GREMLIN Database
Q9HRJ5 - Uncharacterized protein
UniProt: Q9HRJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (231)
Sequences: 21436 (14912)
Seq/√Len: 981.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_F211_G5.4241.00
12_T16_R3.9861.00
157_I240_V3.4081.00
147_A208_F3.0921.00
10_E107_A3.0011.00
121_A141_A2.9431.00
8_R12_T2.8201.00
7_V110_L2.7911.00
11_A114_V2.5531.00
14_A108_H2.4521.00
149_V234_A2.4491.00
11_A110_L2.4411.00
150_L234_A2.3881.00
194_A198_P2.3741.00
146_A231_L2.3161.00
16_R19_L2.2231.00
100_S103_E2.1951.00
225_F229_V2.1691.00
56_Q59_G2.1521.00
228_G232_V2.0561.00
224_V228_G2.0431.00
19_L22_R1.9421.00
229_V232_V1.9351.00
125_V129_L1.9311.00
7_V103_E1.8321.00
194_A197_R1.8261.00
232_V236_V1.8151.00
197_R201_N1.8091.00
7_V11_A1.7611.00
200_L206_V1.7441.00
157_I244_L1.7421.00
239_G243_A1.6941.00
189_P200_L1.6891.00
207_Y226_N1.6821.00
233_L237_A1.6751.00
157_I237_A1.6691.00
150_L237_A1.6621.00
117_V145_P1.6301.00
153_G234_A1.6251.00
164_G167_G1.6031.00
219_G223_V1.6011.00
229_V233_L1.5741.00
57_P60_Y1.5461.00
147_A151_F1.5351.00
7_V106_A1.5301.00
236_V240_V1.5091.00
225_F228_G1.5001.00
144_V208_F1.4971.00
143_F227_A1.4861.00
195_W198_P1.4851.00
13_G85_Y1.4511.00
201_N207_Y1.4361.00
153_G238_F1.4161.00
162_A171_A1.4001.00
79_G82_V1.3621.00
158_L162_A1.3481.00
136_V139_W1.3461.00
37_V41_G1.3351.00
124_V128_L1.3301.00
210_R226_N1.3301.00
143_F215_A1.3181.00
218_T223_V1.3151.00
198_P201_N1.3051.00
15_M19_L1.2981.00
113_V145_P1.2951.00
31_F35_L1.2851.00
231_L235_V1.2831.00
146_A227_A1.2771.00
57_P61_Y1.2731.00
87_A165_Q1.2621.00
7_V107_A1.2621.00
116_I148_S1.2561.00
210_R214_A1.2261.00
227_A231_L1.2231.00
207_Y211_G1.2231.00
93_K99_L1.2211.00
93_K98_P1.2191.00
135_T138_P1.2191.00
107_A111_V1.2161.00
11_A15_M1.2151.00
90_R93_K1.2081.00
185_T209_A1.2071.00
201_N206_V1.2051.00
150_L230_V1.1901.00
94_L98_P1.1861.00
146_A234_A1.1821.00
66_L69_V1.1751.00
79_G168_A1.1751.00
11_A107_A1.1731.00
113_V149_V1.1671.00
8_R11_A1.1651.00
73_T77_R1.1641.00
108_H112_N1.1641.00
195_W199_L1.1621.00
198_P202_A1.1501.00
234_A238_F1.1361.00
16_R20_R1.1341.00
133_N138_P1.1191.00
220_G223_V1.1101.00
144_V212_V1.1071.00
192_F197_R1.0961.00
26_F30_F1.0961.00
160_S244_L1.0951.00
207_Y229_V1.0951.00
161_L244_L1.0871.00
102_A106_A1.0651.00
206_V210_R1.0611.00
35_L39_F1.0561.00
179_L203_S1.0541.00
32_P38_I1.0531.00
40_A129_L1.0531.00
15_M111_V1.0481.00
197_R200_L1.0381.00
58_T61_Y1.0331.00
236_V239_G1.0281.00
173_N177_L1.0141.00
60_Y63_P1.0141.00
59_G62_L1.0071.00
153_G241_G1.0071.00
240_V244_L1.0041.00
85_Y90_R1.0041.00
63_P66_L1.0011.00
87_A94_L0.9751.00
162_A167_G0.9731.00
85_Y108_H0.9711.00
105_L241_G0.9711.00
94_L99_L0.9551.00
9_A12_T0.9541.00
157_I241_G0.9521.00
105_L242_A0.9491.00
87_A91_F0.9441.00
189_P206_V0.9441.00
83_A168_A0.9371.00
11_A111_V0.9301.00
226_N230_V0.9261.00
142_F146_A0.9241.00
135_T139_W0.9221.00
204_P208_F0.9191.00
189_P197_R0.9151.00
176_A180_L0.9101.00
38_I42_L0.9041.00
56_Q60_Y0.9011.00
71_L77_R0.8991.00
154_I175_I0.8931.00
142_F227_A0.8931.00
58_T63_P0.8881.00
81_E84_R0.8841.00
203_S206_V0.8831.00
174_G178_P0.8831.00
230_V233_L0.8821.00
54_F59_G0.8791.00
207_Y210_R0.8741.00
62_L65_Y0.8741.00
228_G231_L0.8711.00
14_A111_V0.8681.00
123_L140_L0.8611.00
167_G170_A0.8611.00
150_L233_L0.8601.00
60_Y66_L0.8521.00
154_I237_A0.8461.00
214_A218_T0.8361.00
85_Y92_E0.8311.00
62_L73_T0.8311.00
55_S59_G0.8271.00
55_S63_P0.8231.00
224_V227_A0.8211.00
57_P63_P0.8181.00
153_G237_A0.8151.00
80_S83_A0.8141.00
221_D225_F0.8121.00
117_V121_A0.8081.00
163_D167_G0.8001.00
193_P197_R0.8001.00
14_A17_T0.7981.00
86_R93_K0.7951.00
237_A241_G0.7941.00
32_P35_L0.7941.00
89_N92_E0.7931.00
63_P68_T0.7911.00
63_P67_A0.7901.00
109_A238_F0.7851.00
18_F28_T0.7841.00
103_E107_A0.7831.00
14_A112_N0.7821.00
65_Y69_V0.7811.00
66_L74_P0.7811.00
60_Y64_A0.7751.00
21_R24_A0.7701.00
169_I173_N0.7661.00
226_N229_V0.7631.00
240_V243_A0.7621.00
90_R94_L0.7591.00
146_A230_V0.7591.00
156_A241_G0.7571.00
189_P201_N0.7561.00
86_R91_F0.7551.00
64_A71_L0.7521.00
211_G226_N0.7481.00
231_L234_A0.7481.00
15_M114_V0.7441.00
64_A72_F0.7421.00
71_L74_P0.7401.00
207_Y233_L0.7401.00
65_Y68_T0.7401.00
40_A130_T0.7401.00
141_A145_P0.7371.00
57_P62_L0.7311.00
173_N178_P0.7311.00
102_A242_A0.7291.00
209_A213_R0.7281.00
166_D170_A0.7251.00
225_F232_V0.7241.00
105_L156_A0.7161.00
219_G222_G0.7131.00
37_V40_A0.7121.00
110_L114_V0.7101.00
127_L131_G0.7071.00
73_T76_S0.7061.00
55_S60_Y0.7051.00
235_V239_G0.7041.00
22_R25_V0.7041.00
94_L97_T0.6991.00
229_V237_A0.6981.00
41_G44_R0.6971.00
202_A207_Y0.6961.00
158_L175_I0.6931.00
33_V125_V0.6901.00
84_R87_A0.6881.00
61_Y64_A0.6871.00
148_S152_C0.6821.00
188_Q191_L0.6821.00
59_G63_P0.6801.00
87_A90_R0.6791.00
184_E188_Q0.6781.00
233_L236_V0.6741.00
83_A87_A0.6741.00
222_G225_F0.6721.00
143_F208_F0.6721.00
208_F211_G0.6691.00
91_F104_W0.6651.00
70_V73_T0.6621.00
120_A145_P0.6581.00
93_K97_T0.6571.00
63_P77_R0.6551.00
156_A159_G0.6551.00
61_Y65_Y0.6531.00
10_E103_E0.6531.00
235_V238_F0.6501.00
36_I122_V0.6471.00
62_L66_L0.6471.00
156_A160_S0.6401.00
72_F77_R0.6331.00
54_F57_P0.6331.00
215_A223_V0.6331.00
112_N156_A0.6321.00
109_A153_G0.6301.00
39_F43_V0.6281.00
79_G83_A0.6261.00
89_N98_P0.6261.00
214_A226_N0.6231.00
223_V226_N0.6191.00
56_Q64_A0.6181.00
90_R95_A0.6171.00
214_A220_G0.6171.00
187_V191_L0.6151.00
178_P181_F0.6131.00
12_T15_M0.6131.00
67_A205_L0.6101.00
112_N160_S0.6091.00
18_F115_L0.6051.00
63_P71_L0.6041.00
114_V117_V0.6031.00
38_I41_G0.6031.00
72_F75_L0.6031.00
126_A130_T0.5991.00
158_L172_S0.5991.00
57_P65_Y0.5971.00
120_A144_V0.5971.00
124_V127_L0.5931.00
193_P196_F0.5891.00
91_F94_L0.5881.00
93_K96_T0.5871.00
114_V118_L0.5861.00
89_N93_K0.5851.00
113_V152_C0.5841.00
70_V77_R0.5811.00
35_L38_I0.5801.00
64_A69_V0.5751.00
19_L25_V0.5741.00
59_G64_A0.5741.00
62_L68_T0.5711.00
109_A152_C0.5701.00
91_F95_A0.5681.00
149_V153_G0.5681.00
67_A70_V0.5671.00
106_A110_L0.5671.00
23_T27_F0.5641.00
213_R217_F0.5631.00
155_G159_G0.5621.00
33_V37_V0.5601.00
238_F242_A0.5591.00
13_G17_T0.5561.00
177_L180_L0.5561.00
192_F196_F0.5541.00
128_L134_F0.5511.00
67_A74_P0.5501.00
23_T26_F0.5501.00
155_G182_L0.5491.00
180_L183_S0.5491.00
157_I160_S0.5481.00
32_P36_I0.5481.00
99_L104_W0.5471.00
90_R98_P0.5461.00
221_D224_V0.5441.00
7_V102_A0.5411.00
182_L203_S0.5391.00
179_L205_L0.5381.00
126_A140_L0.5351.00
188_Q192_F0.5311.00
60_Y69_V0.5301.00
92_E98_P0.5301.00
62_L76_S0.5291.00
74_P77_R0.5291.00
131_G134_F0.5271.00
66_L70_V0.5271.00
92_E95_A0.5271.00
67_A75_L0.5241.00
85_Y94_L0.5231.00
116_I119_A0.5221.00
218_T221_D0.5191.00
119_A208_F0.5181.00
30_F33_V0.5171.00
64_A67_A0.5171.00
63_P72_F0.5161.00
57_P66_L0.5161.00
133_N137_S0.5151.00
170_A173_N0.5111.00
68_T73_T0.5091.00
62_L72_F0.5081.00
239_G242_A0.5071.00
124_V139_W0.5061.00
68_T72_F0.5041.00
65_Y70_V0.5041.00
172_S176_A0.5031.00
55_S64_A0.5011.00
125_V128_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.3373 5.5 0.94 Contact Map
2mfrA 1 0.1727 2.3 0.95 Contact Map
2kluA 1 0.1446 1.9 0.952 Contact Map
2wswA 3 0.6104 1.9 0.952 Contact Map
4cadC 1 0.7952 1.7 0.953 Contact Map
3wdoA 1 0.7952 1.5 0.955 Contact Map
2m20A 2 0.1205 1.5 0.955 Contact Map
2jwaA 2 0.1526 1.4 0.955 Contact Map
1iijA 1 0.1406 1.3 0.956 Contact Map
4i0uA 4 0.3092 1.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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