Q9HRJ1 - HALSA - GREMLIN Contacts

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Q9HRJ1 - Uncharacterized protein

UniProt:	Q9HRJ1	Sequences: MPANQPDLVADLLAGKHRALARAITKIEDRNDGYRDIVSALYPHTGQADVIGITGSPGSGKSTLVDKLASQYRERGLTVGVIAVDPSSPFTGGAVLGDRIRMASTATDMDVFFRSMSARGSLGGLSTATADAVKALDAFGKDKVIIETVGAGQNEVDIVKTADTVAVLVPPSSGDDVQMLKAGILEIGDVFVVNKADLDGANKTVTELRNMLDLRDPDDDTDWSPEITETVAERGTGVTDLLDVFDAHTTWLDESGRRTEKRRTRYAEELRTLLRADANEVLEAELADRGGVDELVARIDSGATTPYEVAADVLDPIRDALRED	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	324 (308)
Sequences:	2187 (1373)
Seq/√Len:	78.3

ECOLI - ARGK
HALSA - Q9HRJ1
SULSO - Q97WF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
73_R	108_D	4.618	1.00
13_L	44_H	4.026	1.00
20_L	135_A	3.864	1.00
298_R	303_A	3.848	1.00
11_D	16_K	3.391	1.00
192_V	241_L	3.091	1.00
164_T	248_H	2.937	1.00
193_V	205_V	2.836	1.00
12_L	23_A	2.720	1.00
80_G	136_L	2.706	1.00
244_V	247_A	2.689	1.00
249_T	253_D	2.672	1.00
82_I	132_A	2.655	1.00
275_R	279_N	2.576	1.00
69_A	81_V	2.484	1.00
45_T	134_K	2.479	1.00
70_S	108_D	2.468	1.00
8_L	19_A	2.453	1.00
11_D	19_A	2.418	1.00
73_R	110_D	2.394	1.00
230_T	241_L	2.393	1.00
53_I	166_A	2.379	1.00
164_T	190_V	2.343	1.00
27_I	135_A	2.334	1.00
226_E	247_A	2.270	1.00
133_V	146_I	2.258	1.00
43_P	46_G	2.234	1.00
59_S	170_P	2.211	1.00
305_T	308_E	2.200	1.00
51_I	145_I	2.199	1.00
38_V	43_P	2.163	1.00
282_L	313_V	2.152	1.00
77_L	142_D	2.149	1.00
167_V	185_L	2.119	1.00
15_G	78_T	2.107	1.00
66_D	104_S	2.095	1.00
7_D	10_A	2.031	1.00
166_A	192_V	2.005	1.00
205_V	229_E	1.958	1.00
64_L	241_L	1.951	1.00
71_Q	75_R	1.949	1.00
80_G	141_K	1.943	1.00
70_S	104_S	1.907	1.00
205_V	209_R	1.882	1.00
213_D	224_S	1.857	1.00
260_E	263_R	1.857	1.00
9_V	40_A	1.840	1.00
49_D	249_T	1.837	1.00
20_L	136_L	1.829	1.00
171_P	201_A	1.823	1.00
64_L	168_L	1.814	1.00
69_A	111_V	1.799	1.00
166_A	241_L	1.782	1.00
243_D	247_A	1.775	1.00
71_Q	239_T	1.765	1.00
311_A	315_D	1.758	1.00
77_L	143_K	1.738	1.00
116_M	132_A	1.717	1.00
297_A	301_S	1.711	1.00
24_I	132_A	1.710	1.00
170_P	173_S	1.689	1.00
51_I	68_L	1.685	1.00
74_E	108_D	1.677	1.00
59_S	168_L	1.663	1.00
246_D	250_T	1.662	1.00
75_R	243_D	1.646	1.00
306_P	310_A	1.638	1.00
202_N	229_E	1.633	1.00
163_D	262_R	1.624	1.00
75_R	246_D	1.614	1.00
228_T	244_V	1.607	1.00
10_A	14_A	1.606	1.00
48_A	137_D	1.605	1.00
64_L	230_T	1.586	1.00
69_A	105_T	1.567	0.99
146_I	162_A	1.556	0.99
75_R	242_L	1.524	0.99
253_D	258_R	1.508	0.99
78_T	110_D	1.462	0.99
70_S	73_R	1.461	0.99
169_V	208_L	1.454	0.99
250_T	254_E	1.444	0.99
25_T	29_D	1.435	0.99
51_I	245_F	1.421	0.99
38_V	42_Y	1.417	0.99
53_I	65_V	1.414	0.99
23_A	135_A	1.402	0.99
248_H	252_L	1.383	0.99
312_D	315_D	1.367	0.99
295_L	309_V	1.364	0.99
240_D	243_D	1.363	0.99
143_K	242_L	1.361	0.99
59_S	204_T	1.329	0.98
294_E	298_R	1.314	0.98
23_A	37_I	1.312	0.98
222_D	225_P	1.305	0.98
192_V	230_T	1.289	0.98
71_Q	238_V	1.277	0.98
252_L	257_R	1.276	0.98
172_S	198_L	1.272	0.98
125_L	161_T	1.267	0.98
95_V	180_L	1.256	0.98
194_N	232_A	1.253	0.97
294_E	297_A	1.247	0.97
298_R	312_D	1.246	0.97
36_D	40_A	1.238	0.97
72_Y	79_V	1.229	0.97
89_P	120_G	1.225	0.97
20_L	139_F	1.223	0.97
277_D	280_E	1.213	0.97
213_D	225_P	1.203	0.97
185_L	215_R	1.202	0.97
291_G	294_E	1.197	0.97
46_G	137_D	1.176	0.96
134_K	269_E	1.171	0.96
16_K	19_A	1.167	0.96
223_W	248_H	1.164	0.96
70_S	74_E	1.163	0.96
291_G	312_D	1.120	0.95
18_R	21_A	1.119	0.95
298_R	301_S	1.119	0.95
213_D	222_D	1.115	0.95
38_V	41_L	1.109	0.95
20_L	141_K	1.107	0.95
100_I	177_V	1.107	0.95
116_M	126_S	1.100	0.95
271_R	296_V	1.079	0.94
10_A	40_A	1.076	0.94
41_L	135_A	1.070	0.94
72_Y	242_L	1.070	0.94
9_V	13_L	1.068	0.94
41_L	45_T	1.066	0.94
56_S	170_P	1.066	0.94
185_L	208_L	1.065	0.94
24_I	139_F	1.059	0.93
190_V	244_V	1.058	0.93
12_L	135_A	1.057	0.93
113_F	151_A	1.032	0.93
277_D	281_V	1.023	0.92
248_H	251_W	1.022	0.92
166_A	245_F	1.022	0.92
298_R	304_T	1.022	0.92
305_T	312_D	1.019	0.92
169_V	193_V	1.014	0.92
304_T	309_V	1.012	0.92
260_E	264_T	1.012	0.92
304_T	312_D	1.008	0.92
299_I	309_V	1.007	0.92
310_A	314_L	1.006	0.92
54_T	172_S	1.004	0.91
9_V	37_I	0.998	0.91
274_L	310_A	0.990	0.91
67_K	232_A	0.982	0.91
73_R	79_V	0.978	0.90
25_T	28_E	0.974	0.90
16_K	311_A	0.963	0.90
124_G	154_N	0.961	0.90
220_D	257_R	0.942	0.89
8_L	11_D	0.928	0.88
7_D	11_D	0.926	0.88
172_S	207_E	0.926	0.88
226_E	244_V	0.921	0.88
151_A	155_E	0.914	0.87
202_N	205_V	0.911	0.87
250_T	294_E	0.910	0.87
84_V	203_K	0.907	0.87
53_I	68_L	0.904	0.87
168_L	194_N	0.901	0.86
196_A	229_E	0.883	0.85
12_L	139_F	0.881	0.85
166_A	190_V	0.881	0.85
169_V	185_L	0.878	0.85
125_L	129_T	0.876	0.85
267_A	296_V	0.875	0.85
237_G	240_D	0.875	0.85
258_R	262_R	0.871	0.84
71_Q	235_G	0.871	0.84
309_V	314_L	0.869	0.84
308_E	312_D	0.864	0.84
9_V	23_A	0.858	0.84
200_G	203_K	0.856	0.83
99_R	115_S	0.855	0.83
118_A	159_V	0.850	0.83
10_A	260_E	0.848	0.83
259_T	263_R	0.848	0.83
165_V	189_D	0.841	0.82
130_A	161_T	0.837	0.82
8_L	26_K	0.834	0.82
272_T	275_R	0.831	0.82
285_E	288_D	0.831	0.82
43_P	47_Q	0.821	0.81
122_L	154_N	0.821	0.81
49_D	246_D	0.821	0.81
118_A	154_N	0.818	0.81
118_A	151_A	0.815	0.80
48_A	248_H	0.813	0.80
169_V	204_T	0.812	0.80
105_T	113_F	0.811	0.80
276_A	280_E	0.807	0.80
79_V	145_I	0.799	0.79
112_F	141_K	0.794	0.79
251_W	255_S	0.793	0.78
164_T	252_L	0.792	0.78
84_V	154_N	0.791	0.78
46_G	140_G	0.790	0.78
120_G	123_G	0.788	0.78
104_S	107_T	0.787	0.78
105_T	111_V	0.780	0.77
103_A	185_L	0.779	0.77
17_H	21_A	0.773	0.77
264_T	267_A	0.773	0.77
82_I	136_L	0.772	0.77
42_Y	45_T	0.770	0.76
29_D	154_N	0.768	0.76
80_G	117_S	0.764	0.76
257_R	260_E	0.762	0.76
31_N	34_Y	0.760	0.75
203_K	207_E	0.757	0.75
121_S	157_D	0.757	0.75
74_E	235_G	0.756	0.75
220_D	225_P	0.754	0.75
262_R	265_R	0.753	0.75
250_T	253_D	0.752	0.75
127_T	276_A	0.751	0.75
73_R	109_M	0.748	0.74
278_A	282_L	0.748	0.74
22_R	138_A	0.748	0.74
51_I	143_K	0.746	0.74
126_S	129_T	0.745	0.74
28_E	116_M	0.743	0.74
65_V	145_I	0.738	0.73
87_S	118_A	0.737	0.73
297_A	300_D	0.736	0.73
176_D	180_L	0.735	0.73
171_P	230_T	0.734	0.73
37_I	112_F	0.733	0.73
98_D	155_E	0.732	0.73
247_A	254_E	0.731	0.73
56_S	173_S	0.730	0.72
286_L	290_G	0.726	0.72
304_T	308_E	0.722	0.72
243_D	259_T	0.721	0.72
271_R	283_E	0.720	0.71
71_Q	74_E	0.718	0.71
169_V	173_S	0.718	0.71
267_A	300_D	0.714	0.71
295_L	304_T	0.713	0.71
42_Y	144_V	0.712	0.71
287_A	290_G	0.710	0.70
91_T	230_T	0.710	0.70
169_V	207_E	0.710	0.70
257_R	261_K	0.710	0.70
167_V	214_L	0.709	0.70
294_E	315_D	0.709	0.70
284_A	294_E	0.708	0.70
264_T	268_E	0.707	0.70
63_T	232_A	0.707	0.70
221_T	257_R	0.704	0.70
122_L	129_T	0.704	0.70
7_D	259_T	0.704	0.70
38_V	44_H	0.702	0.69
288_D	313_V	0.697	0.69
10_A	239_T	0.695	0.69
131_D	269_E	0.694	0.69
294_E	311_A	0.693	0.69
91_T	264_T	0.693	0.69
185_L	191_F	0.692	0.68
188_G	242_L	0.692	0.68
129_T	161_T	0.690	0.68
183_G	187_I	0.688	0.68
8_L	37_I	0.688	0.68
300_D	304_T	0.687	0.68
249_T	258_R	0.686	0.68
265_R	269_E	0.685	0.68
130_A	269_E	0.681	0.67
243_D	246_D	0.679	0.67
268_E	272_T	0.678	0.67
270_L	296_V	0.677	0.67
39_S	42_Y	0.677	0.67
277_D	284_A	0.676	0.67
249_T	252_L	0.672	0.66
25_T	154_N	0.672	0.66
68_L	238_V	0.668	0.66
63_T	231_V	0.666	0.65
67_K	235_G	0.666	0.65
292_V	299_I	0.666	0.65
182_A	208_L	0.666	0.65
193_V	204_T	0.664	0.65
133_V	162_A	0.662	0.65
39_S	308_E	0.662	0.65
128_A	132_A	0.660	0.65
22_R	277_D	0.659	0.65
73_R	111_V	0.659	0.65
25_T	163_D	0.658	0.65
295_L	298_R	0.658	0.65
277_D	311_A	0.656	0.64
165_V	187_I	0.655	0.64
206_T	210_N	0.654	0.64
273_L	276_A	0.652	0.64
180_L	211_M	0.651	0.64
37_I	43_P	0.651	0.64
291_G	295_L	0.649	0.63
49_D	248_H	0.649	0.63
104_S	235_G	0.648	0.63
170_P	180_L	0.647	0.63
63_T	196_A	0.647	0.63
67_K	238_V	0.647	0.63
87_S	197_D	0.647	0.63
50_V	133_V	0.646	0.63
232_A	235_G	0.645	0.63
190_V	245_F	0.644	0.63
170_P	198_L	0.644	0.63
295_L	312_D	0.643	0.63
24_I	28_E	0.636	0.62
247_A	251_W	0.635	0.62
292_V	295_L	0.631	0.61
131_D	134_K	0.631	0.61
185_L	272_T	0.630	0.61
144_V	249_T	0.629	0.61
96_L	194_N	0.629	0.61
223_W	252_L	0.628	0.61
177_V	265_R	0.628	0.61
270_L	279_N	0.627	0.61
47_Q	260_E	0.627	0.61
68_L	71_Q	0.627	0.61
182_A	215_R	0.626	0.61
25_T	139_F	0.626	0.61
78_T	141_K	0.625	0.61
89_P	156_V	0.623	0.60
156_V	187_I	0.622	0.60
247_A	280_E	0.622	0.60
169_V	182_A	0.622	0.60
9_V	12_L	0.620	0.60
122_L	155_E	0.619	0.60
9_V	33_G	0.617	0.60
20_L	131_D	0.617	0.60
208_L	227_I	0.616	0.59
230_T	238_V	0.616	0.59
21_A	84_V	0.614	0.59
36_D	144_V	0.611	0.59
66_D	99_R	0.610	0.59
176_D	208_L	0.609	0.59
48_A	140_G	0.609	0.59
252_L	261_K	0.607	0.58
290_G	294_E	0.605	0.58
115_S	182_A	0.604	0.58
172_S	200_G	0.603	0.58
299_I	305_T	0.602	0.58
82_I	133_V	0.602	0.58
170_P	179_M	0.601	0.58
167_V	184_I	0.599	0.57
276_A	284_A	0.597	0.57
123_G	149_V	0.596	0.57
275_R	283_E	0.593	0.57
94_A	176_D	0.592	0.56
296_V	300_D	0.591	0.56
17_H	25_T	0.591	0.56
179_M	198_L	0.591	0.56
49_D	245_F	0.589	0.56
224_S	247_A	0.585	0.56
26_K	29_D	0.584	0.55
193_V	215_R	0.584	0.55
38_V	91_T	0.583	0.55
35_R	310_A	0.583	0.55
205_V	227_I	0.583	0.55
40_A	112_F	0.583	0.55
20_L	23_A	0.582	0.55
71_Q	242_L	0.581	0.55
160_K	268_E	0.580	0.55
173_S	208_L	0.577	0.55
30_R	227_I	0.576	0.54
234_R	239_T	0.576	0.54
113_F	149_V	0.574	0.54
14_A	17_H	0.572	0.54
65_V	69_A	0.572	0.54
64_L	127_T	0.571	0.54
14_A	260_E	0.570	0.54
91_T	193_V	0.570	0.54
102_M	188_G	0.569	0.54
86_P	98_D	0.568	0.53
133_V	144_V	0.568	0.53
161_T	170_P	0.565	0.53
193_V	201_A	0.563	0.53
13_L	78_T	0.561	0.52
309_V	312_D	0.559	0.52
148_T	158_I	0.558	0.52
39_S	257_R	0.556	0.52
130_A	134_K	0.556	0.52
24_I	82_I	0.555	0.52
173_S	179_M	0.555	0.52
40_A	43_P	0.555	0.52
99_R	168_L	0.552	0.51
88_S	186_E	0.550	0.51
232_A	238_V	0.550	0.51
209_R	224_S	0.550	0.51
43_P	48_A	0.549	0.51
274_L	282_L	0.548	0.51
249_T	280_E	0.548	0.51
66_D	232_A	0.547	0.51
121_S	188_G	0.547	0.51
89_P	118_A	0.546	0.51
91_T	167_V	0.546	0.51
135_A	139_F	0.545	0.50
164_T	244_V	0.545	0.50
256_G	259_T	0.545	0.50
56_S	184_I	0.545	0.50
288_D	294_E	0.545	0.50
131_D	154_N	0.543	0.50
25_T	128_A	0.543	0.50
83_A	231_V	0.542	0.50
22_R	207_E	0.541	0.50
154_N	198_L	0.539	0.50
18_R	89_P	0.538	0.50
72_Y	143_K	0.536	0.49
57_P	149_V	0.535	0.49
16_K	233_E	0.535	0.49
68_L	245_F	0.534	0.49
291_G	297_A	0.534	0.49
273_L	310_A	0.533	0.49
109_M	246_D	0.532	0.49
12_L	41_L	0.532	0.49
122_L	177_V	0.530	0.49
267_A	271_R	0.530	0.49
258_R	304_T	0.529	0.48
184_I	270_L	0.529	0.48
21_A	24_I	0.529	0.48
185_L	206_T	0.527	0.48
301_S	315_D	0.526	0.48
173_S	204_T	0.526	0.48
124_G	149_V	0.525	0.48
214_L	241_L	0.525	0.48
180_L	210_N	0.525	0.48
39_S	305_T	0.525	0.48
64_L	232_A	0.523	0.48
197_D	299_I	0.523	0.48
88_S	149_V	0.522	0.47
53_I	102_M	0.522	0.47
239_T	243_D	0.521	0.47
167_V	282_L	0.520	0.47
159_V	216_D	0.519	0.47
121_S	131_D	0.518	0.47
259_T	301_S	0.518	0.47
63_T	126_S	0.518	0.47
75_R	247_A	0.516	0.47
41_L	44_H	0.515	0.47
172_S	176_D	0.515	0.47
65_V	245_F	0.515	0.47
54_T	184_I	0.515	0.47
29_D	134_K	0.514	0.46
27_I	76_G	0.513	0.46
66_D	94_A	0.513	0.46
19_A	92_G	0.513	0.46
8_L	12_L	0.513	0.46
236_T	239_T	0.510	0.46
220_D	255_S	0.509	0.46
295_L	299_I	0.509	0.46
99_R	182_A	0.508	0.46
257_R	264_T	0.508	0.46
28_E	154_N	0.505	0.45
240_D	244_V	0.502	0.45
188_G	191_F	0.500	0.45
77_L	246_D	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wwwA	2	0.8981	100	0.495	Contact Map
2qm8A	2	0.9815	100	0.551	Contact Map
2p67A	2	0.9012	100	0.578	Contact Map
3p32A	2	0.9228	100	0.594	Contact Map
4xc8A	2	0.9907	100	0.668	Contact Map
2j69A	1	0.963	100	0.743	Contact Map
2wsmA	2	0.6296	99.9	0.791	Contact Map
4hi0E	2	0.571	99.9	0.801	Contact Map
3t34A	2	0.8642	99.9	0.804	Contact Map
2akaB	1	0.8056	99.9	0.804	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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