GREMLIN Database
Q9HRL4 - NADH dehydrogenase/oxidoreductase-like protein
UniProt: Q9HRL4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 100 (96)
Sequences: 1568 (746)
Seq/√Len: 76.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_G34_S5.9461.00
4_M52_F2.8361.00
89_D94_N2.6291.00
32_L45_N2.4721.00
43_G65_V2.4151.00
4_M48_A2.4151.00
46_L61_F2.2081.00
15_F38_M2.1461.00
45_N49_F2.1371.00
9_L13_A2.0061.00
91_D94_N1.9891.00
42_A45_N1.9431.00
7_Y48_A1.8781.00
31_F92_V1.7891.00
19_V38_M1.7191.00
30_L33_M1.6971.00
45_N48_A1.6951.00
83_L95_A1.6951.00
87_F97_T1.6411.00
24_T40_N1.6221.00
20_F24_T1.6151.00
11_S45_N1.5940.99
10_L14_V1.5680.99
40_N66_M1.5640.99
4_M53_H1.4960.99
23_L30_L1.4710.99
46_L58_G1.4420.99
20_F77_L1.4270.99
40_N83_L1.4270.99
82_T85_R1.3290.98
19_V22_V1.3280.98
62_T66_M1.3030.98
50_S56_L1.2550.97
8_L45_N1.2170.97
28_A92_V1.1970.96
22_V34_S1.1910.96
89_D96_T1.1510.95
10_L44_I1.1380.95
75_V82_T1.1010.94
8_L12_A1.0550.93
11_S56_L1.0440.92
63_L67_A1.0400.92
18_G31_F1.0370.92
32_L80_I1.0200.92
28_A35_V1.0140.91
69_A76_G0.9500.88
22_V38_M0.9490.88
74_A79_I0.9470.88
14_V77_L0.9460.88
20_F66_M0.9340.88
19_V84_Y0.9310.87
46_L90_I0.9210.87
22_V31_F0.9150.86
37_L49_F0.9120.86
40_N43_G0.9100.86
13_A17_I0.9060.86
40_N73_V0.8870.85
43_G62_T0.8840.84
8_L49_F0.8790.84
26_R66_M0.8760.84
92_V95_A0.8640.83
18_G38_M0.8510.82
11_S15_F0.8290.80
45_N62_T0.8200.80
11_S41_A0.8180.80
41_A44_I0.8170.79
54_G95_A0.7900.77
10_L48_A0.7870.77
28_A73_V0.7870.77
30_L79_I0.7770.76
22_V66_M0.7750.76
50_S81_L0.7640.75
7_Y79_I0.7560.74
44_I48_A0.7520.74
10_L63_L0.7410.73
17_I21_G0.7390.72
16_C20_F0.7310.71
6_Y9_L0.7280.71
95_A98_M0.7260.71
50_S60_A0.7190.70
6_Y10_L0.7180.70
46_L59_Q0.7130.70
87_F95_A0.7030.69
76_G87_F0.7020.68
32_L71_A0.7020.68
38_M76_G0.6880.67
35_V78_G0.6860.67
78_G82_T0.6840.66
78_G96_T0.6740.65
14_V32_L0.6520.63
12_A16_C0.6510.63
25_R57_S0.6490.62
30_L73_V0.6440.62
69_A73_V0.6430.62
64_F99_R0.6390.61
33_M65_V0.6330.60
25_R30_L0.6270.60
27_S90_I0.6200.59
26_R93_T0.6150.58
24_T63_L0.6140.58
7_Y67_A0.6130.58
64_F67_A0.6080.57
87_F94_N0.6060.57
52_F65_V0.6050.57
11_S29_L0.6020.57
62_T91_D0.6020.57
18_G34_S0.5980.56
64_F70_A0.5970.56
9_L12_A0.5910.55
43_G49_F0.5900.55
66_M82_T0.5880.55
21_G67_A0.5870.55
51_W82_T0.5820.54
26_R85_R0.5820.54
26_R63_L0.5770.53
49_F71_A0.5760.53
34_S63_L0.5710.53
37_L71_A0.5610.51
29_L95_A0.5580.51
21_G53_H0.5580.51
42_A53_H0.5550.51
30_L50_S0.5550.51
8_L52_F0.5550.51
14_V17_I0.5540.51
58_G61_F0.5470.50
27_S58_G0.5470.50
72_E75_V0.5450.49
28_A93_T0.5430.49
67_A82_T0.5420.49
11_S44_I0.5420.49
73_V80_I0.5420.49
31_F42_A0.5390.49
18_G40_N0.5390.49
78_G86_N0.5370.48
20_F63_L0.5340.48
6_Y98_M0.5320.48
57_S97_T0.5180.46
12_A73_V0.5130.45
11_S17_I0.5120.45
27_S33_M0.5100.45
47_V93_T0.5040.44
37_L85_R0.5040.44
26_R91_D0.5030.44
14_V47_V0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoK 1 1 99.9 0.366 Contact Map
4he8K 1 0.95 99.9 0.438 Contact Map
4he8M 1 0.96 8.6 0.935 Contact Map
3rkoN 1 0.95 7.5 0.936 Contact Map
3rkoL 1 0.96 6.1 0.939 Contact Map
3rkoM 1 0.99 5.7 0.94 Contact Map
4cz8A 2 0.87 5.3 0.941 Contact Map
4he8N 1 0.94 4.7 0.942 Contact Map
3mpyA 5 0.8 4.5 0.943 Contact Map
4he8L 1 0.95 4.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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