GREMLIN Database
Q9HRJ0 - Uncharacterized protein
UniProt: Q9HRJ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (259)
Sequences: 54080 (43929)
Seq/√Len: 2729.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_T88_H5.0431.00
95_P115_F3.8901.00
79_V297_C3.3111.00
117_A142_A3.1361.00
292_H295_S2.9081.00
257_R282_D2.7721.00
279_T299_A2.7051.00
127_P149_S2.6951.00
86_D301_G2.6931.00
252_T303_A2.6421.00
155_C259_A2.5841.00
281_L299_A2.5001.00
154_V296_F2.4791.00
47_D101_D2.4791.00
51_T73_S2.2931.00
42_R47_D2.2551.00
117_A121_G2.1811.00
120_I128_A2.0871.00
117_A147_S2.0851.00
257_R280_V2.0481.00
40_T47_D2.0361.00
82_T297_C2.0001.00
136_G156_P1.9961.00
49_S99_H1.9871.00
129_V139_A1.9541.00
60_D90_L1.9101.00
284_A292_H1.9011.00
50_Y119_F1.8821.00
271_A276_V1.8741.00
121_G147_S1.8731.00
59_P149_S1.8441.00
52_T90_L1.8211.00
143_A151_L1.7891.00
60_D125_D1.7771.00
49_S73_S1.7741.00
53_A91_A1.7481.00
264_L280_V1.7361.00
60_D88_H1.7291.00
139_A151_L1.6961.00
65_H97_F1.6741.00
269_A273_A1.6551.00
252_T279_T1.6491.00
92_P116_V1.6241.00
299_A302_A1.6221.00
65_H94_L1.6171.00
44_R118_S1.5841.00
142_A148_V1.5841.00
298_D302_A1.5761.00
94_L138_W1.5731.00
64_L116_V1.5591.00
113_E141_M1.5451.00
64_L94_L1.5271.00
71_A75_A1.5181.00
116_V142_A1.4901.00
125_D128_A1.4641.00
49_S93_D1.4601.00
142_A147_S1.4101.00
90_L119_F1.3891.00
152_A300_L1.3801.00
82_T301_G1.3631.00
243_A246_S1.3631.00
64_L139_A1.3601.00
54_G88_H1.3591.00
63_L130_V1.3491.00
108_T111_L1.3451.00
140_A153_L1.3421.00
295_S299_A1.3401.00
86_D305_P1.3401.00
80_V91_A1.3391.00
133_S286_A1.3101.00
53_A80_V1.3031.00
46_F95_P1.3021.00
48_V115_F1.3001.00
152_A252_T1.2991.00
59_P150_A1.2891.00
153_L156_P1.2881.00
132_S289_H1.2731.00
70_A97_F1.2731.00
206_P209_L1.2711.00
141_M144_A1.2691.00
82_T85_E1.2681.00
73_S93_D1.2601.00
295_S298_D1.2591.00
130_V154_V1.2541.00
63_L89_V1.2501.00
264_L268_R1.2431.00
254_V281_L1.2331.00
61_L87_Y1.2271.00
281_L284_A1.2231.00
59_P87_Y1.2111.00
268_R272_D1.2101.00
62_V120_I1.2081.00
40_T49_S1.1981.00
66_G133_S1.1961.00
75_A289_H1.1761.00
130_V300_L1.1561.00
119_F123_V1.1471.00
144_A243_A1.1421.00
73_S99_H1.1401.00
245_Q273_A1.1391.00
82_T294_A1.1321.00
255_W278_L1.1291.00
186_S189_G1.1251.00
93_D98_G1.1091.00
92_P119_F1.1071.00
53_A84_A1.1001.00
59_P127_P1.0991.00
255_W267_G1.0951.00
277_R299_A1.0951.00
255_W280_V1.0881.00
87_Y304_L1.0831.00
296_F300_L1.0701.00
301_G305_P1.0621.00
252_T277_R1.0621.00
269_A272_D1.0591.00
55_D88_H1.0581.00
64_L129_V1.0541.00
279_T302_A1.0521.00
50_Y123_V1.0501.00
84_A89_V1.0491.00
257_R283_D1.0381.00
70_A133_S1.0381.00
207_A211_D1.0331.00
294_A298_D1.0281.00
227_A231_G1.0211.00
281_L295_S1.0191.00
63_L76_F1.0171.00
62_V128_A1.0171.00
120_I142_A1.0131.00
150_A250_P1.0091.00
226_P229_F0.9971.00
113_E138_W0.9961.00
285_G291_E0.9941.00
77_A91_A0.9811.00
168_R171_L0.9781.00
254_V299_A0.9761.00
90_L123_V0.9751.00
41_T50_Y0.9751.00
128_A148_V0.9681.00
229_F232_G0.9681.00
268_R271_A0.9651.00
284_A288_P0.9651.00
55_D58_D0.9621.00
132_S287_V0.9601.00
131_A139_A0.9471.00
185_V189_G0.9421.00
284_A291_E0.9401.00
255_W264_L0.9391.00
228_S231_G0.9391.00
43_W118_S0.9391.00
268_R280_V0.9351.00
48_V100_T0.9341.00
279_T295_S0.9241.00
128_A147_S0.9241.00
46_F101_D0.9241.00
271_A278_L0.9231.00
78_G81_D0.9191.00
73_S91_A0.9131.00
64_L92_P0.9111.00
230_A233_M0.9101.00
111_L114_A0.9051.00
110_A141_M0.8981.00
61_L89_V0.8981.00
211_D215_R0.8971.00
56_P88_H0.8961.00
61_L130_V0.8891.00
154_V288_P0.8881.00
150_A303_A0.8861.00
51_T77_A0.8821.00
62_V116_V0.8731.00
120_I125_D0.8711.00
143_A148_V0.8701.00
94_L134_L0.8691.00
124_A127_P0.8681.00
154_V289_H0.8671.00
167_V170_L0.8661.00
253_L276_V0.8651.00
224_L228_S0.8641.00
216_T220_P0.8591.00
118_S122_D0.8531.00
80_V89_V0.8521.00
167_V171_L0.8501.00
141_M243_A0.8491.00
228_S232_G0.8481.00
229_F233_M0.8441.00
60_D87_Y0.8411.00
74_R77_A0.8371.00
187_R191_R0.8361.00
58_D88_H0.8331.00
67_V70_A0.8291.00
118_S121_G0.8281.00
129_V142_A0.8261.00
191_R195_N0.8261.00
240_L243_A0.8251.00
192_C195_N0.8241.00
168_R172_R0.8231.00
268_R278_L0.8231.00
188_R192_C0.8221.00
227_A230_A0.8191.00
151_L251_V0.8171.00
248_P274_A0.8151.00
87_Y301_G0.8151.00
61_L304_L0.8131.00
117_A120_I0.8131.00
87_Y305_P0.8111.00
150_A304_L0.8101.00
267_G278_L0.8081.00
281_L292_H0.8041.00
114_A118_S0.8011.00
155_C288_P0.8001.00
256_G288_P0.7991.00
283_D292_H0.7941.00
41_T122_D0.7931.00
211_D214_H0.7931.00
131_A136_G0.7911.00
106_A111_L0.7891.00
258_E283_D0.7881.00
208_G212_Y0.7871.00
185_V188_R0.7871.00
73_S92_P0.7851.00
65_H92_P0.7841.00
212_Y215_R0.7841.00
216_T219_Q0.7781.00
62_V129_V0.7721.00
112_Y134_L0.7701.00
265_A268_R0.7561.00
81_D84_A0.7521.00
225_A229_F0.7521.00
297_C301_G0.7491.00
129_V148_V0.7481.00
132_S155_C0.7481.00
81_D85_E0.7421.00
79_V296_F0.7401.00
94_L112_Y0.7381.00
113_E142_A0.7351.00
85_E301_G0.7331.00
190_L194_T0.7331.00
177_G180_V0.7331.00
53_A81_D0.7311.00
298_D301_G0.7221.00
148_V249_A0.7211.00
49_S100_T0.7181.00
94_L97_F0.7181.00
48_V95_P0.7181.00
226_P230_A0.7151.00
225_A228_S0.7151.00
257_R264_L0.7131.00
152_A303_A0.7121.00
169_R173_T0.7101.00
144_A246_S0.7031.00
254_V296_F0.7031.00
126_D147_S0.7031.00
143_A249_A0.7031.00
95_P112_Y0.7011.00
114_A117_A0.6981.00
155_C256_G0.6971.00
132_S154_V0.6951.00
79_V82_T0.6911.00
130_V152_A0.6911.00
239_D243_A0.6891.00
43_W46_F0.6881.00
76_F79_V0.6861.00
189_G193_F0.6851.00
155_C255_W0.6841.00
190_L193_F0.6831.00
131_A135_T0.6821.00
152_A304_L0.6811.00
67_V134_L0.6811.00
93_D99_H0.6791.00
186_S193_F0.6761.00
44_R114_A0.6751.00
63_L83_L0.6661.00
186_S194_T0.6661.00
259_A286_A0.6651.00
77_A81_D0.6651.00
82_T86_D0.6611.00
168_R174_P0.6601.00
242_D245_Q0.6591.00
63_L91_A0.6581.00
44_R111_L0.6581.00
149_S152_A0.6571.00
171_L174_P0.6541.00
215_R219_Q0.6511.00
188_R191_R0.6511.00
207_A210_L0.6501.00
94_L116_V0.6481.00
60_D128_A0.6481.00
76_F80_V0.6391.00
88_H125_D0.6381.00
152_A254_V0.6381.00
223_R226_P0.6381.00
170_L173_T0.6381.00
51_T91_A0.6351.00
128_A142_A0.6341.00
192_C196_R0.6311.00
277_R302_A0.6311.00
90_L125_D0.6301.00
293_P297_C0.6291.00
67_V71_A0.6281.00
177_G181_F0.6281.00
52_T123_V0.6211.00
189_G192_C0.6181.00
208_G211_D0.6171.00
61_L83_L0.6171.00
289_H296_F0.6131.00
52_T55_D0.6121.00
112_Y138_W0.6111.00
153_L253_L0.6111.00
302_A305_P0.6091.00
128_A149_S0.6051.00
214_H218_H0.6051.00
209_L212_Y0.6051.00
266_D269_A0.6041.00
67_V97_F0.6011.00
75_A132_S0.5991.00
113_E117_A0.5981.00
133_S287_V0.5951.00
170_L174_P0.5941.00
178_T181_F0.5911.00
137_A140_A0.5901.00
109_S141_M0.5891.00
212_Y216_T0.5881.00
40_T50_Y0.5881.00
80_V84_A0.5871.00
169_R172_R0.5871.00
300_L304_L0.5841.00
163_R166_A0.5831.00
239_D242_D0.5811.00
167_V173_T0.5811.00
217_S220_P0.5791.00
136_G153_L0.5751.00
78_G209_L0.5741.00
224_L227_A0.5721.00
225_A230_A0.5711.00
120_I147_S0.5711.00
253_L278_L0.5711.00
282_D295_S0.5701.00
83_L300_L0.5671.00
184_L187_R0.5651.00
213_Q216_T0.5651.00
150_A252_T0.5641.00
254_V279_T0.5631.00
42_R45_G0.5601.00
223_R227_A0.5601.00
253_L271_A0.5571.00
64_L138_W0.5561.00
169_R174_P0.5551.00
267_G271_A0.5551.00
151_L249_A0.5541.00
57_D88_H0.5521.00
137_A157_I0.5481.00
253_L267_G0.5481.00
203_A206_P0.5471.00
71_A290_V0.5441.00
222_A225_A0.5441.00
288_P296_F0.5431.00
140_A156_P0.5431.00
201_Q204_N0.5401.00
79_V289_H0.5391.00
41_T119_F0.5371.00
109_S134_L0.5371.00
191_R196_R0.5341.00
189_G194_T0.5341.00
51_T74_R0.5331.00
66_G132_S0.5321.00
258_E284_A0.5301.00
132_S288_P0.5281.00
74_R99_H0.5281.00
185_V192_C0.5271.00
96_G107_Y0.5261.00
159_D162_Q0.5221.00
287_V290_V0.5211.00
157_I161_G0.5211.00
75_A290_V0.5171.00
210_L214_H0.5161.00
134_L138_W0.5161.00
82_T298_D0.5131.00
270_L273_A0.5101.00
127_P147_S0.5081.00
186_S190_L0.5081.00
168_R173_T0.5071.00
62_V92_P0.5071.00
58_D87_Y0.5061.00
40_T99_H0.5031.00
178_T182_N0.5031.00
143_A247_V0.5021.00
297_C302_A0.5011.00
107_Y111_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.8645 100 0.263 Contact Map
4inzA 1 0.8452 100 0.279 Contact Map
4psuA 1 0.8871 100 0.29 Contact Map
3om8A 4 0.8419 100 0.298 Contact Map
4ns4A 1 0.8387 100 0.302 Contact Map
2pujA 4 0.8484 100 0.304 Contact Map
1iupA 2 0.8419 100 0.304 Contact Map
2xuaA 2 0.8226 100 0.305 Contact Map
2wueA 4 0.8516 100 0.309 Contact Map
3oosA 1 0.8548 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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