GREMLIN Database
Q9HRI8 - 3-ketoacyl-CoA thiolase
UniProt: Q9HRI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (347)
Sequences: 15306 (8443)
Seq/√Len: 453.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_K174_N3.5051.00
3_D222_E3.4521.00
224_Y228_H3.4151.00
163_D296_E3.3101.00
103_A106_V3.1021.00
169_V189_V2.9531.00
91_L344_V2.8691.00
32_A35_D2.8051.00
347_L367_A2.7691.00
224_Y227_T2.7651.00
222_E226_D2.7071.00
155_E200_E2.7011.00
170_K173_A2.6921.00
177_D181_A2.6701.00
9_V345_A2.4481.00
30_G107_V2.4381.00
273_V366_T2.4171.00
267_A271_A2.4091.00
10_G36_D2.4071.00
5_R225_A2.4041.00
98_V219_L2.3981.00
351_L364_A2.2301.00
33_A218_V2.2081.00
105_V220_V2.2031.00
160_S163_D2.1701.00
267_A383_V2.1591.00
94_A106_V2.1401.00
234_V348_T2.1351.00
98_V221_S2.0471.00
238_G271_A2.0251.00
7_A220_V2.0141.00
26_F49_Y2.0061.00
40_A43_D1.9951.00
3_D235_A1.9941.00
279_D364_A1.9841.00
280_V325_L1.9621.00
162_E166_H1.9051.00
233_P352_R1.8931.00
278_V366_T1.8851.00
235_A385_E1.8751.00
43_D228_H1.8711.00
215_S341_T1.8521.00
354_D364_A1.8311.00
295_T302_D1.8161.00
326_S350_L1.7761.00
192_A205_Y1.7641.00
176_V180_R1.7591.00
237_T385_E1.7561.00
220_V224_Y1.7531.00
153_Y159_G1.7461.00
238_G267_A1.7261.00
104_D224_Y1.7191.00
295_T323_V1.7061.00
275_A281_A1.6961.00
350_L354_D1.6921.00
104_D221_S1.6871.00
169_V173_A1.6871.00
265_T269_A1.6831.00
156_Q248_L1.6611.00
220_V225_A1.6591.00
278_V281_A1.6531.00
273_V278_V1.6471.00
191_D194_E1.6451.00
221_S224_Y1.6381.00
33_A37_A1.6181.00
97_D103_A1.6091.00
49_Y109_G1.6011.00
264_A370_H1.5971.00
96_R102_E1.5931.00
78_T93_R1.5881.00
8_G37_A1.5841.00
278_V383_V1.5741.00
170_K302_D1.5621.00
179_D187_I1.5601.00
217_L341_T1.5531.00
166_H189_V1.5461.00
166_H170_K1.5381.00
262_D265_T1.5361.00
5_R235_A1.5231.00
105_V224_Y1.5171.00
280_V350_L1.5161.00
113_R116_N1.4951.00
147_A199_A1.4841.00
31_L35_D1.4841.00
94_A219_L1.4721.00
344_V384_L1.4691.00
350_L353_G1.4541.00
347_L369_A1.4391.00
29_A216_A1.4341.00
20_R28_E1.4171.00
29_A214_A1.4131.00
266_E269_A1.3951.00
26_F67_V1.3851.00
240_G266_E1.3821.00
32_A36_D1.3751.00
173_A177_D1.3631.00
185_Q352_R1.3591.00
268_Y275_A1.3571.00
281_A368_V1.3561.00
237_T366_T1.3361.00
240_G267_A1.3111.00
223_S227_T1.3061.00
151_A200_E1.3011.00
301_F322_P1.2991.00
8_G33_A1.2911.00
92_R382_H1.2871.00
325_L350_L1.2641.00
45_A103_A1.2601.00
30_G67_V1.2581.00
92_R239_T1.2511.00
163_D166_H1.2471.00
4_A219_L1.2451.00
345_A349_R1.2311.00
348_T352_R1.2301.00
51_N54_G1.2281.00
265_T297_S1.2231.00
14_F338_A1.2151.00
28_E32_A1.2081.00
365_Q385_E1.2061.00
161_R203_H1.2051.00
91_L217_L1.2011.00
85_A373_G1.2001.00
24_D70_A1.1981.00
261_T265_T1.1951.00
107_V218_V1.1931.00
244_D251_R1.1901.00
148_L200_E1.1861.00
49_Y216_A1.1831.00
159_G164_L1.1801.00
242_G262_D1.1801.00
274_S277_D1.1721.00
85_A379_A1.1621.00
43_D224_Y1.1611.00
44_V105_V1.1511.00
65_P69_E1.1451.00
5_R222_E1.1391.00
167_I291_E1.1361.00
63_Q111_A1.1331.00
368_V383_V1.1311.00
280_V354_D1.1161.00
248_L251_R1.1151.00
9_V349_R1.1131.00
88_G344_V1.1061.00
185_Q353_G1.0941.00
14_F332_K1.0931.00
152_S156_Q1.0931.00
273_V383_V1.0871.00
9_V348_T1.0871.00
48_H106_V1.0851.00
45_A104_D1.0841.00
173_A176_V1.0771.00
91_L219_L1.0761.00
188_T191_D1.0761.00
159_G292_V1.0671.00
99_R102_E1.0671.00
102_E270_D1.0661.00
236_V382_H1.0631.00
167_I292_V1.0601.00
6_V384_L1.0601.00
179_D184_Q1.0551.00
279_D322_P1.0541.00
279_D366_T1.0511.00
251_R261_T1.0501.00
94_A108_V1.0491.00
18_P126_L1.0471.00
5_R220_V1.0461.00
189_V193_L1.0421.00
89_V93_R1.0411.00
96_R100_N1.0361.00
278_V368_V1.0361.00
169_V192_A1.0341.00
275_A278_V1.0311.00
133_L138_A1.0301.00
21_T24_D1.0301.00
27_A31_L1.0281.00
67_V71_L1.0261.00
10_G32_A1.0251.00
238_G270_D1.0091.00
242_G266_E0.9991.00
147_A198_V0.9971.00
50_G86_S0.9971.00
151_A155_E0.9951.00
264_A368_V0.9951.00
271_A383_V0.9871.00
8_G36_D0.9811.00
43_D227_T0.9811.00
342_S346_E0.9801.00
325_L354_D0.9781.00
123_T128_I0.9761.00
351_L367_A0.9761.00
366_T385_E0.9711.00
14_F211_T0.9701.00
222_E235_A0.9681.00
326_S353_G0.9671.00
280_V347_L0.9621.00
124_D128_I0.9611.00
3_D99_R0.9601.00
156_Q247_A0.9581.00
162_E193_L0.9541.00
279_D351_L0.9531.00
132_G135_E0.9501.00
266_E270_D0.9491.00
195_S205_Y0.9401.00
215_S338_A0.9381.00
264_A298_L0.9371.00
185_Q349_R0.9351.00
12_T29_A0.9331.00
186_A346_E0.9331.00
154_F289_I0.9251.00
300_F323_V0.9221.00
157_F251_R0.9151.00
95_V99_R0.9101.00
157_F297_S0.9051.00
12_T25_L0.9031.00
279_D365_Q0.9031.00
27_A70_A0.9021.00
263_A380_V0.9021.00
48_H94_A0.8961.00
88_G369_A0.8961.00
343_Q369_A0.8931.00
281_A300_F0.8891.00
233_P348_T0.8881.00
34_L39_V0.8851.00
13_H28_E0.8841.00
181_A353_G0.8781.00
63_Q69_E0.8741.00
9_V217_L0.8731.00
95_V236_V0.8731.00
134_Y138_A0.8721.00
153_Y293_M0.8701.00
220_V230_V0.8701.00
152_S155_E0.8681.00
12_T28_E0.8641.00
153_Y251_R0.8611.00
14_F342_S0.8581.00
29_A32_A0.8531.00
7_A230_V0.8531.00
63_Q67_V0.8521.00
4_A221_S0.8511.00
344_V382_H0.8481.00
48_H78_T0.8471.00
196_P204_L0.8441.00
138_A143_P0.8441.00
165_A206_D0.8411.00
195_S203_H0.8411.00
61_G66_L0.8391.00
215_S345_A0.8391.00
125_A129_A0.8361.00
354_D363_D0.8301.00
261_T297_S0.8281.00
288_T330_K0.8281.00
162_E189_V0.8281.00
295_T300_F0.8281.00
48_H90_A0.8271.00
197_P200_E0.8241.00
46_A97_D0.8241.00
251_R297_S0.8241.00
33_A107_V0.8221.00
108_V217_L0.8211.00
223_S226_D0.8191.00
373_G379_A0.8181.00
190_A194_E0.8171.00
326_S354_D0.8161.00
238_G383_V0.8141.00
169_V188_T0.8111.00
236_V239_T0.8051.00
45_A266_E0.8021.00
265_T298_L0.8011.00
97_D102_E0.7991.00
4_A95_V0.7991.00
251_R293_M0.7931.00
222_E225_A0.7931.00
33_A216_A0.7921.00
62_H65_P0.7911.00
174_N177_D0.7891.00
82_S89_V0.7861.00
43_D105_V0.7861.00
244_D262_D0.7831.00
57_S116_N0.7831.00
20_R24_D0.7821.00
283_V370_H0.7801.00
30_G73_L0.7771.00
291_E295_T0.7761.00
47_V75_V0.7691.00
29_A33_A0.7681.00
329_L339_T0.7671.00
63_Q66_L0.7671.00
140_M143_P0.7661.00
102_E239_T0.7651.00
163_D292_V0.7651.00
93_R97_D0.7641.00
170_K303_P0.7631.00
28_E31_L0.7611.00
92_R379_A0.7611.00
177_D180_R0.7601.00
66_L69_E0.7581.00
31_L41_R0.7571.00
26_F109_G0.7561.00
47_V68_A0.7561.00
127_A131_D0.7551.00
90_A341_T0.7531.00
175_A179_D0.7491.00
93_R96_R0.7481.00
34_L44_V0.7471.00
44_V107_V0.7461.00
107_V216_A0.7431.00
231_S352_R0.7401.00
115_N212_D0.7391.00
65_P71_L0.7391.00
202_L207_A0.7361.00
10_G29_A0.7361.00
23_R57_S0.7351.00
344_V369_A0.7331.00
126_L129_A0.7321.00
22_S111_A0.7301.00
135_E138_A0.7251.00
139_G143_P0.7231.00
150_A289_I0.7231.00
96_R99_R0.7231.00
169_V191_D0.7201.00
127_A130_A0.7191.00
133_L137_R0.7191.00
206_D288_T0.7181.00
34_L73_L0.7171.00
233_P349_R0.7141.00
51_N57_S0.7131.00
4_A99_R0.7121.00
104_D227_T0.7081.00
34_L41_R0.7061.00
264_A283_V0.7001.00
133_L145_A0.6961.00
273_V277_D0.6961.00
293_M297_S0.6941.00
42_E74_D0.6941.00
363_D366_T0.6931.00
176_V179_D0.6921.00
268_Y273_V0.6881.00
276_D322_P0.6871.00
148_L152_S0.6861.00
276_D299_G0.6851.00
237_T271_A0.6831.00
48_H93_R0.6811.00
21_T116_N0.6801.00
366_T383_V0.6741.00
49_Y64_G0.6721.00
283_V294_A0.6701.00
46_A241_Q0.6691.00
65_P72_G0.6691.00
175_A331_A0.6671.00
6_V348_T0.6651.00
348_T384_L0.6651.00
97_D106_V0.6651.00
159_G163_D0.6641.00
245_K248_L0.6641.00
20_R116_N0.6621.00
52_F336_V0.6621.00
4_A98_V0.6601.00
275_A300_F0.6571.00
150_A154_F0.6571.00
45_A106_V0.6561.00
10_G33_A0.6541.00
264_A380_V0.6521.00
139_G142_F0.6511.00
91_L108_V0.6501.00
76_P241_Q0.6501.00
125_A130_A0.6461.00
104_D270_D0.6451.00
165_A193_L0.6431.00
267_A368_V0.6420.99
37_A218_V0.6420.99
121_E128_I0.6410.99
88_G382_H0.6410.99
63_Q72_G0.6360.99
134_Y137_R0.6350.99
153_Y157_F0.6350.99
233_P237_T0.6340.99
30_G216_A0.6340.99
63_Q71_L0.6340.99
189_V192_A0.6340.99
7_A225_A0.6330.99
82_S241_Q0.6330.99
137_R141_T0.6310.99
138_A142_F0.6300.99
34_L38_G0.6290.99
172_H176_V0.6290.99
264_A275_A0.6290.99
46_A82_S0.6290.99
57_S60_Q0.6280.99
217_L345_A0.6260.99
128_I131_D0.6250.99
24_D27_A0.6240.99
219_L236_V0.6230.99
373_G377_A0.6230.99
105_V228_H0.6190.99
125_A131_D0.6170.99
241_Q379_A0.6170.99
78_T89_V0.6150.99
64_G69_E0.6150.99
64_G67_V0.6140.99
144_G148_L0.6120.99
5_R221_S0.6100.99
172_H330_K0.6060.99
240_G270_D0.6050.99
133_L136_V0.6030.99
6_V219_L0.6030.99
280_V364_A0.6030.99
291_E323_V0.6020.99
119_T124_D0.6000.99
269_A274_S0.6000.99
220_V228_H0.5990.99
265_T299_G0.5980.99
132_G137_R0.5970.99
5_R224_Y0.5970.99
159_G296_E0.5950.99
198_V204_L0.5950.99
264_A294_A0.5930.99
8_G233_P0.5920.99
150_A202_L0.5920.99
94_A103_A0.5910.99
174_N302_D0.5910.99
237_T273_V0.5900.99
34_L37_A0.5900.99
20_R113_R0.5880.99
262_D266_E0.5860.99
26_F111_A0.5850.99
30_G34_L0.5840.99
30_G71_L0.5830.99
339_T343_Q0.5830.99
80_Y93_R0.5820.99
7_A224_Y0.5800.99
109_G216_A0.5790.99
124_D129_A0.5780.99
135_E139_G0.5770.99
144_G247_A0.5750.99
166_H302_D0.5750.99
136_V140_M0.5730.99
114_M336_V0.5720.99
54_G79_R0.5720.99
147_A201_P0.5710.99
332_K342_S0.5710.99
175_A332_K0.5710.99
39_V218_V0.5710.99
51_N63_Q0.5710.99
46_A103_A0.5710.99
149_M249_Q0.5710.99
47_V107_V0.5700.99
67_V73_L0.5690.99
286_C334_H0.5680.99
268_Y271_A0.5680.99
292_V296_E0.5670.99
56_L120_A0.5670.99
277_D366_T0.5650.99
10_G37_A0.5620.99
89_V92_R0.5610.99
62_H377_A0.5600.99
134_Y139_G0.5600.99
280_V367_A0.5590.99
165_A189_V0.5590.99
99_R239_T0.5580.99
264_A268_Y0.5550.99
68_A71_L0.5540.99
190_A193_L0.5520.98
188_T192_A0.5510.98
124_D127_A0.5510.98
168_A288_T0.5500.98
338_A341_T0.5490.98
68_A73_L0.5490.98
89_V97_D0.5480.98
290_A294_A0.5450.98
157_F293_M0.5450.98
90_A108_V0.5440.98
157_F296_E0.5440.98
5_R228_H0.5420.98
64_G71_L0.5420.98
60_Q63_Q0.5410.98
89_V241_Q0.5400.98
158_G296_E0.5370.98
73_L107_V0.5370.98
281_A370_H0.5360.98
244_D248_L0.5350.98
236_V384_L0.5350.98
65_P68_A0.5330.98
145_A148_L0.5330.98
239_T382_H0.5300.98
23_R70_A0.5300.98
267_A380_V0.5290.98
369_A384_L0.5280.98
135_E141_T0.5280.98
295_T301_F0.5270.98
168_A192_A0.5260.98
283_V291_E0.5240.98
296_E299_G0.5240.98
168_A172_H0.5240.98
88_G379_A0.5210.98
61_G64_G0.5210.98
289_I293_M0.5190.98
46_A106_V0.5190.98
181_A326_S0.5180.98
263_A267_A0.5180.98
170_K291_E0.5160.98
86_S337_G0.5160.98
157_F248_L0.5160.98
166_H169_V0.5160.98
172_H209_P0.5160.98
108_V341_T0.5140.98
268_Y278_V0.5110.98
60_Q66_L0.5080.97
97_D100_N0.5070.97
92_R96_R0.5070.97
65_P73_L0.5070.97
281_A322_P0.5060.97
7_A105_V0.5060.97
341_T345_A0.5050.97
67_V72_G0.5050.97
8_G218_V0.5040.97
52_F83_A0.5030.97
48_H80_Y0.5030.97
151_A202_L0.5020.97
136_V139_G0.5020.97
244_D252_Q0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9722 100 0.239 Contact Map
4u4eA 1 0.8861 100 0.313 Contact Map
1wdkC 2 0.8835 100 0.343 Contact Map
1ulqA 4 0.8861 100 0.351 Contact Map
3goaA 2 0.8684 100 0.357 Contact Map
2wu9A 2 0.9063 100 0.358 Contact Map
4n46A 4 0.8886 100 0.365 Contact Map
2vu1A 4 0.8861 100 0.365 Contact Map
4e1lA 4 0.8709 100 0.368 Contact Map
3svkA 2 0.7975 100 0.369 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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