Q9HRJ6 - HALSA - GREMLIN Contacts

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Q9HRJ6 - Uncharacterized protein

UniProt:	Q9HRJ6	Sequences: MDSVLVADDVAKSYGDAAALRGVSLSVSEGEVFALVGPNGAGKTTLVRCLTGTTTPDGGRVELLGEPPQDAQKQRLGLLPQSFSPPDRLTAAELVGYYAGLYADSRAPDAVLESVGLDPDDATRYGDLSGGQRRRACVAAALVNDPDVLFLDEPTTGVDPAGRHALWSVFEGLAADGTTIVLTTHDMAEASALADRVGLLADGDIAATGTPADLVAAHAGSPRLVVDTDADPELAGFDCTRTDAGLVFEGVDPTAVGEIAAALDDADVAFDALSWREPSLEDAYLALAGDAERGEVVQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	298 (232)
Sequences:	85429 (50042)
Seq/√Len:	3285.4

ECOLI - YADG FBPC METN PROV CYSA MALK YDCT POTG UGPC YCJV POTA MACB RBSA YEHX MODC SAPD DPPF ARAG OPPD DPPD OPPF YHES DDPD UUP DDPF ZNUC GSIA PHNC FEPC MLAF TAUB SSUB HISP LSRA SAPF MDLB YTFR FECE YECC FHUC MDLA NIKE GLNQ XYLG CYDC YHDZ LPTB GLTL YOJI YPHE MSBA LIVF PHNK CYDD LIVG SUFC MODF ALSA ETTA ARTP BTUD MGLA PSTB THIQ FTSE NIKD LOLD FETA YBBA CCMA YDDA PHNL YNJD YEJF YBHF YBIT YHIH
BACSU - YHCH YCBN YVFR YDBJ YFIL OPUBA YVRA OPUCA YXLF YHAQ OPUAA MSMX METN YURJ TAGH DPPD APPD YKFD YTRB OPPD APPF YFMM RBSA OPPF YFMR YKPA YUSV YDIF ECFA1 FHUC YXDL YFMF TCYN SUNT YCLP YLMA YHEH YKOD YFIC ECSA SUFC SKFE YXEO ECFA2 YTHP YKNV YFIB YGAD SSUB BMRA YTLC TCYC YWJA YKNU NATA ALBC YHEI GLNQ BCEA YVCR MNTB ARTM CYDD FTSE YJKB YUFO PSTB1 PSTB2 CYDC YHCG YVRO EXPZ YKNY YYBJ ZNUC YYDI YCLH YTRE
HALSA - Q9HRJ6 Q9HMU8 BTUDA Q9HHQ5 Q9HMX3 Q9HR06 Q9HNZ9 Q9HMW0 Q9HMT3 Q9HRH8 Q9HMX2 Q9HMG1 Q9HHM2 PHNC PSTB2 Q9HSQ7 Q9HMG6 Q9HNY3 Q9HRZ9 Y1631 Q9HS04 Y2317 Q9HHR7 Q9HRV7 PSTB1 Q9HR96 Q9HQA8 Q9HR21 Q9HT03 Q9HMC1 Q9HMW1
SULSO - Q7LX64 Q97YY4 Q97UF2 Q97X18 Q97YK2 Q97UY8 Q97VH6 Q97ZC0 Q97YQ7 Q97VC1 Q97UH3 Q97VF5 Q97VK9 Q97VK8 Q97YP3 Q97YP7 Q97UD4 Q97UJ9 Q97YP8 Q97VF4 Q97Z03 Q97U54 Y2030 Q97UH4 Q7LY07 Y1893 Q980W0 Q97W42 Q97V00 PSTB Q97V01 Q97VM2 Q97VY4 Q7LX80 Q7LXM4 Q97UG5 Q97Z56 Q97Z96 Q97UC2 Q97YP4 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_E	196_R	3.620	1.00
75_R	147_D	3.188	1.00
18_A	21_R	3.068	1.00
6_V	26_S	3.039	1.00
9_D	22_G	3.028	1.00
33_F	198_G	2.962	1.00
8_D	60_R	2.858	1.00
34_A	194_A	2.697	1.00
196_R	208_T	2.686	1.00
60_R	67_P	2.610	1.00
28_S	31_E	2.533	1.00
13_S	18_A	2.525	1.00
6_V	62_E	2.472	1.00
21_R	204_D	2.341	1.00
12_K	49_C	2.339	1.00
210_T	213_D	2.335	1.00
209_G	213_D	2.275	1.00
11_A	58_G	2.227	1.00
120_D	123_T	2.189	1.00
11_A	18_A	2.157	1.00
11_A	22_G	2.135	1.00
198_G	205_I	2.108	1.00
7_A	10_V	2.055	1.00
8_D	62_E	2.035	1.00
64_L	147_D	2.025	1.00
107_A	145_D	1.978	1.00
29_E	147_D	1.942	1.00
91_A	128_L	1.942	1.00
198_G	208_T	1.914	1.00
47_V	183_T	1.801	1.00
172_G	176_D	1.800	1.00
110_A	114_S	1.777	1.00
191_S	212_A	1.742	1.00
184_T	190_A	1.692	1.00
145_D	178_T	1.680	1.00
92_A	96_G	1.662	1.00
113_E	118_D	1.653	1.00
105_S	109_D	1.652	1.00
171_E	192_A	1.638	1.00
107_A	110_A	1.635	1.00
14_Y	45_T	1.609	1.00
47_V	150_F	1.605	1.00
123_T	127_D	1.604	1.00
14_Y	19_A	1.573	1.00
92_A	122_A	1.567	1.00
114_S	172_G	1.552	1.00
114_S	176_D	1.539	1.00
209_G	214_L	1.536	1.00
12_K	57_D	1.529	1.00
67_P	70_D	1.518	1.00
96_G	104_D	1.506	1.00
9_D	24_S	1.486	1.00
12_K	54_T	1.470	1.00
7_A	25_L	1.463	1.00
25_L	198_G	1.433	1.00
31_E	195_D	1.416	1.00
173_L	178_T	1.415	1.00
96_G	108_P	1.414	1.00
64_L	75_R	1.407	1.00
111_V	143_V	1.396	1.00
92_A	105_S	1.396	1.00
33_F	208_T	1.388	1.00
111_V	115_V	1.366	1.00
11_A	21_R	1.365	1.00
10_V	56_P	1.352	1.00
95_V	112_L	1.335	1.00
27_V	33_F	1.306	1.00
13_S	57_D	1.302	1.00
34_A	190_A	1.271	1.00
96_G	105_S	1.260	1.00
213_D	217_A	1.258	1.00
20_L	49_C	1.225	1.00
52_G	55_T	1.218	1.00
62_E	67_P	1.216	1.00
81_Q	130_G	1.210	1.00
32_V	174_A	1.208	1.00
28_S	196_R	1.198	1.00
109_D	113_E	1.194	1.00
7_A	50_L	1.191	1.00
90_T	93_E	1.190	1.00
106_R	110_A	1.175	1.00
4_V	64_L	1.167	1.00
23_V	46_L	1.167	1.00
25_L	46_L	1.166	1.00
220_G	223_R	1.166	1.00
8_D	26_S	1.165	1.00
167_W	189_E	1.154	1.00
35_L	46_L	1.153	1.00
151_L	180_I	1.143	1.00
92_A	108_P	1.141	1.00
49_C	56_P	1.134	1.00
100_G	104_D	1.130	1.00
33_F	196_R	1.127	1.00
111_V	139_A	1.117	1.00
51_T	78_L	1.116	1.00
118_D	121_D	1.104	1.00
89_L	93_E	1.102	1.00
94_L	140_A	1.097	1.00
112_L	117_L	1.088	1.00
35_L	181_V	1.063	1.00
107_A	111_V	1.057	1.00
171_E	174_A	1.055	1.00
92_A	109_D	1.052	1.00
221_S	224_L	1.050	1.00
29_E	64_L	1.044	1.00
48_R	54_T	1.039	1.00
218_H	222_P	1.037	1.00
95_V	143_V	1.029	1.00
163_R	189_E	1.027	1.00
201_A	206_A	1.026	1.00
158_V	166_L	1.023	1.00
8_D	24_S	1.020	1.00
174_A	180_I	1.014	1.00
164_H	168_S	1.014	1.00
149_L	178_T	1.013	1.00
90_T	122_A	1.006	1.00
128_L	136_A	1.006	1.00
71_A	74_Q	1.003	1.00
109_D	121_D	1.002	1.00
212_A	216_A	0.997	1.00
112_L	121_D	0.988	1.00
32_V	194_A	0.985	1.00
77_G	146_P	0.980	1.00
9_D	58_G	0.978	1.00
93_E	96_G	0.974	1.00
116_G	165_A	0.966	1.00
79_L	151_L	0.966	1.00
46_L	200_L	0.965	1.00
32_V	180_I	0.964	1.00
99_A	104_D	0.963	1.00
102_Y	144_N	0.961	1.00
88_R	93_E	0.961	1.00
104_D	108_P	0.960	1.00
92_A	121_D	0.954	1.00
7_A	61_V	0.948	1.00
66_E	75_R	0.942	1.00
110_A	113_E	0.939	1.00
115_V	139_A	0.935	1.00
125_Y	136_A	0.933	1.00
163_R	186_D	0.926	1.00
99_A	143_V	0.924	1.00
197_V	211_P	0.924	1.00
213_D	216_A	0.920	1.00
169_V	172_G	0.918	1.00
7_A	46_L	0.916	1.00
221_S	225_V	0.911	1.00
222_P	226_V	0.907	1.00
149_L	180_I	0.900	1.00
66_E	71_A	0.893	1.00
104_D	107_A	0.893	1.00
174_A	195_D	0.892	1.00
153_E	185_H	0.882	1.00
50_L	181_V	0.876	1.00
96_G	100_G	0.873	1.00
38_P	201_A	0.868	1.00
170_F	180_I	0.867	1.00
51_T	150_F	0.862	1.00
105_S	108_P	0.858	1.00
90_T	124_R	0.856	1.00
91_A	136_A	0.848	1.00
151_L	170_F	0.845	1.00
79_L	138_V	0.844	1.00
77_G	141_A	0.844	1.00
88_R	126_G	0.837	1.00
12_K	45_T	0.835	1.00
79_L	141_A	0.833	1.00
35_L	198_G	0.827	1.00
10_V	49_C	0.823	1.00
32_V	182_L	0.823	1.00
13_S	21_R	0.821	1.00
49_C	61_V	0.820	1.00
124_R	127_D	0.818	1.00
206_A	220_G	0.815	1.00
5_L	50_L	0.815	1.00
89_L	94_L	0.811	1.00
207_A	217_A	0.810	1.00
54_T	57_D	0.795	1.00
211_P	221_S	0.792	1.00
48_R	53_T	0.790	1.00
85_P	133_R	0.789	1.00
168_S	171_E	0.789	1.00
201_A	225_V	0.784	1.00
29_E	177_G	0.783	1.00
22_G	204_D	0.782	1.00
111_V	114_S	0.780	1.00
128_L	132_Q	0.777	1.00
33_F	181_V	0.776	1.00
49_C	54_T	0.776	1.00
147_D	178_T	0.773	1.00
23_V	205_I	0.769	1.00
108_P	111_V	0.766	1.00
167_W	192_A	0.765	1.00
95_V	108_P	0.764	1.00
211_P	215_V	0.762	1.00
41_A	200_L	0.762	1.00
94_L	125_Y	0.761	1.00
150_F	181_V	0.759	1.00
98_Y	140_A	0.759	1.00
99_A	107_A	0.759	1.00
121_D	128_L	0.758	1.00
191_S	215_V	0.755	1.00
224_L	228_T	0.754	1.00
155_T	166_L	0.753	1.00
90_T	94_L	0.753	1.00
171_E	175_A	0.752	1.00
27_V	179_T	0.745	1.00
168_S	172_G	0.743	1.00
55_T	69_Q	0.740	1.00
106_R	109_D	0.738	1.00
72_Q	76_L	0.731	1.00
32_V	171_E	0.730	1.00
191_S	211_P	0.730	1.00
28_S	179_T	0.728	1.00
64_L	148_V	0.728	1.00
116_G	172_G	0.721	1.00
56_P	69_Q	0.720	1.00
109_D	117_L	0.716	1.00
182_L	194_A	0.715	1.00
13_S	19_A	0.714	1.00
223_R	227_D	0.712	1.00
113_E	119_P	0.708	1.00
171_E	193_L	0.708	1.00
20_L	23_V	0.707	1.00
205_I	208_T	0.704	1.00
71_A	75_R	0.697	1.00
165_A	168_S	0.696	1.00
22_G	58_G	0.695	1.00
27_V	148_V	0.695	1.00
36_V	190_A	0.689	1.00
89_L	97_Y	0.686	1.00
110_A	145_D	0.686	1.00
207_A	218_H	0.680	1.00
130_G	135_R	0.674	1.00
13_S	16_D	0.674	1.00
223_R	226_V	0.674	1.00
109_D	112_L	0.667	1.00
148_V	179_T	0.666	1.00
20_L	46_L	0.665	1.00
111_V	142_L	0.665	1.00
9_D	12_K	0.664	1.00
14_Y	54_T	0.662	1.00
60_R	69_Q	0.658	1.00
27_V	181_V	0.658	1.00
18_A	22_G	0.656	1.00
50_L	61_V	0.655	1.00
32_V	193_L	0.653	1.00
76_L	148_V	0.644	1.00
5_L	63_L	0.642	1.00
187_M	215_V	0.640	1.00
194_A	197_V	0.640	1.00
36_V	187_M	0.635	1.00
225_V	228_T	0.633	1.00
145_D	176_D	0.632	1.00
168_S	192_A	0.632	1.00
77_G	144_N	0.631	1.00
5_L	148_V	0.630	1.00
199_L	218_H	0.628	1.00
199_L	214_L	0.626	1.00
26_S	208_T	0.625	1.00
109_D	119_P	0.625	1.00
214_L	223_R	0.624	1.00
62_E	65_G	0.620	1.00
99_A	102_Y	0.620	1.00
31_E	208_T	0.619	1.00
4_V	63_L	0.617	1.00
232_P	235_A	0.614	1.00
36_V	199_L	0.614	1.00
225_V	229_D	0.609	1.00
4_V	29_E	0.608	1.00
220_G	224_L	0.608	1.00
98_Y	144_N	0.606	1.00
218_H	221_S	0.605	1.00
207_A	219_A	0.605	1.00
229_D	232_P	0.602	1.00
19_A	45_T	0.600	1.00
189_E	193_L	0.599	1.00
182_L	193_L	0.598	1.00
83_F	133_R	0.598	1.00
97_Y	101_L	0.597	1.00
39_N	162_G	0.597	1.00
12_K	20_L	0.596	1.00
109_D	118_D	0.595	1.00
184_T	189_E	0.594	1.00
188_A	192_A	0.594	1.00
79_L	137_C	0.593	1.00
201_A	220_G	0.592	1.00
122_A	125_Y	0.592	1.00
201_A	204_D	0.590	1.00
148_V	181_V	0.588	1.00
39_N	153_E	0.587	1.00
13_S	58_G	0.586	1.00
112_L	115_V	0.585	1.00
30_G	179_T	0.584	1.00
29_E	179_T	0.583	1.00
66_E	70_D	0.582	1.00
207_A	214_L	0.579	1.00
10_V	61_V	0.575	1.00
155_T	189_E	0.570	1.00
49_C	57_D	0.568	1.00
87_D	133_R	0.564	1.00
194_A	211_P	0.563	1.00
82_S	133_R	0.561	1.00
172_G	175_A	0.560	1.00
64_L	68_P	0.558	1.00
52_G	69_Q	0.557	1.00
4_V	28_S	0.556	1.00
12_K	15_G	0.556	1.00
106_R	113_E	0.555	1.00
190_A	197_V	0.555	1.00
51_T	76_L	0.552	1.00
50_L	150_F	0.550	1.00
63_L	75_R	0.550	1.00
86_P	89_L	0.548	1.00
87_D	126_G	0.545	1.00
190_A	194_A	0.545	1.00
32_V	195_D	0.543	1.00
44_T	48_R	0.539	1.00
63_L	148_V	0.539	1.00
4_V	179_T	0.539	1.00
105_S	122_A	0.539	1.00
66_E	72_Q	0.539	1.00
4_V	148_V	0.538	1.00
162_G	165_A	0.538	1.00
53_T	80_P	0.534	1.00
213_D	219_A	0.531	1.00
138_V	166_L	0.531	1.00
21_R	202_D	0.530	1.00
83_F	137_C	0.527	1.00
7_A	49_C	0.525	1.00
117_L	120_D	0.525	1.00
98_Y	101_L	0.523	1.00
202_D	225_V	0.522	1.00
35_L	200_L	0.520	1.00
224_L	227_D	0.517	1.00
17_A	202_D	0.514	1.00
13_S	17_A	0.513	1.00
125_Y	133_R	0.513	1.00
86_P	94_L	0.510	1.00
85_P	125_Y	0.508	1.00
142_L	178_T	0.507	1.00
134_R	157_G	0.507	1.00
120_D	132_Q	0.507	1.00
170_F	182_L	0.507	1.00
92_A	95_V	0.504	1.00
65_G	68_P	0.501	1.00
12_K	19_A	0.501	1.00
91_A	95_V	0.500	1.00
129_S	132_Q	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yerA	2	0.9094	100	0.119	Contact Map
3tuiC	2	0.9933	100	0.177	Contact Map
4u00A	1	0.7718	100	0.181	Contact Map
2oljA	2	0.7718	100	0.186	Contact Map
1b0uA	2	0.7852	100	0.195	Contact Map
4rvcA	4	0.7785	100	0.197	Contact Map
4ymuJ	2	0.7651	100	0.197	Contact Map
4mkiB	2	0.8859	100	0.198	Contact Map
4huqB	1	0.8792	100	0.202	Contact Map
1v43A	2	0.9564	100	0.202	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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