GREMLIN Database
Q9HRJ6 - Uncharacterized protein
UniProt: Q9HRJ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (232)
Sequences: 85429 (50042)
Seq/√Len: 3285.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E196_R3.6201.00
75_R147_D3.1881.00
18_A21_R3.0681.00
6_V26_S3.0391.00
9_D22_G3.0281.00
33_F198_G2.9621.00
8_D60_R2.8581.00
34_A194_A2.6971.00
196_R208_T2.6861.00
60_R67_P2.6101.00
28_S31_E2.5331.00
13_S18_A2.5251.00
6_V62_E2.4721.00
21_R204_D2.3411.00
12_K49_C2.3391.00
210_T213_D2.3351.00
209_G213_D2.2751.00
11_A58_G2.2271.00
120_D123_T2.1891.00
11_A18_A2.1571.00
11_A22_G2.1351.00
198_G205_I2.1081.00
7_A10_V2.0551.00
8_D62_E2.0351.00
64_L147_D2.0251.00
107_A145_D1.9781.00
29_E147_D1.9421.00
91_A128_L1.9421.00
198_G208_T1.9141.00
47_V183_T1.8011.00
172_G176_D1.8001.00
110_A114_S1.7771.00
191_S212_A1.7421.00
184_T190_A1.6921.00
145_D178_T1.6801.00
92_A96_G1.6621.00
113_E118_D1.6531.00
105_S109_D1.6521.00
171_E192_A1.6381.00
107_A110_A1.6351.00
14_Y45_T1.6091.00
47_V150_F1.6051.00
123_T127_D1.6041.00
14_Y19_A1.5731.00
92_A122_A1.5671.00
114_S172_G1.5521.00
114_S176_D1.5391.00
209_G214_L1.5361.00
12_K57_D1.5291.00
67_P70_D1.5181.00
96_G104_D1.5061.00
9_D24_S1.4861.00
12_K54_T1.4701.00
7_A25_L1.4631.00
25_L198_G1.4331.00
31_E195_D1.4161.00
173_L178_T1.4151.00
96_G108_P1.4141.00
64_L75_R1.4071.00
111_V143_V1.3961.00
92_A105_S1.3961.00
33_F208_T1.3881.00
111_V115_V1.3661.00
11_A21_R1.3651.00
10_V56_P1.3521.00
95_V112_L1.3351.00
27_V33_F1.3061.00
13_S57_D1.3021.00
34_A190_A1.2711.00
96_G105_S1.2601.00
213_D217_A1.2581.00
20_L49_C1.2251.00
52_G55_T1.2181.00
62_E67_P1.2161.00
81_Q130_G1.2101.00
32_V174_A1.2081.00
28_S196_R1.1981.00
109_D113_E1.1941.00
7_A50_L1.1911.00
90_T93_E1.1901.00
106_R110_A1.1751.00
4_V64_L1.1671.00
23_V46_L1.1671.00
25_L46_L1.1661.00
220_G223_R1.1661.00
8_D26_S1.1651.00
167_W189_E1.1541.00
35_L46_L1.1531.00
151_L180_I1.1431.00
92_A108_P1.1411.00
49_C56_P1.1341.00
100_G104_D1.1301.00
33_F196_R1.1271.00
111_V139_A1.1171.00
51_T78_L1.1161.00
118_D121_D1.1041.00
89_L93_E1.1021.00
94_L140_A1.0971.00
112_L117_L1.0881.00
35_L181_V1.0631.00
107_A111_V1.0571.00
171_E174_A1.0551.00
92_A109_D1.0521.00
221_S224_L1.0501.00
29_E64_L1.0441.00
48_R54_T1.0391.00
218_H222_P1.0371.00
95_V143_V1.0291.00
163_R189_E1.0271.00
201_A206_A1.0261.00
158_V166_L1.0231.00
8_D24_S1.0201.00
174_A180_I1.0141.00
164_H168_S1.0141.00
149_L178_T1.0131.00
90_T122_A1.0061.00
128_L136_A1.0061.00
71_A74_Q1.0031.00
109_D121_D1.0021.00
212_A216_A0.9971.00
112_L121_D0.9881.00
32_V194_A0.9851.00
77_G146_P0.9801.00
9_D58_G0.9781.00
93_E96_G0.9741.00
116_G165_A0.9661.00
79_L151_L0.9661.00
46_L200_L0.9651.00
32_V180_I0.9641.00
99_A104_D0.9631.00
102_Y144_N0.9611.00
88_R93_E0.9611.00
104_D108_P0.9601.00
92_A121_D0.9541.00
7_A61_V0.9481.00
66_E75_R0.9421.00
110_A113_E0.9391.00
115_V139_A0.9351.00
125_Y136_A0.9331.00
163_R186_D0.9261.00
99_A143_V0.9241.00
197_V211_P0.9241.00
213_D216_A0.9201.00
169_V172_G0.9181.00
7_A46_L0.9161.00
221_S225_V0.9111.00
222_P226_V0.9071.00
149_L180_I0.9001.00
66_E71_A0.8931.00
104_D107_A0.8931.00
174_A195_D0.8921.00
153_E185_H0.8821.00
50_L181_V0.8761.00
96_G100_G0.8731.00
38_P201_A0.8681.00
170_F180_I0.8671.00
51_T150_F0.8621.00
105_S108_P0.8581.00
90_T124_R0.8561.00
91_A136_A0.8481.00
151_L170_F0.8451.00
79_L138_V0.8441.00
77_G141_A0.8441.00
88_R126_G0.8371.00
12_K45_T0.8351.00
79_L141_A0.8331.00
35_L198_G0.8271.00
10_V49_C0.8231.00
32_V182_L0.8231.00
13_S21_R0.8211.00
49_C61_V0.8201.00
124_R127_D0.8181.00
206_A220_G0.8151.00
5_L50_L0.8151.00
89_L94_L0.8111.00
207_A217_A0.8101.00
54_T57_D0.7951.00
211_P221_S0.7921.00
48_R53_T0.7901.00
85_P133_R0.7891.00
168_S171_E0.7891.00
201_A225_V0.7841.00
29_E177_G0.7831.00
22_G204_D0.7821.00
111_V114_S0.7801.00
128_L132_Q0.7771.00
33_F181_V0.7761.00
49_C54_T0.7761.00
147_D178_T0.7731.00
23_V205_I0.7691.00
108_P111_V0.7661.00
167_W192_A0.7651.00
95_V108_P0.7641.00
211_P215_V0.7621.00
41_A200_L0.7621.00
94_L125_Y0.7611.00
150_F181_V0.7591.00
98_Y140_A0.7591.00
99_A107_A0.7591.00
121_D128_L0.7581.00
191_S215_V0.7551.00
224_L228_T0.7541.00
155_T166_L0.7531.00
90_T94_L0.7531.00
171_E175_A0.7521.00
27_V179_T0.7451.00
168_S172_G0.7431.00
55_T69_Q0.7401.00
106_R109_D0.7381.00
72_Q76_L0.7311.00
32_V171_E0.7301.00
191_S211_P0.7301.00
28_S179_T0.7281.00
64_L148_V0.7281.00
116_G172_G0.7211.00
56_P69_Q0.7201.00
109_D117_L0.7161.00
182_L194_A0.7151.00
13_S19_A0.7141.00
223_R227_D0.7121.00
113_E119_P0.7081.00
171_E193_L0.7081.00
20_L23_V0.7071.00
205_I208_T0.7041.00
71_A75_R0.6971.00
165_A168_S0.6961.00
22_G58_G0.6951.00
27_V148_V0.6951.00
36_V190_A0.6891.00
89_L97_Y0.6861.00
110_A145_D0.6861.00
207_A218_H0.6801.00
130_G135_R0.6741.00
13_S16_D0.6741.00
223_R226_V0.6741.00
109_D112_L0.6671.00
148_V179_T0.6661.00
20_L46_L0.6651.00
111_V142_L0.6651.00
9_D12_K0.6641.00
14_Y54_T0.6621.00
60_R69_Q0.6581.00
27_V181_V0.6581.00
18_A22_G0.6561.00
50_L61_V0.6551.00
32_V193_L0.6531.00
76_L148_V0.6441.00
5_L63_L0.6421.00
187_M215_V0.6401.00
194_A197_V0.6401.00
36_V187_M0.6351.00
225_V228_T0.6331.00
145_D176_D0.6321.00
168_S192_A0.6321.00
77_G144_N0.6311.00
5_L148_V0.6301.00
199_L218_H0.6281.00
199_L214_L0.6261.00
26_S208_T0.6251.00
109_D119_P0.6251.00
214_L223_R0.6241.00
62_E65_G0.6201.00
99_A102_Y0.6201.00
31_E208_T0.6191.00
4_V63_L0.6171.00
232_P235_A0.6141.00
36_V199_L0.6141.00
225_V229_D0.6091.00
4_V29_E0.6081.00
220_G224_L0.6081.00
98_Y144_N0.6061.00
218_H221_S0.6051.00
207_A219_A0.6051.00
229_D232_P0.6021.00
19_A45_T0.6001.00
189_E193_L0.5991.00
182_L193_L0.5981.00
83_F133_R0.5981.00
97_Y101_L0.5971.00
39_N162_G0.5971.00
12_K20_L0.5961.00
109_D118_D0.5951.00
184_T189_E0.5941.00
188_A192_A0.5941.00
79_L137_C0.5931.00
201_A220_G0.5921.00
122_A125_Y0.5921.00
201_A204_D0.5901.00
148_V181_V0.5881.00
39_N153_E0.5871.00
13_S58_G0.5861.00
112_L115_V0.5851.00
30_G179_T0.5841.00
29_E179_T0.5831.00
66_E70_D0.5821.00
207_A214_L0.5791.00
10_V61_V0.5751.00
155_T189_E0.5701.00
49_C57_D0.5681.00
87_D133_R0.5641.00
194_A211_P0.5631.00
82_S133_R0.5611.00
172_G175_A0.5601.00
64_L68_P0.5581.00
52_G69_Q0.5571.00
4_V28_S0.5561.00
12_K15_G0.5561.00
106_R113_E0.5551.00
190_A197_V0.5551.00
51_T76_L0.5521.00
50_L150_F0.5501.00
63_L75_R0.5501.00
86_P89_L0.5481.00
87_D126_G0.5451.00
190_A194_A0.5451.00
32_V195_D0.5431.00
44_T48_R0.5391.00
63_L148_V0.5391.00
4_V179_T0.5391.00
105_S122_A0.5391.00
66_E72_Q0.5391.00
4_V148_V0.5381.00
162_G165_A0.5381.00
53_T80_P0.5341.00
213_D219_A0.5311.00
138_V166_L0.5311.00
21_R202_D0.5301.00
83_F137_C0.5271.00
7_A49_C0.5251.00
117_L120_D0.5251.00
98_Y101_L0.5231.00
202_D225_V0.5221.00
35_L200_L0.5201.00
224_L227_D0.5171.00
17_A202_D0.5141.00
13_S17_A0.5131.00
125_Y133_R0.5131.00
86_P94_L0.5101.00
85_P125_Y0.5081.00
142_L178_T0.5071.00
134_R157_G0.5071.00
120_D132_Q0.5071.00
170_F182_L0.5071.00
92_A95_V0.5041.00
65_G68_P0.5011.00
12_K19_A0.5011.00
91_A95_V0.5001.00
129_S132_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9094 100 0.119 Contact Map
3tuiC 2 0.9933 100 0.177 Contact Map
4u00A 1 0.7718 100 0.181 Contact Map
2oljA 2 0.7718 100 0.186 Contact Map
1b0uA 2 0.7852 100 0.195 Contact Map
4rvcA 4 0.7785 100 0.197 Contact Map
4ymuJ 2 0.7651 100 0.197 Contact Map
4mkiB 2 0.8859 100 0.198 Contact Map
4huqB 1 0.8792 100 0.202 Contact Map
1v43A 2 0.9564 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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