GREMLIN Database
Q9HRK0 - Biotin acetyl-CoA carboxylase ligase
UniProt: Q9HRK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (237)
Sequences: 4712 (3745)
Seq/√Len: 243.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_V262_E3.5001.00
69_S161_V3.2411.00
22_C28_I3.0811.00
19_R22_C2.8461.00
94_D204_H2.8311.00
94_D224_A2.8221.00
21_T47_E2.7711.00
28_I31_A2.5721.00
93_A228_R2.5281.00
263_R269_V2.4831.00
254_D258_A2.4701.00
29_A71_V2.3411.00
46_D194_P2.3211.00
98_S204_H2.3211.00
61_S67_W2.3041.00
104_R230_A2.2451.00
94_D208_W2.2171.00
97_A228_R2.1821.00
226_R252_A2.1731.00
23_P27_D2.1581.00
237_R247_T2.1301.00
68_S198_A2.1191.00
66_V198_A2.0331.00
23_P28_I1.9621.00
254_D270_H1.9581.00
222_V226_R1.9291.00
23_P31_A1.8761.00
98_S200_T1.8571.00
237_R245_P1.8411.00
89_G105_L1.8351.00
29_A43_V1.8331.00
252_A260_V1.8111.00
235_R247_T1.8061.00
92_A201_L1.7151.00
92_A125_C1.7151.00
208_W224_A1.7001.00
113_V124_L1.6971.00
42_F202_H1.6941.00
235_R264_P1.6901.00
44_I198_A1.6841.00
19_R28_I1.6781.00
183_T188_E1.6761.00
235_R249_T1.6721.00
88_G162_L1.6491.00
260_V270_H1.6311.00
183_T187_A1.6021.00
249_T262_E1.5931.00
113_V188_E1.5821.00
84_L160_A1.5781.00
95_T201_L1.5711.00
91_A208_W1.5711.00
239_T245_P1.5691.00
33_A71_V1.5221.00
231_T250_A1.4861.00
32_E43_V1.4691.00
168_A197_V1.4361.00
260_V268_R1.3771.00
47_E63_P1.3741.00
21_T49_T1.3731.00
42_F70_T1.3511.00
238_V271_V1.3451.00
263_R267_A1.3451.00
111_V125_C1.3301.00
97_A102_D1.3271.00
93_A103_A1.3231.00
17_V32_E1.3071.00
26_N161_V1.3051.00
112_V230_A1.3031.00
17_V41_T1.2931.00
92_A111_V1.2921.00
164_I201_L1.2831.00
93_A97_A1.2731.00
251_V268_R1.2721.00
20_E46_D1.2721.00
171_D186_R1.2531.00
95_T204_H1.2351.00
229_S250_A1.2331.00
262_E268_R1.2321.00
258_A272_T1.2251.00
239_T277_Q1.2181.00
19_R43_V1.2161.00
29_A69_S1.2031.00
28_I32_E1.1971.00
85_T129_T1.1941.00
258_A270_H1.1921.00
193_D196_A1.1911.00
61_S65_G1.1831.00
86_L89_G1.1771.00
103_A113_V1.1761.00
30_R161_V1.1761.00
39_D209_V1.1551.00
51_G61_S1.1511.00
204_H207_T1.1411.00
208_W211_R1.1401.00
223_A227_E1.1271.00
18_H46_D1.1231.00
114_A188_E1.0951.00
225_V229_S1.0831.00
70_T205_L1.0751.00
246_V269_V1.0721.00
184_T187_A1.0721.00
52_R130_E1.0721.00
189_R192_V1.0691.00
229_S232_L1.0661.00
125_C166_V1.0481.00
27_D52_R1.0381.00
256_R270_H1.0281.00
62_P67_W1.0251.00
238_V276_C1.0101.00
68_S201_L1.0081.00
27_D50_A1.0021.00
73_R159_F1.0021.00
200_T204_H0.9911.00
31_A35_A0.9901.00
92_A164_I0.9831.00
248_G263_R0.9821.00
132_V159_F0.9801.00
88_G205_L0.9771.00
14_A206_R0.9751.00
91_A95_T0.9681.00
204_H208_W0.9661.00
26_N69_S0.9661.00
200_T203_E0.9641.00
244_D269_V0.9551.00
238_V261_V0.9521.00
65_G170_L0.9501.00
224_A227_E0.9501.00
211_R216_G0.9491.00
66_V168_A0.9491.00
197_V201_L0.9451.00
83_R212_V0.9431.00
240_R244_D0.9431.00
28_I43_V0.9401.00
38_T41_T0.9371.00
87_A212_V0.9291.00
218_M222_V0.9271.00
68_S164_I0.9241.00
30_R130_E0.9221.00
129_T160_A0.9181.00
169_A186_R0.9171.00
42_F68_S0.9171.00
18_H44_I0.9121.00
168_A194_P0.9051.00
233_G251_V0.9011.00
30_R132_V0.9001.00
29_A41_T0.8981.00
226_R232_L0.8971.00
37_A71_V0.8931.00
95_T99_F0.8901.00
195_T199_A0.8901.00
37_A41_T0.8810.99
246_V271_V0.8750.99
13_S206_R0.8680.99
250_A259_L0.8660.99
103_A111_V0.8640.99
38_T73_R0.8640.99
166_V201_L0.8620.99
27_D31_A0.8600.99
166_V197_V0.8550.99
231_T234_K0.8550.99
225_V253_I0.8540.99
222_V255_D0.8530.99
18_H195_T0.8460.99
97_A103_A0.8460.99
238_V274_G0.8420.99
57_N275_V0.8380.99
248_G261_V0.8380.99
104_R115_A0.8370.99
236_V250_A0.8370.99
88_G164_I0.8350.99
129_T162_L0.8310.99
240_R269_V0.8280.99
196_A199_A0.8250.99
32_E41_T0.8230.99
74_A209_V0.8230.99
199_A203_E0.8230.99
99_F200_T0.8170.99
17_V28_I0.8170.99
115_A234_K0.8160.99
186_R189_R0.8150.99
40_G206_R0.8120.99
94_D228_R0.8120.99
246_V263_R0.8110.99
83_R218_M0.8000.99
90_L208_W0.7990.99
240_R246_V0.7990.99
92_A166_V0.7980.99
41_T71_V0.7970.99
59_W108_P0.7960.99
170_L173_D0.7900.99
14_A40_G0.7880.99
96_A99_F0.7880.99
196_A200_T0.7870.99
169_A190_G0.7860.99
37_A40_G0.7840.99
240_R243_D0.7830.99
25_T45_A0.7820.99
247_T264_P0.7820.99
232_L252_A0.7810.99
46_D63_P0.7800.99
72_V209_V0.7780.99
20_E63_P0.7760.99
205_L209_V0.7760.99
95_T200_T0.7750.99
39_D73_R0.7730.99
86_L257_G0.7700.99
208_W221_A0.7690.99
33_A159_F0.7570.98
231_T236_V0.7560.98
42_F198_A0.7540.98
44_I68_S0.7520.98
96_A197_V0.7520.98
100_G103_A0.7520.98
47_E61_S0.7500.98
80_H83_R0.7470.98
39_D213_Q0.7460.98
248_G271_V0.7460.98
210_S213_Q0.7450.98
45_A67_W0.7430.98
203_E207_T0.7420.98
207_T211_R0.7390.98
251_V260_V0.7380.98
131_A160_A0.7380.98
102_D114_A0.7340.98
209_V213_Q0.7330.98
46_D64_G0.7310.98
88_G129_T0.7300.98
93_A105_L0.7300.98
201_L205_L0.7250.98
232_L250_A0.7230.98
22_C45_A0.7190.98
91_A204_H0.7190.98
87_A90_L0.7190.98
224_A228_R0.7160.98
32_E35_A0.7150.98
239_T243_D0.7150.98
90_L221_A0.7120.98
96_A124_L0.7100.98
47_E67_W0.7100.98
71_V159_F0.7090.98
90_L224_A0.7080.98
250_A261_V0.6980.97
202_H206_R0.6970.97
219_D255_D0.6940.97
115_A230_A0.6900.97
162_L205_L0.6900.97
96_A185_L0.6880.97
231_T276_C0.6880.97
124_L183_T0.6810.97
226_R229_S0.6800.97
153_A156_D0.6800.97
39_D72_V0.6770.97
54_R275_V0.6770.97
198_A202_H0.6760.97
234_K250_A0.6750.97
231_T278_R0.6730.97
57_N274_G0.6690.97
90_L225_V0.6690.97
172_P187_A0.6670.97
22_C43_V0.6670.97
217_G220_D0.6670.97
92_A96_A0.6660.97
34_R132_V0.6630.96
30_R34_R0.6610.96
112_V231_T0.6570.96
68_S202_H0.6560.96
15_P37_A0.6520.96
72_V162_L0.6520.96
96_A103_A0.6510.96
70_T202_H0.6490.96
122_S183_T0.6480.96
211_R224_A0.6430.96
26_N130_E0.6410.96
15_P41_T0.6400.96
87_A208_W0.6380.96
95_T197_V0.6370.96
93_A111_V0.6320.95
31_A34_R0.6310.95
238_V246_V0.6310.95
211_R220_D0.6300.95
74_A157_M0.6260.95
90_L228_R0.6240.95
77_A80_H0.6230.95
23_P50_A0.6180.95
15_P38_T0.6130.95
177_D181_A0.6130.95
206_R210_S0.6110.94
262_E267_A0.6090.94
27_D30_R0.6080.94
13_S40_G0.6080.94
229_S252_A0.6040.94
47_E60_A0.6020.94
26_N128_L0.6010.94
66_V201_L0.5970.94
113_V183_T0.5970.94
170_L184_T0.5960.94
76_I80_H0.5960.94
84_L212_V0.5950.94
83_R222_V0.5950.94
39_D71_V0.5940.94
261_V271_V0.5920.94
83_R87_A0.5910.93
96_A166_V0.5910.93
254_D260_V0.5840.93
87_A91_A0.5830.93
40_G72_V0.5770.93
94_D207_T0.5770.93
81_V157_M0.5760.93
90_L94_D0.5760.93
168_A192_V0.5760.93
40_G71_V0.5750.93
24_S48_Q0.5750.93
171_D174_S0.5750.93
218_M253_I0.5740.92
262_E266_G0.5690.92
48_Q51_G0.5680.92
76_I212_V0.5680.92
16_V44_I0.5660.92
252_A268_R0.5640.92
91_A205_L0.5640.92
184_T190_G0.5630.92
62_P170_L0.5630.92
71_V74_A0.5610.92
32_E36_G0.5570.91
79_S256_R0.5560.91
154_N157_M0.5510.91
81_V131_A0.5510.91
98_S203_E0.5500.91
192_V197_V0.5480.91
48_Q61_S0.5440.90
19_R23_P0.5440.90
78_A81_V0.5430.90
88_G127_V0.5420.90
220_D223_A0.5340.90
17_V43_V0.5330.89
169_A191_A0.5330.89
171_D184_T0.5300.89
96_A111_V0.5290.89
169_A192_V0.5290.89
83_R221_A0.5250.89
212_V217_G0.5230.89
40_G73_R0.5210.88
22_C25_T0.5200.88
82_G85_T0.5200.88
170_L187_A0.5170.88
94_D97_A0.5140.88
25_T69_S0.5140.88
221_A225_V0.5130.88
168_A185_L0.5130.88
131_A157_M0.5100.87
75_D213_Q0.5080.87
223_A226_R0.5050.87
174_S177_D0.5050.87
67_W170_L0.5030.87
229_S253_I0.5000.86
99_F197_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4op0A 1 0.8546 100 0.182 Contact Map
3rkxA 1 0.8404 100 0.183 Contact Map
1biaA 1 0.7837 100 0.197 Contact Map
2dxuA 2 0.8156 100 0.205 Contact Map
2eayA 2 0.7766 100 0.211 Contact Map
2ej9A 1 0.8121 100 0.218 Contact Map
3bfmA 2 0.7979 100 0.362 Contact Map
1vqzA 1 0.8404 99.9 0.669 Contact Map
2p5iA 1 0.7128 99.8 0.718 Contact Map
2qhsA 1 0.6418 99.6 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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