GREMLIN Database
Q9HRL8 - NADH dehydrogenase/oxidoreductase
UniProt: Q9HRL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (294)
Sequences: 5221 (2443)
Seq/√Len: 142.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_T155_E4.9211.00
185_F241_I3.9411.00
10_P37_I3.8871.00
17_T276_S3.8101.00
189_V270_F3.6461.00
239_A260_F3.5161.00
20_F276_S3.4121.00
242_A260_F3.2261.00
239_A264_I2.7971.00
119_S216_T2.7111.00
246_L267_V2.5181.00
193_L274_C2.4641.00
188_F241_I2.4511.00
38_V41_S2.4271.00
178_A246_L2.4181.00
159_I177_F2.4171.00
71_A233_H2.4161.00
49_L222_Y2.3791.00
148_T177_F2.3781.00
155_E158_A2.3251.00
196_V271_T2.3121.00
178_A185_F2.2041.00
97_F138_V2.0961.00
71_A232_I2.0841.00
212_A215_Q2.0771.00
74_A236_L2.0761.00
67_L106_G2.0601.00
238_G267_V2.0511.00
235_F268_Y1.9901.00
111_G123_G1.9451.00
255_P259_W1.9351.00
158_A161_Q1.9221.00
146_L306_A1.9211.00
45_L224_V1.8841.00
59_A109_M1.8831.00
192_N237_G1.8681.00
189_V193_L1.8461.00
190_V294_L1.8121.00
73_F95_F1.7791.00
9_G268_Y1.7721.00
67_L229_G1.7481.00
16_I269_F1.7371.00
8_A37_I1.7201.00
184_A245_F1.6981.00
95_F99_I1.6811.00
43_R47_K1.6801.00
181_N305_T1.6741.00
85_Q154_S1.6651.00
6_A232_I1.6551.00
162_N175_A1.6441.00
266_A270_F1.6401.00
175_A179_F1.6211.00
12_A269_F1.6201.00
77_V95_F1.5791.00
143_S184_A1.5521.00
20_F273_W1.5391.00
148_T159_I1.5391.00
152_Q155_E1.5271.00
255_P258_V1.5271.00
206_A210_I1.5221.00
129_Q286_L1.5101.00
215_Q223_F1.4911.00
2_L232_I1.4611.00
96_V100_A1.4591.00
136_P191_A1.4571.00
203_T286_L1.4361.00
192_N241_I1.4281.00
184_A301_N1.4231.00
16_I272_Q1.4081.00
144_V156_I1.4051.00
19_A24_I1.3991.00
273_W277_A1.3841.00
126_A204_P1.3601.00
223_F227_Y1.3541.00
176_W263_K1.3471.00
6_A228_L1.3401.00
16_I20_F1.3401.00
66_V70_S1.3191.00
24_I27_N1.2961.00
89_P95_F1.2931.00
141_A244_L1.2811.00
146_L309_L1.2711.00
206_A209_E1.2611.00
289_I294_L1.2591.00
139_L302_L1.2571.00
5_T265_W1.2531.00
61_D222_Y1.2471.00
203_T281_V1.2451.00
116_N119_S1.2381.00
122_G204_P1.2381.00
136_P298_S1.2341.00
81_G84_I1.2311.00
31_P35_G1.2301.00
242_A246_L1.2291.00
137_L191_A1.2041.00
194_A201_F1.1941.00
154_S158_A1.1881.00
36_T40_D1.1871.00
52_P60_Y1.1781.00
283_I287_I1.1751.00
110_G113_A1.1711.00
148_T156_I1.1681.00
241_I267_V1.1661.00
155_E159_I1.1641.00
188_F237_G1.1591.00
234_I271_T1.1550.99
19_A27_N1.1540.99
63_A110_G1.1530.99
108_I127_V1.1440.99
15_K19_A1.1420.99
211_V216_T1.1420.99
60_Y64_P1.1320.99
234_I268_Y1.1310.99
88_D154_S1.1270.99
182_P186_V1.1260.99
139_L299_F1.1220.99
136_P290_G1.1190.99
63_A109_M1.1150.99
143_S298_S1.1080.99
160_Q177_F1.1070.99
260_F264_I1.1040.99
45_L221_A1.1030.99
88_D152_Q1.0920.99
13_K198_R1.0910.99
254_L258_V1.0860.99
147_F181_N1.0830.99
76_A95_F1.0740.99
221_A224_V1.0730.99
42_V46_S1.0720.99
182_P185_F1.0710.99
269_F273_W1.0700.99
104_S130_N1.0690.99
13_K275_R1.0660.99
8_A34_L1.0600.99
5_T235_F1.0600.99
176_W179_F1.0590.99
19_A32_W1.0550.99
246_L263_K1.0450.99
242_A264_I1.0450.99
186_V190_V1.0410.99
203_T210_I1.0410.99
11_W34_L1.0380.99
175_A180_V1.0350.99
12_A16_I1.0330.99
75_F236_L1.0330.99
52_P55_V1.0330.99
105_L283_I1.0320.99
73_F99_I1.0300.99
150_T156_I1.0250.99
196_V237_G1.0230.99
160_Q247_G1.0180.99
4_M38_V1.0150.99
239_A243_T1.0140.99
38_V42_V1.0040.99
203_T285_Q0.9960.98
158_A162_N0.9900.98
248_G263_K0.9900.98
51_I61_D0.9900.98
187_L297_L0.9890.98
282_R287_I0.9880.98
68_A72_L0.9830.98
10_P231_F0.9770.98
27_N32_W0.9750.98
93_L145_V0.9690.98
267_V270_F0.9660.98
124_L204_P0.9650.98
12_A272_Q0.9630.98
143_S302_L0.9610.98
136_P295_L0.9600.98
92_G152_Q0.9590.98
110_G226_F0.9590.98
147_F309_L0.9570.98
110_G218_Y0.9440.98
11_W37_I0.9330.98
161_Q250_G0.9300.98
210_I214_Y0.9230.97
41_S46_S0.9220.97
63_A113_A0.9160.97
68_A229_G0.9160.97
44_L224_V0.9150.97
270_F274_C0.9130.97
77_V92_G0.9120.97
63_A106_G0.9060.97
18_A24_I0.9050.97
202_D280_R0.9050.97
68_A225_L0.9000.97
273_W278_I0.8980.97
181_N301_N0.8960.97
199_N278_I0.8920.97
8_A38_V0.8910.97
301_N305_T0.8900.97
70_S99_I0.8800.97
140_T191_A0.8740.97
85_Q88_D0.8730.96
41_S45_L0.8700.96
140_T187_L0.8660.96
206_A280_R0.8660.96
29_V36_T0.8560.96
198_R202_D0.8550.96
157_V249_P0.8530.96
179_F182_P0.8480.96
256_G259_W0.8480.96
93_L153_L0.8470.96
281_V285_Q0.8420.96
67_L226_F0.8400.96
185_F245_F0.8390.96
189_V271_T0.8390.96
41_S228_L0.8370.96
143_S181_N0.8340.95
80_M86_L0.8310.95
89_P96_V0.8260.95
93_L156_I0.8190.95
202_D205_E0.8180.95
17_T275_R0.8170.95
44_L227_Y0.8080.95
15_K47_K0.8070.95
7_F17_T0.8010.94
129_Q133_Y0.8000.94
61_D65_I0.8000.94
160_Q176_W0.7930.94
129_Q197_G0.7920.94
188_F245_F0.7920.94
188_F192_N0.7920.94
215_Q227_Y0.7910.94
297_L301_N0.7860.94
71_A236_L0.7780.93
21_T26_V0.7780.93
3_T72_L0.7760.93
305_T309_L0.7720.93
159_I162_N0.7710.93
27_N33_G0.7700.93
96_V153_L0.7690.93
97_F141_A0.7670.93
224_V228_L0.7660.93
68_A216_T0.7640.93
78_I239_A0.7630.93
10_P13_K0.7580.93
86_L228_L0.7570.92
136_P294_L0.7560.92
195_E198_R0.7540.92
112_Y115_N0.7520.92
208_T211_V0.7510.92
59_A63_A0.7500.92
220_S224_V0.7460.92
40_D43_R0.7450.92
209_E280_R0.7420.92
11_W17_T0.7420.92
11_W19_A0.7400.92
88_D92_G0.7390.92
8_A11_W0.7360.91
194_A286_L0.7360.91
24_I28_R0.7360.91
62_L65_I0.7340.91
56_D115_N0.7330.91
193_L271_T0.7330.91
30_G35_G0.7320.91
189_V241_I0.7310.91
204_P214_Y0.7290.91
5_T8_A0.7280.91
106_G109_M0.7280.91
36_T43_R0.7260.91
89_P226_F0.7250.91
60_Y218_Y0.7240.91
140_T143_S0.7240.91
247_G263_K0.7240.91
82_N158_A0.7150.90
17_T22_D0.7140.90
143_S301_N0.7140.90
35_G38_V0.7130.90
145_V151_L0.7120.90
280_R284_D0.7120.90
77_V96_V0.7110.90
13_K231_F0.7110.90
14_R205_E0.7110.90
126_A206_A0.7070.90
157_V248_G0.7040.90
132_A287_I0.7030.89
77_V80_M0.7020.89
116_N271_T0.7010.89
107_L126_A0.6980.89
14_R40_D0.6970.89
5_T268_Y0.6960.89
282_R285_Q0.6960.89
258_V262_I0.6950.89
288_G292_K0.6940.89
114_S218_Y0.6910.89
304_L307_T0.6890.89
126_A210_I0.6880.88
242_A263_K0.6880.88
137_L290_G0.6850.88
260_F263_K0.6830.88
187_L190_V0.6790.88
7_F11_W0.6770.88
67_L103_A0.6750.87
284_D287_I0.6750.87
13_K17_T0.6720.87
5_T232_I0.6710.87
41_S224_V0.6680.87
100_A103_A0.6650.87
199_N208_T0.6640.87
16_I273_W0.6610.86
137_L140_T0.6600.86
205_E213_G0.6570.86
64_P218_Y0.6560.86
257_F261_T0.6560.86
266_A269_F0.6560.86
176_W248_G0.6540.86
142_A145_V0.6510.86
189_V273_W0.6500.85
178_A182_P0.6440.85
133_Y194_A0.6420.85
67_L107_L0.6310.84
7_F41_S0.6300.84
122_G126_A0.6300.84
212_A227_Y0.6300.84
26_V36_T0.6280.83
249_P263_K0.6270.83
119_S212_A0.6270.83
298_S305_T0.6240.83
52_P64_P0.6230.83
295_L298_S0.6230.83
51_I57_R0.6220.83
129_Q132_A0.6200.83
130_N138_V0.6200.83
93_L141_A0.6200.83
160_Q248_G0.6190.83
264_I268_Y0.6180.82
11_W32_W0.6180.82
227_Y275_R0.6170.82
42_V45_L0.6140.82
54_G220_S0.6140.82
14_R23_R0.6130.82
242_A256_G0.6120.82
10_P41_S0.6110.82
55_V60_Y0.6080.81
30_G36_T0.6080.81
11_W15_K0.6070.81
70_S103_A0.6060.81
176_W247_G0.6050.81
147_F180_V0.6040.81
15_K34_L0.6020.81
208_T212_A0.6020.81
122_G211_V0.6020.81
189_V267_V0.6010.81
72_L232_I0.6000.81
62_L66_V0.5990.80
202_D209_E0.5980.80
185_F246_L0.5950.80
237_G241_I0.5940.80
286_L295_L0.5940.80
144_V244_L0.5930.80
39_V117_K0.5910.80
23_R213_G0.5900.80
202_D210_I0.5900.80
268_Y272_Q0.5890.79
290_G293_G0.5870.79
252_P255_P0.5840.79
153_L240_I0.5830.79
109_M113_A0.5830.79
114_S119_S0.5800.78
142_A302_L0.5760.78
69_G304_L0.5750.78
231_F275_R0.5750.78
281_V290_G0.5750.78
18_A23_R0.5730.78
49_L60_Y0.5730.78
47_K292_K0.5730.78
132_A295_L0.5720.77
270_F273_W0.5720.77
183_F301_N0.5700.77
78_I236_L0.5700.77
19_A138_V0.5700.77
37_I75_F0.5690.77
15_K27_N0.5690.77
158_A248_G0.5690.77
272_Q275_R0.5670.77
156_I243_T0.5670.77
203_T206_A0.5650.77
289_I293_G0.5650.77
21_T217_E0.5650.77
262_I265_W0.5650.77
67_L74_A0.5630.76
140_T184_A0.5620.76
196_V233_H0.5620.76
69_G158_A0.5580.76
177_F180_V0.5560.75
80_M239_A0.5520.75
77_V190_V0.5520.75
86_L303_V0.5520.75
32_W61_D0.5510.75
198_R231_F0.5490.74
86_L91_V0.5470.74
30_G224_V0.5470.74
19_A272_Q0.5460.74
143_S305_T0.5450.74
100_A241_I0.5440.74
204_P215_Q0.5420.74
107_L197_G0.5410.73
51_I55_V0.5370.73
4_M7_F0.5360.73
197_G230_E0.5340.72
183_F300_A0.5340.72
136_P283_I0.5340.72
78_I86_L0.5340.72
105_L137_L0.5330.72
214_Y227_Y0.5330.72
286_L291_W0.5310.72
119_S309_L0.5310.72
280_R283_I0.5290.72
96_V236_L0.5280.72
138_V141_A0.5270.71
60_Y110_G0.5260.71
7_F228_L0.5220.71
5_T9_G0.5220.71
102_I293_G0.5210.71
298_S302_L0.5160.70
272_Q276_S0.5150.70
128_A287_I0.5140.70
255_P262_I0.5140.70
14_R21_T0.5130.69
249_P256_G0.5120.69
112_Y124_L0.5100.69
13_K272_Q0.5100.69
14_R207_P0.5090.69
156_I244_L0.5090.69
3_T7_F0.5080.69
40_D280_R0.5080.69
37_I44_L0.5080.69
106_G138_V0.5070.69
66_V308_A0.5070.69
161_Q177_F0.5070.69
197_G233_H0.5030.68
133_Y291_W0.5030.68
306_A309_L0.5030.68
14_R201_F0.5020.68
88_D91_V0.5020.68
148_T155_E0.5010.68
242_A267_V0.5010.68
231_F286_L0.5010.68
100_A130_N0.5000.68
63_A101_S0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.7834 100 0.046 Contact Map
2jpkA 1 0.1115 6.3 0.971 Contact Map
1qleD 1 0.1369 4.1 0.974 Contact Map
1q2fA 1 0.0987 3.9 0.974 Contact Map
4h25C 1 0.0701 3.2 0.975 Contact Map
1q90G 1 0.0701 2.9 0.976 Contact Map
3dacP 1 0.0414 2.4 0.977 Contact Map
2ll2A 1 0.0828 2.3 0.977 Contact Map
1vryA 1 0.1943 2.2 0.977 Contact Map
3w4tA 1 0.9076 2 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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