GREMLIN Database
Q9HRK1 - Cytochrome c oxidase subunit III
UniProt: Q9HRK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (251)
Sequences: 2714 (1290)
Seq/√Len: 81.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_T260_T4.2781.00
115_A118_G4.2301.00
178_F245_G4.0501.00
35_T78_G3.7941.00
183_V242_M3.6421.00
38_G74_A3.6251.00
258_V262_S3.2751.00
116_T226_L3.1501.00
45_G71_S3.0461.00
162_T184_S2.9391.00
175_R248_G2.8651.00
165_F181_L2.8331.00
38_G75_F2.7141.00
123_Y219_A2.4741.00
193_I232_T2.3641.00
179_L246_L2.3131.00
166_A245_G2.3051.00
34_I78_G2.2921.00
127_I215_L2.2521.00
174_N177_R2.2331.00
163_L238_I2.2081.00
239_G243_V2.2021.00
223_L279_L2.2001.00
90_A102_L2.1811.00
175_R179_L2.1451.00
35_T79_L2.0951.00
125_F278_V2.0851.00
162_T185_T2.0041.00
166_A178_F1.9771.00
140_I144_F1.9611.00
75_F79_L1.9301.00
155_I195_G1.8821.00
42_F75_F1.8791.00
41_G71_S1.8401.00
229_L233_M1.8001.00
241_I261_V1.7961.00
173_G252_A1.7811.00
190_V239_G1.7761.00
45_G67_V1.6931.00
232_T236_V1.6831.00
235_A239_G1.6751.00
237_L261_V1.6521.00
194_G198_Y1.6341.00
154_A158_V1.6291.00
148_L195_G1.6221.00
111_G115_A1.5821.00
91_Y249_Q1.5651.00
242_M246_L1.5581.00
148_L198_Y1.5551.00
163_L166_A1.5491.00
186_L239_G1.5400.99
76_L80_Y1.5260.99
166_A258_V1.5250.99
179_L242_M1.5200.99
84_Y88_V1.5200.99
106_M110_L1.5040.99
170_L178_F1.5010.99
278_V283_S1.4880.99
197_V201_Y1.4550.99
193_I235_A1.4500.99
190_V232_T1.4390.99
176_S180_A1.4270.99
191_V195_G1.4090.99
186_L235_A1.3820.99
166_A181_L1.3750.99
170_L258_V1.3690.99
169_A181_L1.3690.99
186_L242_M1.3680.99
164_H167_H1.3480.99
111_G114_I1.3450.99
190_V194_G1.3430.99
41_G74_A1.3170.98
183_V187_V1.3120.98
83_V237_L1.3010.98
240_I243_V1.2990.98
190_V235_A1.2920.98
81_G84_Y1.2800.98
77_A81_G1.2730.98
99_S103_R1.2730.98
182_L245_G1.2610.98
127_I219_A1.2560.98
194_G197_V1.2460.98
40_A43_Y1.2320.98
49_Y65_P1.2250.97
222_G229_L1.2240.97
157_V273_I1.2230.97
179_L245_G1.2210.97
266_H269_D1.2190.97
34_I74_A1.2140.97
158_V161_F1.2030.97
165_F177_R1.1940.97
223_L226_L1.1910.97
169_A177_R1.1830.97
114_I271_V1.1720.97
182_L238_I1.1690.97
87_F249_Q1.1620.96
99_S254_R1.1470.96
227_H230_H1.1420.96
122_A126_F1.1340.96
177_R181_L1.1270.96
198_Y202_E1.1250.96
244_R249_Q1.1090.95
163_L182_L1.1090.95
69_I73_F1.1020.95
85_H88_V1.0990.95
120_G222_G1.0890.95
277_V281_A1.0850.95
74_A78_G1.0790.95
223_L275_L1.0740.95
243_V247_R1.0680.94
38_G71_S1.0670.94
131_T135_T1.0630.94
35_T39_A1.0550.94
98_G160_S1.0400.94
162_T188_L1.0260.93
131_T136_A1.0230.93
166_A182_L1.0200.93
48_L53_R1.0160.93
79_L83_V1.0080.92
65_P68_F1.0040.92
41_G67_V1.0030.92
180_A183_V0.9950.92
34_I37_I0.9780.91
241_I257_S0.9780.91
43_Y47_A0.9730.91
49_Y68_F0.9710.91
76_L79_L0.9660.91
279_L283_S0.9600.90
120_G223_L0.9520.90
164_H259_S0.9460.90
181_L184_S0.9390.89
106_M256_T0.9350.89
182_L242_M0.9250.89
234_G265_W0.9210.89
91_Y254_R0.9190.88
98_G101_A0.9160.88
44_I48_L0.9110.88
46_A50_V0.9090.88
244_R250_Y0.9070.88
141_P144_F0.9030.88
273_I277_V0.9020.87
183_V246_L0.8990.87
94_N98_G0.8890.87
171_R259_S0.8870.87
83_V86_A0.8850.86
160_S164_H0.8830.86
95_D98_G0.8830.86
50_V211_L0.8810.86
211_L217_E0.8800.86
218_S222_G0.8740.86
231_V268_V0.8730.86
167_H259_S0.8670.85
139_A144_F0.8660.85
66_G70_A0.8660.85
265_W272_W0.8660.85
19_E154_A0.8630.85
46_A49_Y0.8530.84
29_S32_P0.8510.84
163_L262_S0.8480.84
154_A278_V0.8440.84
138_S142_D0.8430.84
231_V234_G0.8430.84
103_R119_A0.8410.84
90_A254_R0.8400.83
222_G226_L0.8380.83
140_I143_G0.8280.83
133_W137_A0.8240.82
203_F208_G0.8130.81
140_I145_L0.8130.81
150_V168_V0.8060.81
31_W85_H0.8050.81
164_H168_V0.7990.80
46_A68_F0.7970.80
155_I191_V0.7950.80
157_V161_F0.7950.80
151_V195_G0.7940.80
96_G100_T0.7910.80
269_D272_W0.7870.79
264_Y280_Y0.7870.79
31_W81_G0.7850.79
129_A282_G0.7830.79
133_W136_A0.7800.79
36_A41_G0.7790.79
214_G217_E0.7780.79
80_Y87_F0.7690.78
238_I241_I0.7670.78
134_S139_A0.7660.77
106_M128_R0.7650.77
265_W268_V0.7630.77
126_F130_G0.7600.77
72_T229_L0.7590.77
100_T104_W0.7580.77
264_Y267_F0.7550.76
117_F192_F0.7530.76
135_T138_S0.7500.76
201_Y208_G0.7480.76
182_L258_V0.7400.75
165_F169_A0.7400.75
20_D198_Y0.7380.75
172_K262_S0.7370.75
192_F227_H0.7360.75
97_G100_T0.7360.75
70_A74_A0.7360.75
272_W280_Y0.7360.75
21_W24_G0.7360.75
146_G276_V0.7330.74
30_W85_H0.7320.74
136_A139_A0.7260.74
124_Y128_R0.7240.73
196_Q200_Y0.7240.73
65_P69_I0.7170.73
37_I41_G0.7160.73
110_L263_M0.7150.72
211_L222_G0.7150.72
192_F230_H0.7150.72
37_I78_G0.7050.71
42_F46_A0.7050.71
244_R257_S0.7040.71
116_T120_G0.7000.71
268_V272_W0.6980.71
139_A143_G0.6970.71
154_A189_G0.6970.71
160_S281_A0.6950.70
152_N275_L0.6940.70
170_L262_S0.6910.70
25_F50_V0.6910.70
159_S269_D0.6830.69
270_I275_L0.6820.69
264_Y268_V0.6810.69
173_G194_G0.6760.68
39_A43_Y0.6760.68
268_V271_V0.6730.68
85_H89_A0.6710.68
192_F199_E0.6700.68
245_G250_Y0.6650.67
106_M185_T0.6650.67
66_G69_I0.6640.67
79_L233_M0.6630.67
236_V240_I0.6620.67
200_Y224_T0.6590.66
231_V265_W0.6570.66
48_L67_V0.6550.66
123_Y283_S0.6530.66
21_W25_F0.6520.65
266_H272_W0.6480.65
223_L274_F0.6460.65
125_F274_F0.6450.65
102_L256_T0.6450.65
70_A183_V0.6440.64
132_Q135_T0.6430.64
46_A189_G0.6420.64
180_A184_S0.6420.64
135_T143_G0.6400.64
34_I81_G0.6400.64
28_A161_F0.6390.64
148_L155_I0.6380.64
256_T262_S0.6360.63
199_E230_H0.6360.63
164_H262_S0.6330.63
189_G234_G0.6320.63
82_W89_A0.6310.63
137_A142_D0.6270.62
41_G44_I0.6260.62
247_R277_V0.6260.62
262_S273_I0.6250.62
216_F279_L0.6250.62
83_V88_V0.6240.62
48_L66_G0.6240.62
99_S256_T0.6240.62
47_A52_G0.6190.61
53_R64_G0.6180.61
49_Y103_R0.6160.61
189_G265_W0.6150.61
269_D275_L0.6130.61
119_A125_F0.6120.61
156_L192_F0.6110.60
20_D49_Y0.6100.60
33_F37_I0.6100.60
20_D158_V0.6070.60
106_M120_G0.6070.60
131_T134_S0.6060.60
132_Q154_A0.6030.59
195_G281_A0.6020.59
42_F65_P0.5980.59
163_L239_G0.5960.59
26_G30_W0.5950.58
107_I111_G0.5940.58
230_H264_Y0.5920.58
30_W84_Y0.5890.58
86_A102_L0.5880.57
230_H234_G0.5870.57
232_T235_A0.5870.57
138_S215_L0.5870.57
94_N102_L0.5850.57
179_L183_V0.5850.57
106_M162_T0.5790.56
159_S268_V0.5760.56
210_T218_S0.5750.56
155_I188_L0.5750.56
173_G190_V0.5750.56
234_G267_F0.5750.56
35_T38_G0.5700.55
66_G74_A0.5690.55
243_V246_L0.5680.55
29_S85_H0.5650.55
245_G248_G0.5640.54
220_F228_G0.5630.54
238_I261_V0.5620.54
44_I47_A0.5620.54
24_G101_A0.5620.54
209_F216_F0.5610.54
157_V181_L0.5580.54
24_G105_G0.5570.53
52_G64_G0.5550.53
228_G231_V0.5550.53
87_F91_Y0.5540.53
53_R246_L0.5540.53
74_A177_R0.5530.53
183_V239_G0.5530.53
122_A139_A0.5530.53
44_I174_N0.5530.53
42_F72_T0.5510.53
34_I41_G0.5510.53
213_G217_E0.5480.52
34_I43_Y0.5470.52
87_F244_R0.5460.52
38_G78_G0.5440.52
120_G263_M0.5440.52
241_I250_Y0.5440.52
202_E221_F0.5420.52
222_G233_M0.5400.51
21_W47_A0.5390.51
176_S246_L0.5390.51
47_A71_S0.5360.51
126_F134_S0.5330.50
53_R68_F0.5320.50
40_A64_G0.5280.50
223_L278_V0.5270.50
83_V165_F0.5250.49
19_E22_P0.5250.49
141_P145_L0.5250.49
69_I187_V0.5240.49
126_F129_A0.5240.49
129_A136_A0.5230.49
147_S202_E0.5230.49
108_G122_A0.5220.49
233_M237_L0.5220.49
35_T81_G0.5210.49
157_V160_S0.5210.49
87_F92_W0.5190.49
64_G77_A0.5190.49
189_G214_G0.5190.49
264_Y272_W0.5180.48
41_G70_A0.5180.48
214_G221_F0.5180.48
244_R255_H0.5180.48
218_S274_F0.5170.48
151_V171_R0.5170.48
179_L190_V0.5140.48
199_E269_D0.5140.48
19_E33_F0.5120.48
101_A108_G0.5110.47
160_S270_I0.5090.47
219_A223_L0.5090.47
210_T229_L0.5070.47
214_G218_S0.5070.47
36_A39_A0.5060.47
123_Y169_A0.5040.47
170_L174_N0.5040.47
210_T217_E0.5040.47
130_G134_S0.5020.46
25_F30_W0.5020.46
28_A99_S0.5010.46
24_G98_G0.5010.46
168_V259_S0.5000.46
19_E142_D0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v54C 1 0.8877 100 0.192 Contact Map
1m56C 2 0.8947 100 0.192 Contact Map
1qleC 1 0.9228 100 0.194 Contact Map
2yevA 1 0.9228 100 0.254 Contact Map
1fftC 1 0.6456 100 0.429 Contact Map
1fftA 1 0 89.1 0.942 Contact Map
2mmuA 1 0.1719 6.2 0.973 Contact Map
2xq2A 2 0.2596 2.6 0.978 Contact Map
2wswA 3 0.2702 2.1 0.979 Contact Map
2a65A 2 0.5474 1.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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