GREMLIN Database
Q9HRL1 - NADH dehydrogenase/oxidoreductase
UniProt: Q9HRL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (355)
Sequences: 24192 (12651)
Seq/√Len: 671.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
260_G297_F4.7981.00
29_L42_S4.6221.00
96_G99_A3.6861.00
55_S67_G3.5751.00
69_K140_E3.3451.00
253_V308_A3.0111.00
209_N275_R2.9741.00
250_H312_S2.9241.00
197_M335_N2.9151.00
193_A230_A2.8611.00
227_I332_A2.5971.00
39_V164_V2.5771.00
208_E278_E2.5311.00
274_G279_D2.5111.00
131_S226_L2.4851.00
94_V99_A2.4791.00
26_G45_L2.4411.00
295_T347_V2.4381.00
228_G316_L2.4181.00
276_T279_D2.4161.00
214_L265_V2.3951.00
84_G120_M2.3941.00
126_A131_S2.3001.00
142_Y150_S2.2141.00
298_M343_Y2.1331.00
205_A341_F2.0031.00
198_T335_N1.9871.00
213_M277_F1.9801.00
130_A138_A1.9641.00
217_S342_Y1.9481.00
12_S15_E1.8911.00
187_L191_A1.8891.00
142_Y158_K1.8791.00
126_A192_L1.8421.00
385_A388_P1.8251.00
84_G124_G1.7981.00
99_A102_D1.7981.00
122_V126_A1.7871.00
158_K218_S1.7801.00
261_A297_F1.7481.00
34_N98_P1.7361.00
208_E276_T1.7261.00
317_F332_A1.6961.00
207_Q212_R1.6831.00
366_T370_V1.6731.00
287_A290_A1.6621.00
345_R349_A1.6571.00
53_L149_V1.6501.00
377_V381_A1.6371.00
201_N220_G1.6311.00
81_M124_G1.6171.00
190_A230_A1.6101.00
33_A38_T1.6051.00
320_A329_A1.6051.00
166_F247_S1.6011.00
184_D187_L1.6001.00
246_A319_G1.5971.00
249_M312_S1.5801.00
371_A374_A1.5721.00
210_V346_V1.5671.00
225_V247_S1.5561.00
132_V195_V1.5561.00
318_A322_Q1.5531.00
54_V145_A1.5531.00
36_L168_V1.5421.00
201_N335_N1.5401.00
326_A330_G1.5201.00
87_L117_G1.5171.00
19_L52_V1.5121.00
376_A380_I1.5111.00
166_F229_L1.5101.00
140_E212_R1.5061.00
26_G42_S1.5031.00
163_A167_R1.4891.00
112_G116_L1.4871.00
191_A195_V1.4851.00
193_A227_I1.4841.00
186_S190_A1.4821.00
142_Y154_S1.4721.00
36_L100_I1.4631.00
229_L247_S1.4601.00
84_G117_G1.4541.00
131_S192_L1.4411.00
125_F164_V1.4361.00
60_D63_S1.4341.00
89_Y95_M1.4321.00
65_E69_K1.4261.00
366_T369_Y1.4211.00
204_A342_Y1.4081.00
227_I320_A1.4041.00
31_A163_A1.4041.00
99_A103_T1.4001.00
194_V331_I1.3971.00
27_M156_A1.3961.00
139_P216_Y1.3851.00
30_M160_A1.3851.00
199_L203_A1.3821.00
193_A223_G1.3711.00
378_G382_L1.3531.00
66_A144_G1.3531.00
190_A328_L1.3511.00
365_P368_L1.3501.00
122_V189_F1.3481.00
220_G339_S1.3471.00
91_A117_G1.3471.00
294_M298_M1.3471.00
84_G121_L1.3441.00
35_S95_M1.3251.00
77_S127_F1.3231.00
294_M346_V1.3201.00
361_L364_Q1.3151.00
81_M85_I1.3141.00
284_S291_C1.3001.00
264_F294_M1.2981.00
189_F230_A1.2861.00
127_F134_F1.2841.00
295_T351_W1.2831.00
373_L377_V1.2661.00
256_F378_G1.2641.00
35_S96_G1.2631.00
197_M223_G1.2581.00
379_T383_L1.2571.00
87_L91_A1.2381.00
327_W330_G1.2341.00
22_L49_P1.2251.00
21_L25_T1.2251.00
374_A378_G1.2171.00
290_A363_G1.2131.00
187_L190_A1.2001.00
80_V120_M1.1911.00
330_G334_I1.1891.00
298_M347_V1.1881.00
200_G223_G1.1851.00
314_Y318_A1.1841.00
291_C347_V1.1721.00
119_V123_A1.1711.00
301_L343_Y1.1691.00
26_G49_P1.1621.00
289_V292_V1.1581.00
339_S342_Y1.1581.00
269_E275_R1.1571.00
228_G247_S1.1541.00
197_M332_A1.1451.00
380_I383_L1.1351.00
221_H250_H1.1301.00
253_V312_S1.1281.00
129_T162_F1.1271.00
257_M300_S1.1221.00
210_V265_V1.1191.00
37_V95_M1.1151.00
86_S90_A1.1121.00
23_A27_M1.1061.00
143_E209_N1.1021.00
254_Y258_N1.1011.00
155_S159_A1.0881.00
200_G203_A1.0881.00
28_T32_A1.0831.00
201_N342_Y1.0791.00
73_I136_F1.0781.00
296_V376_A1.0741.00
85_I121_L1.0701.00
362_S365_P1.0701.00
297_F376_A1.0691.00
231_A320_A1.0691.00
87_L113_V1.0661.00
171_T174_P1.0641.00
64_I67_G1.0631.00
165_L226_L1.0581.00
147_A211_K1.0581.00
132_V199_L1.0571.00
39_V97_L1.0451.00
138_A142_Y1.0411.00
302_A340_L1.0341.00
98_P102_D1.0341.00
154_S262_F1.0261.00
321_V329_A1.0221.00
289_V293_A1.0161.00
268_A283_L1.0141.00
291_C352_I1.0121.00
156_A159_A1.0121.00
315_V318_A1.0061.00
91_A113_V1.0041.00
209_N276_T1.0001.00
162_F222_A0.9981.00
51_Y67_G0.9941.00
116_L120_M0.9941.00
57_L60_D0.9901.00
40_F82_L0.9891.00
30_M39_V0.9871.00
364_Q367_G0.9821.00
378_G383_L0.9821.00
190_A193_A0.9801.00
195_V199_L0.9741.00
14_A18_A0.9731.00
34_N96_G0.9731.00
381_A385_A0.9721.00
36_L85_I0.9721.00
246_A315_V0.9691.00
264_F372_V0.9611.00
60_D143_E0.9601.00
115_G184_D0.9571.00
289_V373_L0.9501.00
249_M253_V0.9491.00
162_F225_V0.9491.00
221_H342_Y0.9481.00
165_L229_L0.9441.00
257_M309_G0.9421.00
62_G143_E0.9411.00
190_A194_V0.9371.00
202_F338_L0.9261.00
281_N349_A0.9221.00
40_F44_E0.9171.00
221_H339_S0.9161.00
122_V165_L0.9151.00
183_I186_S0.9081.00
95_M99_A0.9071.00
94_V100_I0.9071.00
380_I384_V0.9051.00
200_G220_G0.9041.00
147_A150_S0.9031.00
303_G313_K0.8971.00
142_Y145_A0.8961.00
151_A263_L0.8961.00
50_S153_I0.8921.00
151_A259_T0.8891.00
97_L101_A0.8861.00
112_G115_G0.8801.00
162_F251_L0.8801.00
308_A382_L0.8791.00
364_Q369_Y0.8771.00
115_G185_W0.8751.00
290_A364_Q0.8751.00
300_S309_G0.8731.00
293_A297_F0.8731.00
317_F329_A0.8651.00
298_M346_V0.8601.00
293_A376_A0.8601.00
203_A216_Y0.8571.00
277_F350_L0.8531.00
331_I335_N0.8521.00
35_S38_T0.8521.00
381_A388_P0.8511.00
224_Y316_L0.8501.00
250_H253_V0.8471.00
31_A159_A0.8421.00
347_V352_I0.8411.00
335_N338_L0.8411.00
198_T202_F0.8411.00
145_A150_S0.8381.00
94_V97_L0.8341.00
210_V280_Y0.8341.00
218_S254_Y0.8331.00
356_R359_L0.8311.00
27_M46_A0.8311.00
43_L81_M0.8301.00
146_P149_V0.8281.00
271_W287_A0.8281.00
291_C351_W0.8281.00
190_A227_I0.8271.00
197_M227_I0.8261.00
362_S366_T0.8261.00
308_A379_T0.8251.00
370_V373_L0.8221.00
234_S245_G0.8171.00
136_F139_P0.8161.00
24_A28_T0.8151.00
61_R65_E0.8151.00
188_L191_A0.8141.00
250_H257_M0.8141.00
111_V114_L0.8141.00
367_G371_A0.8131.00
33_A42_S0.8131.00
159_A222_A0.8121.00
27_M160_A0.8121.00
26_G30_M0.8111.00
368_L371_A0.8081.00
271_W368_L0.8071.00
154_S218_S0.8041.00
21_L24_A0.8031.00
40_F85_I0.7981.00
292_V296_V0.7971.00
340_L344_S0.7971.00
260_G375_A0.7961.00
281_N356_R0.7961.00
319_G323_S0.7951.00
272_D280_Y0.7951.00
293_A373_L0.7841.00
20_T152_F0.7831.00
131_S222_A0.7821.00
182_V186_S0.7811.00
344_S348_K0.7801.00
13_V17_Y0.7801.00
154_S258_N0.7761.00
89_Y92_T0.7751.00
68_L72_L0.7741.00
292_V351_W0.7741.00
343_Y346_V0.7741.00
27_M157_S0.7741.00
307_G311_L0.7701.00
117_G121_L0.7691.00
194_V227_I0.7671.00
270_Y362_S0.7661.00
193_A226_L0.7651.00
267_L290_A0.7651.00
54_V141_A0.7631.00
375_A379_T0.7621.00
366_T371_A0.7621.00
62_G144_G0.7601.00
145_A154_S0.7591.00
88_V100_I0.7571.00
23_A50_S0.7571.00
277_F346_V0.7551.00
319_G322_Q0.7551.00
221_H258_N0.7551.00
373_L376_A0.7541.00
293_A372_V0.7531.00
115_G119_V0.7531.00
143_E212_R0.7521.00
92_T100_I0.7501.00
299_F304_L0.7501.00
20_T24_A0.7491.00
369_Y373_L0.7481.00
363_G366_T0.7441.00
168_V172_A0.7411.00
139_P219_V0.7391.00
259_T263_L0.7351.00
383_L386_F0.7311.00
154_S158_K0.7301.00
188_L192_L0.7291.00
150_S158_K0.7281.00
155_S258_N0.7261.00
300_S307_G0.7241.00
270_Y368_L0.7241.00
147_A266_A0.7241.00
306_V384_V0.7201.00
194_V198_T0.7181.00
77_S124_G0.7171.00
155_S158_K0.7171.00
118_I185_W0.7171.00
198_T331_I0.7161.00
88_V117_G0.7161.00
23_A152_F0.7131.00
142_Y218_S0.7121.00
267_L372_V0.7121.00
376_A379_T0.7111.00
75_A78_S0.7111.00
43_L160_A0.7101.00
225_V251_L0.7101.00
34_N38_T0.7071.00
62_G65_E0.7061.00
84_G88_V0.7041.00
228_G246_A0.7021.00
246_A316_L0.7011.00
111_V115_G0.7011.00
80_V123_A0.6981.00
132_V200_G0.6961.00
274_G280_Y0.6961.00
51_Y74_G0.6961.00
347_V351_W0.6931.00
16_F148_P0.6921.00
207_Q213_M0.6921.00
201_N217_S0.6881.00
214_L261_A0.6861.00
54_V153_I0.6841.00
129_T165_L0.6821.00
46_A158_K0.6821.00
259_T375_A0.6791.00
337_A341_F0.6791.00
292_V295_T0.6771.00
281_N353_E0.6751.00
201_N339_S0.6741.00
294_M351_W0.6741.00
194_V328_L0.6731.00
221_H301_L0.6701.00
30_M47_S0.6701.00
357_D360_S0.6661.00
217_S254_Y0.6621.00
47_S78_S0.6611.00
44_E128_K0.6611.00
257_M301_L0.6591.00
148_P266_A0.6591.00
152_F156_A0.6581.00
383_L387_D0.6581.00
213_M346_V0.6581.00
202_F206_T0.6511.00
129_T161_G0.6511.00
40_F78_S0.6501.00
191_A194_V0.6481.00
46_A160_A0.6461.00
287_A363_G0.6431.00
116_L119_V0.6421.00
113_V116_L0.6421.00
98_P101_A0.6421.00
50_S157_S0.6411.00
277_F349_A0.6401.00
159_A255_G0.6401.00
267_L364_Q0.6391.00
286_R361_L0.6391.00
203_A206_T0.6351.00
175_L183_I0.6321.00
16_F149_V0.6311.00
333_A336_S0.6281.00
175_L184_D0.6271.00
228_G232_L0.6271.00
132_V135_H0.6271.00
190_A231_A0.6231.00
63_S143_E0.6201.00
81_M125_F0.6201.00
122_V192_L0.6161.00
233_Q319_G0.6141.00
364_Q368_L0.6141.00
317_F333_A0.6091.00
251_L255_G0.6081.00
264_F297_F0.6071.00
382_L389_V0.6071.00
305_P310_F0.6071.00
125_F165_L0.6061.00
298_M302_A0.6061.00
313_K336_S0.6051.00
311_L386_F0.6041.00
217_S258_N0.6041.00
101_A171_T0.6031.00
255_G259_T0.6021.00
40_F51_Y0.6011.00
286_R355_P0.5981.00
224_Y335_N0.5981.00
291_C295_T0.5981.00
167_R171_T0.5981.00
363_G369_Y0.5981.00
15_E19_L0.5961.00
375_A378_G0.5961.00
82_L86_S0.5951.00
100_I103_T0.5951.00
207_Q216_Y0.5951.00
184_D188_L0.5941.00
288_P291_C0.5941.00
118_I172_A0.5941.00
166_F244_L0.5901.00
118_I122_V0.5891.00
162_F226_L0.5891.00
142_Y215_A0.5881.00
377_V380_I0.5861.00
92_T96_G0.5851.00
88_V91_A0.5841.00
372_V375_A0.5821.00
217_S221_H0.5801.00
30_M42_S0.5761.00
201_N338_L0.5761.00
114_L117_G0.5741.00
256_F308_A0.5731.00
150_S211_K0.5721.00
370_V374_A0.5721.00
289_V369_Y0.5651.00
303_G307_G0.5651.00
36_L97_L0.5651.00
361_L365_P0.5641.00
158_K222_A0.5631.00
73_I127_F0.5621.00
258_N262_F0.5581.00
263_L371_A0.5581.00
367_G370_V0.5571.00
321_V324_G0.5571.00
50_S141_A0.5561.00
264_F293_A0.5561.00
19_L49_P0.5551.00
384_V388_P0.5551.00
39_V81_M0.5541.00
361_L366_T0.5531.00
231_A323_S0.5531.00
378_G381_A0.5531.00
113_V117_G0.5491.00
382_L386_F0.5491.00
200_G219_V0.5481.00
197_M224_Y0.5481.00
228_G319_G0.5481.00
88_V121_L0.5481.00
135_H139_P0.5471.00
257_M379_T0.5431.00
47_S74_G0.5421.00
217_S343_Y0.5421.00
252_L255_G0.5411.00
122_V185_W0.5411.00
268_A280_Y0.5401.00
267_L271_W0.5401.00
121_L168_V0.5391.00
296_V380_I0.5391.00
34_N167_R0.5371.00
254_Y262_F0.5341.00
66_A141_A0.5341.00
23_A157_S0.5331.00
155_S259_T0.5331.00
282_G285_K0.5331.00
50_S53_L0.5301.00
378_G384_V0.5301.00
345_R348_K0.5291.00
154_S254_Y0.5291.00
310_F314_Y0.5281.00
23_A49_P0.5271.00
341_F345_R0.5271.00
382_L385_A0.5261.00
267_L368_L0.5250.99
150_S262_F0.5240.99
81_M121_L0.5200.99
208_E217_S0.5200.99
330_G333_A0.5190.99
193_A197_M0.5160.99
311_L315_V0.5160.99
22_L26_G0.5150.99
363_G368_L0.5150.99
29_L32_A0.5140.99
203_A207_Q0.5140.99
45_L49_P0.5140.99
154_S159_A0.5140.99
151_A262_F0.5140.99
159_A254_Y0.5130.99
384_V387_D0.5110.99
196_T223_G0.5110.99
317_F336_S0.5100.99
194_V197_M0.5100.99
142_Y155_S0.5090.99
16_F56_Y0.5080.99
97_L171_T0.5080.99
293_A369_Y0.5080.99
327_W331_I0.5080.99
218_S258_N0.5070.99
36_L88_V0.5060.99
297_F379_T0.5050.99
261_A294_M0.5050.99
285_K354_D0.5050.99
284_S351_W0.5040.99
332_A336_S0.5040.99
211_K254_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9529 100 0.118 Contact Map
3rkoN 1 0.9305 100 0.129 Contact Map
4he8L 1 0.9553 100 0.133 Contact Map
3rkoL 1 0.9529 100 0.133 Contact Map
4he8M 1 0.9404 100 0.148 Contact Map
4he8N 1 0.8759 100 0.207 Contact Map
4he8K 1 0.2308 38.5 0.957 Contact Map
3rkoK 1 0.2407 31.4 0.959 Contact Map
2gfpA 2 0.7419 15.3 0.965 Contact Map
1pw4A 1 0.7841 14.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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