I2.4340.72
82_S87_L2.3340.68
70_I137_N2.2980.67
56_N108_P2.2630.66
134_N140_T2.2480.65
66_L102_A2.2390.65
122_V155_A2.2060.64
90_F171_R2.1890.63
114_K126_M2.0760.59
113_S126_M1.8870.51
54_F104_V1.8780.51
77_M137_N1.8770.51
106_I135_M1.7800.47
88_D92_A1.7730.47
165_I175_L1.7640.46
104_V175_L1.7590.46
122_V172_P1.7280.45
121_R124_D1.6610.42
98_S130_K1.6220.41
68_F151_V1.6160.40
147_E172_P1.6020.40
88_D179_V1.5920.40
199_Y207_L1.5910.40
74_S81_Y1.5840.39
134_N137_N1.5760.39
177_Y181_K1.5440.38
210_D213_V1.5410.38
114_K135_M1.5380.37
50_K186_I1.5190.37
64_F149_Y1.4990.36
77_M134_N1.4830.35
63_M186_I1.4790.35
81_Y106_I1.4770.35
70_I140_T1.4640.35
26_G36_R1.4540.34
139_S159_I1.4430.34
134_N145_F1.4350.34
56_N98_S1.4290.33
137_N178_G1.4270.33
128_E186_I1.4100.33
94_V187_A1.3990.32
108_P126_M1.3990.32
110_T174_A1.3900.32
107_V158_V1.3880.32
56_N130_K1.3680.31
85_H173_E1.3590.31
77_M195_T1.3520.31
144_P147_E1.3480.31
66_L130_K1.3460.31
180_A214_D1.3400.30
49_T163_I1.3220.30
84_K120_K1.3190.30
206_D213_V1.2830.28
209_R212_I1.2710.28
84_K185_R1.2670.28
42_G45_P1.2530.28
137_N140_T1.2480.27
120_K124_D1.2460.27
68_F105_M1.2440.27
67_Q74_S1.2410.27
118_R171_R1.1990.26
206_D210_D1.1930.26
70_I134_N1.1890.26
141_S172_P1.1860.25
151_V178_G1.1590.25
210_D214_D1.1570.25
149_Y161_V1.1550.24
70_I195_T1.1540.24
131_F134_N1.1470.24
56_N173_E1.1440.24
114_K152_V1.1380.24
141_S171_R1.1160.23
209_R215_K1.1080.23
75_I130_K1.1030.23
98_S101_Q1.1010.23
144_P153_K1.0860.23
77_M140_T1.0820.22
205_G212_I1.0710.22
50_K199_Y1.0690.22
71_A149_Y1.0680.22
158_V201_L1.0460.21
124_D209_R1.0240.21
71_A151_V1.0170.21
71_A94_V1.0130.21
78_M104_V1.0040.20
66_L98_S1.0030.20
205_G208_E1.0020.20
130_K165_I0.9990.20
42_G46_F0.9930.20
82_S121_R0.9890.20
144_P172_P0.9880.20
65_M155_A0.9860.20
52_D173_E0.9860.20
206_D212_I0.9830.20
87_L121_R0.9660.19
141_S153_K0.9510.19
68_F178_G0.9500.19
107_V139_S0.9380.19
147_E150_N0.9370.19
75_I145_F0.9310.18
105_M108_P0.9280.18
147_E153_K0.9250.18
110_T140_T0.9200.18
95_P175_L0.9190.18
85_H165_I0.9160.18
207_L210_D0.9150.18
51_F191_S0.9130.18
180_A183_Q0.9040.18
30_D37_L0.9020.18
148_G153_K0.8970.18
75_I140_T0.8970.18
156_E164_H0.8960.18
207_L214_D0.8950.18
47_I199_Y0.8940.18
120_K184_E0.8930.18
99_P109_G0.8840.17
211_E214_D0.8760.17
66_L105_M0.8720.17
92_A127_P0.8710.17
149_Y210_D0.8680.17
25_M28_G0.8670.17
100_R109_G0.8650.17
155_A172_P0.8630.17
87_L178_G0.8620.17
71_A118_R0.8570.17
65_M108_P0.8550.17
120_K215_K0.8530.17
80_T87_L0.8520.17
165_I171_R0.8510.17
151_V165_I0.8480.17
131_F139_S0.8460.16
197_K211_E0.8450.16
33_F36_R0.8440.16
53_K187_A0.8440.16
147_E157_E0.8340.16
45_P163_I0.8340.16
130_K178_G0.8330.16
65_M135_M0.8310.16
137_N165_I0.8290.16
25_M29_V0.8260.16
209_R213_V0.8230.16
127_P180_A0.8220.16
37_L83_V0.8180.16
123_Y129_P0.8060.16
203_E207_L0.8060.16
126_M132_V0.7960.15
141_S146_Q0.7920.15
41_F190_E0.7890.15
24_R30_D0.7850.15
82_S155_A0.7840.15
63_M104_V0.7760.15
110_T151_V0.7750.15
158_V183_Q0.7700.15
184_E187_A0.7640.15
88_D141_S0.7620.15
206_D209_R0.7590.15
133_V150_N0.7560.15
150_N195_T0.7550.15
141_S147_E0.7550.15
78_M81_Y0.7540.15
61_S141_S0.7490.14
199_Y209_R0.7490.14
84_K175_L0.7490.14
60_G186_I0.7480.14
44_T149_Y0.7480.14
98_S207_L0.7430.14
153_K158_V0.7420.14
48_L102_A0.7400.14
38_R41_F0.7380.14
204_F213_V0.7340.14
94_V117_P0.7290.14
48_L187_A0.7270.14
121_R180_A0.7240.14
39_E42_G0.7220.14
83_V130_K0.7190.14
207_L213_V0.7140.14
101_Q173_E0.7130.14
74_S78_M0.7120.14
120_K139_S0.7110.14
81_Y92_A0.7100.14
111_I161_V0.7080.14
94_V180_A0.7050.14
40_A46_F0.7010.14
144_P150_N0.7010.14
68_F165_I0.6960.13
78_M95_P0.6920.13
107_V159_I0.6910.13
175_L183_Q0.6870.13
71_A122_V0.6870.13
116_A159_I0.6830.13
141_S144_P0.6800.13
122_V163_I0.6770.13
111_I115_F0.6700.13
79_H171_R0.6580.13
45_P171_R0.6580.13
96_R109_G0.6510.13
37_L116_A0.6450.13
52_D185_R0.6440.13
106_I175_L0.6400.12
171_R188_N0.6350.12
69_G150_N0.6340.12
34_N37_L0.6310.12
68_F183_Q0.6300.12
131_F150_N0.6280.12
142_G154_G0.6270.12
43_S128_E0.6270.12
131_F140_T0.6260.12
103_D136_G0.6240.12
85_H137_N0.6240.12
52_D101_Q0.6240.12
117_P161_V0.6190.12
68_F75_I0.6130.12
87_L186_I0.6020.12
128_E164_H0.5970.12
46_F51_F0.5960.12
96_R100_R0.5950.12
199_Y205_G0.5940.12
199_Y204_F0.5920.12
212_I215_K0.5900.12
31_D34_N0.5900.12
102_A122_V0.5900.12
111_I155_A0.5890.12
49_T113_S0.5860.12
138_C161_V0.5860.12
48_L213_V0.5850.12
87_L92_A0.5830.11
45_P172_P0.5820.11
206_D214_D0.5820.11
80_T197_K0.5800.11
117_P182_L0.5790.11
29_V34_N0.5750.11
35_S40_A0.5740.11
198_P202_E0.5680.11
96_R99_P0.5680.11
75_I134_N0.5670.11
119_M155_A0.5640.11
24_R28_G0.5630.11
100_R103_D0.5600.11
36_R63_M0.5600.11
198_P214_D0.5590.11
31_D111_I0.5590.11
44_T52_D0.5580.11
59_R105_M0.5560.11
32_R38_R0.5550.11
91_H136_G0.5510.11
82_S131_F0.5510.11
89_R109_G0.5490.11
199_Y203_E0.5400.11
58_V61_S0.5370.11
36_R41_F0.5340.11
64_F164_H0.5340.11
65_M156_E0.5330.11
207_L212_I0.5320.11
31_D70_I0.5310.11
209_R214_D0.5280.11
41_F207_L0.5270.11
67_Q81_Y0.5260.11
178_G203_E0.5260.11
200_E209_R0.5260.11
99_P103_D0.5250.11
39_E204_F0.5240.11
31_D77_M0.5220.11
61_S120_K0.5200.10
54_F126_M0.5200.10
85_H203_E0.5180.10
25_M189_G0.5170.10
193_P198_P0.5140.10
45_P79_H0.5090.10
63_M155_A0.5080.10
101_Q127_P0.5060.10
91_H103_D0.5060.10
198_P208_E0.5040.10
137_N195_T0.5030.10
140_T195_T0.5030.10
75_I193_P0.5020.10
105_M159_I0.5010.10
81_Y147_E0.5000.10
32_R37_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v6 1 0.617 100 0.475 Contact Map
1h2aS 1 0.7021 100 0.65 Contact Map
2wpnA 1 0.7447 100 0.656 Contact Map
3ayxB 2 0.6979 100 0.658 Contact Map
4ue3S 2 0.7106 100 0.667 Contact Map
4uqlA 1 0.7106 100 0.668 Contact Map
1yq9A 2 0.7277 100 0.678 Contact Map
3myrA 3 0.7064 100 0.679 Contact Map
3ze9A 1 0.7021 100 0.68 Contact Map
4u9hS 1 0.7064 100 0.683 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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