GREMLIN Database
Q9HRI9 - Uncharacterized protein
UniProt: Q9HRI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 127 (110)
Sequences: 2174 (1449)
Seq/√Len: 138.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E52_A3.3861.00
40_C43_C3.0691.00
26_A51_T2.7541.00
27_C43_C2.6891.00
29_D47_E2.6581.00
59_I107_V2.5431.00
27_C40_C2.5161.00
28_P49_T2.4821.00
86_G106_E2.4071.00
11_D15_D2.2991.00
57_G107_V2.2981.00
56_T86_G2.2831.00
84_S89_R2.2111.00
16_A23_Y2.1781.00
20_D113_E1.9161.00
59_I101_V1.9081.00
33_S41_P1.8571.00
59_I81_A1.8491.00
56_T108_A1.7901.00
31_H42_H1.7791.00
24_Y53_L1.7321.00
28_P47_E1.7041.00
25_L33_S1.6561.00
55_E87_A1.6171.00
83_A92_G1.5121.00
12_D50_E1.5031.00
58_T106_E1.4781.00
23_Y52_A1.4751.00
33_S48_L1.4571.00
81_A94_V1.4311.00
58_T84_S1.4061.00
26_A32_G1.4031.00
20_D111_V1.3611.00
62_C103_I1.3291.00
54_P87_A1.2951.00
96_A105_D1.2811.00
25_L48_L1.2741.00
54_P86_G1.2681.00
32_G51_T1.2651.00
60_D84_S1.2551.00
56_T106_E1.2411.00
15_D19_A1.2041.00
64_T79_V1.1781.00
115_A118_G1.1350.99
57_G83_A1.1270.99
17_L111_V1.0930.99
97_E100_T1.0870.99
24_Y88_V1.0780.99
62_C101_V1.0690.99
61_S82_V1.0500.99
58_T104_G1.0380.99
94_V101_V0.9960.98
10_Y14_I0.9690.98
81_A92_G0.9660.98
98_P101_V0.9630.98
65_L69_T0.9450.98
64_T98_P0.9380.97
96_A100_T0.9290.97
39_A46_R0.9240.97
18_A120_R0.9170.97
20_D120_R0.8920.97
65_L78_Y0.8920.97
45_A48_L0.8860.96
102_E105_D0.8820.96
59_I105_D0.8790.96
12_D16_A0.8790.96
32_G53_L0.8770.96
26_A49_T0.8730.96
13_A17_L0.8620.96
16_A19_A0.8570.96
39_A44_G0.8560.96
16_A21_E0.8450.95
29_D45_A0.8380.95
60_D89_R0.8350.95
66_H77_P0.8330.95
113_E118_G0.8240.95
33_S37_R0.8110.94
9_G38_H0.8100.94
26_A30_G0.8070.94
85_F88_V0.8010.94
82_V91_T0.7980.94
115_A120_R0.7930.94
115_A119_D0.7810.93
13_A16_A0.7750.93
12_D15_D0.7730.93
18_A118_G0.7630.92
19_A23_Y0.7590.92
62_C79_V0.7520.92
63_S80_L0.7500.92
82_V89_R0.7300.90
24_Y32_G0.7180.90
53_L88_V0.7180.90
78_Y93_Q0.7140.89
100_T105_D0.7100.89
22_G53_L0.7080.89
79_V101_V0.7050.89
37_R41_P0.7050.89
53_L85_F0.7050.89
9_G32_G0.7040.89
95_R110_T0.6900.88
25_L34_L0.6870.88
84_S88_V0.6740.87
95_R112_G0.6740.87
17_L109_A0.6680.86
31_H41_P0.6650.86
101_V107_V0.6560.85
62_C94_V0.6470.84
73_A76_A0.6420.84
22_G34_L0.6270.82
42_H76_A0.6170.81
24_Y85_F0.6120.81
79_V96_A0.6110.81
57_G92_G0.6110.81
83_A107_V0.6090.81
24_Y51_T0.6070.80
17_L90_L0.6060.80
25_L50_E0.6060.80
27_C45_A0.6040.80
68_A77_P0.6030.80
9_G63_S0.6010.80
31_H90_L0.5990.79
40_C45_A0.5880.78
57_G90_L0.5840.78
17_L120_R0.5810.77
79_V94_V0.5790.77
69_T76_A0.5780.77
39_A48_L0.5750.77
54_P109_A0.5700.76
113_E120_R0.5680.76
35_P88_V0.5660.76
62_C105_D0.5620.75
32_G87_A0.5570.74
63_S66_H0.5560.74
25_L121_L0.5520.74
53_L91_T0.5510.74
18_A119_D0.5440.73
48_L59_I0.5430.73
36_P50_E0.5380.72
30_G51_T0.5380.72
34_L90_L0.5350.71
37_R50_E0.5340.71
68_A76_A0.5320.71
18_A56_T0.5300.71
65_L72_F0.5290.71
36_P69_T0.5270.70
112_G121_L0.5270.70
22_G77_P0.5250.70
112_G115_A0.5240.70
38_H62_C0.5240.70
48_L82_V0.5240.70
59_I103_I0.5220.70
30_G43_C0.5170.69
34_L88_V0.5120.68
44_G76_A0.5120.68
24_Y34_L0.5120.68
10_Y34_L0.5110.68
10_Y109_A0.5090.68
82_V92_G0.5070.67
41_P67_V0.5070.67
79_V98_P0.5060.67
69_T90_L0.5040.67
22_G109_A0.5040.67
53_L87_A0.5030.67
13_A75_D0.5010.66
19_A52_A0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.9291 100 0.303 Contact Map
3qcpA 1 0.622 39.6 0.917 Contact Map
3t58A 1 0.5669 36.4 0.919 Contact Map
3llkA 1 0.5591 27.6 0.924 Contact Map
2lcqA 1 0.4252 22.1 0.927 Contact Map
3h0gL 1 0.3228 21.7 0.927 Contact Map
2kdxA 1 0.5118 21.4 0.928 Contact Map
4egvA 1 0.8346 13.7 0.934 Contact Map
1zud1 2 0.3307 11.7 0.936 Contact Map
2d7eA 4 0.4094 11.1 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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