Q9HRK0 - HALSA - GREMLIN Contacts

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Q9HRK0 - Biotin acetyl-CoA carboxylase ligase

UniProt:	Q9HRK0	Sequences: MTVDPAALQRQVSAPVVHRETCPSTNDIARAEARAGATDGTFVIADEQTAGRGRTGNAWASPPGGVWSSTVVRADIAASHVGRLTLAGGLAAADTAASFGVDARLKWPNDVVVAAADGSDQSKLCGVLTEAVIDEVPVAGKPVGSVLPETDPANADMSFAVLGIGVNAALDPDSLGDLDRAVTTLRAERGAVDPTAVAATLHEHLRTWVSRVQTAGGMDDAVAAVRERSATLGKRVRVTRFDDDPVTGTAVAIDDRGALVVERPDGARVHVTEGVCQRLRRA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	282 (237)
Sequences:	4712 (3745)
Seq/√Len:	243.3

ECOLI - BIRA
BACSU - BIRA
HALSA - Q9HRK0
SULSO - Q7LXP4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
251_V	262_E	3.500	1.00
69_S	161_V	3.241	1.00
22_C	28_I	3.081	1.00
19_R	22_C	2.846	1.00
94_D	204_H	2.831	1.00
94_D	224_A	2.822	1.00
21_T	47_E	2.771	1.00
28_I	31_A	2.572	1.00
93_A	228_R	2.528	1.00
263_R	269_V	2.483	1.00
254_D	258_A	2.470	1.00
29_A	71_V	2.341	1.00
46_D	194_P	2.321	1.00
98_S	204_H	2.321	1.00
61_S	67_W	2.304	1.00
104_R	230_A	2.245	1.00
94_D	208_W	2.217	1.00
97_A	228_R	2.182	1.00
226_R	252_A	2.173	1.00
23_P	27_D	2.158	1.00
237_R	247_T	2.130	1.00
68_S	198_A	2.119	1.00
66_V	198_A	2.033	1.00
23_P	28_I	1.962	1.00
254_D	270_H	1.958	1.00
222_V	226_R	1.929	1.00
23_P	31_A	1.876	1.00
98_S	200_T	1.857	1.00
237_R	245_P	1.841	1.00
89_G	105_L	1.835	1.00
29_A	43_V	1.833	1.00
252_A	260_V	1.811	1.00
235_R	247_T	1.806	1.00
92_A	201_L	1.715	1.00
92_A	125_C	1.715	1.00
208_W	224_A	1.700	1.00
113_V	124_L	1.697	1.00
42_F	202_H	1.694	1.00
235_R	264_P	1.690	1.00
44_I	198_A	1.684	1.00
19_R	28_I	1.678	1.00
183_T	188_E	1.676	1.00
235_R	249_T	1.672	1.00
88_G	162_L	1.649	1.00
260_V	270_H	1.631	1.00
183_T	187_A	1.602	1.00
249_T	262_E	1.593	1.00
113_V	188_E	1.582	1.00
84_L	160_A	1.578	1.00
95_T	201_L	1.571	1.00
91_A	208_W	1.571	1.00
239_T	245_P	1.569	1.00
33_A	71_V	1.522	1.00
231_T	250_A	1.486	1.00
32_E	43_V	1.469	1.00
168_A	197_V	1.436	1.00
260_V	268_R	1.377	1.00
47_E	63_P	1.374	1.00
21_T	49_T	1.373	1.00
42_F	70_T	1.351	1.00
238_V	271_V	1.345	1.00
263_R	267_A	1.345	1.00
111_V	125_C	1.330	1.00
97_A	102_D	1.327	1.00
93_A	103_A	1.323	1.00
17_V	32_E	1.307	1.00
26_N	161_V	1.305	1.00
112_V	230_A	1.303	1.00
17_V	41_T	1.293	1.00
92_A	111_V	1.292	1.00
164_I	201_L	1.283	1.00
93_A	97_A	1.273	1.00
251_V	268_R	1.272	1.00
20_E	46_D	1.272	1.00
171_D	186_R	1.253	1.00
95_T	204_H	1.235	1.00
229_S	250_A	1.233	1.00
262_E	268_R	1.232	1.00
258_A	272_T	1.225	1.00
239_T	277_Q	1.218	1.00
19_R	43_V	1.216	1.00
29_A	69_S	1.203	1.00
28_I	32_E	1.197	1.00
85_T	129_T	1.194	1.00
258_A	270_H	1.192	1.00
193_D	196_A	1.191	1.00
61_S	65_G	1.183	1.00
86_L	89_G	1.177	1.00
103_A	113_V	1.176	1.00
30_R	161_V	1.176	1.00
39_D	209_V	1.155	1.00
51_G	61_S	1.151	1.00
204_H	207_T	1.141	1.00
208_W	211_R	1.140	1.00
223_A	227_E	1.127	1.00
18_H	46_D	1.123	1.00
114_A	188_E	1.095	1.00
225_V	229_S	1.083	1.00
70_T	205_L	1.075	1.00
246_V	269_V	1.072	1.00
184_T	187_A	1.072	1.00
52_R	130_E	1.072	1.00
189_R	192_V	1.069	1.00
229_S	232_L	1.066	1.00
125_C	166_V	1.048	1.00
27_D	52_R	1.038	1.00
256_R	270_H	1.028	1.00
62_P	67_W	1.025	1.00
238_V	276_C	1.010	1.00
68_S	201_L	1.008	1.00
27_D	50_A	1.002	1.00
73_R	159_F	1.002	1.00
200_T	204_H	0.991	1.00
31_A	35_A	0.990	1.00
92_A	164_I	0.983	1.00
248_G	263_R	0.982	1.00
132_V	159_F	0.980	1.00
88_G	205_L	0.977	1.00
14_A	206_R	0.975	1.00
91_A	95_T	0.968	1.00
204_H	208_W	0.966	1.00
26_N	69_S	0.966	1.00
200_T	203_E	0.964	1.00
244_D	269_V	0.955	1.00
238_V	261_V	0.952	1.00
65_G	170_L	0.950	1.00
224_A	227_E	0.950	1.00
211_R	216_G	0.949	1.00
66_V	168_A	0.949	1.00
197_V	201_L	0.945	1.00
83_R	212_V	0.943	1.00
240_R	244_D	0.943	1.00
28_I	43_V	0.940	1.00
38_T	41_T	0.937	1.00
87_A	212_V	0.929	1.00
218_M	222_V	0.927	1.00
68_S	164_I	0.924	1.00
30_R	130_E	0.922	1.00
129_T	160_A	0.918	1.00
169_A	186_R	0.917	1.00
42_F	68_S	0.917	1.00
18_H	44_I	0.912	1.00
168_A	194_P	0.905	1.00
233_G	251_V	0.901	1.00
30_R	132_V	0.900	1.00
29_A	41_T	0.898	1.00
226_R	232_L	0.897	1.00
37_A	71_V	0.893	1.00
95_T	99_F	0.890	1.00
195_T	199_A	0.890	1.00
37_A	41_T	0.881	0.99
246_V	271_V	0.875	0.99
13_S	206_R	0.868	0.99
250_A	259_L	0.866	0.99
103_A	111_V	0.864	0.99
38_T	73_R	0.864	0.99
166_V	201_L	0.862	0.99
27_D	31_A	0.860	0.99
166_V	197_V	0.855	0.99
231_T	234_K	0.855	0.99
225_V	253_I	0.854	0.99
222_V	255_D	0.853	0.99
18_H	195_T	0.846	0.99
97_A	103_A	0.846	0.99
238_V	274_G	0.842	0.99
57_N	275_V	0.838	0.99
248_G	261_V	0.838	0.99
104_R	115_A	0.837	0.99
236_V	250_A	0.837	0.99
88_G	164_I	0.835	0.99
129_T	162_L	0.831	0.99
240_R	269_V	0.828	0.99
196_A	199_A	0.825	0.99
32_E	41_T	0.823	0.99
74_A	209_V	0.823	0.99
199_A	203_E	0.823	0.99
99_F	200_T	0.817	0.99
17_V	28_I	0.817	0.99
115_A	234_K	0.816	0.99
186_R	189_R	0.815	0.99
40_G	206_R	0.812	0.99
94_D	228_R	0.812	0.99
246_V	263_R	0.811	0.99
83_R	218_M	0.800	0.99
90_L	208_W	0.799	0.99
240_R	246_V	0.799	0.99
92_A	166_V	0.798	0.99
41_T	71_V	0.797	0.99
59_W	108_P	0.796	0.99
170_L	173_D	0.790	0.99
14_A	40_G	0.788	0.99
96_A	99_F	0.788	0.99
196_A	200_T	0.787	0.99
169_A	190_G	0.786	0.99
37_A	40_G	0.784	0.99
240_R	243_D	0.783	0.99
25_T	45_A	0.782	0.99
247_T	264_P	0.782	0.99
232_L	252_A	0.781	0.99
46_D	63_P	0.780	0.99
72_V	209_V	0.778	0.99
20_E	63_P	0.776	0.99
205_L	209_V	0.776	0.99
95_T	200_T	0.775	0.99
39_D	73_R	0.773	0.99
86_L	257_G	0.770	0.99
208_W	221_A	0.769	0.99
33_A	159_F	0.757	0.98
231_T	236_V	0.756	0.98
42_F	198_A	0.754	0.98
44_I	68_S	0.752	0.98
96_A	197_V	0.752	0.98
100_G	103_A	0.752	0.98
47_E	61_S	0.750	0.98
80_H	83_R	0.747	0.98
39_D	213_Q	0.746	0.98
248_G	271_V	0.746	0.98
210_S	213_Q	0.745	0.98
45_A	67_W	0.743	0.98
203_E	207_T	0.742	0.98
207_T	211_R	0.739	0.98
251_V	260_V	0.738	0.98
131_A	160_A	0.738	0.98
102_D	114_A	0.734	0.98
209_V	213_Q	0.733	0.98
46_D	64_G	0.731	0.98
88_G	129_T	0.730	0.98
93_A	105_L	0.730	0.98
201_L	205_L	0.725	0.98
232_L	250_A	0.723	0.98
22_C	45_A	0.719	0.98
91_A	204_H	0.719	0.98
87_A	90_L	0.719	0.98
224_A	228_R	0.716	0.98
32_E	35_A	0.715	0.98
239_T	243_D	0.715	0.98
90_L	221_A	0.712	0.98
96_A	124_L	0.710	0.98
47_E	67_W	0.710	0.98
71_V	159_F	0.709	0.98
90_L	224_A	0.708	0.98
250_A	261_V	0.698	0.97
202_H	206_R	0.697	0.97
219_D	255_D	0.694	0.97
115_A	230_A	0.690	0.97
162_L	205_L	0.690	0.97
96_A	185_L	0.688	0.97
231_T	276_C	0.688	0.97
124_L	183_T	0.681	0.97
226_R	229_S	0.680	0.97
153_A	156_D	0.680	0.97
39_D	72_V	0.677	0.97
54_R	275_V	0.677	0.97
198_A	202_H	0.676	0.97
234_K	250_A	0.675	0.97
231_T	278_R	0.673	0.97
57_N	274_G	0.669	0.97
90_L	225_V	0.669	0.97
172_P	187_A	0.667	0.97
22_C	43_V	0.667	0.97
217_G	220_D	0.667	0.97
92_A	96_A	0.666	0.97
34_R	132_V	0.663	0.96
30_R	34_R	0.661	0.96
112_V	231_T	0.657	0.96
68_S	202_H	0.656	0.96
15_P	37_A	0.652	0.96
72_V	162_L	0.652	0.96
96_A	103_A	0.651	0.96
70_T	202_H	0.649	0.96
122_S	183_T	0.648	0.96
211_R	224_A	0.643	0.96
26_N	130_E	0.641	0.96
15_P	41_T	0.640	0.96
87_A	208_W	0.638	0.96
95_T	197_V	0.637	0.96
93_A	111_V	0.632	0.95
31_A	34_R	0.631	0.95
238_V	246_V	0.631	0.95
211_R	220_D	0.630	0.95
74_A	157_M	0.626	0.95
90_L	228_R	0.624	0.95
77_A	80_H	0.623	0.95
23_P	50_A	0.618	0.95
15_P	38_T	0.613	0.95
177_D	181_A	0.613	0.95
206_R	210_S	0.611	0.94
262_E	267_A	0.609	0.94
27_D	30_R	0.608	0.94
13_S	40_G	0.608	0.94
229_S	252_A	0.604	0.94
47_E	60_A	0.602	0.94
26_N	128_L	0.601	0.94
66_V	201_L	0.597	0.94
113_V	183_T	0.597	0.94
170_L	184_T	0.596	0.94
76_I	80_H	0.596	0.94
84_L	212_V	0.595	0.94
83_R	222_V	0.595	0.94
39_D	71_V	0.594	0.94
261_V	271_V	0.592	0.94
83_R	87_A	0.591	0.93
96_A	166_V	0.591	0.93
254_D	260_V	0.584	0.93
87_A	91_A	0.583	0.93
40_G	72_V	0.577	0.93
94_D	207_T	0.577	0.93
81_V	157_M	0.576	0.93
90_L	94_D	0.576	0.93
168_A	192_V	0.576	0.93
40_G	71_V	0.575	0.93
24_S	48_Q	0.575	0.93
171_D	174_S	0.575	0.93
218_M	253_I	0.574	0.92
262_E	266_G	0.569	0.92
48_Q	51_G	0.568	0.92
76_I	212_V	0.568	0.92
16_V	44_I	0.566	0.92
252_A	268_R	0.564	0.92
91_A	205_L	0.564	0.92
184_T	190_G	0.563	0.92
62_P	170_L	0.563	0.92
71_V	74_A	0.561	0.92
32_E	36_G	0.557	0.91
79_S	256_R	0.556	0.91
154_N	157_M	0.551	0.91
81_V	131_A	0.551	0.91
98_S	203_E	0.550	0.91
192_V	197_V	0.548	0.91
48_Q	61_S	0.544	0.90
19_R	23_P	0.544	0.90
78_A	81_V	0.543	0.90
88_G	127_V	0.542	0.90
220_D	223_A	0.534	0.90
17_V	43_V	0.533	0.89
169_A	191_A	0.533	0.89
171_D	184_T	0.530	0.89
96_A	111_V	0.529	0.89
169_A	192_V	0.529	0.89
83_R	221_A	0.525	0.89
212_V	217_G	0.523	0.89
40_G	73_R	0.521	0.88
22_C	25_T	0.520	0.88
82_G	85_T	0.520	0.88
170_L	187_A	0.517	0.88
94_D	97_A	0.514	0.88
25_T	69_S	0.514	0.88
221_A	225_V	0.513	0.88
168_A	185_L	0.513	0.88
131_A	157_M	0.510	0.87
75_D	213_Q	0.508	0.87
223_A	226_R	0.505	0.87
174_S	177_D	0.505	0.87
67_W	170_L	0.503	0.87
229_S	253_I	0.500	0.86
99_F	197_V	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4op0A	1	0.8546	100	0.182	Contact Map
3rkxA	1	0.8404	100	0.183	Contact Map
1biaA	1	0.7837	100	0.197	Contact Map
2dxuA	2	0.8156	100	0.205	Contact Map
2eayA	2	0.7766	100	0.211	Contact Map
2ej9A	1	0.8121	100	0.218	Contact Map
3bfmA	2	0.7979	100	0.362	Contact Map
1vqzA	1	0.8404	99.9	0.669	Contact Map
2p5iA	1	0.7128	99.8	0.718	Contact Map
2qhsA	1	0.6418	99.6	0.771	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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