Q9HRJ5 - HALSA - GREMLIN Contacts

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Q9HRJ5 - Uncharacterized protein

UniProt:	Q9HRJ5	Sequences: MSAAGRVRAEATGAMRTFLRRRTAVFFTFFFPVVLIVIFAGLVRTQGGSSAGLFSQPTGYYLPAYLATVVLFTPLSRVGSEVARYRADNRFEKLATTPLSRAEWLAAHALVNVVLIVLAAAVLVVALLLTGANFTVSPWLAFFVPAASVLFCGIGAILGSLADGQDGAIAASNGIALPLLFLSETFVQPALFPAWFRPLLNASPLVYFARGVRAATFTGGDGVVFNAGVVLVLAVVAFGVGAALIPWTE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (231)
Sequences:	21436 (14912)
Seq/√Len:	981.1

ECOLI - YADH YHHJ YBHR YBHS
BACSU - YVFS TAGG YFIM YFIN NATB
HALSA - Q9HRJ5 Q9HMU9
SULSO - Q97WP5 Q97VH7 Q97U55 Q7LY08 Q97Z04 Q97W41

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
143_F	211_G	5.424	1.00
12_T	16_R	3.986	1.00
157_I	240_V	3.408	1.00
147_A	208_F	3.092	1.00
10_E	107_A	3.001	1.00
121_A	141_A	2.943	1.00
8_R	12_T	2.820	1.00
7_V	110_L	2.791	1.00
11_A	114_V	2.553	1.00
14_A	108_H	2.452	1.00
149_V	234_A	2.449	1.00
11_A	110_L	2.441	1.00
150_L	234_A	2.388	1.00
194_A	198_P	2.374	1.00
146_A	231_L	2.316	1.00
16_R	19_L	2.223	1.00
100_S	103_E	2.195	1.00
225_F	229_V	2.169	1.00
56_Q	59_G	2.152	1.00
228_G	232_V	2.056	1.00
224_V	228_G	2.043	1.00
19_L	22_R	1.942	1.00
229_V	232_V	1.935	1.00
125_V	129_L	1.931	1.00
7_V	103_E	1.832	1.00
194_A	197_R	1.826	1.00
232_V	236_V	1.815	1.00
197_R	201_N	1.809	1.00
7_V	11_A	1.761	1.00
200_L	206_V	1.744	1.00
157_I	244_L	1.742	1.00
239_G	243_A	1.694	1.00
189_P	200_L	1.689	1.00
207_Y	226_N	1.682	1.00
233_L	237_A	1.675	1.00
157_I	237_A	1.669	1.00
150_L	237_A	1.662	1.00
117_V	145_P	1.630	1.00
153_G	234_A	1.625	1.00
164_G	167_G	1.603	1.00
219_G	223_V	1.601	1.00
229_V	233_L	1.574	1.00
57_P	60_Y	1.546	1.00
147_A	151_F	1.535	1.00
7_V	106_A	1.530	1.00
236_V	240_V	1.509	1.00
225_F	228_G	1.500	1.00
144_V	208_F	1.497	1.00
143_F	227_A	1.486	1.00
195_W	198_P	1.485	1.00
13_G	85_Y	1.451	1.00
201_N	207_Y	1.436	1.00
153_G	238_F	1.416	1.00
162_A	171_A	1.400	1.00
79_G	82_V	1.362	1.00
158_L	162_A	1.348	1.00
136_V	139_W	1.346	1.00
37_V	41_G	1.335	1.00
124_V	128_L	1.330	1.00
210_R	226_N	1.330	1.00
143_F	215_A	1.318	1.00
218_T	223_V	1.315	1.00
198_P	201_N	1.305	1.00
15_M	19_L	1.298	1.00
113_V	145_P	1.295	1.00
31_F	35_L	1.285	1.00
231_L	235_V	1.283	1.00
146_A	227_A	1.277	1.00
57_P	61_Y	1.273	1.00
87_A	165_Q	1.262	1.00
7_V	107_A	1.262	1.00
116_I	148_S	1.256	1.00
210_R	214_A	1.226	1.00
227_A	231_L	1.223	1.00
207_Y	211_G	1.223	1.00
93_K	99_L	1.221	1.00
93_K	98_P	1.219	1.00
135_T	138_P	1.219	1.00
107_A	111_V	1.216	1.00
11_A	15_M	1.215	1.00
90_R	93_K	1.208	1.00
185_T	209_A	1.207	1.00
201_N	206_V	1.205	1.00
150_L	230_V	1.190	1.00
94_L	98_P	1.186	1.00
146_A	234_A	1.182	1.00
66_L	69_V	1.175	1.00
79_G	168_A	1.175	1.00
11_A	107_A	1.173	1.00
113_V	149_V	1.167	1.00
8_R	11_A	1.165	1.00
73_T	77_R	1.164	1.00
108_H	112_N	1.164	1.00
195_W	199_L	1.162	1.00
198_P	202_A	1.150	1.00
234_A	238_F	1.136	1.00
16_R	20_R	1.134	1.00
133_N	138_P	1.119	1.00
220_G	223_V	1.110	1.00
144_V	212_V	1.107	1.00
192_F	197_R	1.096	1.00
26_F	30_F	1.096	1.00
160_S	244_L	1.095	1.00
207_Y	229_V	1.095	1.00
161_L	244_L	1.087	1.00
102_A	106_A	1.065	1.00
206_V	210_R	1.061	1.00
35_L	39_F	1.056	1.00
179_L	203_S	1.054	1.00
32_P	38_I	1.053	1.00
40_A	129_L	1.053	1.00
15_M	111_V	1.048	1.00
197_R	200_L	1.038	1.00
58_T	61_Y	1.033	1.00
236_V	239_G	1.028	1.00
173_N	177_L	1.014	1.00
60_Y	63_P	1.014	1.00
59_G	62_L	1.007	1.00
153_G	241_G	1.007	1.00
240_V	244_L	1.004	1.00
85_Y	90_R	1.004	1.00
63_P	66_L	1.001	1.00
87_A	94_L	0.975	1.00
162_A	167_G	0.973	1.00
85_Y	108_H	0.971	1.00
105_L	241_G	0.971	1.00
94_L	99_L	0.955	1.00
9_A	12_T	0.954	1.00
157_I	241_G	0.952	1.00
105_L	242_A	0.949	1.00
87_A	91_F	0.944	1.00
189_P	206_V	0.944	1.00
83_A	168_A	0.937	1.00
11_A	111_V	0.930	1.00
226_N	230_V	0.926	1.00
142_F	146_A	0.924	1.00
135_T	139_W	0.922	1.00
204_P	208_F	0.919	1.00
189_P	197_R	0.915	1.00
176_A	180_L	0.910	1.00
38_I	42_L	0.904	1.00
56_Q	60_Y	0.901	1.00
71_L	77_R	0.899	1.00
154_I	175_I	0.893	1.00
142_F	227_A	0.893	1.00
58_T	63_P	0.888	1.00
81_E	84_R	0.884	1.00
203_S	206_V	0.883	1.00
174_G	178_P	0.883	1.00
230_V	233_L	0.882	1.00
54_F	59_G	0.879	1.00
207_Y	210_R	0.874	1.00
62_L	65_Y	0.874	1.00
228_G	231_L	0.871	1.00
14_A	111_V	0.868	1.00
123_L	140_L	0.861	1.00
167_G	170_A	0.861	1.00
150_L	233_L	0.860	1.00
60_Y	66_L	0.852	1.00
154_I	237_A	0.846	1.00
214_A	218_T	0.836	1.00
85_Y	92_E	0.831	1.00
62_L	73_T	0.831	1.00
55_S	59_G	0.827	1.00
55_S	63_P	0.823	1.00
224_V	227_A	0.821	1.00
57_P	63_P	0.818	1.00
153_G	237_A	0.815	1.00
80_S	83_A	0.814	1.00
221_D	225_F	0.812	1.00
117_V	121_A	0.808	1.00
163_D	167_G	0.800	1.00
193_P	197_R	0.800	1.00
14_A	17_T	0.798	1.00
86_R	93_K	0.795	1.00
237_A	241_G	0.794	1.00
32_P	35_L	0.794	1.00
89_N	92_E	0.793	1.00
63_P	68_T	0.791	1.00
63_P	67_A	0.790	1.00
109_A	238_F	0.785	1.00
18_F	28_T	0.784	1.00
103_E	107_A	0.783	1.00
14_A	112_N	0.782	1.00
65_Y	69_V	0.781	1.00
66_L	74_P	0.781	1.00
60_Y	64_A	0.775	1.00
21_R	24_A	0.770	1.00
169_I	173_N	0.766	1.00
226_N	229_V	0.763	1.00
240_V	243_A	0.762	1.00
90_R	94_L	0.759	1.00
146_A	230_V	0.759	1.00
156_A	241_G	0.757	1.00
189_P	201_N	0.756	1.00
86_R	91_F	0.755	1.00
64_A	71_L	0.752	1.00
211_G	226_N	0.748	1.00
231_L	234_A	0.748	1.00
15_M	114_V	0.744	1.00
64_A	72_F	0.742	1.00
71_L	74_P	0.740	1.00
207_Y	233_L	0.740	1.00
65_Y	68_T	0.740	1.00
40_A	130_T	0.740	1.00
141_A	145_P	0.737	1.00
57_P	62_L	0.731	1.00
173_N	178_P	0.731	1.00
102_A	242_A	0.729	1.00
209_A	213_R	0.728	1.00
166_D	170_A	0.725	1.00
225_F	232_V	0.724	1.00
105_L	156_A	0.716	1.00
219_G	222_G	0.713	1.00
37_V	40_A	0.712	1.00
110_L	114_V	0.710	1.00
127_L	131_G	0.707	1.00
73_T	76_S	0.706	1.00
55_S	60_Y	0.705	1.00
235_V	239_G	0.704	1.00
22_R	25_V	0.704	1.00
94_L	97_T	0.699	1.00
229_V	237_A	0.698	1.00
41_G	44_R	0.697	1.00
202_A	207_Y	0.696	1.00
158_L	175_I	0.693	1.00
33_V	125_V	0.690	1.00
84_R	87_A	0.688	1.00
61_Y	64_A	0.687	1.00
148_S	152_C	0.682	1.00
188_Q	191_L	0.682	1.00
59_G	63_P	0.680	1.00
87_A	90_R	0.679	1.00
184_E	188_Q	0.678	1.00
233_L	236_V	0.674	1.00
83_A	87_A	0.674	1.00
222_G	225_F	0.672	1.00
143_F	208_F	0.672	1.00
208_F	211_G	0.669	1.00
91_F	104_W	0.665	1.00
70_V	73_T	0.662	1.00
120_A	145_P	0.658	1.00
93_K	97_T	0.657	1.00
63_P	77_R	0.655	1.00
156_A	159_G	0.655	1.00
61_Y	65_Y	0.653	1.00
10_E	103_E	0.653	1.00
235_V	238_F	0.650	1.00
36_I	122_V	0.647	1.00
62_L	66_L	0.647	1.00
156_A	160_S	0.640	1.00
72_F	77_R	0.633	1.00
54_F	57_P	0.633	1.00
215_A	223_V	0.633	1.00
112_N	156_A	0.632	1.00
109_A	153_G	0.630	1.00
39_F	43_V	0.628	1.00
79_G	83_A	0.626	1.00
89_N	98_P	0.626	1.00
214_A	226_N	0.623	1.00
223_V	226_N	0.619	1.00
56_Q	64_A	0.618	1.00
90_R	95_A	0.617	1.00
214_A	220_G	0.617	1.00
187_V	191_L	0.615	1.00
178_P	181_F	0.613	1.00
12_T	15_M	0.613	1.00
67_A	205_L	0.610	1.00
112_N	160_S	0.609	1.00
18_F	115_L	0.605	1.00
63_P	71_L	0.604	1.00
114_V	117_V	0.603	1.00
38_I	41_G	0.603	1.00
72_F	75_L	0.603	1.00
126_A	130_T	0.599	1.00
158_L	172_S	0.599	1.00
57_P	65_Y	0.597	1.00
120_A	144_V	0.597	1.00
124_V	127_L	0.593	1.00
193_P	196_F	0.589	1.00
91_F	94_L	0.588	1.00
93_K	96_T	0.587	1.00
114_V	118_L	0.586	1.00
89_N	93_K	0.585	1.00
113_V	152_C	0.584	1.00
70_V	77_R	0.581	1.00
35_L	38_I	0.580	1.00
64_A	69_V	0.575	1.00
19_L	25_V	0.574	1.00
59_G	64_A	0.574	1.00
62_L	68_T	0.571	1.00
109_A	152_C	0.570	1.00
91_F	95_A	0.568	1.00
149_V	153_G	0.568	1.00
67_A	70_V	0.567	1.00
106_A	110_L	0.567	1.00
23_T	27_F	0.564	1.00
213_R	217_F	0.563	1.00
155_G	159_G	0.562	1.00
33_V	37_V	0.560	1.00
238_F	242_A	0.559	1.00
13_G	17_T	0.556	1.00
177_L	180_L	0.556	1.00
192_F	196_F	0.554	1.00
128_L	134_F	0.551	1.00
67_A	74_P	0.550	1.00
23_T	26_F	0.550	1.00
155_G	182_L	0.549	1.00
180_L	183_S	0.549	1.00
157_I	160_S	0.548	1.00
32_P	36_I	0.548	1.00
99_L	104_W	0.547	1.00
90_R	98_P	0.546	1.00
221_D	224_V	0.544	1.00
7_V	102_A	0.541	1.00
182_L	203_S	0.539	1.00
179_L	205_L	0.538	1.00
126_A	140_L	0.535	1.00
188_Q	192_F	0.531	1.00
60_Y	69_V	0.530	1.00
92_E	98_P	0.530	1.00
62_L	76_S	0.529	1.00
74_P	77_R	0.529	1.00
131_G	134_F	0.527	1.00
66_L	70_V	0.527	1.00
92_E	95_A	0.527	1.00
67_A	75_L	0.524	1.00
85_Y	94_L	0.523	1.00
116_I	119_A	0.522	1.00
218_T	221_D	0.519	1.00
119_A	208_F	0.518	1.00
30_F	33_V	0.517	1.00
64_A	67_A	0.517	1.00
63_P	72_F	0.516	1.00
57_P	66_L	0.516	1.00
133_N	137_S	0.515	1.00
170_A	173_N	0.511	1.00
68_T	73_T	0.509	1.00
62_L	72_F	0.508	1.00
239_G	242_A	0.507	1.00
124_V	139_W	0.506	1.00
68_T	72_F	0.504	1.00
65_Y	70_V	0.504	1.00
172_S	176_A	0.503	1.00
55_S	64_A	0.501	1.00
125_V	128_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a65A	2	0.3373	5.5	0.94	Contact Map
2mfrA	1	0.1727	2.3	0.95	Contact Map
2kluA	1	0.1446	1.9	0.952	Contact Map
2wswA	3	0.6104	1.9	0.952	Contact Map
4cadC	1	0.7952	1.7	0.953	Contact Map
3wdoA	1	0.7952	1.5	0.955	Contact Map
2m20A	2	0.1205	1.5	0.955	Contact Map
2jwaA	2	0.1526	1.4	0.955	Contact Map
1iijA	1	0.1406	1.3	0.956	Contact Map
4i0uA	4	0.3092	1.3	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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