GREMLIN Database
Q9HRI6 - Acyl-CoA dehydrogenase
UniProt: Q9HRI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (369)
Sequences: 33481 (19140)
Seq/√Len: 996.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_A236_R4.0531.00
168_S234_D3.8671.00
309_K347_E3.4301.00
40_E61_E3.2781.00
212_I233_D2.9111.00
160_R239_A2.8901.00
130_P135_D2.8481.00
121_D125_H2.8261.00
161_D236_R2.8051.00
47_T51_A2.7901.00
82_D85_T2.7031.00
34_A92_E2.7011.00
199_S242_L2.6791.00
302_K351_E2.3941.00
281_E285_D2.3831.00
130_P136_D2.3011.00
204_R207_E2.2551.00
273_R314_E2.2271.00
170_E231_R2.2041.00
322_D326_R2.0601.00
35_E39_E2.0581.00
121_D124_K2.0581.00
292_A295_D2.0511.00
245_E248_D2.0491.00
187_A201_F2.0391.00
161_D164_A1.9961.00
120_S123_Q1.9571.00
283_A355_I1.9551.00
363_K368_E1.9321.00
248_D251_K1.8871.00
368_E372_R1.8671.00
91_S314_E1.8641.00
73_P116_Y1.8611.00
23_S26_H1.8411.00
165_Y201_F1.7851.00
343_E384_S1.7841.00
170_E229_E1.7761.00
61_E64_D1.7641.00
60_A64_D1.7601.00
276_L310_L1.7511.00
95_R277_D1.7331.00
26_H85_T1.7171.00
273_R277_D1.6941.00
177_G228_A1.6911.00
287_D292_A1.6771.00
139_A183_V1.6711.00
160_R246_E1.6621.00
183_V206_A1.6451.00
238_P241_R1.6361.00
159_Q168_S1.6351.00
298_T301_H1.6231.00
92_E95_R1.6111.00
323_L333_E1.5991.00
190_D193_A1.5911.00
283_A299_I1.5881.00
166_V236_R1.5801.00
306_M348_V1.5791.00
126_D240_D1.5741.00
161_D166_V1.5641.00
126_D130_P1.5631.00
163_D236_R1.5491.00
166_V234_D1.5461.00
143_S173_W1.5341.00
74_E80_G1.5311.00
208_D235_M1.5271.00
319_K323_L1.5171.00
312_A340_Y1.5141.00
204_R241_R1.5141.00
165_Y239_A1.5141.00
31_E35_E1.5101.00
242_L246_E1.5021.00
291_Q295_D1.4981.00
144_E171_K1.4921.00
130_P133_R1.4871.00
212_I231_R1.4871.00
359_Y365_F1.4851.00
27_D30_A1.4761.00
163_D239_A1.4741.00
26_H82_D1.4731.00
168_S233_D1.4711.00
28_Q31_E1.4691.00
76_Y124_K1.4541.00
125_H129_A1.4511.00
178_S228_A1.4441.00
288_Q296_F1.4351.00
239_A242_L1.4311.00
28_Q32_M1.4271.00
275_A349_A1.4271.00
313_A341_A1.4241.00
278_D366_D1.4241.00
160_R164_A1.4231.00
299_I355_I1.4211.00
214_A229_E1.4101.00
214_A231_R1.4091.00
278_D281_E1.4081.00
158_A201_F1.4061.00
204_R208_D1.3921.00
311_Q319_K1.3871.00
167_I201_F1.3801.00
280_R284_Q1.3731.00
37_V96_G1.3611.00
122_D126_D1.3581.00
347_E351_E1.3571.00
346_R378_E1.3571.00
274_A278_D1.3561.00
95_R273_R1.3521.00
339_L384_S1.3441.00
306_M351_E1.3421.00
30_A92_E1.3351.00
97_S100_L1.3301.00
70_M89_A1.3291.00
91_S318_H1.3281.00
118_Y255_E1.3251.00
33_V67_L1.3161.00
48_I224_G1.3111.00
83_Y325_I1.3091.00
350_N375_K1.3081.00
237_V241_R1.3061.00
164_A239_A1.2931.00
206_A211_F1.2881.00
84_H322_D1.2851.00
218_D363_K1.2801.00
305_D388_R1.2801.00
26_H88_T1.2751.00
123_Q127_Y1.2741.00
91_S273_R1.2731.00
141_A174_I1.2501.00
122_D240_D1.2491.00
27_D31_E1.2361.00
131_L138_G1.2351.00
279_A352_G1.2351.00
50_K218_D1.2311.00
24_A27_D1.2291.00
272_A310_L1.2291.00
211_F235_M1.2281.00
266_A317_M1.2161.00
129_A133_R1.2131.00
160_R165_Y1.2111.00
276_L280_R1.2091.00
310_L348_V1.1951.00
350_N378_E1.1901.00
345_S374_A1.1811.00
272_A348_V1.1801.00
94_A101_G1.1771.00
260_G381_E1.1741.00
82_D325_I1.1721.00
24_A28_Q1.1681.00
87_A321_A1.1671.00
146_G155_E1.1641.00
60_A63_S1.1571.00
72_F132_S1.1571.00
258_N331_I1.1541.00
302_K385_E1.1541.00
189_T199_S1.1521.00
335_A387_L1.1521.00
87_A266_A1.1511.00
250_F254_L1.1511.00
274_A370_Y1.1461.00
319_K322_D1.1441.00
291_Q296_F1.1431.00
127_Y182_T1.1401.00
307_D311_Q1.1391.00
124_K128_L1.1381.00
208_D241_R1.1381.00
278_D356_H1.1371.00
159_Q166_V1.1361.00
81_L85_T1.1351.00
186_F200_S1.1291.00
352_G367_A1.1281.00
30_A88_T1.1251.00
46_A50_K1.1231.00
136_D181_D1.1221.00
126_D241_R1.1161.00
375_K378_E1.1051.00
61_E65_L1.1051.00
206_A213_V1.0981.00
32_M65_L1.0981.00
156_T167_I1.0971.00
323_L328_E1.0921.00
313_A344_I1.0921.00
167_I185_V1.0871.00
346_R350_N1.0831.00
157_T168_S1.0791.00
210_G235_M1.0741.00
165_Y246_E1.0721.00
44_R48_I1.0711.00
119_G123_Q1.0711.00
122_D125_H1.0651.00
308_T336_Q1.0611.00
309_K351_E1.0611.00
63_S68_M1.0581.00
165_Y189_T1.0511.00
123_Q202_I1.0511.00
111_A138_G1.0501.00
60_A135_D1.0471.00
378_E384_S1.0451.00
141_A183_V1.0451.00
185_V203_V1.0401.00
269_V310_L1.0341.00
211_F230_L1.0291.00
75_E125_H1.0231.00
33_V37_V1.0221.00
186_F198_I1.0221.00
138_G182_T1.0161.00
159_Q234_D1.0151.00
32_M67_L1.0111.00
309_K344_I1.0071.00
158_A187_A1.0051.00
44_R47_T1.0021.00
269_V317_M1.0011.00
57_D60_A1.0011.00
56_A60_A0.9891.00
236_R239_A0.9851.00
343_E347_E0.9791.00
117_E255_E0.9781.00
349_A374_A0.9731.00
346_R371_Y0.9711.00
141_A232_F0.9701.00
185_V232_F0.9661.00
268_S377_N0.9641.00
183_V230_L0.9641.00
343_E378_E0.9581.00
284_Q294_S0.9571.00
167_I187_A0.9571.00
36_F61_E0.9541.00
283_A293_I0.9471.00
339_L388_R0.9451.00
280_R303_L0.9441.00
275_A370_Y0.9441.00
111_A184_T0.9421.00
183_V211_F0.9421.00
150_D153_A0.9401.00
190_D197_G0.9371.00
344_I347_E0.9351.00
159_Q190_D0.9331.00
384_S388_R0.9321.00
201_F242_L0.9241.00
167_I237_V0.9231.00
315_L319_K0.9171.00
126_D204_R0.9151.00
220_L371_Y0.9121.00
99_G224_G0.9101.00
177_G213_V0.9081.00
305_D309_K0.9061.00
199_S246_E0.9061.00
34_A38_D0.9051.00
320_A337_A0.9041.00
33_V89_A0.9021.00
173_W359_Y0.8971.00
72_F112_G0.8951.00
222_D376_L0.8931.00
118_Y252_H0.8911.00
343_E388_R0.8911.00
283_A294_S0.8901.00
307_D336_Q0.8841.00
172_L229_E0.8831.00
162_G236_R0.8801.00
182_T204_R0.8801.00
342_S384_S0.8791.00
84_H325_I0.8771.00
123_Q241_R0.8731.00
37_V93_I0.8721.00
50_K363_K0.8701.00
49_D372_R0.8681.00
75_E121_D0.8681.00
73_P76_Y0.8661.00
209_D236_R0.8651.00
221_G373_D0.8631.00
277_D281_E0.8611.00
139_A180_A0.8561.00
353_I371_Y0.8541.00
376_L380_Y0.8511.00
120_S124_K0.8501.00
281_E284_Q0.8501.00
36_F65_L0.8491.00
141_A185_V0.8431.00
309_K340_Y0.8431.00
44_R57_D0.8381.00
301_H389_N0.8331.00
173_W362_T0.8331.00
344_I348_V0.8331.00
208_D211_F0.8301.00
300_Q389_N0.8271.00
149_S386_I0.8261.00
346_R375_K0.8251.00
220_L368_E0.8211.00
182_T202_I0.8151.00
199_S247_G0.8131.00
38_D95_R0.8121.00
32_M35_E0.8121.00
271_L370_Y0.8121.00
271_L345_S0.8111.00
188_K198_I0.8091.00
279_A355_I0.8091.00
62_M67_L0.8081.00
283_A303_L0.8071.00
165_Y242_L0.8041.00
377_N380_Y0.8031.00
232_F235_M0.8031.00
36_F62_M0.8011.00
142_L257_L0.8001.00
158_A189_T0.7981.00
84_H318_H0.7961.00
279_A356_H0.7931.00
207_E211_F0.7931.00
353_I367_A0.7931.00
271_L374_A0.7921.00
71_P86_Y0.7921.00
181_D207_E0.7911.00
30_A34_A0.7901.00
136_D182_T0.7891.00
301_H305_D0.7871.00
213_V230_L0.7871.00
311_Q314_E0.7861.00
36_F40_E0.7861.00
272_A344_I0.7861.00
164_A238_P0.7851.00
46_A369_R0.7831.00
201_F237_V0.7821.00
139_A206_A0.7821.00
349_A370_Y0.7821.00
84_H88_T0.7791.00
264_I381_E0.7741.00
184_T200_S0.7731.00
276_L307_D0.7701.00
269_V313_A0.7691.00
158_A165_Y0.7691.00
311_Q315_L0.7691.00
76_Y121_D0.7671.00
350_N371_Y0.7661.00
154_M186_F0.7641.00
47_T50_K0.7601.00
302_K355_I0.7591.00
38_D96_G0.7591.00
306_M352_G0.7551.00
349_A371_Y0.7541.00
57_D61_E0.7531.00
156_T171_K0.7531.00
265_A337_A0.7521.00
75_E124_K0.7521.00
58_L100_L0.7521.00
305_D351_E0.7461.00
308_T340_Y0.7441.00
371_Y375_K0.7431.00
88_T92_E0.7421.00
279_A283_A0.7421.00
330_F333_E0.7421.00
164_A240_D0.7401.00
278_D370_Y0.7371.00
282_Y359_Y0.7361.00
305_D347_E0.7351.00
141_A230_L0.7281.00
26_H84_H0.7271.00
154_M198_I0.7261.00
340_Y344_I0.7261.00
273_R307_D0.7241.00
293_I296_F0.7231.00
308_T339_L0.7201.00
167_I203_V0.7191.00
316_L336_Q0.7191.00
275_A352_G0.7181.00
140_F253_A0.7181.00
265_A317_M0.7141.00
127_Y241_R0.7131.00
95_R274_A0.7121.00
112_G131_L0.7101.00
347_E350_N0.7091.00
316_L337_A0.7091.00
297_Q301_H0.7061.00
189_T197_G0.7051.00
88_T318_H0.7041.00
268_S342_S0.7031.00
286_R289_F0.6981.00
188_K193_A0.6981.00
199_S244_G0.6981.00
296_F300_Q0.6971.00
349_A367_A0.6941.00
144_E156_T0.6941.00
190_D247_G0.6941.00
354_Q375_K0.6931.00
37_V41_V0.6931.00
75_E80_G0.6881.00
389_N393_N0.6871.00
181_D206_A0.6871.00
312_A316_L0.6871.00
41_V58_L0.6861.00
127_Y202_I0.6851.00
184_T243_L0.6831.00
188_K191_P0.6821.00
142_L151_V0.6801.00
321_A325_I0.6801.00
154_M188_K0.6771.00
188_K197_G0.6751.00
387_L390_T0.6721.00
242_L245_E0.6721.00
248_D252_H0.6701.00
345_S349_A0.6681.00
70_M81_L0.6661.00
222_D380_Y0.6651.00
56_A181_D0.6621.00
38_D42_K0.6581.00
75_E78_G0.6561.00
35_E38_D0.6551.00
300_Q392_A0.6541.00
353_I360_G0.6531.00
218_D223_K0.6511.00
265_A341_A0.6511.00
317_M341_A0.6501.00
309_K312_A0.6501.00
189_T246_E0.6491.00
58_L61_E0.6471.00
30_A91_S0.6471.00
160_R163_D0.6461.00
131_L182_T0.6461.00
127_Y136_D0.6441.00
369_R373_D0.6441.00
186_F253_A0.6411.00
356_H367_A0.6411.00
25_E28_Q0.6371.00
174_I230_L0.6371.00
170_E214_A0.6351.00
314_E318_H0.6341.00
160_R166_V0.6331.00
383_T386_I0.6331.00
178_S226_P0.6311.00
53_E56_A0.6301.00
72_F76_Y0.6271.00
316_L340_Y0.6251.00
329_S333_E0.6241.00
145_A170_E0.6201.00
221_G361_Y0.6161.00
73_P78_G0.6131.00
42_K45_A0.6131.00
114_M256_T0.6111.00
156_T232_F0.6101.00
161_D239_A0.6101.00
299_I303_L0.6051.00
279_A306_M0.6051.00
272_A313_A0.6041.00
302_K305_D0.6041.00
162_G166_V0.6031.00
339_L391_I0.6011.00
336_Q391_I0.6001.00
34_A95_R0.5981.00
157_T191_P0.5981.00
272_A275_A0.5961.00
45_A369_R0.5951.00
332_K394_E0.5951.00
258_N334_A0.5951.00
266_A270_G0.5941.00
262_I321_A0.5931.00
288_Q293_I0.5931.00
29_I85_T0.5921.00
177_G230_L0.5901.00
29_I33_V0.5891.00
309_K343_E0.5881.00
239_A246_E0.5871.00
302_K354_Q0.5871.00
274_A366_D0.5841.00
52_D218_D0.5841.00
223_K363_K0.5841.00
102_T222_D0.5841.00
29_I89_A0.5831.00
313_A340_Y0.5821.00
324_K330_F0.5811.00
119_G124_K0.5741.00
299_I302_K0.5711.00
274_A277_D0.5701.00
269_V273_R0.5691.00
156_T169_G0.5681.00
319_K333_E0.5681.00
185_V235_M0.5681.00
25_E85_T0.5661.00
219_K227_T0.5641.00
289_F296_F0.5631.00
123_Q126_D0.5631.00
193_A196_R0.5611.00
98_G271_L0.5591.00
313_A337_A0.5561.00
83_Y324_K0.5551.00
111_A114_M0.5551.00
201_F241_R0.5541.00
311_Q316_L0.5541.00
194_G197_G0.5531.00
111_A131_L0.5531.00
86_Y263_T0.5521.00
23_S85_T0.5511.00
346_R374_A0.5511.00
308_T312_A0.5501.00
76_Y129_A0.5501.00
339_L343_E0.5481.00
175_S225_C0.5471.00
112_G128_L0.5461.00
203_V232_F0.5451.00
316_L320_A0.5451.00
342_S377_N0.5441.00
182_T241_R0.5441.00
262_I317_M0.5431.00
126_D129_A0.5411.00
358_G361_Y0.5401.00
114_M252_H0.5401.00
201_F239_A0.5381.00
115_V119_G0.5371.00
52_D223_K0.5371.00
88_T91_S0.5371.00
305_D343_E0.5361.00
56_A179_V0.5361.00
313_A348_V0.5351.00
386_I389_N0.5341.00
175_S227_T0.5331.00
282_Y365_F0.5321.00
305_D308_T0.5301.00
62_M100_L0.5291.00
375_K379_I0.5291.00
203_V235_M0.5271.00
273_R310_L0.5261.00
306_M355_I0.5251.00
211_F232_F0.5251.00
32_M79_A0.5241.00
87_A318_H0.5241.00
286_R358_G0.5241.00
202_I243_L0.5241.00
220_L372_R0.5231.00
323_L329_S0.5231.00
41_V100_L0.5231.00
67_L89_A0.5211.00
156_T185_V0.5211.00
114_M118_Y0.5191.00
69_G132_S0.5191.00
293_I299_I0.5181.00
160_R236_R0.5181.00
296_F299_I0.5171.00
246_E249_G0.5161.00
179_V226_P0.5161.00
251_K255_E0.5161.00
287_D295_D0.5151.00
69_G79_A0.5141.00
116_Y124_K0.5131.00
52_D363_K0.5121.00
142_L186_F0.5121.00
46_A366_D0.5101.00
147_A155_E0.5071.00
245_E252_H0.5071.00
52_D215_G0.5051.00
34_A96_G0.5041.00
49_D223_K0.5041.00
282_Y285_D0.5031.00
216_T229_E0.5031.00
157_T190_D0.5031.00
160_R201_F0.5021.00
387_L391_I0.5011.00
113_N117_E0.5011.00
278_D367_A0.5011.00
257_L260_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d29A 4 0.9572 100 0.122 Contact Map
4l1fA 4 0.9547 100 0.122 Contact Map
1bucA 4 0.9547 100 0.125 Contact Map
2jifA 4 0.9547 100 0.128 Contact Map
1ivhA 4 0.9622 100 0.129 Contact Map
1ukwA 4 0.9521 100 0.131 Contact Map
3pfdA 4 0.9295 100 0.135 Contact Map
3ii9A 4 0.9748 100 0.136 Contact Map
2vigA 6 0.9446 100 0.137 Contact Map
4m9aA 4 0.9471 100 0.137 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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