GREMLIN Database
Q9HRL0 - Uncharacterized protein
UniProt: Q9HRL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (431)
Sequences: 1147 (859)
Seq/√Len: 41.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_G220_D8.5701.00
434_L442_V7.3861.00
437_G442_V5.3231.00
224_L227_H3.8011.00
443_G447_A3.7241.00
351_Q443_G3.4961.00
438_L441_A3.3501.00
370_L390_G3.2581.00
231_G254_D3.2501.00
151_D217_A3.0661.00
173_L223_A3.0541.00
434_L437_G3.0101.00
19_S23_R2.9891.00
353_N451_T2.9571.00
270_S292_L2.8721.00
169_A270_S2.8591.00
18_G22_D2.7861.00
437_G445_D2.7511.00
293_L322_A2.7451.00
65_V85_A2.6381.00
395_T435_P2.6001.00
153_R217_A2.5981.00
83_I86_D2.5441.00
222_V240_T2.5331.00
153_R183_D2.4741.00
83_I87_A2.4181.00
416_A449_T2.4151.00
285_R288_V2.4051.00
294_Y327_L2.3911.00
79_R83_I2.3201.00
65_V83_I2.3151.00
209_R212_E2.3031.00
384_A406_D2.2961.00
79_R85_A2.2321.00
147_L177_A2.2211.00
413_L431_G2.2141.00
396_I439_F2.1370.99
84_A87_A2.1200.99
172_G273_L2.0460.99
69_V85_A2.0350.99
360_C439_F2.0080.99
274_V292_L2.0050.99
85_A89_H1.9990.99
196_E199_A1.9630.99
193_S196_E1.9510.99
143_L244_I1.9400.99
345_A348_R1.9090.99
156_V184_S1.8920.99
227_H233_N1.8910.99
449_T453_M1.8910.99
210_N213_T1.8890.99
278_R317_W1.8690.98
349_N359_S1.8450.98
65_V69_V1.8400.98
162_P166_A1.8300.98
185_Q220_D1.8170.98
196_E204_L1.7900.98
415_S452_E1.7820.98
46_A383_V1.7700.98
69_V86_D1.7640.98
193_S200_F1.7470.98
199_A204_L1.7400.97
360_C443_G1.7160.97
65_V87_A1.7020.97
173_L177_A1.6830.97
59_T62_D1.6810.97
56_A82_A1.6410.96
193_S197_N1.6360.96
222_V237_A1.6320.96
21_A24_R1.6260.96
394_G435_P1.6250.96
129_N308_T1.6210.96
156_V173_L1.6180.96
64_S69_V1.6120.96
448_T452_E1.6110.96
389_Y443_G1.6100.96
14_H17_I1.6090.96
81_A85_A1.5910.96
69_V83_I1.5870.96
155_G185_Q1.5790.96
56_A60_L1.5760.95
398_V446_A1.5720.95
156_V174_Q1.5720.95
343_I372_Q1.5680.95
346_G359_S1.5630.95
147_L154_L1.5520.95
64_S85_A1.5370.95
79_R84_A1.5330.95
20_L24_R1.5180.94
65_V79_R1.5160.94
16_V20_L1.5140.94
187_C236_L1.5130.94
20_L23_R1.5060.94
182_V186_A1.4900.94
351_Q447_A1.4880.94
352_L383_V1.4840.94
65_V86_D1.4750.94
146_T221_A1.4680.93
452_E455_E1.4620.93
79_R86_D1.4610.93
193_S198_R1.4550.93
65_V84_A1.4470.93
174_Q184_S1.4390.93
444_E448_T1.4320.92
177_A184_S1.4320.92
65_V89_H1.4280.92
198_R204_L1.4150.92
72_G85_A1.4060.92
66_D83_I1.3980.92
275_E310_R1.3980.92
156_V382_G1.3930.91
64_S79_R1.3820.91
66_D85_A1.3750.91
175_R288_V1.3740.91
69_V72_G1.3720.91
198_R202_N1.3500.90
65_V72_G1.3480.90
176_I280_Y1.3450.90
169_A269_T1.3390.90
290_T326_V1.3300.89
441_A445_D1.3240.89
160_D234_D1.3060.88
253_T269_T1.2990.88
416_A442_V1.2880.88
143_L223_A1.2880.88
329_R403_R1.2860.88
274_V284_V1.2590.87
192_I199_A1.2580.87
400_A413_L1.2570.86
207_D220_D1.2530.86
83_I89_H1.2520.86
374_A388_V1.2450.86
79_R87_A1.2410.86
64_S86_D1.2360.86
265_D308_T1.2350.86
154_L220_D1.2320.85
132_T136_A1.2140.85
163_D168_A1.2100.84
85_A94_L1.2050.84
69_V81_A1.2050.84
192_I198_R1.2040.84
78_N82_A1.2020.84
78_N85_A1.1970.84
415_S453_M1.1930.83
251_P255_V1.1920.83
24_R393_D1.1810.83
166_A170_A1.1760.83
68_V84_A1.1750.83
391_Y412_V1.1690.82
81_A86_D1.1660.82
303_F315_A1.1630.82
174_Q178_E1.1630.82
312_F316_A1.1530.81
210_N214_Q1.1450.81
151_D158_M1.1390.80
20_L25_G1.1380.80
191_E198_R1.1380.80
63_R66_D1.1230.80
387_F412_V1.1220.79
150_I221_A1.1220.79
174_Q179_D1.1220.79
169_A172_G1.1170.79
165_D169_A1.1120.79
199_A203_L1.1090.79
197_N200_F1.1050.78
437_G441_A1.0970.78
358_A447_A1.0880.77
80_L83_I1.0840.77
81_A84_A1.0830.77
151_D219_F1.0810.77
66_D81_A1.0770.77
246_I276_Y1.0750.76
313_T320_P1.0720.76
359_S382_G1.0720.76
451_T454_I1.0690.76
143_L173_L1.0640.76
28_F412_V1.0630.76
66_D86_D1.0610.76
85_A95_V1.0580.75
163_D167_I1.0540.75
177_A223_A1.0520.75
81_A87_A1.0510.75
268_A275_E1.0470.75
69_V87_A1.0430.74
360_C440_D1.0430.74
255_V260_T1.0430.74
69_V84_A1.0420.74
170_A225_V1.0310.73
64_S83_I1.0270.73
17_I20_L1.0240.73
343_I373_T1.0200.73
64_S84_A1.0200.73
193_S204_L1.0180.72
72_G83_I1.0150.72
210_N215_S1.0020.71
165_D401_R0.9990.71
57_A68_V0.9980.71
80_L85_A0.9970.71
154_L223_A0.9960.71
222_V435_P0.9910.70
233_N237_A0.9870.70
245_V262_I0.9870.70
196_E206_F0.9870.70
442_V449_T0.9850.70
133_E136_A0.9850.70
113_V321_N0.9830.70
249_H299_D0.9820.70
153_R185_Q0.9820.70
227_H262_I0.9810.70
234_D238_P0.9800.70
154_L177_A0.9800.70
108_H269_T0.9750.69
246_I270_S0.9730.69
263_R310_R0.9710.69
397_Y431_G0.9710.69
72_G87_A0.9690.69
286_T323_D0.9680.69
96_V173_L0.9680.69
359_S373_T0.9640.68
342_T373_T0.9600.68
80_L86_D0.9570.68
52_V450_L0.9510.67
265_D427_A0.9490.67
168_A172_G0.9480.67
279_G308_T0.9460.67
293_L297_R0.9460.67
224_L237_A0.9430.66
113_V116_R0.9410.66
66_D79_R0.9360.66
151_D154_L0.9360.66
413_L432_A0.9360.66
359_S388_V0.9290.65
445_D449_T0.9290.65
196_E200_F0.9270.65
398_V413_L0.9240.65
200_F291_A0.9230.65
72_G86_D0.9200.65
445_D448_T0.9190.64
17_I23_R0.9190.64
55_P224_L0.9190.64
185_Q188_Y0.9180.64
154_L182_V0.9160.64
415_S449_T0.9160.64
109_R118_V0.9160.64
197_N204_L0.9150.64
173_L336_S0.9110.64
68_V86_D0.9060.63
335_L352_L0.9040.63
34_E237_A0.9030.63
398_V442_V0.9010.63
200_F204_L0.9000.63
447_A451_T0.8990.63
16_V19_S0.8990.63
64_S71_A0.8990.63
48_E133_E0.8950.62
269_T372_Q0.8950.62
273_L292_L0.8940.62
192_I196_E0.8940.62
391_Y450_L0.8900.62
88_A211_V0.8900.62
18_G23_R0.8860.62
198_R208_L0.8850.62
191_E196_E0.8820.61
396_I442_V0.8820.61
78_N81_A0.8810.61
437_G444_E0.8800.61
163_D172_G0.8760.61
21_A448_T0.8690.60
267_G414_R0.8640.60
396_I437_G0.8630.60
64_S81_A0.8600.59
395_T433_Q0.8590.59
63_R364_I0.8580.59
162_P167_I0.8560.59
86_D94_L0.8530.59
65_V94_L0.8530.59
86_D89_H0.8520.59
389_Y431_G0.8510.58
331_E335_L0.8510.58
156_V177_A0.8500.58
67_M83_I0.8460.58
83_I95_V0.8460.58
438_L445_D0.8430.58
28_F348_R0.8400.57
76_D79_R0.8380.57
290_T450_L0.8370.57
450_L453_M0.8370.57
26_E447_A0.8360.57
82_A118_V0.8350.57
65_V81_A0.8340.57
59_T343_I0.8320.57
264_P343_I0.8300.57
391_Y394_G0.8290.56
334_S339_T0.8270.56
171_V176_I0.8260.56
387_F446_A0.8260.56
37_V40_L0.8260.56
224_L233_N0.8260.56
192_I202_N0.8250.56
306_E427_A0.8250.56
166_A379_A0.8210.56
389_Y397_Y0.8160.55
176_I277_L0.8130.55
191_E277_L0.8090.55
64_S72_G0.8090.55
146_T244_I0.8090.55
233_N252_T0.8050.54
229_G252_T0.8040.54
378_L388_V0.8010.54
78_N86_D0.8000.54
429_M446_A0.7990.54
283_D340_F0.7960.53
183_D389_Y0.7900.53
215_S238_P0.7890.53
367_R390_G0.7870.53
79_R89_H0.7870.53
407_L454_I0.7850.52
396_I434_L0.7830.52
82_A85_A0.7810.52
15_A19_S0.7800.52
117_V320_P0.7790.52
347_I357_L0.7790.52
297_R427_A0.7740.51
175_R178_E0.7730.51
17_I24_R0.7720.51
412_V435_P0.7720.51
294_Y446_A0.7640.50
268_A295_G0.7640.50
436_L441_A0.7620.50
375_D404_R0.7610.50
170_A270_S0.7610.50
66_D84_A0.7580.50
66_D78_N0.7580.50
342_T369_T0.7570.50
133_E137_S0.7570.50
129_N310_R0.7550.50
356_V387_F0.7550.50
273_L370_L0.7520.49
197_N201_V0.7510.49
313_T316_A0.7500.49
169_A350_R0.7500.49
78_N83_I0.7480.49
276_Y359_S0.7480.49
356_V454_I0.7420.48
232_V431_G0.7410.48
198_R206_F0.7410.48
27_L102_A0.7390.48
68_V89_H0.7390.48
222_V232_V0.7380.48
416_A445_D0.7370.48
86_D117_V0.7340.48
407_L412_V0.7330.48
161_N166_A0.7320.47
109_R116_R0.7300.47
184_S273_L0.7230.47
207_D215_S0.7220.47
131_L446_A0.7220.47
129_N265_D0.7220.47
228_S428_D0.7220.47
188_Y191_E0.7210.46
17_I178_E0.7180.46
267_G271_T0.7160.46
416_A432_A0.7150.46
254_D315_A0.7140.46
315_A372_Q0.7140.46
277_L343_I0.7140.46
179_D333_P0.7130.46
227_H292_L0.7130.46
237_A240_T0.7130.46
438_L444_E0.7120.46
151_D319_L0.7110.46
74_R78_N0.7110.46
212_E215_S0.7110.46
331_E365_T0.7100.45
412_V450_L0.7100.45
84_A302_D0.7080.45
161_N192_I0.7070.45
165_D168_A0.7060.45
309_P366_A0.7060.45
66_D69_V0.7050.45
161_N167_I0.7050.45
87_A95_V0.7040.45
229_G254_D0.7020.45
132_T135_G0.7020.45
69_V79_R0.7000.44
155_G239_D0.6980.44
83_I94_L0.6980.44
442_V445_D0.6950.44
191_E199_A0.6930.44
39_S258_G0.6930.44
209_R214_Q0.6920.44
440_D452_E0.6920.44
44_S51_D0.6910.44
32_G138_Q0.6880.43
84_A319_L0.6880.43
434_L441_A0.6880.43
192_I204_L0.6880.43
84_A89_H0.6870.43
69_V89_H0.6870.43
203_L206_F0.6860.43
22_D56_A0.6860.43
199_A202_N0.6830.43
448_T455_E0.6830.43
26_E282_I0.6820.43
72_G81_A0.6800.43
222_V236_L0.6790.43
134_S279_G0.6780.42
68_V146_T0.6760.42
19_S22_D0.6760.42
140_L158_M0.6750.42
424_G431_G0.6750.42
112_S116_R0.6740.42
164_P293_L0.6710.42
224_L262_I0.6690.42
249_H424_G0.6690.42
64_S87_A0.6680.42
439_F451_T0.6670.41
333_P372_Q0.6660.41
305_R400_A0.6660.41
238_P435_P0.6640.41
332_A356_V0.6630.41
358_A389_Y0.6620.41
345_A349_N0.6610.41
93_G289_A0.6580.41
65_V71_A0.6560.40
25_G245_V0.6550.40
406_D444_E0.6530.40
209_R213_T0.6510.40
148_Q180_A0.6490.40
210_N439_F0.6450.40
61_P413_L0.6450.40
301_D375_D0.6440.39
115_D118_V0.6430.39
162_P169_A0.6420.39
246_I273_L0.6420.39
80_L87_A0.6420.39
162_P165_D0.6410.39
384_A396_I0.6400.39
207_D285_R0.6400.39
111_D308_T0.6370.39
132_T137_S0.6340.39
202_N206_F0.6340.39
331_E334_S0.6310.38
88_A108_H0.6310.38
413_L449_T0.6310.38
31_D113_V0.6300.38
378_L386_T0.6290.38
116_R414_R0.6290.38
271_T311_D0.6270.38
22_D25_G0.6270.38
364_I391_Y0.6260.38
165_D173_L0.6260.38
162_P176_I0.6250.38
87_A94_L0.6240.38
44_S52_V0.6230.38
120_P259_F0.6190.37
53_T290_T0.6190.37
155_G319_L0.6190.37
146_T258_G0.6190.37
293_L332_A0.6180.37
58_I84_A0.6180.37
216_D441_A0.6180.37
38_D98_L0.6180.37
197_N368_D0.6170.37
165_D170_A0.6170.37
331_E389_Y0.6130.37
153_R216_D0.6130.37
184_S187_C0.6100.36
141_Q144_R0.6100.36
435_P443_G0.6090.36
261_D298_V0.6090.36
24_R391_Y0.6080.36
355_S384_A0.6080.36
284_V349_N0.6070.36
29_V305_R0.6070.36
358_A446_A0.6070.36
137_S158_M0.6050.36
250_P414_R0.6050.36
410_G414_R0.6040.36
86_D95_V0.6040.36
18_G360_C0.6030.36
115_D310_R0.6030.36
177_A346_G0.6030.36
389_Y439_F0.6020.36
116_R312_F0.6010.36
173_L206_F0.6010.36
196_E201_V0.6000.36
134_S138_Q0.5990.35
156_V356_V0.5990.35
125_L286_T0.5990.35
46_A50_R0.5980.35
68_V80_L0.5980.35
148_Q216_D0.5970.35
299_D424_G0.5970.35
82_A91_D0.5940.35
332_A431_G0.5930.35
334_S379_A0.5930.35
263_R275_E0.5900.35
346_G369_T0.5890.35
201_V276_Y0.5890.35
108_H427_A0.5890.35
162_P293_L0.5870.34
146_T246_I0.5860.34
350_R377_L0.5850.34
30_F48_E0.5840.34
78_N84_A0.5840.34
437_G455_E0.5840.34
17_I452_E0.5830.34
138_Q142_A0.5820.34
68_V83_I0.5810.34
371_A377_L0.5810.34
305_R428_D0.5810.34
81_A89_H0.5810.34
215_S438_L0.5800.34
415_S451_T0.5780.34
66_D82_A0.5770.34
314_A321_N0.5760.34
62_D96_V0.5740.33
111_D357_L0.5740.33
163_D169_A0.5730.33
131_L272_I0.5720.33
133_E317_W0.5710.33
342_T346_G0.5710.33
162_P429_M0.5700.33
115_D163_D0.5690.33
223_A258_G0.5670.33
73_E77_R0.5650.33
218_E241_D0.5640.33
116_R267_G0.5640.33
399_S424_G0.5630.32
106_D301_D0.5620.32
183_D186_A0.5620.32
167_I305_R0.5620.32
208_L213_T0.5620.32
165_D378_L0.5600.32
130_S294_Y0.5600.32
168_A270_S0.5590.32
173_L176_I0.5590.32
45_V227_H0.5570.32
434_L445_D0.5570.32
219_F360_C0.5570.32
96_V145_Q0.5560.32
136_A151_D0.5560.32
21_A173_L0.5550.32
19_S25_G0.5550.32
126_S331_E0.5540.32
252_T298_V0.5540.32
437_G443_G0.5530.32
239_D439_F0.5520.32
407_L450_L0.5520.32
165_D172_G0.5520.32
65_V80_L0.5510.32
98_L291_A0.5510.32
270_S274_V0.5500.31
416_A448_T0.5490.31
70_V85_A0.5480.31
164_P169_A0.5480.31
127_H296_I0.5470.31
134_S371_A0.5460.31
167_I199_A0.5460.31
351_Q445_D0.5450.31
174_Q177_A0.5440.31
18_G25_G0.5420.31
245_V406_D0.5410.31
228_S262_I0.5400.31
260_T332_A0.5400.31
187_C224_L0.5400.31
272_I427_A0.5390.31
137_S146_T0.5390.31
254_D415_S0.5390.31
176_I179_D0.5380.30
99_G145_Q0.5380.30
21_A438_L0.5370.30
166_A224_L0.5370.30
60_L149_G0.5370.30
15_A22_D0.5370.30
100_F187_C0.5370.30
31_D310_R0.5360.30
14_H220_D0.5360.30
394_G452_E0.5350.30
133_E453_M0.5330.30
67_M415_S0.5330.30
135_G142_A0.5320.30
151_D400_A0.5320.30
192_I331_E0.5320.30
230_P245_V0.5310.30
273_L276_Y0.5310.30
262_I428_D0.5300.30
310_R315_A0.5300.30
312_F380_M0.5290.30
291_A428_D0.5290.30
61_P66_D0.5280.30
330_I382_G0.5270.30
78_N89_H0.5270.30
328_E380_M0.5260.30
57_A61_P0.5260.30
183_D188_Y0.5250.29
80_L84_A0.5250.29
236_L433_Q0.5250.29
66_D87_A0.5250.29
109_R114_A0.5240.29
165_D399_S0.5240.29
108_H173_L0.5240.29
76_D81_A0.5230.29
220_D227_H0.5230.29
175_R179_D0.5230.29
132_T230_P0.5200.29
208_L212_E0.5200.29
193_S203_L0.5200.29
58_I90_P0.5190.29
116_R142_A0.5170.29
156_V225_V0.5170.29
193_S206_F0.5170.29
125_L245_V0.5160.29
344_A347_I0.5160.29
305_R429_M0.5160.29
23_R56_A0.5160.29
16_V23_R0.5160.29
27_L273_L0.5160.29
218_E412_V0.5150.29
427_A431_G0.5150.29
25_G255_V0.5150.29
168_A181_G0.5140.29
26_E33_D0.5140.29
184_S207_D0.5130.29
355_S383_V0.5130.29
118_V127_H0.5120.28
353_N447_A0.5110.28
228_S232_V0.5110.28
82_A87_A0.5100.28
45_V51_D0.5090.28
79_R82_A0.5080.28
129_N314_A0.5080.28
441_A444_E0.5070.28
306_E431_G0.5070.28
229_G432_A0.5060.28
220_D240_T0.5060.28
111_D291_A0.5050.28
191_E204_L0.5040.28
51_D55_P0.5040.28
216_D345_A0.5020.28
202_N218_E0.5010.28
130_S308_T0.5010.28
154_L158_M0.5010.28
112_S267_G0.5010.28
268_A371_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4py9A 2 0.6625 100 0.597 Contact Map
4ls9A 2 0.6352 100 0.601 Contact Map
3devA 2 0.6331 100 0.624 Contact Map
2hawA 2 0.6101 100 0.648 Contact Map
4rpaA 3 0.5996 100 0.649 Contact Map
1k20A 2 0.6017 100 0.655 Contact Map
2eb0A 2 0.5849 100 0.678 Contact Map
2qb7A 1 0.673 100 0.71 Contact Map
1wpnA 2 0.3795 100 0.729 Contact Map
2zxrA 1 0.7023 100 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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