Q9HRK9 - HALSA - GREMLIN Contacts

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Q9HRK9 - Inosine-5'-monophosphate dehydrogenase

UniProt:	Q9HRK9	Sequences: MDEALAHANGETPAVGDYMTRDVATVSADDTVSDVAARISESDHNGFPVTDGRHVEGFVSARDLLLADPDELLFKVMTEDLVVAHPEMDVTDAARVILRSGIQKLPVVDDAGNLVGIITNADVIRSQIERATPEKVGKLMRTLETIHGVSITEERRTVTISDVVPTQGKVYADELEGRRYELENGLAEPLVVIDNGSTGDDGSLLLADGHHRVMAAERAGVAEMDAYVIVLERAVDLGMARTARTEGLDSIADIDVVDYARHPLVETIERLQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (230)
Sequences:	1862 (1521)
Seq/√Len:	100.3

HALSA - Q9HRK9
SULSO - Q97U20

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_V	47_F	4.571	1.00
61_A	65_L	3.359	1.00
187_A	190_L	3.327	1.00
26_V	30_D	3.089	1.00
32_V	71_E	3.015	1.00
139_L	142_T	3.001	1.00
127_Q	130_R	2.984	1.00
84_A	107_V	2.930	1.00
71_E	75_K	2.888	1.00
195_N	212_R	2.860	1.00
59_V	76_V	2.557	1.00
220_G	223_E	2.554	1.00
26_V	49_V	2.477	1.00
40_S	66_L	2.179	1.00
86_P	109_D	2.177	1.00
109_D	113_N	2.169	1.00
183_E	186_L	2.165	1.00
133_P	136_V	2.153	1.00
24_A	44_H	2.144	1.00
35_V	73_L	2.119	1.00
209_G	213_V	2.117	1.00
26_V	35_V	2.097	1.00
88_M	92_D	2.044	1.00
59_V	73_L	1.992	1.00
164_V	168_G	1.953	1.00
26_V	47_F	1.949	1.00
28_A	56_E	1.930	1.00
51_D	54_H	1.913	1.00
38_R	42_S	1.891	1.00
31_T	34_D	1.852	1.00
86_P	115_V	1.828	1.00
27_S	30_D	1.815	1.00
34_D	37_A	1.805	1.00
203_S	207_A	1.784	1.00
139_L	143_L	1.782	1.00
68_D	71_E	1.749	1.00
142_T	146_I	1.722	1.00
178_R	182_L	1.721	1.00
30_D	34_D	1.704	1.00
33_S	37_A	1.703	1.00
28_A	74_F	1.650	1.00
178_R	181_E	1.620	1.00
153_E	160_I	1.589	1.00
31_T	35_V	1.580	1.00
48_P	114_L	1.546	1.00
26_V	73_L	1.537	1.00
193_I	212_R	1.534	1.00
127_Q	131_A	1.528	1.00
93_A	105_L	1.503	1.00
157_T	160_I	1.502	1.00
165_P	168_G	1.472	1.00
48_P	55_V	1.472	1.00
15_V	18_Y	1.453	1.00
35_V	59_V	1.421	1.00
16_G	87_E	1.408	1.00
185_G	234_A	1.404	1.00
133_P	137_G	1.395	1.00
128_I	131_A	1.386	0.99
225_D	229_I	1.382	0.99
134_E	137_G	1.381	0.99
84_A	105_L	1.375	0.99
84_A	88_M	1.367	0.99
29_D	74_F	1.366	0.99
82_V	100_S	1.346	0.99
55_V	106_P	1.344	0.99
168_G	171_Y	1.341	0.99
165_P	171_Y	1.332	0.99
197_S	210_H	1.330	0.99
139_L	146_I	1.328	0.99
180_Y	235_V	1.326	0.99
85_H	88_M	1.287	0.99
237_L	240_A	1.287	0.99
142_T	145_T	1.283	0.99
219_A	224_M	1.259	0.99
192_V	235_V	1.258	0.99
153_E	156_R	1.249	0.99
63_D	97_I	1.238	0.99
67_A	76_V	1.238	0.99
173_D	180_Y	1.232	0.99
164_V	171_Y	1.229	0.99
233_R	237_L	1.229	0.99
150_S	154_E	1.220	0.99
176_E	214_M	1.212	0.99
103_Q	120_N	1.208	0.99
164_V	169_K	1.196	0.99
134_E	139_L	1.193	0.98
24_A	42_S	1.186	0.98
14_A	17_D	1.183	0.98
37_A	41_E	1.175	0.98
183_E	187_A	1.173	0.98
183_E	188_E	1.170	0.98
130_R	133_P	1.148	0.98
63_D	77_M	1.117	0.98
57_G	77_M	1.113	0.98
150_S	153_E	1.112	0.98
196_G	202_G	1.111	0.98
153_E	157_T	1.109	0.98
61_A	103_Q	1.108	0.98
16_G	86_P	1.100	0.97
127_Q	132_T	1.098	0.97
200_D	209_G	1.095	0.97
197_S	200_D	1.082	0.97
133_P	138_K	1.080	0.97
230_V	233_R	1.080	0.97
112_G	115_V	1.065	0.97
174_E	178_R	1.058	0.97
219_A	225_D	1.057	0.97
106_P	114_L	1.056	0.97
150_S	157_T	1.046	0.97
44_H	117_I	1.045	0.96
154_E	157_T	1.042	0.96
24_A	47_F	1.038	0.96
139_L	144_E	1.034	0.96
54_H	113_N	1.024	0.96
221_V	225_D	1.021	0.96
139_L	145_T	1.010	0.96
83_V	108_V	0.979	0.95
186_L	189_P	0.969	0.95
197_S	208_D	0.966	0.95
38_R	47_F	0.964	0.94
143_L	147_H	0.963	0.94
164_V	167_Q	0.950	0.94
114_L	117_I	0.948	0.94
167_Q	170_V	0.944	0.94
30_D	38_R	0.944	0.94
14_A	89_D	0.943	0.94
81_L	106_P	0.941	0.94
166_T	171_Y	0.931	0.93
135_K	138_K	0.930	0.93
141_R	145_T	0.930	0.93
173_D	178_R	0.922	0.93
133_P	142_T	0.910	0.93
53_R	113_N	0.910	0.93
150_S	160_I	0.908	0.93
186_L	190_L	0.907	0.92
206_L	209_G	0.906	0.92
211_H	214_M	0.901	0.92
130_R	136_V	0.898	0.92
55_V	114_L	0.898	0.92
49_V	77_M	0.893	0.92
58_F	63_D	0.891	0.92
13_P	17_D	0.885	0.92
90_V	126_S	0.880	0.91
63_D	78_T	0.876	0.91
33_S	70_D	0.873	0.91
161_S	165_P	0.866	0.91
190_L	228_V	0.862	0.90
195_N	202_G	0.860	0.90
198_T	207_A	0.855	0.90
24_A	38_R	0.854	0.90
30_D	35_V	0.849	0.90
222_A	226_A	0.842	0.89
44_H	47_F	0.840	0.89
19_M	114_L	0.836	0.89
49_V	57_G	0.833	0.89
153_E	158_V	0.832	0.89
229_I	233_R	0.829	0.89
85_H	110_D	0.828	0.89
104_K	122_D	0.824	0.88
39_I	63_D	0.824	0.88
58_F	81_L	0.817	0.88
48_P	106_P	0.814	0.88
193_I	198_T	0.812	0.88
15_V	118_I	0.812	0.88
207_A	210_H	0.804	0.87
99_R	177_G	0.799	0.87
184_N	218_R	0.799	0.87
62_R	121_A	0.798	0.87
40_S	61_A	0.798	0.87
63_D	106_P	0.798	0.87
34_D	38_R	0.795	0.87
179_R	238_G	0.794	0.86
49_V	74_F	0.791	0.86
58_F	80_D	0.790	0.86
131_A	134_E	0.788	0.86
239_M	243_A	0.779	0.85
226_A	233_R	0.779	0.85
75_K	79_E	0.771	0.85
165_P	169_K	0.770	0.85
107_V	116_G	0.770	0.85
46_G	117_I	0.765	0.84
171_Y	198_T	0.765	0.84
199_G	204_L	0.764	0.84
196_G	200_D	0.764	0.84
133_P	141_R	0.761	0.84
50_T	56_E	0.760	0.84
21_R	122_D	0.755	0.84
39_I	60_S	0.751	0.83
22_D	42_S	0.748	0.83
25_T	50_T	0.748	0.83
15_V	84_A	0.744	0.83
179_R	182_L	0.743	0.83
195_N	205_L	0.742	0.83
134_E	142_T	0.741	0.82
49_V	73_L	0.737	0.82
227_Y	231_L	0.728	0.81
129_E	133_P	0.716	0.80
220_G	224_M	0.711	0.80
218_R	223_E	0.708	0.79
152_T	160_I	0.705	0.79
154_E	158_V	0.703	0.79
65_L	91_T	0.701	0.79
27_S	50_T	0.701	0.79
183_E	189_P	0.700	0.79
102_I	122_D	0.698	0.79
130_R	134_E	0.695	0.78
109_D	112_G	0.695	0.78
51_D	56_E	0.695	0.78
91_T	120_N	0.693	0.78
147_H	150_S	0.692	0.78
32_V	75_K	0.685	0.77
135_K	142_T	0.682	0.77
166_T	199_G	0.682	0.77
197_S	202_G	0.679	0.77
166_T	170_V	0.679	0.77
189_P	228_V	0.678	0.77
175_L	182_L	0.677	0.76
128_I	132_T	0.675	0.76
85_H	108_V	0.673	0.76
222_A	225_D	0.672	0.76
239_M	242_T	0.672	0.76
84_A	93_A	0.670	0.76
18_Y	90_V	0.668	0.75
97_I	100_S	0.667	0.75
226_A	229_I	0.664	0.75
55_V	80_D	0.663	0.75
219_A	223_E	0.663	0.75
32_V	69_P	0.662	0.75
63_D	193_I	0.662	0.75
189_P	227_Y	0.662	0.75
154_E	160_I	0.660	0.75
86_P	108_V	0.659	0.74
63_D	102_I	0.656	0.74
136_V	142_T	0.655	0.74
235_V	238_G	0.652	0.74
213_V	228_V	0.651	0.74
26_V	114_L	0.648	0.73
232_E	236_D	0.648	0.73
46_G	122_D	0.647	0.73
97_I	118_I	0.643	0.73
143_L	146_I	0.642	0.73
168_G	190_L	0.642	0.73
38_R	41_E	0.640	0.72
206_L	210_H	0.639	0.72
114_L	122_D	0.634	0.72
72_L	75_K	0.631	0.71
133_P	143_L	0.630	0.71
48_P	244_R	0.630	0.71
60_S	102_I	0.630	0.71
32_V	68_D	0.629	0.71
22_D	29_D	0.629	0.71
194_D	201_D	0.628	0.71
151_I	154_E	0.628	0.71
152_T	158_V	0.625	0.71
31_T	72_L	0.622	0.70
127_Q	133_P	0.621	0.70
138_K	156_R	0.621	0.70
150_S	203_S	0.621	0.70
133_P	139_L	0.621	0.70
90_V	123_V	0.619	0.70
173_D	207_A	0.618	0.70
153_E	159_T	0.617	0.70
18_Y	98_L	0.615	0.69
201_D	205_L	0.615	0.69
15_V	93_A	0.613	0.69
60_S	104_K	0.613	0.69
122_D	125_R	0.611	0.69
28_A	51_D	0.610	0.69
194_D	198_T	0.610	0.69
67_A	78_T	0.609	0.69
198_T	206_L	0.607	0.68
58_F	104_K	0.607	0.68
165_P	175_L	0.606	0.68
226_A	230_V	0.603	0.68
139_L	157_T	0.597	0.67
166_T	169_K	0.596	0.67
45_N	119_T	0.596	0.67
19_M	117_I	0.594	0.67
209_G	243_A	0.593	0.67
191_V	216_A	0.592	0.66
19_M	23_V	0.592	0.66
33_S	69_P	0.592	0.66
105_L	190_L	0.591	0.66
202_G	214_M	0.589	0.66
188_E	220_G	0.588	0.66
234_A	237_L	0.587	0.66
23_V	117_I	0.583	0.65
63_D	104_K	0.581	0.65
210_H	213_V	0.581	0.65
151_I	156_R	0.580	0.65
23_V	114_L	0.574	0.64
37_A	226_A	0.571	0.64
18_Y	118_I	0.571	0.64
110_D	226_A	0.568	0.63
50_T	54_H	0.567	0.63
163_V	169_K	0.567	0.63
16_G	109_D	0.564	0.63
167_Q	171_Y	0.564	0.63
134_E	143_L	0.562	0.62
216_A	219_A	0.562	0.62
171_Y	207_A	0.561	0.62
45_N	62_R	0.559	0.62
46_G	97_I	0.559	0.62
78_T	106_P	0.558	0.62
215_A	221_V	0.555	0.61
80_D	108_V	0.555	0.61
86_P	107_V	0.554	0.61
165_P	215_A	0.549	0.61
85_H	112_G	0.549	0.61
40_S	65_L	0.548	0.60
180_Y	213_V	0.547	0.60
108_V	112_G	0.547	0.60
210_H	214_M	0.543	0.60
173_D	182_L	0.542	0.60
200_D	210_H	0.541	0.59
29_D	34_D	0.540	0.59
213_V	217_E	0.538	0.59
149_V	153_E	0.537	0.59
196_G	199_G	0.537	0.59
196_G	208_D	0.537	0.59
52_G	185_G	0.536	0.59
138_K	142_T	0.536	0.59
31_T	68_D	0.534	0.59
147_H	154_E	0.530	0.58
238_G	242_T	0.530	0.58
228_V	231_L	0.527	0.58
85_H	205_L	0.526	0.57
151_I	160_I	0.524	0.57
190_L	227_Y	0.523	0.57
32_V	35_V	0.518	0.56
195_N	203_S	0.516	0.56
173_D	176_E	0.515	0.56
91_T	95_R	0.514	0.56
149_V	152_T	0.511	0.55
157_T	163_V	0.511	0.55
210_H	239_M	0.510	0.55
80_D	106_P	0.508	0.55
85_H	89_D	0.508	0.55
30_D	53_R	0.507	0.55
192_V	232_E	0.507	0.55
146_I	150_S	0.507	0.55
219_A	236_D	0.506	0.55
55_V	81_L	0.504	0.54
161_S	170_V	0.502	0.54
200_D	212_R	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l2bA	2	0.4118	99.9	0.633	Contact Map
1vr9A	1	0.4412	99.9	0.644	Contact Map
4cooA	2	0.4743	99.9	0.65	Contact Map
2zy9A	2	0.9522	99.9	0.651	Contact Map
3pc3A	2	0.4816	99.9	0.658	Contact Map
3orgA	2	0.4559	99.9	0.66	Contact Map
2ef7A	3	0.4596	99.9	0.662	Contact Map
4esyA	2	0.4743	99.9	0.664	Contact Map
2qrdG	1	0.511	99.9	0.664	Contact Map
2nycA	2	0.4412	99.9	0.667	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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