GREMLIN Database
Q9HRL2 - F420H2:quinone oxidoreductase chain M
UniProt: Q9HRL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 519 (457)
Sequences: 20115 (12530)
Seq/√Len: 586.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_D274_R4.7621.00
355_L392_A4.6231.00
128_G141_F4.5341.00
196_D199_A4.0711.00
90_V131_T3.7001.00
154_G165_A3.5261.00
348_A403_A3.2851.00
97_T123_E3.1981.00
299_V433_G3.0921.00
167_K247_D3.0861.00
311_D370_R3.0701.00
194_T199_A3.0221.00
345_Q407_G2.9381.00
390_I445_M2.8261.00
310_R373_G2.7821.00
295_A332_V2.6211.00
93_S130_F2.6011.00
316_V360_V2.5991.00
369_T374_D2.5921.00
11_L124_A2.5771.00
125_S144_F2.5621.00
90_V127_L2.5021.00
182_G227_A2.4811.00
371_M374_D2.4681.00
104_A115_F2.4561.00
238_T328_I2.4411.00
393_A441_L2.3171.00
315_I372_V2.2761.00
94_T127_L2.2691.00
307_L439_G2.2551.00
81_G133_L2.2211.00
329_L430_A2.1781.00
330_G411_I2.0021.00
44_F48_D1.9991.00
265_L320_S1.9971.00
29_A33_S1.9731.00
289_V293_A1.9661.00
344_F407_G1.9171.00
300_I433_G1.8821.00
382_M385_T1.8241.00
199_A202_Q1.8181.00
319_S440_Y1.8171.00
233_A238_T1.8121.00
303_A322_S1.7901.00
310_R371_M1.7701.00
135_F275_F1.7561.00
443_F447_R1.7391.00
18_M21_P1.7361.00
164_A251_Q1.7261.00
312_L444_A1.7251.00
466_L470_V1.7141.00
199_A203_A1.7061.00
83_D86_S1.7041.00
412_F430_A1.6931.00
37_V44_F1.6931.00
135_F200_I1.6901.00
92_L350_G1.6861.00
286_Q289_V1.6861.00
86_S270_Y1.6831.00
341_G414_G1.6761.00
424_Q428_A1.6741.00
292_A332_V1.6671.00
138_W271_A1.6601.00
379_A386_A1.6471.00
385_T463_P1.6401.00
158_G251_Q1.6321.00
29_A40_S1.6271.00
111_R114_Q1.6231.00
273_L331_L1.6231.00
485_V488_V1.6221.00
34_L38_V1.6081.00
477_L481_V1.6061.00
351_L478_L1.6051.00
296_V429_L1.6041.00
237_P245_L1.5981.00
333_A338_G1.5981.00
309_Q314_R1.5961.00
133_L198_P1.5851.00
229_F233_A1.5721.00
40_S43_M1.5661.00
42_W46_Q1.5631.00
239_V297_L1.5551.00
24_I27_K1.5441.00
132_A137_V1.5301.00
118_L151_F1.5221.00
88_P347_V1.5111.00
415_G427_T1.5071.00
101_I116_Y1.4981.00
134_D196_D1.4911.00
291_I332_V1.4891.00
36_P40_S1.4891.00
43_M47_F1.4801.00
219_T223_V1.4761.00
81_G84_G1.4721.00
391_A476_L1.4621.00
26_G29_A1.4461.00
101_I119_M1.4411.00
413_L417_G1.4391.00
182_G231_G1.4381.00
158_G161_R1.4341.00
40_S47_F1.4291.00
13_S32_L1.4291.00
389_F393_A1.4181.00
303_A433_G1.4161.00
41_V45_V1.4151.00
134_D195_M1.4131.00
7_L10_T1.4121.00
33_S37_V1.4081.00
292_A426_F1.4081.00
331_L342_A1.3921.00
238_T294_L1.3901.00
232_F271_A1.3891.00
152_L256_A1.3861.00
67_H77_N1.3841.00
47_F51_G1.3801.00
129_V267_M1.3791.00
386_A450_F1.3771.00
229_F291_I1.3721.00
474_A478_L1.3641.00
37_V41_V1.3561.00
327_V342_A1.3541.00
33_S36_P1.3471.00
88_P343_T1.3461.00
272_L328_I1.3441.00
82_I131_T1.3411.00
288_A292_A1.3401.00
43_M46_Q1.3321.00
273_L342_A1.3271.00
190_L224_A1.3231.00
487_N491_G1.3201.00
35_L39_G1.3181.00
32_L36_P1.3021.00
182_G228_M1.3001.00
389_F444_A1.2941.00
160_R251_Q1.2921.00
103_S358_M1.2901.00
330_G338_G1.2861.00
352_I395_G1.2851.00
333_A415_G1.2811.00
79_H133_L1.2781.00
465_A468_D1.2731.00
179_M231_G1.2701.00
386_A445_M1.2691.00
21_P113_S1.2691.00
65_M77_N1.2601.00
329_L415_G1.2591.00
473_V477_L1.2571.00
138_W197_M1.2551.00
40_S94_T1.2471.00
356_M392_A1.2461.00
330_G342_A1.2371.00
198_P202_Q1.2361.00
7_L124_A1.2351.00
301_Y305_L1.2201.00
14_A18_M1.2171.00
348_A407_G1.2141.00
182_G224_A1.2131.00
46_Q50_S1.2131.00
466_L469_T1.2121.00
6_L10_T1.2081.00
135_F183_F1.2071.00
171_Y243_T1.2041.00
14_A17_V1.1981.00
67_H70_T1.1971.00
372_V448_V1.1951.00
471_P474_A1.1871.00
64_T67_H1.1851.00
96_L354_G1.1851.00
247_D314_R1.1801.00
122_M126_L1.1771.00
40_S44_F1.1741.00
38_V42_W1.1721.00
94_T98_T1.1601.00
388_V476_L1.1561.00
28_L31_G1.1511.00
488_V491_G1.1481.00
30_A34_L1.1451.00
96_L350_G1.1431.00
233_A294_L1.1381.00
99_L474_A1.1271.00
26_G30_A1.1271.00
29_A37_V1.1251.00
341_G410_F1.1231.00
70_T73_P1.1211.00
36_P39_G1.1201.00
396_Y441_L1.1181.00
322_S437_V1.1151.00
85_I273_L1.1111.00
5_A9_V1.1101.00
136_F195_M1.1061.00
393_A445_M1.1051.00
139_F180_F1.1031.00
133_L196_D1.1011.00
394_F399_L1.0991.00
163_Y167_K1.0991.00
416_F427_T1.0981.00
30_A44_F1.0971.00
390_I449_L1.0941.00
29_A32_L1.0931.00
293_A297_L1.0931.00
359_C389_F1.0921.00
183_F228_M1.0911.00
17_V21_P1.0901.00
359_C472_I1.0811.00
392_A476_L1.0791.00
425_L428_A1.0761.00
28_L32_L1.0751.00
388_V472_I1.0751.00
89_L346_M1.0751.00
36_P43_M1.0681.00
175_A234_V1.0651.00
364_Y370_R1.0631.00
336_Y340_G1.0541.00
295_A325_G1.0521.00
30_A37_V1.0521.00
98_T102_T1.0511.00
82_I87_M1.0491.00
239_V301_Y1.0481.00
366_T382_M1.0471.00
96_L262_G1.0441.00
437_V440_Y1.0391.00
86_S274_R1.0391.00
384_V387_A1.0371.00
478_L482_A1.0341.00
185_A189_G1.0301.00
194_T200_I1.0301.00
45_V49_G1.0291.00
30_A33_S1.0281.00
376_S454_A1.0271.00
229_F272_L1.0271.00
410_F413_L1.0261.00
119_M259_M1.0261.00
234_V241_L1.0191.00
467_H471_P1.0171.00
34_L98_T1.0171.00
224_A228_M1.0141.00
179_M183_F1.0121.00
285_Q288_A1.0121.00
23_R27_K1.0091.00
384_V473_V1.0061.00
105_W108_I1.0051.00
389_F449_L0.9991.00
197_M201_A0.9971.00
236_V269_T0.9941.00
120_L124_A0.9801.00
338_G414_G0.9751.00
222_T287_Y0.9731.00
289_V292_A0.9721.00
386_A449_L0.9661.00
428_A432_F0.9641.00
419_D423_A0.9631.00
363_I378_I0.9621.00
93_S123_E0.9601.00
302_G325_G0.9601.00
385_T464_A0.9601.00
269_T327_V0.9601.00
355_L475_L0.9571.00
403_A482_A0.9541.00
95_V99_L0.9521.00
103_S361_G0.9501.00
254_T313_K0.9501.00
85_I343_T0.9461.00
367_A375_L0.9451.00
388_V473_V0.9451.00
384_V388_V0.9441.00
23_R26_G0.9421.00
86_S90_V0.9331.00
14_A121_L0.9321.00
185_A188_F0.9311.00
441_L444_A0.9311.00
312_L360_V0.9301.00
194_T197_M0.9271.00
272_L331_L0.9261.00
258_V358_M0.9251.00
335_N338_G0.9231.00
304_M436_I0.9221.00
161_R251_Q0.9221.00
14_A117_A0.9221.00
365_N462_V0.9201.00
362_V385_T0.9201.00
97_T119_M0.9181.00
366_T468_D0.9161.00
188_F195_M0.9161.00
159_P163_Y0.9141.00
349_H353_S0.9131.00
433_G436_I0.9121.00
257_S265_L0.9091.00
46_Q49_G0.9071.00
246_P318_Y0.9071.00
10_T14_A0.9061.00
223_V227_A0.9041.00
89_L270_Y0.9021.00
186_L220_L0.8991.00
372_V447_R0.8981.00
178_L227_A0.8951.00
270_Y274_R0.8931.00
362_V464_A0.8931.00
335_N414_G0.8921.00
139_F183_F0.8911.00
121_L148_P0.8911.00
295_A329_L0.8891.00
162_K165_A0.8851.00
269_T346_M0.8841.00
125_S148_P0.8831.00
273_L339_V0.8791.00
153_I248_A0.8771.00
445_M450_F0.8761.00
312_L375_L0.8751.00
149_M264_L0.8731.00
30_A47_F0.8731.00
412_F427_T0.8711.00
330_G341_G0.8681.00
362_V472_I0.8671.00
344_F348_A0.8661.00
222_T286_Q0.8641.00
48_D51_G0.8641.00
323_S345_Q0.8631.00
217_A220_L0.8591.00
327_V346_M0.8581.00
315_I444_A0.8531.00
37_V40_S0.8531.00
381_K453_F0.8521.00
481_V485_V0.8521.00
226_F230_I0.8521.00
299_V325_G0.8491.00
297_L301_Y0.8491.00
139_F143_E0.8481.00
311_D371_M0.8441.00
145_V264_L0.8431.00
376_S447_R0.8431.00
269_T328_I0.8431.00
320_S349_H0.8421.00
100_A358_M0.8411.00
299_V329_L0.8401.00
292_A295_A0.8391.00
323_S437_V0.8391.00
303_A436_I0.8371.00
409_L413_L0.8351.00
323_S440_Y0.8351.00
296_V426_F0.8351.00
178_L230_I0.8321.00
106_T109_D0.8311.00
44_F47_F0.8271.00
387_A391_A0.8271.00
31_G35_L0.8241.00
29_A44_F0.8241.00
30_A40_S0.8241.00
92_L347_V0.8151.00
283_I286_Q0.8121.00
80_V131_T0.8101.00
303_A440_Y0.8071.00
127_L131_T0.8051.00
79_H196_D0.8041.00
284_A288_A0.8041.00
476_L480_I0.8031.00
122_M149_M0.8021.00
295_A328_I0.8021.00
7_L80_V0.8011.00
29_A51_G0.7981.00
195_M199_A0.7981.00
192_V200_I0.7961.00
7_L131_T0.7961.00
218_E222_T0.7941.00
115_F255_P0.7931.00
47_F50_S0.7921.00
302_G305_L0.7921.00
261_A353_S0.7911.00
386_A390_I0.7911.00
37_V51_G0.7891.00
454_A457_T0.7871.00
296_V329_L0.7871.00
13_S17_V0.7841.00
22_D26_G0.7841.00
403_A479_V0.7821.00
126_L263_V0.7821.00
30_A48_D0.7801.00
125_S141_F0.7781.00
476_L479_V0.7771.00
6_L18_M0.7751.00
126_L145_V0.7741.00
306_A440_Y0.7741.00
25_A29_A0.7741.00
91_V95_V0.7721.00
130_F270_Y0.7701.00
292_A296_V0.7701.00
225_F287_Y0.7681.00
218_E221_K0.7681.00
150_Y165_A0.7661.00
269_T324_M0.7651.00
376_S451_G0.7641.00
292_A329_L0.7631.00
219_T222_T0.7631.00
8_G12_L0.7621.00
9_V13_S0.7601.00
29_A43_M0.7601.00
326_Y411_I0.7591.00
187_V224_A0.7591.00
217_A221_K0.7561.00
37_V43_M0.7551.00
87_M91_V0.7541.00
22_D27_K0.7541.00
43_M51_G0.7521.00
393_A444_A0.7501.00
32_L44_F0.7491.00
63_E79_H0.7481.00
142_W179_M0.7471.00
10_T13_S0.7441.00
105_W109_D0.7431.00
395_G402_M0.7431.00
150_Y172_T0.7421.00
201_A278_T0.7401.00
14_A124_A0.7381.00
470_V474_A0.7381.00
302_G322_S0.7351.00
40_S48_D0.7351.00
418_A423_A0.7341.00
134_D137_V0.7331.00
469_T473_V0.7331.00
387_A449_L0.7331.00
464_A469_T0.7321.00
316_V356_M0.7321.00
22_D25_A0.7311.00
358_M471_P0.7311.00
381_K459_Y0.7301.00
333_A418_A0.7301.00
93_S126_L0.7291.00
37_V49_G0.7281.00
29_A50_S0.7271.00
397_M438_A0.7261.00
29_A47_F0.7221.00
28_L33_S0.7221.00
96_L259_M0.7211.00
222_T226_F0.7201.00
76_L136_F0.7201.00
112_Q116_Y0.7171.00
419_D424_Q0.7161.00
27_K30_A0.7161.00
173_N176_S0.7141.00
99_L475_L0.7141.00
30_A36_P0.7131.00
29_A39_G0.7121.00
62_F65_M0.7111.00
25_A28_L0.7111.00
18_M117_A0.7111.00
382_M463_P0.7091.00
352_I479_V0.7091.00
46_Q51_G0.7071.00
126_L264_L0.7071.00
166_I170_V0.7041.00
300_I304_M0.7031.00
27_K31_G0.7031.00
352_I404_G0.7031.00
257_S313_K0.7021.00
153_I260_L0.7011.00
312_L448_V0.7011.00
401_L484_T0.7011.00
175_A231_G0.6991.00
67_H75_T0.6991.00
145_V267_M0.6991.00
319_S349_H0.6971.00
380_D383_P0.6961.00
36_P46_Q0.6931.00
40_S51_G0.6911.00
113_S117_A0.6901.00
435_V439_G0.6901.00
27_K32_L0.6881.00
160_R250_V0.6881.00
345_Q352_I0.6861.00
153_I252_A0.6861.00
36_P42_W0.6831.00
470_V473_V0.6821.00
31_G36_P0.6821.00
309_Q318_Y0.6821.00
387_A390_I0.6781.00
369_T375_L0.6781.00
82_I86_S0.6771.00
30_A39_G0.6741.00
25_A30_A0.6731.00
250_V311_D0.6721.00
402_M406_A0.6711.00
13_S36_P0.6711.00
122_M264_L0.6701.00
303_A319_S0.6701.00
463_P469_T0.6701.00
275_F279_M0.6691.00
5_A10_T0.6681.00
252_A257_S0.6671.00
142_W267_M0.6661.00
160_R163_Y0.6651.00
95_V478_L0.6641.00
99_L354_G0.6631.00
100_A258_V0.6611.00
290_P293_A0.6601.00
429_L433_G0.6561.00
300_I429_L0.6551.00
79_H134_D0.6551.00
28_L40_S0.6551.00
99_L471_P0.6541.00
438_A442_L0.6521.00
102_T471_P0.6501.00
42_W45_V0.6501.00
28_L36_P0.6491.00
216_G219_T0.6491.00
442_L446_Q0.6491.00
29_A36_P0.6461.00
355_L472_I0.6451.00
33_S43_M0.6451.00
34_L37_V0.6441.00
30_A50_S0.6421.00
381_K461_I0.6411.00
296_V300_I0.6381.00
33_S40_S0.6351.00
13_S120_L0.6351.00
254_T361_G0.6331.00
439_G443_F0.6321.00
398_G408_E0.6311.00
10_T21_P0.6301.00
190_L220_L0.6281.00
286_Q290_P0.6281.00
100_A262_G0.6261.00
445_M449_L0.6181.00
81_G198_P0.6181.00
323_S353_S0.6181.00
91_V94_T0.6171.00
85_I270_Y0.6151.00
261_A349_H0.6151.00
221_K224_A0.6151.00
482_A489_F0.6151.00
69_I76_L0.6131.00
245_L248_A0.6131.00
388_V469_T0.6121.00
25_A33_S0.6111.00
245_L265_L0.6101.00
37_V48_D0.6091.00
133_L137_V0.6091.00
303_A437_V0.6091.00
345_Q348_A0.6071.00
41_V95_V0.6061.00
103_S258_V0.6061.00
326_Y433_G0.6041.00
384_V469_T0.6041.00
115_F256_A0.6031.00
94_T123_E0.6031.00
347_V489_F0.6031.00
262_G354_G0.6001.00
299_V326_Y0.5991.00
135_F197_M0.5991.00
114_Q118_L0.5991.00
481_V488_V0.5981.00
225_F229_F0.5981.00
44_F49_G0.5971.00
97_T259_M0.5971.00
338_G342_A0.5961.00
138_W179_M0.5951.00
33_S51_G0.5951.00
186_L224_A0.5931.00
15_L18_M0.5931.00
63_E66_T0.5931.00
305_L318_Y0.5921.00
379_A449_L0.5921.00
36_P49_G0.5921.00
254_T257_S0.5901.00
32_L47_F0.5901.00
257_S260_L0.5901.00
359_C388_V0.5891.00
408_E434_I0.5891.00
410_F490_Y0.5871.00
395_G404_G0.5861.00
121_L125_S0.5851.00
412_F434_I0.5831.00
102_T470_V0.5831.00
9_V21_P0.5821.00
104_A255_P0.5811.00
349_H357_F0.5801.00
13_S18_M0.5801.00
362_V366_T0.5801.00
32_L50_S0.5801.00
388_V392_A0.5791.00
319_S323_S0.5781.00
28_L46_Q0.5781.00
41_V44_F0.5781.00
28_L43_M0.5761.00
246_P321_V0.5741.00
32_L40_S0.5741.00
391_A480_I0.5731.00
461_I464_A0.5721.00
351_L403_A0.5721.00
7_L21_P0.5711.00
257_S349_H0.5701.00
7_L14_A0.5691.00
100_A255_P0.5691.00
293_A296_V0.5671.00
192_V196_D0.5661.00
431_M434_I0.5651.00
309_Q315_I0.5651.00
390_I450_F0.5641.00
43_M48_D0.5641.00
304_M308_A0.5630.99
122_M259_M0.5630.99
223_V226_F0.5630.99
93_S97_T0.5620.99
13_S21_P0.5600.99
305_L308_A0.5590.99
295_A299_V0.5590.99
319_S353_S0.5580.99
85_I89_L0.5570.99
89_L93_S0.5550.99
394_F442_L0.5550.99
406_A410_F0.5530.99
243_T246_P0.5520.99
320_S324_M0.5500.99
282_G285_Q0.5500.99
31_G39_G0.5480.99
198_P201_A0.5440.99
44_F91_V0.5440.99
261_A357_F0.5440.99
100_A119_M0.5420.99
187_V200_I0.5420.99
126_L267_M0.5410.99
239_V302_G0.5410.99
362_V468_D0.5400.99
382_M461_I0.5400.99
378_I382_M0.5400.99
398_G404_G0.5400.99
253_P313_K0.5390.99
392_A479_V0.5390.99
93_S127_L0.5380.99
220_L224_A0.5380.99
33_S47_F0.5370.99
39_G43_M0.5370.99
347_V482_A0.5360.99
45_V48_D0.5340.99
480_I483_G0.5320.99
236_V272_L0.5310.99
225_F280_M0.5300.99
31_G38_V0.5300.99
200_I203_A0.5290.99
40_S49_G0.5280.99
29_A116_Y0.5280.99
21_P25_A0.5260.99
379_A390_I0.5260.99
11_L15_L0.5260.99
28_L51_G0.5250.99
487_N490_Y0.5250.99
118_L121_L0.5240.99
372_V375_L0.5240.99
60_L63_E0.5230.99
35_L40_S0.5220.99
6_L9_V0.5220.99
359_C392_A0.5210.99
30_A46_Q0.5210.99
340_G490_Y0.5200.99
274_R278_T0.5190.99
143_E235_K0.5190.99
37_V47_F0.5190.99
377_G453_F0.5180.99
383_P386_A0.5170.99
250_V314_R0.5170.99
425_L429_L0.5160.99
278_T281_P0.5160.99
225_F279_M0.5160.99
183_F231_G0.5150.99
123_E127_L0.5140.99
220_L223_V0.5140.99
416_F424_Q0.5140.99
312_L363_I0.5140.99
305_L309_Q0.5130.99
432_F436_I0.5130.99
139_F176_S0.5120.99
44_F51_G0.5120.99
262_G266_K0.5120.99
344_F410_F0.5110.99
92_L346_M0.5100.99
400_P405_F0.5090.99
352_I396_Y0.5090.99
115_F155_I0.5090.99
36_P48_D0.5080.99
451_G454_A0.5060.99
386_A448_V0.5060.99
163_Y247_D0.5050.99
389_F441_L0.5050.99
31_G37_V0.5040.99
39_G42_W0.5030.99
32_L35_L0.5030.99
32_L48_D0.5020.99
323_S326_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9403 100 0.169 Contact Map
4he8M 1 0.8902 100 0.212 Contact Map
3rkoL 1 0.948 100 0.213 Contact Map
4he8L 1 0.9403 100 0.227 Contact Map
3rkoN 1 0.8748 100 0.236 Contact Map
4he8N 1 0.8227 100 0.282 Contact Map
4he8K 1 0.1773 31.4 0.966 Contact Map
3rkoK 1 0.185 27.7 0.967 Contact Map
4b4aA 1 0.2697 9.5 0.973 Contact Map
3wu2X 1 0.0713 6.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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