Q9HRI8 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HRI8 - 3-ketoacyl-CoA thiolase

UniProt:	Q9HRI8	Sequences: MTDARVAGVGLTHFGVHPERTSRDLFAEAGLAALDDAGVAREDVAAVHYGNFMGELSEHQGHQGPLVAEALGLDVPATRYESACASSGVALRRAVRDVRNGEADVVVVGGAERMNNLETAESTDALAIAADGLYEVRAGMTFPGAYALMAASYFEQFGGSREDLAHIAVKNHANAVDNDRAQYQQAITVADALESPPVAEPLHLYDACPVTDGASALVLVSESYADTHDVSAPVAVTGTGQGGDKMALQDRQNMATSPAATDAATEAYADAGVSADDVDVAEVHDCFTIAEVMATESLGFFDPGAGITAAREGVTTKDGRLPVNLSGGLKAKGHPVGATGTSQVAELTRLLRGDHVNSEHVADAQTAVAHNAGGTVASAVVHVLETVADTEADAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	395 (347)
Sequences:	15306 (8443)
Seq/√Len:	453.2

ECOLI - ATOB PAAJ YQEF FADA FADI
BACSU - THL YHFS FADA
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q97UW8 Q97VJ9 Q97WQ6 Q97UA5 Q97VD4 Q97VU9 Q97WQ7 Q7LXW2 Q97VV9 Q97W61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_K	174_N	3.505	1.00
3_D	222_E	3.452	1.00
224_Y	228_H	3.415	1.00
163_D	296_E	3.310	1.00
103_A	106_V	3.102	1.00
169_V	189_V	2.953	1.00
91_L	344_V	2.869	1.00
32_A	35_D	2.805	1.00
347_L	367_A	2.769	1.00
224_Y	227_T	2.765	1.00
222_E	226_D	2.707	1.00
155_E	200_E	2.701	1.00
170_K	173_A	2.692	1.00
177_D	181_A	2.670	1.00
9_V	345_A	2.448	1.00
30_G	107_V	2.438	1.00
273_V	366_T	2.417	1.00
267_A	271_A	2.409	1.00
10_G	36_D	2.407	1.00
5_R	225_A	2.404	1.00
98_V	219_L	2.398	1.00
351_L	364_A	2.230	1.00
33_A	218_V	2.208	1.00
105_V	220_V	2.203	1.00
160_S	163_D	2.170	1.00
267_A	383_V	2.159	1.00
94_A	106_V	2.140	1.00
234_V	348_T	2.135	1.00
98_V	221_S	2.047	1.00
238_G	271_A	2.025	1.00
7_A	220_V	2.014	1.00
26_F	49_Y	2.006	1.00
40_A	43_D	1.995	1.00
3_D	235_A	1.994	1.00
279_D	364_A	1.984	1.00
280_V	325_L	1.962	1.00
162_E	166_H	1.905	1.00
233_P	352_R	1.893	1.00
278_V	366_T	1.885	1.00
235_A	385_E	1.875	1.00
43_D	228_H	1.871	1.00
215_S	341_T	1.852	1.00
354_D	364_A	1.831	1.00
295_T	302_D	1.816	1.00
326_S	350_L	1.776	1.00
192_A	205_Y	1.764	1.00
176_V	180_R	1.759	1.00
237_T	385_E	1.756	1.00
220_V	224_Y	1.753	1.00
153_Y	159_G	1.746	1.00
238_G	267_A	1.726	1.00
104_D	224_Y	1.719	1.00
295_T	323_V	1.706	1.00
275_A	281_A	1.696	1.00
350_L	354_D	1.692	1.00
104_D	221_S	1.687	1.00
169_V	173_A	1.687	1.00
265_T	269_A	1.683	1.00
156_Q	248_L	1.661	1.00
220_V	225_A	1.659	1.00
278_V	281_A	1.653	1.00
273_V	278_V	1.647	1.00
191_D	194_E	1.645	1.00
221_S	224_Y	1.638	1.00
33_A	37_A	1.618	1.00
97_D	103_A	1.609	1.00
49_Y	109_G	1.601	1.00
264_A	370_H	1.597	1.00
96_R	102_E	1.593	1.00
78_T	93_R	1.588	1.00
8_G	37_A	1.584	1.00
278_V	383_V	1.574	1.00
170_K	302_D	1.562	1.00
179_D	187_I	1.560	1.00
217_L	341_T	1.553	1.00
166_H	189_V	1.546	1.00
166_H	170_K	1.538	1.00
262_D	265_T	1.536	1.00
5_R	235_A	1.523	1.00
105_V	224_Y	1.517	1.00
280_V	350_L	1.516	1.00
113_R	116_N	1.495	1.00
147_A	199_A	1.484	1.00
31_L	35_D	1.484	1.00
94_A	219_L	1.472	1.00
344_V	384_L	1.469	1.00
350_L	353_G	1.454	1.00
347_L	369_A	1.439	1.00
29_A	216_A	1.434	1.00
20_R	28_E	1.417	1.00
29_A	214_A	1.413	1.00
266_E	269_A	1.395	1.00
26_F	67_V	1.385	1.00
240_G	266_E	1.382	1.00
32_A	36_D	1.375	1.00
173_A	177_D	1.363	1.00
185_Q	352_R	1.359	1.00
268_Y	275_A	1.357	1.00
281_A	368_V	1.356	1.00
237_T	366_T	1.336	1.00
240_G	267_A	1.311	1.00
223_S	227_T	1.306	1.00
151_A	200_E	1.301	1.00
301_F	322_P	1.299	1.00
8_G	33_A	1.291	1.00
92_R	382_H	1.287	1.00
325_L	350_L	1.264	1.00
45_A	103_A	1.260	1.00
30_G	67_V	1.258	1.00
92_R	239_T	1.251	1.00
163_D	166_H	1.247	1.00
4_A	219_L	1.245	1.00
345_A	349_R	1.231	1.00
348_T	352_R	1.230	1.00
51_N	54_G	1.228	1.00
265_T	297_S	1.223	1.00
14_F	338_A	1.215	1.00
28_E	32_A	1.208	1.00
365_Q	385_E	1.206	1.00
161_R	203_H	1.205	1.00
91_L	217_L	1.201	1.00
85_A	373_G	1.200	1.00
24_D	70_A	1.198	1.00
261_T	265_T	1.195	1.00
107_V	218_V	1.193	1.00
244_D	251_R	1.190	1.00
148_L	200_E	1.186	1.00
49_Y	216_A	1.183	1.00
159_G	164_L	1.180	1.00
242_G	262_D	1.180	1.00
274_S	277_D	1.172	1.00
85_A	379_A	1.162	1.00
43_D	224_Y	1.161	1.00
44_V	105_V	1.151	1.00
65_P	69_E	1.145	1.00
5_R	222_E	1.139	1.00
167_I	291_E	1.136	1.00
63_Q	111_A	1.133	1.00
368_V	383_V	1.131	1.00
280_V	354_D	1.116	1.00
248_L	251_R	1.115	1.00
9_V	349_R	1.113	1.00
88_G	344_V	1.106	1.00
185_Q	353_G	1.094	1.00
14_F	332_K	1.093	1.00
152_S	156_Q	1.093	1.00
273_V	383_V	1.087	1.00
9_V	348_T	1.087	1.00
48_H	106_V	1.085	1.00
45_A	104_D	1.084	1.00
173_A	176_V	1.077	1.00
91_L	219_L	1.076	1.00
188_T	191_D	1.076	1.00
159_G	292_V	1.067	1.00
99_R	102_E	1.067	1.00
102_E	270_D	1.066	1.00
236_V	382_H	1.063	1.00
167_I	292_V	1.060	1.00
6_V	384_L	1.060	1.00
179_D	184_Q	1.055	1.00
279_D	322_P	1.054	1.00
279_D	366_T	1.051	1.00
251_R	261_T	1.050	1.00
94_A	108_V	1.049	1.00
18_P	126_L	1.047	1.00
5_R	220_V	1.046	1.00
189_V	193_L	1.042	1.00
89_V	93_R	1.041	1.00
96_R	100_N	1.036	1.00
278_V	368_V	1.036	1.00
169_V	192_A	1.034	1.00
275_A	278_V	1.031	1.00
133_L	138_A	1.030	1.00
21_T	24_D	1.030	1.00
27_A	31_L	1.028	1.00
67_V	71_L	1.026	1.00
10_G	32_A	1.025	1.00
238_G	270_D	1.009	1.00
242_G	266_E	0.999	1.00
147_A	198_V	0.997	1.00
50_G	86_S	0.997	1.00
151_A	155_E	0.995	1.00
264_A	368_V	0.995	1.00
271_A	383_V	0.987	1.00
8_G	36_D	0.981	1.00
43_D	227_T	0.981	1.00
342_S	346_E	0.980	1.00
325_L	354_D	0.978	1.00
123_T	128_I	0.976	1.00
351_L	367_A	0.976	1.00
366_T	385_E	0.971	1.00
14_F	211_T	0.970	1.00
222_E	235_A	0.968	1.00
326_S	353_G	0.967	1.00
280_V	347_L	0.962	1.00
124_D	128_I	0.961	1.00
3_D	99_R	0.960	1.00
156_Q	247_A	0.958	1.00
162_E	193_L	0.954	1.00
279_D	351_L	0.953	1.00
132_G	135_E	0.950	1.00
266_E	270_D	0.949	1.00
195_S	205_Y	0.940	1.00
215_S	338_A	0.938	1.00
264_A	298_L	0.937	1.00
185_Q	349_R	0.935	1.00
12_T	29_A	0.933	1.00
186_A	346_E	0.933	1.00
154_F	289_I	0.925	1.00
300_F	323_V	0.922	1.00
157_F	251_R	0.915	1.00
95_V	99_R	0.910	1.00
157_F	297_S	0.905	1.00
12_T	25_L	0.903	1.00
279_D	365_Q	0.903	1.00
27_A	70_A	0.902	1.00
263_A	380_V	0.902	1.00
48_H	94_A	0.896	1.00
88_G	369_A	0.896	1.00
343_Q	369_A	0.893	1.00
281_A	300_F	0.889	1.00
233_P	348_T	0.888	1.00
34_L	39_V	0.885	1.00
13_H	28_E	0.884	1.00
181_A	353_G	0.878	1.00
63_Q	69_E	0.874	1.00
9_V	217_L	0.873	1.00
95_V	236_V	0.873	1.00
134_Y	138_A	0.872	1.00
153_Y	293_M	0.870	1.00
220_V	230_V	0.870	1.00
152_S	155_E	0.868	1.00
12_T	28_E	0.864	1.00
153_Y	251_R	0.861	1.00
14_F	342_S	0.858	1.00
29_A	32_A	0.853	1.00
7_A	230_V	0.853	1.00
63_Q	67_V	0.852	1.00
4_A	221_S	0.851	1.00
344_V	382_H	0.848	1.00
48_H	78_T	0.847	1.00
196_P	204_L	0.844	1.00
138_A	143_P	0.844	1.00
165_A	206_D	0.841	1.00
195_S	203_H	0.841	1.00
61_G	66_L	0.839	1.00
215_S	345_A	0.839	1.00
125_A	129_A	0.836	1.00
354_D	363_D	0.830	1.00
261_T	297_S	0.828	1.00
288_T	330_K	0.828	1.00
162_E	189_V	0.828	1.00
295_T	300_F	0.828	1.00
48_H	90_A	0.827	1.00
197_P	200_E	0.824	1.00
46_A	97_D	0.824	1.00
251_R	297_S	0.824	1.00
33_A	107_V	0.822	1.00
108_V	217_L	0.821	1.00
223_S	226_D	0.819	1.00
373_G	379_A	0.818	1.00
190_A	194_E	0.817	1.00
326_S	354_D	0.816	1.00
238_G	383_V	0.814	1.00
169_V	188_T	0.811	1.00
236_V	239_T	0.805	1.00
45_A	266_E	0.802	1.00
265_T	298_L	0.801	1.00
97_D	102_E	0.799	1.00
4_A	95_V	0.799	1.00
251_R	293_M	0.793	1.00
222_E	225_A	0.793	1.00
33_A	216_A	0.792	1.00
62_H	65_P	0.791	1.00
174_N	177_D	0.789	1.00
82_S	89_V	0.786	1.00
43_D	105_V	0.786	1.00
244_D	262_D	0.783	1.00
57_S	116_N	0.783	1.00
20_R	24_D	0.782	1.00
283_V	370_H	0.780	1.00
30_G	73_L	0.777	1.00
291_E	295_T	0.776	1.00
47_V	75_V	0.769	1.00
29_A	33_A	0.768	1.00
329_L	339_T	0.767	1.00
63_Q	66_L	0.767	1.00
140_M	143_P	0.766	1.00
102_E	239_T	0.765	1.00
163_D	292_V	0.765	1.00
93_R	97_D	0.764	1.00
170_K	303_P	0.763	1.00
28_E	31_L	0.761	1.00
92_R	379_A	0.761	1.00
177_D	180_R	0.760	1.00
66_L	69_E	0.758	1.00
31_L	41_R	0.757	1.00
26_F	109_G	0.756	1.00
47_V	68_A	0.756	1.00
127_A	131_D	0.755	1.00
90_A	341_T	0.753	1.00
175_A	179_D	0.749	1.00
93_R	96_R	0.748	1.00
34_L	44_V	0.747	1.00
44_V	107_V	0.746	1.00
107_V	216_A	0.743	1.00
231_S	352_R	0.740	1.00
115_N	212_D	0.739	1.00
65_P	71_L	0.739	1.00
202_L	207_A	0.736	1.00
10_G	29_A	0.736	1.00
23_R	57_S	0.735	1.00
344_V	369_A	0.733	1.00
126_L	129_A	0.732	1.00
22_S	111_A	0.730	1.00
135_E	138_A	0.725	1.00
139_G	143_P	0.723	1.00
150_A	289_I	0.723	1.00
96_R	99_R	0.723	1.00
169_V	191_D	0.720	1.00
127_A	130_A	0.719	1.00
133_L	137_R	0.719	1.00
206_D	288_T	0.718	1.00
34_L	73_L	0.717	1.00
233_P	349_R	0.714	1.00
51_N	57_S	0.713	1.00
4_A	99_R	0.712	1.00
104_D	227_T	0.708	1.00
34_L	41_R	0.706	1.00
264_A	283_V	0.700	1.00
133_L	145_A	0.696	1.00
273_V	277_D	0.696	1.00
293_M	297_S	0.694	1.00
42_E	74_D	0.694	1.00
363_D	366_T	0.693	1.00
176_V	179_D	0.692	1.00
268_Y	273_V	0.688	1.00
276_D	322_P	0.687	1.00
148_L	152_S	0.686	1.00
276_D	299_G	0.685	1.00
237_T	271_A	0.683	1.00
48_H	93_R	0.681	1.00
21_T	116_N	0.680	1.00
366_T	383_V	0.674	1.00
49_Y	64_G	0.672	1.00
283_V	294_A	0.670	1.00
46_A	241_Q	0.669	1.00
65_P	72_G	0.669	1.00
175_A	331_A	0.667	1.00
6_V	348_T	0.665	1.00
348_T	384_L	0.665	1.00
97_D	106_V	0.665	1.00
159_G	163_D	0.664	1.00
245_K	248_L	0.664	1.00
20_R	116_N	0.662	1.00
52_F	336_V	0.662	1.00
4_A	98_V	0.660	1.00
275_A	300_F	0.657	1.00
150_A	154_F	0.657	1.00
45_A	106_V	0.656	1.00
10_G	33_A	0.654	1.00
264_A	380_V	0.652	1.00
139_G	142_F	0.651	1.00
91_L	108_V	0.650	1.00
76_P	241_Q	0.650	1.00
125_A	130_A	0.646	1.00
104_D	270_D	0.645	1.00
165_A	193_L	0.643	1.00
267_A	368_V	0.642	0.99
37_A	218_V	0.642	0.99
121_E	128_I	0.641	0.99
88_G	382_H	0.641	0.99
63_Q	72_G	0.636	0.99
134_Y	137_R	0.635	0.99
153_Y	157_F	0.635	0.99
233_P	237_T	0.634	0.99
30_G	216_A	0.634	0.99
63_Q	71_L	0.634	0.99
189_V	192_A	0.634	0.99
7_A	225_A	0.633	0.99
82_S	241_Q	0.633	0.99
137_R	141_T	0.631	0.99
138_A	142_F	0.630	0.99
34_L	38_G	0.629	0.99
172_H	176_V	0.629	0.99
264_A	275_A	0.629	0.99
46_A	82_S	0.629	0.99
57_S	60_Q	0.628	0.99
217_L	345_A	0.626	0.99
128_I	131_D	0.625	0.99
24_D	27_A	0.624	0.99
219_L	236_V	0.623	0.99
373_G	377_A	0.623	0.99
105_V	228_H	0.619	0.99
125_A	131_D	0.617	0.99
241_Q	379_A	0.617	0.99
78_T	89_V	0.615	0.99
64_G	69_E	0.615	0.99
64_G	67_V	0.614	0.99
144_G	148_L	0.612	0.99
5_R	221_S	0.610	0.99
172_H	330_K	0.606	0.99
240_G	270_D	0.605	0.99
133_L	136_V	0.603	0.99
6_V	219_L	0.603	0.99
280_V	364_A	0.603	0.99
291_E	323_V	0.602	0.99
119_T	124_D	0.600	0.99
269_A	274_S	0.600	0.99
220_V	228_H	0.599	0.99
265_T	299_G	0.598	0.99
132_G	137_R	0.597	0.99
5_R	224_Y	0.597	0.99
159_G	296_E	0.595	0.99
198_V	204_L	0.595	0.99
264_A	294_A	0.593	0.99
8_G	233_P	0.592	0.99
150_A	202_L	0.592	0.99
94_A	103_A	0.591	0.99
174_N	302_D	0.591	0.99
237_T	273_V	0.590	0.99
34_L	37_A	0.590	0.99
20_R	113_R	0.588	0.99
262_D	266_E	0.586	0.99
26_F	111_A	0.585	0.99
30_G	34_L	0.584	0.99
30_G	71_L	0.583	0.99
339_T	343_Q	0.583	0.99
80_Y	93_R	0.582	0.99
7_A	224_Y	0.580	0.99
109_G	216_A	0.579	0.99
124_D	129_A	0.578	0.99
135_E	139_G	0.577	0.99
144_G	247_A	0.575	0.99
166_H	302_D	0.575	0.99
136_V	140_M	0.573	0.99
114_M	336_V	0.572	0.99
54_G	79_R	0.572	0.99
147_A	201_P	0.571	0.99
332_K	342_S	0.571	0.99
175_A	332_K	0.571	0.99
39_V	218_V	0.571	0.99
51_N	63_Q	0.571	0.99
46_A	103_A	0.571	0.99
149_M	249_Q	0.571	0.99
47_V	107_V	0.570	0.99
67_V	73_L	0.569	0.99
286_C	334_H	0.568	0.99
268_Y	271_A	0.568	0.99
292_V	296_E	0.567	0.99
56_L	120_A	0.567	0.99
277_D	366_T	0.565	0.99
10_G	37_A	0.562	0.99
89_V	92_R	0.561	0.99
62_H	377_A	0.560	0.99
134_Y	139_G	0.560	0.99
280_V	367_A	0.559	0.99
165_A	189_V	0.559	0.99
99_R	239_T	0.558	0.99
264_A	268_Y	0.555	0.99
68_A	71_L	0.554	0.99
190_A	193_L	0.552	0.98
188_T	192_A	0.551	0.98
124_D	127_A	0.551	0.98
168_A	288_T	0.550	0.98
338_A	341_T	0.549	0.98
68_A	73_L	0.549	0.98
89_V	97_D	0.548	0.98
290_A	294_A	0.545	0.98
157_F	293_M	0.545	0.98
90_A	108_V	0.544	0.98
157_F	296_E	0.544	0.98
5_R	228_H	0.542	0.98
64_G	71_L	0.542	0.98
60_Q	63_Q	0.541	0.98
89_V	241_Q	0.540	0.98
158_G	296_E	0.537	0.98
73_L	107_V	0.537	0.98
281_A	370_H	0.536	0.98
244_D	248_L	0.535	0.98
236_V	384_L	0.535	0.98
65_P	68_A	0.533	0.98
145_A	148_L	0.533	0.98
239_T	382_H	0.530	0.98
23_R	70_A	0.530	0.98
267_A	380_V	0.529	0.98
369_A	384_L	0.528	0.98
135_E	141_T	0.528	0.98
295_T	301_F	0.527	0.98
168_A	192_A	0.526	0.98
283_V	291_E	0.524	0.98
296_E	299_G	0.524	0.98
168_A	172_H	0.524	0.98
88_G	379_A	0.521	0.98
61_G	64_G	0.521	0.98
289_I	293_M	0.519	0.98
46_A	106_V	0.519	0.98
181_A	326_S	0.518	0.98
263_A	267_A	0.518	0.98
170_K	291_E	0.516	0.98
86_S	337_G	0.516	0.98
157_F	248_L	0.516	0.98
166_H	169_V	0.516	0.98
172_H	209_P	0.516	0.98
108_V	341_T	0.514	0.98
268_Y	278_V	0.511	0.98
60_Q	66_L	0.508	0.97
97_D	100_N	0.507	0.97
92_R	96_R	0.507	0.97
65_P	73_L	0.507	0.97
281_A	322_P	0.506	0.97
7_A	105_V	0.506	0.97
341_T	345_A	0.505	0.97
67_V	72_G	0.505	0.97
8_G	218_V	0.504	0.97
52_F	83_A	0.503	0.97
48_H	80_Y	0.503	0.97
151_A	202_L	0.502	0.97
136_V	139_G	0.502	0.97
244_D	252_Q	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.9722	100	0.239	Contact Map
4u4eA	1	0.8861	100	0.313	Contact Map
1wdkC	2	0.8835	100	0.343	Contact Map
1ulqA	4	0.8861	100	0.351	Contact Map
3goaA	2	0.8684	100	0.357	Contact Map
2wu9A	2	0.9063	100	0.358	Contact Map
4n46A	4	0.8886	100	0.365	Contact Map
2vu1A	4	0.8861	100	0.365	Contact Map
4e1lA	4	0.8709	100	0.368	Contact Map
3svkA	2	0.7975	100	0.369	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.