GREMLIN Database
Q9HRJ3 - Uncharacterized protein
UniProt: Q9HRJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (173)
Sequences: 433 (303)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_F126_V6.1381.00
151_A172_G5.2951.00
24_L28_L3.5621.00
69_G85_M3.1841.00
73_I78_V3.1751.00
20_V24_L3.0121.00
127_K131_L2.7010.99
125_V129_A2.6830.99
70_V76_G2.4440.98
79_R83_A2.4330.98
116_G119_L2.2640.97
65_S91_L2.2440.97
155_G160_P2.2430.97
72_F84_A2.2130.96
72_F80_K1.9590.93
172_G175_A1.8780.91
25_G28_L1.8240.90
63_L184_F1.8080.90
113_I119_L1.7900.89
86_L156_L1.7870.89
145_V148_V1.7200.87
151_A175_A1.7020.86
14_P21_L1.6910.86
113_I116_G1.6690.85
92_I183_L1.6640.85
112_V119_L1.6570.85
19_I22_S1.6170.83
14_P18_T1.6010.83
14_P25_G1.5100.79
118_F121_Q1.5070.79
27_A30_A1.4910.78
132_L136_V1.4770.77
65_S84_A1.4710.77
115_Q119_L1.4700.77
55_I183_L1.4450.76
112_V120_G1.4330.75
139_L142_V1.4270.75
90_T184_F1.3990.73
85_M155_G1.3870.73
67_L71_A1.3630.71
48_V101_W1.3620.71
125_V128_G1.3420.70
77_A80_K1.3280.69
32_A37_V1.2820.66
22_S26_Y1.2760.66
128_G132_L1.2700.66
116_G121_Q1.2620.65
116_G193_L1.2480.64
144_S178_A1.2480.64
156_L159_S1.2360.64
21_L25_G1.2360.64
67_L180_S1.2280.63
62_A145_V1.2270.63
22_S33_F1.2090.62
93_C97_V1.2050.62
154_L172_G1.1960.61
46_P50_L1.1930.61
131_L135_A1.1880.60
33_F36_V1.1800.60
150_Y155_G1.1790.60
19_I23_V1.1590.58
102_K193_L1.1520.58
119_L124_G1.1350.57
36_V40_F1.1310.57
113_I120_G1.1180.56
15_G25_G1.1150.55
55_I98_L1.1140.55
62_A148_V1.1100.55
144_S172_G1.1060.55
53_D57_V1.0940.54
69_G87_T1.0750.53
121_Q124_G1.0710.52
147_V178_A1.0700.52
82_R86_L1.0650.52
121_Q126_V1.0640.52
27_A75_R1.0540.51
92_I176_A1.0530.51
29_V32_A1.0480.51
142_V150_Y1.0470.51
17_V21_L1.0430.50
118_F192_M1.0420.50
133_M147_V1.0420.50
112_V115_Q1.0280.49
13_N16_R1.0280.49
150_Y153_V1.0190.49
126_V131_L1.0080.48
52_A189_T0.9960.47
150_Y171_F0.9800.46
73_I133_M0.9680.45
29_V33_F0.9670.45
18_T22_S0.9570.45
45_D48_V0.9570.45
28_L31_G0.9520.44
71_A129_A0.9490.44
18_T32_A0.9470.44
70_V176_A0.9440.44
34_T143_V0.9420.43
92_I146_P0.9350.43
131_L193_L0.9320.43
144_S147_V0.9310.43
142_V157_T0.9280.43
30_A100_L0.9250.42
156_L171_F0.9220.42
16_R19_I0.9200.42
115_Q131_L0.9200.42
18_T25_G0.9130.42
14_P28_L0.8960.40
26_Y33_F0.8960.40
31_G100_L0.8950.40
31_G34_T0.8900.40
54_L98_L0.8840.40
22_S29_V0.8780.39
117_M127_K0.8770.39
115_Q120_G0.8770.39
16_R20_V0.8760.39
177_T181_L0.8680.39
59_N66_L0.8670.38
86_L152_I0.8620.38
120_G125_V0.8600.38
112_V116_G0.8560.38
173_R185_L0.8540.38
19_I157_T0.8520.37
159_S166_T0.8500.37
60_T171_F0.8430.37
78_V89_F0.8380.37
48_V142_V0.8280.36
89_F93_C0.8210.35
112_V178_A0.8210.35
126_V188_V0.8180.35
54_L58_V0.8160.35
58_V98_L0.8070.35
83_A87_T0.8060.35
14_P153_V0.8040.34
126_V132_L0.8030.34
23_V27_A0.7960.34
27_A143_V0.7940.34
67_L184_F0.7920.34
70_V74_K0.7920.34
160_P169_A0.7890.33
15_G158_H0.7850.33
26_Y29_V0.7850.33
121_Q131_L0.7830.33
136_V185_L0.7790.33
46_P141_S0.7750.33
140_L173_R0.7730.32
20_V23_V0.7680.32
54_L82_R0.7680.32
16_R23_V0.7600.32
85_M91_L0.7550.31
113_I118_F0.7530.31
116_G120_G0.7530.31
133_M187_V0.7520.31
78_V160_P0.7510.31
55_I141_S0.7510.31
63_L92_I0.7410.31
57_V88_A0.7330.30
102_K116_G0.7310.30
68_A90_T0.7270.30
147_V185_L0.7230.30
74_K78_V0.7220.29
90_T94_V0.7200.29
74_K79_R0.7140.29
77_A171_F0.7120.29
83_A178_A0.7090.29
103_V196_V0.7040.28
20_V71_A0.7000.28
77_A83_A0.6970.28
85_M90_T0.6890.28
67_L169_A0.6860.27
59_N149_L0.6860.27
101_W152_I0.6810.27
155_G158_H0.6810.27
69_G89_F0.6790.27
73_I90_T0.6690.26
19_I25_G0.6600.26
88_A147_V0.6590.26
176_A180_S0.6590.26
141_S148_V0.6510.26
60_T187_V0.6430.25
12_A15_G0.6430.25
70_V78_V0.6430.25
13_N100_L0.6410.25
22_S37_V0.6410.25
83_A86_L0.6390.25
51_F102_K0.6370.25
21_L26_Y0.6330.25
75_R87_T0.6320.25
20_V77_A0.6310.24
121_Q128_G0.6290.24
18_T27_A0.6240.24
94_V97_V0.6230.24
18_T28_L0.6230.24
31_G193_L0.6220.24
112_V121_Q0.6210.24
147_V158_H0.6210.24
21_L153_V0.6200.24
153_V157_T0.6200.24
28_L97_V0.6180.24
70_V136_V0.6170.24
57_V68_A0.6090.23
20_V25_G0.6080.23
61_L176_A0.6070.23
17_V150_Y0.6060.23
28_L145_V0.6060.23
63_L180_S0.6020.23
40_F155_G0.6010.23
14_P17_V0.5980.23
91_L183_L0.5980.23
148_V176_A0.5930.23
25_G85_M0.5890.22
12_A23_V0.5880.22
154_L173_R0.5880.22
29_V41_P0.5880.22
157_T166_T0.5860.22
76_G83_A0.5840.22
93_C152_I0.5830.22
22_S34_T0.5820.22
171_F175_A0.5820.22
125_V136_V0.5680.21
85_M158_H0.5650.21
87_T178_A0.5630.21
13_N169_A0.5600.21
182_S185_L0.5540.21
86_L153_V0.5540.21
31_G35_D0.5520.21
167_R170_T0.5510.21
181_L185_L0.5500.21
136_V181_L0.5460.20
79_R170_T0.5460.20
89_F148_V0.5460.20
65_S88_A0.5450.20
57_V61_L0.5430.20
53_D151_A0.5390.20
135_A139_L0.5390.20
103_V177_T0.5380.20
94_V98_L0.5350.20
55_I63_L0.5350.20
58_V94_V0.5340.20
23_V54_L0.5330.20
23_V139_L0.5310.20
158_H174_I0.5290.20
121_Q170_T0.5260.19
142_V167_R0.5240.19
84_A184_F0.5240.19
22_S25_G0.5220.19
85_M92_I0.5210.19
12_A16_R0.5200.19
114_T118_F0.5190.19
15_G18_T0.5190.19
126_V129_A0.5180.19
128_G136_V0.5170.19
26_Y30_A0.5170.19
71_A156_L0.5140.19
61_L88_A0.5140.19
16_R131_L0.5120.19
41_P58_V0.5050.19
151_A154_L0.5050.19
22_S32_A0.5040.19
119_L131_L0.5010.18
61_L65_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.8614 94 0.92 Contact Map
1v54C 1 0.901 89.7 0.929 Contact Map
2yevA 1 0.8861 89.3 0.93 Contact Map
1qleC 1 0.901 81.5 0.937 Contact Map
1m56C 2 0.901 79.7 0.938 Contact Map
4o6yA 2 0.8663 67.4 0.944 Contact Map
2bs2C 2 0.6436 39.3 0.953 Contact Map
4n6hA 1 0.7921 20.6 0.959 Contact Map
3dh4A 3 0.698 12.4 0.963 Contact Map
4ldeA 1 0.7574 10.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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