GREMLIN Database
Q9HRJ2 - Methylmalonyl-CoA mutase
UniProt: Q9HRJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (127)
Sequences: 1670 (611)
Seq/√Len: 54.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_L60_V4.7701.00
76_V96_V4.4391.00
109_E115_A3.2961.00
106_A110_A3.0831.00
62_V95_I2.9411.00
82_G85_E2.6131.00
13_V25_A2.4671.00
80_I94_V2.4601.00
53_Q57_Q2.2751.00
73_N107_D2.2081.00
52_V82_G2.1601.00
53_Q86_Y2.1481.00
16_V51_I2.0001.00
89_A92_T1.9141.00
49_D82_G1.9071.00
117_F129_F1.8620.99
80_I113_V1.8450.99
55_A63_L1.8280.99
78_K81_E1.7740.99
65_I79_I1.7060.99
84_A90_E1.6640.99
81_E85_E1.6040.98
16_V65_I1.5790.98
35_A127_I1.5600.98
83_L89_A1.5300.98
9_V37_F1.5120.97
55_A92_T1.5100.97
46_K50_E1.4360.97
82_G86_Y1.4150.96
40_I58_E1.4120.96
105_R116_I1.3900.96
10_R40_I1.3870.96
32_F126_T1.3610.95
107_D110_A1.3600.95
28_I32_F1.3360.95
14_A51_I1.3350.95
93_L114_D1.3250.95
109_E116_I1.3210.94
62_V130_I1.3030.94
128_S132_S1.2910.94
105_R118_G1.2900.94
56_V86_Y1.2560.93
107_D111_A1.2360.92
124_A128_S1.2330.92
94_V113_V1.2030.91
52_V86_Y1.1880.91
38_E58_E1.1820.90
10_R59_D1.1810.90
80_I84_A1.1730.90
77_P111_A1.1690.90
56_V89_A1.1580.89
72_H101_P1.1390.89
7_R61_D1.1210.88
115_A129_F1.1000.87
22_D26_H1.0950.87
55_A60_V1.0690.85
28_I126_T1.0550.85
96_V113_V1.0470.84
83_L94_V1.0280.83
93_L133_N1.0170.82
51_I75_L1.0060.82
56_V92_T1.0010.81
52_V83_L0.9950.81
93_L129_F0.9780.80
32_F130_I0.9760.80
12_L63_L0.9640.79
8_N61_D0.9630.79
63_L80_I0.9470.77
96_V116_I0.9330.76
106_A109_E0.9300.76
11_C62_V0.9290.76
17_G24_G0.9240.76
42_S46_K0.9220.76
63_L88_A0.8990.74
77_P81_E0.8950.73
65_I76_V0.8890.73
23_R71_A0.8870.73
45_H74_T0.8720.71
77_P107_D0.8710.71
37_F62_V0.8690.71
118_G121_T0.8590.70
49_D78_K0.8500.69
94_V114_D0.8470.69
105_R109_E0.8460.69
73_N111_A0.8450.69
128_S131_E0.8350.68
62_V133_N0.8160.66
22_D71_A0.8160.66
40_I59_D0.8100.66
67_I96_V0.7970.64
93_L130_I0.7870.63
8_N40_I0.7870.63
43_G58_E0.7840.63
16_V79_I0.7830.63
76_V113_V0.7770.62
125_D128_S0.7750.62
27_V31_A0.7730.62
99_I119_P0.7670.61
21_H24_G0.7650.61
31_A120_G0.7580.61
13_V29_T0.7350.58
71_A99_I0.7300.58
122_P125_D0.7210.57
129_F133_N0.7120.56
90_E93_L0.7110.56
28_I95_I0.7070.55
48_P75_L0.7050.55
18_L45_H0.7000.55
26_H29_T0.6930.54
71_A120_G0.6910.54
73_N113_V0.6900.53
81_E84_A0.6870.53
28_I108_L0.6870.53
65_I113_V0.6860.53
52_V63_L0.6860.53
81_E111_A0.6850.53
73_N77_P0.6770.52
38_E59_D0.6760.52
38_E60_V0.6720.52
20_G26_H0.6700.51
15_K101_P0.6650.51
45_H129_F0.6630.51
33_R40_I0.6620.50
43_G51_I0.6610.50
22_D44_L0.6580.50
54_A58_E0.6540.50
38_E54_A0.6490.49
8_N38_E0.6440.49
13_V42_S0.6410.48
25_A42_S0.6400.48
52_V79_I0.6310.47
77_P119_P0.6280.47
22_D72_H0.6270.47
38_E50_E0.6260.47
67_I99_I0.6180.46
48_P79_I0.6160.46
63_L79_I0.6140.45
114_D133_N0.6110.45
88_A92_T0.6110.45
109_E132_S0.6090.45
78_K82_G0.6090.45
20_G72_H0.6060.45
121_T126_T0.6050.44
14_A44_L0.6040.44
37_F131_E0.5990.44
64_G93_L0.5990.44
13_V95_I0.5980.44
45_H69_S0.5940.43
99_I118_G0.5910.43
80_I105_R0.5880.43
90_E110_A0.5870.43
106_A132_S0.5810.42
8_N53_Q0.5800.42
84_A113_V0.5790.42
8_N91_D0.5780.42
99_I116_I0.5740.41
33_R41_Y0.5740.41
94_V101_P0.5700.41
73_N80_I0.5650.40
80_I111_A0.5650.40
35_A126_T0.5590.40
114_D128_S0.5540.39
14_A27_V0.5530.39
23_R101_P0.5480.38
40_I54_A0.5480.38
29_T64_G0.5340.37
15_K24_G0.5320.37
33_R58_E0.5320.37
22_D27_V0.5260.36
54_A60_V0.5250.36
48_P77_P0.5210.36
73_N105_R0.5210.36
20_G45_H0.5210.36
18_L43_G0.5170.35
47_A70_G0.5170.35
52_V56_V0.5140.35
52_V77_P0.5140.35
47_A50_E0.5130.35
6_T131_E0.5100.35
84_A114_D0.5100.35
53_Q107_D0.5090.35
41_Y58_E0.5080.35
23_R26_H0.5080.35
20_G71_A0.5080.35
10_R38_E0.5060.34
17_G41_Y0.5010.34
124_A132_S0.5010.34
102_D106_A0.5010.34
53_Q56_V0.5000.34
32_F42_S0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xijA 2 0.9783 100 0.41 Contact Map
1reqA 1 0.9928 100 0.414 Contact Map
1reqB 1 0.9638 100 0.5 Contact Map
4xc8A 2 0.971 100 0.502 Contact Map
3kp1A 2 0.9855 99.9 0.513 Contact Map
1xrsB 2 0.9783 99.9 0.559 Contact Map
4r3uC 1 0.9493 99.9 0.584 Contact Map
3bulA 1 0.9638 99.9 0.584 Contact Map
3ezxA 2 0.913 99.8 0.629 Contact Map
2i2xB 1 0.9493 99.8 0.633 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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