GREMLIN Database
Q9HRK9 - Inosine-5'-monophosphate dehydrogenase
UniProt: Q9HRK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (230)
Sequences: 1862 (1521)
Seq/√Len: 100.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_V47_F4.5711.00
61_A65_L3.3591.00
187_A190_L3.3271.00
26_V30_D3.0891.00
32_V71_E3.0151.00
139_L142_T3.0011.00
127_Q130_R2.9841.00
84_A107_V2.9301.00
71_E75_K2.8881.00
195_N212_R2.8601.00
59_V76_V2.5571.00
220_G223_E2.5541.00
26_V49_V2.4771.00
40_S66_L2.1791.00
86_P109_D2.1771.00
109_D113_N2.1691.00
183_E186_L2.1651.00
133_P136_V2.1531.00
24_A44_H2.1441.00
35_V73_L2.1191.00
209_G213_V2.1171.00
26_V35_V2.0971.00
88_M92_D2.0441.00
59_V73_L1.9921.00
164_V168_G1.9531.00
26_V47_F1.9491.00
28_A56_E1.9301.00
51_D54_H1.9131.00
38_R42_S1.8911.00
31_T34_D1.8521.00
86_P115_V1.8281.00
27_S30_D1.8151.00
34_D37_A1.8051.00
203_S207_A1.7841.00
139_L143_L1.7821.00
68_D71_E1.7491.00
142_T146_I1.7221.00
178_R182_L1.7211.00
30_D34_D1.7041.00
33_S37_A1.7031.00
28_A74_F1.6501.00
178_R181_E1.6201.00
153_E160_I1.5891.00
31_T35_V1.5801.00
48_P114_L1.5461.00
26_V73_L1.5371.00
193_I212_R1.5341.00
127_Q131_A1.5281.00
93_A105_L1.5031.00
157_T160_I1.5021.00
165_P168_G1.4721.00
48_P55_V1.4721.00
15_V18_Y1.4531.00
35_V59_V1.4211.00
16_G87_E1.4081.00
185_G234_A1.4041.00
133_P137_G1.3951.00
128_I131_A1.3860.99
225_D229_I1.3820.99
134_E137_G1.3810.99
84_A105_L1.3750.99
84_A88_M1.3670.99
29_D74_F1.3660.99
82_V100_S1.3460.99
55_V106_P1.3440.99
168_G171_Y1.3410.99
165_P171_Y1.3320.99
197_S210_H1.3300.99
139_L146_I1.3280.99
180_Y235_V1.3260.99
85_H88_M1.2870.99
237_L240_A1.2870.99
142_T145_T1.2830.99
219_A224_M1.2590.99
192_V235_V1.2580.99
153_E156_R1.2490.99
63_D97_I1.2380.99
67_A76_V1.2380.99
173_D180_Y1.2320.99
164_V171_Y1.2290.99
233_R237_L1.2290.99
150_S154_E1.2200.99
176_E214_M1.2120.99
103_Q120_N1.2080.99
164_V169_K1.1960.99
134_E139_L1.1930.98
24_A42_S1.1860.98
14_A17_D1.1830.98
37_A41_E1.1750.98
183_E187_A1.1730.98
183_E188_E1.1700.98
130_R133_P1.1480.98
63_D77_M1.1170.98
57_G77_M1.1130.98
150_S153_E1.1120.98
196_G202_G1.1110.98
153_E157_T1.1090.98
61_A103_Q1.1080.98
16_G86_P1.1000.97
127_Q132_T1.0980.97
200_D209_G1.0950.97
197_S200_D1.0820.97
133_P138_K1.0800.97
230_V233_R1.0800.97
112_G115_V1.0650.97
174_E178_R1.0580.97
219_A225_D1.0570.97
106_P114_L1.0560.97
150_S157_T1.0460.97
44_H117_I1.0450.96
154_E157_T1.0420.96
24_A47_F1.0380.96
139_L144_E1.0340.96
54_H113_N1.0240.96
221_V225_D1.0210.96
139_L145_T1.0100.96
83_V108_V0.9790.95
186_L189_P0.9690.95
197_S208_D0.9660.95
38_R47_F0.9640.94
143_L147_H0.9630.94
164_V167_Q0.9500.94
114_L117_I0.9480.94
167_Q170_V0.9440.94
30_D38_R0.9440.94
14_A89_D0.9430.94
81_L106_P0.9410.94
166_T171_Y0.9310.93
135_K138_K0.9300.93
141_R145_T0.9300.93
173_D178_R0.9220.93
133_P142_T0.9100.93
53_R113_N0.9100.93
150_S160_I0.9080.93
186_L190_L0.9070.92
206_L209_G0.9060.92
211_H214_M0.9010.92
130_R136_V0.8980.92
55_V114_L0.8980.92
49_V77_M0.8930.92
58_F63_D0.8910.92
13_P17_D0.8850.92
90_V126_S0.8800.91
63_D78_T0.8760.91
33_S70_D0.8730.91
161_S165_P0.8660.91
190_L228_V0.8620.90
195_N202_G0.8600.90
198_T207_A0.8550.90
24_A38_R0.8540.90
30_D35_V0.8490.90
222_A226_A0.8420.89
44_H47_F0.8400.89
19_M114_L0.8360.89
49_V57_G0.8330.89
153_E158_V0.8320.89
229_I233_R0.8290.89
85_H110_D0.8280.89
104_K122_D0.8240.88
39_I63_D0.8240.88
58_F81_L0.8170.88
48_P106_P0.8140.88
193_I198_T0.8120.88
15_V118_I0.8120.88
207_A210_H0.8040.87
99_R177_G0.7990.87
184_N218_R0.7990.87
62_R121_A0.7980.87
40_S61_A0.7980.87
63_D106_P0.7980.87
34_D38_R0.7950.87
179_R238_G0.7940.86
49_V74_F0.7910.86
58_F80_D0.7900.86
131_A134_E0.7880.86
239_M243_A0.7790.85
226_A233_R0.7790.85
75_K79_E0.7710.85
165_P169_K0.7700.85
107_V116_G0.7700.85
46_G117_I0.7650.84
171_Y198_T0.7650.84
199_G204_L0.7640.84
196_G200_D0.7640.84
133_P141_R0.7610.84
50_T56_E0.7600.84
21_R122_D0.7550.84
39_I60_S0.7510.83
22_D42_S0.7480.83
25_T50_T0.7480.83
15_V84_A0.7440.83
179_R182_L0.7430.83
195_N205_L0.7420.83
134_E142_T0.7410.82
49_V73_L0.7370.82
227_Y231_L0.7280.81
129_E133_P0.7160.80
220_G224_M0.7110.80
218_R223_E0.7080.79
152_T160_I0.7050.79
154_E158_V0.7030.79
65_L91_T0.7010.79
27_S50_T0.7010.79
183_E189_P0.7000.79
102_I122_D0.6980.79
130_R134_E0.6950.78
109_D112_G0.6950.78
51_D56_E0.6950.78
91_T120_N0.6930.78
147_H150_S0.6920.78
32_V75_K0.6850.77
135_K142_T0.6820.77
166_T199_G0.6820.77
197_S202_G0.6790.77
166_T170_V0.6790.77
189_P228_V0.6780.77
175_L182_L0.6770.76
128_I132_T0.6750.76
85_H108_V0.6730.76
222_A225_D0.6720.76
239_M242_T0.6720.76
84_A93_A0.6700.76
18_Y90_V0.6680.75
97_I100_S0.6670.75
226_A229_I0.6640.75
55_V80_D0.6630.75
219_A223_E0.6630.75
32_V69_P0.6620.75
63_D193_I0.6620.75
189_P227_Y0.6620.75
154_E160_I0.6600.75
86_P108_V0.6590.74
63_D102_I0.6560.74
136_V142_T0.6550.74
235_V238_G0.6520.74
213_V228_V0.6510.74
26_V114_L0.6480.73
232_E236_D0.6480.73
46_G122_D0.6470.73
97_I118_I0.6430.73
143_L146_I0.6420.73
168_G190_L0.6420.73
38_R41_E0.6400.72
206_L210_H0.6390.72
114_L122_D0.6340.72
72_L75_K0.6310.71
133_P143_L0.6300.71
48_P244_R0.6300.71
60_S102_I0.6300.71
32_V68_D0.6290.71
22_D29_D0.6290.71
194_D201_D0.6280.71
151_I154_E0.6280.71
152_T158_V0.6250.71
31_T72_L0.6220.70
127_Q133_P0.6210.70
138_K156_R0.6210.70
150_S203_S0.6210.70
133_P139_L0.6210.70
90_V123_V0.6190.70
173_D207_A0.6180.70
153_E159_T0.6170.70
18_Y98_L0.6150.69
201_D205_L0.6150.69
15_V93_A0.6130.69
60_S104_K0.6130.69
122_D125_R0.6110.69
28_A51_D0.6100.69
194_D198_T0.6100.69
67_A78_T0.6090.69
198_T206_L0.6070.68
58_F104_K0.6070.68
165_P175_L0.6060.68
226_A230_V0.6030.68
139_L157_T0.5970.67
166_T169_K0.5960.67
45_N119_T0.5960.67
19_M117_I0.5940.67
209_G243_A0.5930.67
191_V216_A0.5920.66
19_M23_V0.5920.66
33_S69_P0.5920.66
105_L190_L0.5910.66
202_G214_M0.5890.66
188_E220_G0.5880.66
234_A237_L0.5870.66
23_V117_I0.5830.65
63_D104_K0.5810.65
210_H213_V0.5810.65
151_I156_R0.5800.65
23_V114_L0.5740.64
37_A226_A0.5710.64
18_Y118_I0.5710.64
110_D226_A0.5680.63
50_T54_H0.5670.63
163_V169_K0.5670.63
16_G109_D0.5640.63
167_Q171_Y0.5640.63
134_E143_L0.5620.62
216_A219_A0.5620.62
171_Y207_A0.5610.62
45_N62_R0.5590.62
46_G97_I0.5590.62
78_T106_P0.5580.62
215_A221_V0.5550.61
80_D108_V0.5550.61
86_P107_V0.5540.61
165_P215_A0.5490.61
85_H112_G0.5490.61
40_S65_L0.5480.60
180_Y213_V0.5470.60
108_V112_G0.5470.60
210_H214_M0.5430.60
173_D182_L0.5420.60
200_D210_H0.5410.59
29_D34_D0.5400.59
213_V217_E0.5380.59
149_V153_E0.5370.59
196_G199_G0.5370.59
196_G208_D0.5370.59
52_G185_G0.5360.59
138_K142_T0.5360.59
31_T68_D0.5340.59
147_H154_E0.5300.58
238_G242_T0.5300.58
228_V231_L0.5270.58
85_H205_L0.5260.57
151_I160_I0.5240.57
190_L227_Y0.5230.57
32_V35_V0.5180.56
195_N203_S0.5160.56
173_D176_E0.5150.56
91_T95_R0.5140.56
149_V152_T0.5110.55
157_T163_V0.5110.55
210_H239_M0.5100.55
80_D106_P0.5080.55
85_H89_D0.5080.55
30_D53_R0.5070.55
192_V232_E0.5070.55
146_I150_S0.5070.55
219_A236_D0.5060.55
55_V81_L0.5040.54
161_S170_V0.5020.54
200_D212_R0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l2bA 2 0.4118 99.9 0.633 Contact Map
1vr9A 1 0.4412 99.9 0.644 Contact Map
4cooA 2 0.4743 99.9 0.65 Contact Map
2zy9A 2 0.9522 99.9 0.651 Contact Map
3pc3A 2 0.4816 99.9 0.658 Contact Map
3orgA 2 0.4559 99.9 0.66 Contact Map
2ef7A 3 0.4596 99.9 0.662 Contact Map
4esyA 2 0.4743 99.9 0.664 Contact Map
2qrdG 1 0.511 99.9 0.664 Contact Map
2nycA 2 0.4412 99.9 0.667 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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