GREMLIN Database
Q9HRJ1 - Uncharacterized protein
UniProt: Q9HRJ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (308)
Sequences: 2187 (1373)
Seq/√Len: 78.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_R108_D4.6181.00
13_L44_H4.0261.00
20_L135_A3.8641.00
298_R303_A3.8481.00
11_D16_K3.3911.00
192_V241_L3.0911.00
164_T248_H2.9371.00
193_V205_V2.8361.00
12_L23_A2.7201.00
80_G136_L2.7061.00
244_V247_A2.6891.00
249_T253_D2.6721.00
82_I132_A2.6551.00
275_R279_N2.5761.00
69_A81_V2.4841.00
45_T134_K2.4791.00
70_S108_D2.4681.00
8_L19_A2.4531.00
11_D19_A2.4181.00
73_R110_D2.3941.00
230_T241_L2.3931.00
53_I166_A2.3791.00
164_T190_V2.3431.00
27_I135_A2.3341.00
226_E247_A2.2701.00
133_V146_I2.2581.00
43_P46_G2.2341.00
59_S170_P2.2111.00
305_T308_E2.2001.00
51_I145_I2.1991.00
38_V43_P2.1631.00
282_L313_V2.1521.00
77_L142_D2.1491.00
167_V185_L2.1191.00
15_G78_T2.1071.00
66_D104_S2.0951.00
7_D10_A2.0311.00
166_A192_V2.0051.00
205_V229_E1.9581.00
64_L241_L1.9511.00
71_Q75_R1.9491.00
80_G141_K1.9431.00
70_S104_S1.9071.00
205_V209_R1.8821.00
213_D224_S1.8571.00
260_E263_R1.8571.00
9_V40_A1.8401.00
49_D249_T1.8371.00
20_L136_L1.8291.00
171_P201_A1.8231.00
64_L168_L1.8141.00
69_A111_V1.7991.00
166_A241_L1.7821.00
243_D247_A1.7751.00
71_Q239_T1.7651.00
311_A315_D1.7581.00
77_L143_K1.7381.00
116_M132_A1.7171.00
297_A301_S1.7111.00
24_I132_A1.7101.00
170_P173_S1.6891.00
51_I68_L1.6851.00
74_E108_D1.6771.00
59_S168_L1.6631.00
246_D250_T1.6621.00
75_R243_D1.6461.00
306_P310_A1.6381.00
202_N229_E1.6331.00
163_D262_R1.6241.00
75_R246_D1.6141.00
228_T244_V1.6071.00
10_A14_A1.6061.00
48_A137_D1.6051.00
64_L230_T1.5861.00
69_A105_T1.5670.99
146_I162_A1.5560.99
75_R242_L1.5240.99
253_D258_R1.5080.99
78_T110_D1.4620.99
70_S73_R1.4610.99
169_V208_L1.4540.99
250_T254_E1.4440.99
25_T29_D1.4350.99
51_I245_F1.4210.99
38_V42_Y1.4170.99
53_I65_V1.4140.99
23_A135_A1.4020.99
248_H252_L1.3830.99
312_D315_D1.3670.99
295_L309_V1.3640.99
240_D243_D1.3630.99
143_K242_L1.3610.99
59_S204_T1.3290.98
294_E298_R1.3140.98
23_A37_I1.3120.98
222_D225_P1.3050.98
192_V230_T1.2890.98
71_Q238_V1.2770.98
252_L257_R1.2760.98
172_S198_L1.2720.98
125_L161_T1.2670.98
95_V180_L1.2560.98
194_N232_A1.2530.97
294_E297_A1.2470.97
298_R312_D1.2460.97
36_D40_A1.2380.97
72_Y79_V1.2290.97
89_P120_G1.2250.97
20_L139_F1.2230.97
277_D280_E1.2130.97
213_D225_P1.2030.97
185_L215_R1.2020.97
291_G294_E1.1970.97
46_G137_D1.1760.96
134_K269_E1.1710.96
16_K19_A1.1670.96
223_W248_H1.1640.96
70_S74_E1.1630.96
291_G312_D1.1200.95
18_R21_A1.1190.95
298_R301_S1.1190.95
213_D222_D1.1150.95
38_V41_L1.1090.95
20_L141_K1.1070.95
100_I177_V1.1070.95
116_M126_S1.1000.95
271_R296_V1.0790.94
10_A40_A1.0760.94
41_L135_A1.0700.94
72_Y242_L1.0700.94
9_V13_L1.0680.94
41_L45_T1.0660.94
56_S170_P1.0660.94
185_L208_L1.0650.94
24_I139_F1.0590.93
190_V244_V1.0580.93
12_L135_A1.0570.93
113_F151_A1.0320.93
277_D281_V1.0230.92
248_H251_W1.0220.92
166_A245_F1.0220.92
298_R304_T1.0220.92
305_T312_D1.0190.92
169_V193_V1.0140.92
304_T309_V1.0120.92
260_E264_T1.0120.92
304_T312_D1.0080.92
299_I309_V1.0070.92
310_A314_L1.0060.92
54_T172_S1.0040.91
9_V37_I0.9980.91
274_L310_A0.9900.91
67_K232_A0.9820.91
73_R79_V0.9780.90
25_T28_E0.9740.90
16_K311_A0.9630.90
124_G154_N0.9610.90
220_D257_R0.9420.89
8_L11_D0.9280.88
7_D11_D0.9260.88
172_S207_E0.9260.88
226_E244_V0.9210.88
151_A155_E0.9140.87
202_N205_V0.9110.87
250_T294_E0.9100.87
84_V203_K0.9070.87
53_I68_L0.9040.87
168_L194_N0.9010.86
196_A229_E0.8830.85
12_L139_F0.8810.85
166_A190_V0.8810.85
169_V185_L0.8780.85
125_L129_T0.8760.85
267_A296_V0.8750.85
237_G240_D0.8750.85
258_R262_R0.8710.84
71_Q235_G0.8710.84
309_V314_L0.8690.84
308_E312_D0.8640.84
9_V23_A0.8580.84
200_G203_K0.8560.83
99_R115_S0.8550.83
118_A159_V0.8500.83
10_A260_E0.8480.83
259_T263_R0.8480.83
165_V189_D0.8410.82
130_A161_T0.8370.82
8_L26_K0.8340.82
272_T275_R0.8310.82
285_E288_D0.8310.82
43_P47_Q0.8210.81
122_L154_N0.8210.81
49_D246_D0.8210.81
118_A154_N0.8180.81
118_A151_A0.8150.80
48_A248_H0.8130.80
169_V204_T0.8120.80
105_T113_F0.8110.80
276_A280_E0.8070.80
79_V145_I0.7990.79
112_F141_K0.7940.79
251_W255_S0.7930.78
164_T252_L0.7920.78
84_V154_N0.7910.78
46_G140_G0.7900.78
120_G123_G0.7880.78
104_S107_T0.7870.78
105_T111_V0.7800.77
103_A185_L0.7790.77
17_H21_A0.7730.77
264_T267_A0.7730.77
82_I136_L0.7720.77
42_Y45_T0.7700.76
29_D154_N0.7680.76
80_G117_S0.7640.76
257_R260_E0.7620.76
31_N34_Y0.7600.75
203_K207_E0.7570.75
121_S157_D0.7570.75
74_E235_G0.7560.75
220_D225_P0.7540.75
262_R265_R0.7530.75
250_T253_D0.7520.75
127_T276_A0.7510.75
73_R109_M0.7480.74
278_A282_L0.7480.74
22_R138_A0.7480.74
51_I143_K0.7460.74
126_S129_T0.7450.74
28_E116_M0.7430.74
65_V145_I0.7380.73
87_S118_A0.7370.73
297_A300_D0.7360.73
176_D180_L0.7350.73
171_P230_T0.7340.73
37_I112_F0.7330.73
98_D155_E0.7320.73
247_A254_E0.7310.73
56_S173_S0.7300.72
286_L290_G0.7260.72
304_T308_E0.7220.72
243_D259_T0.7210.72
271_R283_E0.7200.71
71_Q74_E0.7180.71
169_V173_S0.7180.71
267_A300_D0.7140.71
295_L304_T0.7130.71
42_Y144_V0.7120.71
287_A290_G0.7100.70
91_T230_T0.7100.70
169_V207_E0.7100.70
257_R261_K0.7100.70
167_V214_L0.7090.70
294_E315_D0.7090.70
284_A294_E0.7080.70
264_T268_E0.7070.70
63_T232_A0.7070.70
221_T257_R0.7040.70
122_L129_T0.7040.70
7_D259_T0.7040.70
38_V44_H0.7020.69
288_D313_V0.6970.69
10_A239_T0.6950.69
131_D269_E0.6940.69
294_E311_A0.6930.69
91_T264_T0.6930.69
185_L191_F0.6920.68
188_G242_L0.6920.68
129_T161_T0.6900.68
183_G187_I0.6880.68
8_L37_I0.6880.68
300_D304_T0.6870.68
249_T258_R0.6860.68
265_R269_E0.6850.68
130_A269_E0.6810.67
243_D246_D0.6790.67
268_E272_T0.6780.67
270_L296_V0.6770.67
39_S42_Y0.6770.67
277_D284_A0.6760.67
249_T252_L0.6720.66
25_T154_N0.6720.66
68_L238_V0.6680.66
63_T231_V0.6660.65
67_K235_G0.6660.65
292_V299_I0.6660.65
182_A208_L0.6660.65
193_V204_T0.6640.65
133_V162_A0.6620.65
39_S308_E0.6620.65
128_A132_A0.6600.65
22_R277_D0.6590.65
73_R111_V0.6590.65
25_T163_D0.6580.65
295_L298_R0.6580.65
277_D311_A0.6560.64
165_V187_I0.6550.64
206_T210_N0.6540.64
273_L276_A0.6520.64
180_L211_M0.6510.64
37_I43_P0.6510.64
291_G295_L0.6490.63
49_D248_H0.6490.63
104_S235_G0.6480.63
170_P180_L0.6470.63
63_T196_A0.6470.63
67_K238_V0.6470.63
87_S197_D0.6470.63
50_V133_V0.6460.63
232_A235_G0.6450.63
190_V245_F0.6440.63
170_P198_L0.6440.63
295_L312_D0.6430.63
24_I28_E0.6360.62
247_A251_W0.6350.62
292_V295_L0.6310.61
131_D134_K0.6310.61
185_L272_T0.6300.61
144_V249_T0.6290.61
96_L194_N0.6290.61
223_W252_L0.6280.61
177_V265_R0.6280.61
270_L279_N0.6270.61
47_Q260_E0.6270.61
68_L71_Q0.6270.61
182_A215_R0.6260.61
25_T139_F0.6260.61
78_T141_K0.6250.61
89_P156_V0.6230.60
156_V187_I0.6220.60
247_A280_E0.6220.60
169_V182_A0.6220.60
9_V12_L0.6200.60
122_L155_E0.6190.60
9_V33_G0.6170.60
20_L131_D0.6170.60
208_L227_I0.6160.59
230_T238_V0.6160.59
21_A84_V0.6140.59
36_D144_V0.6110.59
66_D99_R0.6100.59
176_D208_L0.6090.59
48_A140_G0.6090.59
252_L261_K0.6070.58
290_G294_E0.6050.58
115_S182_A0.6040.58
172_S200_G0.6030.58
299_I305_T0.6020.58
82_I133_V0.6020.58
170_P179_M0.6010.58
167_V184_I0.5990.57
276_A284_A0.5970.57
123_G149_V0.5960.57
275_R283_E0.5930.57
94_A176_D0.5920.56
296_V300_D0.5910.56
17_H25_T0.5910.56
179_M198_L0.5910.56
49_D245_F0.5890.56
224_S247_A0.5850.56
26_K29_D0.5840.55
193_V215_R0.5840.55
38_V91_T0.5830.55
35_R310_A0.5830.55
205_V227_I0.5830.55
40_A112_F0.5830.55
20_L23_A0.5820.55
71_Q242_L0.5810.55
160_K268_E0.5800.55
173_S208_L0.5770.55
30_R227_I0.5760.54
234_R239_T0.5760.54
113_F149_V0.5740.54
14_A17_H0.5720.54
65_V69_A0.5720.54
64_L127_T0.5710.54
14_A260_E0.5700.54
91_T193_V0.5700.54
102_M188_G0.5690.54
86_P98_D0.5680.53
133_V144_V0.5680.53
161_T170_P0.5650.53
193_V201_A0.5630.53
13_L78_T0.5610.52
309_V312_D0.5590.52
148_T158_I0.5580.52
39_S257_R0.5560.52
130_A134_K0.5560.52
24_I82_I0.5550.52
173_S179_M0.5550.52
40_A43_P0.5550.52
99_R168_L0.5520.51
88_S186_E0.5500.51
232_A238_V0.5500.51
209_R224_S0.5500.51
43_P48_A0.5490.51
274_L282_L0.5480.51
249_T280_E0.5480.51
66_D232_A0.5470.51
121_S188_G0.5470.51
89_P118_A0.5460.51
91_T167_V0.5460.51
135_A139_F0.5450.50
164_T244_V0.5450.50
256_G259_T0.5450.50
56_S184_I0.5450.50
288_D294_E0.5450.50
131_D154_N0.5430.50
25_T128_A0.5430.50
83_A231_V0.5420.50
22_R207_E0.5410.50
154_N198_L0.5390.50
18_R89_P0.5380.50
72_Y143_K0.5360.49
57_P149_V0.5350.49
16_K233_E0.5350.49
68_L245_F0.5340.49
291_G297_A0.5340.49
273_L310_A0.5330.49
109_M246_D0.5320.49
12_L41_L0.5320.49
122_L177_V0.5300.49
267_A271_R0.5300.49
258_R304_T0.5290.48
184_I270_L0.5290.48
21_A24_I0.5290.48
185_L206_T0.5270.48
301_S315_D0.5260.48
173_S204_T0.5260.48
124_G149_V0.5250.48
214_L241_L0.5250.48
180_L210_N0.5250.48
39_S305_T0.5250.48
64_L232_A0.5230.48
197_D299_I0.5230.48
88_S149_V0.5220.47
53_I102_M0.5220.47
239_T243_D0.5210.47
167_V282_L0.5200.47
159_V216_D0.5190.47
121_S131_D0.5180.47
259_T301_S0.5180.47
63_T126_S0.5180.47
75_R247_A0.5160.47
41_L44_H0.5150.47
172_S176_D0.5150.47
65_V245_F0.5150.47
54_T184_I0.5150.47
29_D134_K0.5140.46
27_I76_G0.5130.46
66_D94_A0.5130.46
19_A92_G0.5130.46
8_L12_L0.5130.46
236_T239_T0.5100.46
220_D255_S0.5090.46
295_L299_I0.5090.46
99_R182_A0.5080.46
257_R264_T0.5080.46
28_E154_N0.5050.45
240_D244_V0.5020.45
188_G191_F0.5000.45
77_L246_D0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wwwA 2 0.8981 100 0.495 Contact Map
2qm8A 2 0.9815 100 0.551 Contact Map
2p67A 2 0.9012 100 0.578 Contact Map
3p32A 2 0.9228 100 0.594 Contact Map
4xc8A 2 0.9907 100 0.668 Contact Map
2j69A 1 0.963 100 0.743 Contact Map
2wsmA 2 0.6296 99.9 0.791 Contact Map
4hi0E 2 0.571 99.9 0.801 Contact Map
3t34A 2 0.8642 99.9 0.804 Contact Map
2akaB 1 0.8056 99.9 0.804 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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