Q9HRJ3 - HALSA - GREMLIN Contacts

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Q9HRJ3 - Uncharacterized protein

UniProt:	Q9HRJ3	Sequences: MVSVRAASYAKANPGRVTIVLSVLGYALVAGAFTDVVALFPPLDDPTVLLFADLIAVVNTLALTSLLAGVAFIKRGAVRKHRAAMLTAFTLICVFLVLYLWKVGGGFEKSIVITQGMFLGQFAGVVKGAYLLMLAVHILLSVVSVPVVLYAIVLGLTHSPAELKRTRHATFGRIAATAWSLSLFLGVVTYVMLNHVYAWVPR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	202 (173)
Sequences:	433 (303)
Seq/√Len:	23.0

BACSU - YOZB
HALSA - Q9HRJ3 Q9HPS5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_F	126_V	6.138	1.00
151_A	172_G	5.295	1.00
24_L	28_L	3.562	1.00
69_G	85_M	3.184	1.00
73_I	78_V	3.175	1.00
20_V	24_L	3.012	1.00
127_K	131_L	2.701	0.99
125_V	129_A	2.683	0.99
70_V	76_G	2.444	0.98
79_R	83_A	2.433	0.98
116_G	119_L	2.264	0.97
65_S	91_L	2.244	0.97
155_G	160_P	2.243	0.97
72_F	84_A	2.213	0.96
72_F	80_K	1.959	0.93
172_G	175_A	1.878	0.91
25_G	28_L	1.824	0.90
63_L	184_F	1.808	0.90
113_I	119_L	1.790	0.89
86_L	156_L	1.787	0.89
145_V	148_V	1.720	0.87
151_A	175_A	1.702	0.86
14_P	21_L	1.691	0.86
113_I	116_G	1.669	0.85
92_I	183_L	1.664	0.85
112_V	119_L	1.657	0.85
19_I	22_S	1.617	0.83
14_P	18_T	1.601	0.83
14_P	25_G	1.510	0.79
118_F	121_Q	1.507	0.79
27_A	30_A	1.491	0.78
132_L	136_V	1.477	0.77
65_S	84_A	1.471	0.77
115_Q	119_L	1.470	0.77
55_I	183_L	1.445	0.76
112_V	120_G	1.433	0.75
139_L	142_V	1.427	0.75
90_T	184_F	1.399	0.73
85_M	155_G	1.387	0.73
67_L	71_A	1.363	0.71
48_V	101_W	1.362	0.71
125_V	128_G	1.342	0.70
77_A	80_K	1.328	0.69
32_A	37_V	1.282	0.66
22_S	26_Y	1.276	0.66
128_G	132_L	1.270	0.66
116_G	121_Q	1.262	0.65
116_G	193_L	1.248	0.64
144_S	178_A	1.248	0.64
156_L	159_S	1.236	0.64
21_L	25_G	1.236	0.64
67_L	180_S	1.228	0.63
62_A	145_V	1.227	0.63
22_S	33_F	1.209	0.62
93_C	97_V	1.205	0.62
154_L	172_G	1.196	0.61
46_P	50_L	1.193	0.61
131_L	135_A	1.188	0.60
33_F	36_V	1.180	0.60
150_Y	155_G	1.179	0.60
19_I	23_V	1.159	0.58
102_K	193_L	1.152	0.58
119_L	124_G	1.135	0.57
36_V	40_F	1.131	0.57
113_I	120_G	1.118	0.56
15_G	25_G	1.115	0.55
55_I	98_L	1.114	0.55
62_A	148_V	1.110	0.55
144_S	172_G	1.106	0.55
53_D	57_V	1.094	0.54
69_G	87_T	1.075	0.53
121_Q	124_G	1.071	0.52
147_V	178_A	1.070	0.52
82_R	86_L	1.065	0.52
121_Q	126_V	1.064	0.52
27_A	75_R	1.054	0.51
92_I	176_A	1.053	0.51
29_V	32_A	1.048	0.51
142_V	150_Y	1.047	0.51
17_V	21_L	1.043	0.50
118_F	192_M	1.042	0.50
133_M	147_V	1.042	0.50
112_V	115_Q	1.028	0.49
13_N	16_R	1.028	0.49
150_Y	153_V	1.019	0.49
126_V	131_L	1.008	0.48
52_A	189_T	0.996	0.47
150_Y	171_F	0.980	0.46
73_I	133_M	0.968	0.45
29_V	33_F	0.967	0.45
18_T	22_S	0.957	0.45
45_D	48_V	0.957	0.45
28_L	31_G	0.952	0.44
71_A	129_A	0.949	0.44
18_T	32_A	0.947	0.44
70_V	176_A	0.944	0.44
34_T	143_V	0.942	0.43
92_I	146_P	0.935	0.43
131_L	193_L	0.932	0.43
144_S	147_V	0.931	0.43
142_V	157_T	0.928	0.43
30_A	100_L	0.925	0.42
156_L	171_F	0.922	0.42
16_R	19_I	0.920	0.42
115_Q	131_L	0.920	0.42
18_T	25_G	0.913	0.42
14_P	28_L	0.896	0.40
26_Y	33_F	0.896	0.40
31_G	100_L	0.895	0.40
31_G	34_T	0.890	0.40
54_L	98_L	0.884	0.40
22_S	29_V	0.878	0.39
117_M	127_K	0.877	0.39
115_Q	120_G	0.877	0.39
16_R	20_V	0.876	0.39
177_T	181_L	0.868	0.39
59_N	66_L	0.867	0.38
86_L	152_I	0.862	0.38
120_G	125_V	0.860	0.38
112_V	116_G	0.856	0.38
173_R	185_L	0.854	0.38
19_I	157_T	0.852	0.37
159_S	166_T	0.850	0.37
60_T	171_F	0.843	0.37
78_V	89_F	0.838	0.37
48_V	142_V	0.828	0.36
89_F	93_C	0.821	0.35
112_V	178_A	0.821	0.35
126_V	188_V	0.818	0.35
54_L	58_V	0.816	0.35
58_V	98_L	0.807	0.35
83_A	87_T	0.806	0.35
14_P	153_V	0.804	0.34
126_V	132_L	0.803	0.34
23_V	27_A	0.796	0.34
27_A	143_V	0.794	0.34
67_L	184_F	0.792	0.34
70_V	74_K	0.792	0.34
160_P	169_A	0.789	0.33
15_G	158_H	0.785	0.33
26_Y	29_V	0.785	0.33
121_Q	131_L	0.783	0.33
136_V	185_L	0.779	0.33
46_P	141_S	0.775	0.33
140_L	173_R	0.773	0.32
20_V	23_V	0.768	0.32
54_L	82_R	0.768	0.32
16_R	23_V	0.760	0.32
85_M	91_L	0.755	0.31
113_I	118_F	0.753	0.31
116_G	120_G	0.753	0.31
133_M	187_V	0.752	0.31
78_V	160_P	0.751	0.31
55_I	141_S	0.751	0.31
63_L	92_I	0.741	0.31
57_V	88_A	0.733	0.30
102_K	116_G	0.731	0.30
68_A	90_T	0.727	0.30
147_V	185_L	0.723	0.30
74_K	78_V	0.722	0.29
90_T	94_V	0.720	0.29
74_K	79_R	0.714	0.29
77_A	171_F	0.712	0.29
83_A	178_A	0.709	0.29
103_V	196_V	0.704	0.28
20_V	71_A	0.700	0.28
77_A	83_A	0.697	0.28
85_M	90_T	0.689	0.28
67_L	169_A	0.686	0.27
59_N	149_L	0.686	0.27
101_W	152_I	0.681	0.27
155_G	158_H	0.681	0.27
69_G	89_F	0.679	0.27
73_I	90_T	0.669	0.26
19_I	25_G	0.660	0.26
88_A	147_V	0.659	0.26
176_A	180_S	0.659	0.26
141_S	148_V	0.651	0.26
60_T	187_V	0.643	0.25
12_A	15_G	0.643	0.25
70_V	78_V	0.643	0.25
13_N	100_L	0.641	0.25
22_S	37_V	0.641	0.25
83_A	86_L	0.639	0.25
51_F	102_K	0.637	0.25
21_L	26_Y	0.633	0.25
75_R	87_T	0.632	0.25
20_V	77_A	0.631	0.24
121_Q	128_G	0.629	0.24
18_T	27_A	0.624	0.24
94_V	97_V	0.623	0.24
18_T	28_L	0.623	0.24
31_G	193_L	0.622	0.24
112_V	121_Q	0.621	0.24
147_V	158_H	0.621	0.24
21_L	153_V	0.620	0.24
153_V	157_T	0.620	0.24
28_L	97_V	0.618	0.24
70_V	136_V	0.617	0.24
57_V	68_A	0.609	0.23
20_V	25_G	0.608	0.23
61_L	176_A	0.607	0.23
17_V	150_Y	0.606	0.23
28_L	145_V	0.606	0.23
63_L	180_S	0.602	0.23
40_F	155_G	0.601	0.23
14_P	17_V	0.598	0.23
91_L	183_L	0.598	0.23
148_V	176_A	0.593	0.23
25_G	85_M	0.589	0.22
12_A	23_V	0.588	0.22
154_L	173_R	0.588	0.22
29_V	41_P	0.588	0.22
157_T	166_T	0.586	0.22
76_G	83_A	0.584	0.22
93_C	152_I	0.583	0.22
22_S	34_T	0.582	0.22
171_F	175_A	0.582	0.22
125_V	136_V	0.568	0.21
85_M	158_H	0.565	0.21
87_T	178_A	0.563	0.21
13_N	169_A	0.560	0.21
182_S	185_L	0.554	0.21
86_L	153_V	0.554	0.21
31_G	35_D	0.552	0.21
167_R	170_T	0.551	0.21
181_L	185_L	0.550	0.21
136_V	181_L	0.546	0.20
79_R	170_T	0.546	0.20
89_F	148_V	0.546	0.20
65_S	88_A	0.545	0.20
57_V	61_L	0.543	0.20
53_D	151_A	0.539	0.20
135_A	139_L	0.539	0.20
103_V	177_T	0.538	0.20
94_V	98_L	0.535	0.20
55_I	63_L	0.535	0.20
58_V	94_V	0.534	0.20
23_V	54_L	0.533	0.20
23_V	139_L	0.531	0.20
158_H	174_I	0.529	0.20
121_Q	170_T	0.526	0.19
142_V	167_R	0.524	0.19
84_A	184_F	0.524	0.19
22_S	25_G	0.522	0.19
85_M	92_I	0.521	0.19
12_A	16_R	0.520	0.19
114_T	118_F	0.519	0.19
15_G	18_T	0.519	0.19
126_V	129_A	0.518	0.19
128_G	136_V	0.517	0.19
26_Y	30_A	0.517	0.19
71_A	156_L	0.514	0.19
61_L	88_A	0.514	0.19
16_R	131_L	0.512	0.19
41_P	58_V	0.505	0.19
151_A	154_L	0.505	0.19
22_S	32_A	0.504	0.19
119_L	131_L	0.501	0.18
61_L	65_S	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fftC	1	0.8614	94	0.92	Contact Map
1v54C	1	0.901	89.7	0.929	Contact Map
2yevA	1	0.8861	89.3	0.93	Contact Map
1qleC	1	0.901	81.5	0.937	Contact Map
1m56C	2	0.901	79.7	0.938	Contact Map
4o6yA	2	0.8663	67.4	0.944	Contact Map
2bs2C	2	0.6436	39.3	0.953	Contact Map
4n6hA	1	0.7921	20.6	0.959	Contact Map
3dh4A	3	0.698	12.4	0.963	Contact Map
4ldeA	1	0.7574	10.6	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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