GREMLIN Database
Q9HRI5 - Farnesyl-diphosphate farnesyltransferase
UniProt: Q9HRI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (297)
Sequences: 1063 (601)
Seq/√Len: 34.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_S203_E5.8131.00
275_H297_R5.5011.00
56_D159_S5.0441.00
274_D297_R4.6331.00
275_H293_S3.4021.00
271_W298_V3.2221.00
82_M222_L3.0201.00
182_G211_V3.0181.00
199_Q203_E2.8601.00
336_G364_V2.7541.00
252_A341_L2.7091.00
241_S308_D2.5711.00
115_E184_A2.5531.00
292_A345_P2.5101.00
90_Y94_R2.4901.00
86_I219_V2.4381.00
163_S167_A2.4021.00
256_R260_E2.3901.00
212_A216_G2.3640.99
59_W62_S2.3570.99
211_V251_V2.3390.99
97_D258_D2.2860.99
212_A215_V2.2650.99
209_W240_R2.2600.99
57_R84_T2.2020.99
118_D184_A2.1690.99
71_F212_A2.1610.99
212_A250_N2.0780.99
185_S206_E2.0760.99
122_D173_R2.0740.99
68_S71_F2.0510.98
189_R203_E2.0120.98
288_A351_E1.9750.98
300_D342_G1.9550.98
247_Q250_N1.9270.98
90_Y250_N1.9130.98
199_Q269_Q1.8960.97
71_F215_V1.8880.97
243_A253_K1.8790.97
212_A247_Q1.8300.97
271_W275_H1.8280.97
271_W297_R1.7920.96
97_D254_D1.7890.96
96_A117_Y1.7730.96
254_D258_D1.7720.96
174_P178_E1.6870.95
249_V338_M1.6820.95
85_R168_A1.6810.95
346_A352_G1.6800.95
253_K264_N1.6690.95
161_F165_D1.6460.94
208_C213_G1.6400.94
109_E112_Q1.6240.94
90_Y216_G1.6170.94
115_E185_S1.5610.92
333_L356_V1.5610.92
182_G251_V1.5370.92
57_R163_S1.5340.92
249_V306_V1.5150.91
94_R216_G1.5130.91
243_A250_N1.5000.91
211_V215_V1.4990.91
71_F211_V1.4910.91
93_C218_L1.4760.90
71_F250_N1.4640.90
118_D177_R1.4600.90
252_A338_M1.4530.89
65_Q72_A1.4500.89
95_V157_V1.4460.89
95_V155_T1.4390.89
179_M183_M1.4260.88
334_A337_T1.4010.88
45_D48_Q1.3910.87
90_Y212_A1.3660.86
106_P109_E1.3550.86
69_R355_K1.3510.86
165_D168_A1.3370.85
276_D281_D1.3330.85
94_R250_N1.3230.84
340_E354_V1.3190.84
303_R342_G1.2990.83
85_R249_V1.2880.83
271_W294_V1.2830.82
70_T73_L1.2800.82
250_N337_T1.2740.82
72_A302_A1.2550.81
248_L301_R1.2410.80
71_F182_G1.2340.80
71_F216_G1.2300.80
359_E366_G1.2270.80
94_R212_A1.2270.80
197_R279_P1.2260.79
285_P289_G1.2220.79
216_G250_N1.2220.79
125_C316_M1.2200.79
68_S211_V1.2180.79
68_S213_G1.2170.79
64_V91_L1.2050.78
59_W153_N1.1930.78
313_L327_W1.1920.77
205_E244_L1.1890.77
301_R304_G1.1810.77
223_L323_T1.1810.77
168_A226_D1.1800.77
94_R97_D1.1730.76
93_C215_V1.1640.76
296_E343_N1.1600.76
160_A163_S1.1570.75
71_F246_L1.1460.75
68_S215_V1.1210.73
127_T140_V1.1200.73
64_V68_S1.1170.73
239_A243_A1.1020.72
97_D101_D1.0980.71
90_Y97_D1.0970.71
71_F90_Y1.0940.71
253_K334_A1.0880.71
90_Y254_D1.0870.71
116_T119_A1.0840.70
90_Y247_Q1.0820.70
179_M215_V1.0810.70
241_S305_Y1.0810.70
120_A123_P1.0800.70
280_E293_S1.0740.70
92_L176_V1.0710.69
70_T253_K1.0660.69
95_V158_V1.0560.68
122_D286_E1.0540.68
66_D363_A1.0500.68
51_Q54_A1.0490.68
181_T206_E1.0460.68
175_T214_T1.0410.67
68_S182_G1.0400.67
256_R348_V1.0390.67
73_L356_V1.0390.67
101_D258_D1.0390.67
278_A281_D1.0340.67
59_W67_V1.0330.67
90_Y258_D1.0290.66
276_D282_V1.0240.66
101_D254_D1.0200.66
256_R352_G1.0180.65
292_A296_E1.0180.65
182_G212_A1.0160.65
219_V327_W1.0140.65
277_L294_V1.0120.65
275_H290_R1.0100.65
179_M213_G1.0020.64
174_P221_E0.9990.64
79_E82_M0.9820.63
94_R258_D0.9770.62
82_M317_P0.9760.62
245_L306_V0.9750.62
65_Q76_D0.9640.61
68_S246_L0.9620.61
295_V316_M0.9600.61
277_L281_D0.9500.60
247_Q254_D0.9480.60
263_N348_V0.9410.59
275_H294_V0.9410.59
49_S52_P0.9380.59
216_G247_Q0.9350.59
97_D247_Q0.9320.59
70_T242_F0.9300.58
297_R307_A0.9280.58
122_D177_R0.9240.58
201_P301_R0.9220.58
286_E316_M0.9220.58
247_Q258_D0.9140.57
347_D350_R0.9130.57
281_D302_A0.9130.57
238_N315_V0.9120.57
71_F208_C0.9100.57
248_L305_Y0.9090.57
46_G49_S0.9020.56
105_M113_L0.8960.56
304_G307_A0.8960.56
68_S212_A0.8950.55
60_C338_M0.8920.55
243_A247_Q0.8920.55
259_Y263_N0.8860.55
78_L207_Y0.8840.55
94_R254_D0.8840.55
166_D170_A0.8810.54
363_A367_L0.8760.54
182_G213_G0.8590.52
306_V334_A0.8590.52
68_S93_C0.8580.52
212_A243_A0.8490.52
318_T324_L0.8470.51
47_R50_H0.8430.51
182_G247_Q0.8390.51
312_W337_T0.8330.50
71_F94_R0.8330.50
182_G246_L0.8320.50
90_Y243_A0.8310.50
216_G239_A0.8290.50
62_S360_E0.8280.50
108_T119_A0.8280.50
59_W63_A0.8270.50
62_S66_D0.8240.49
219_V326_A0.8240.49
271_W274_D0.8230.49
215_V250_N0.8210.49
77_A325_A0.8200.49
248_L272_L0.8190.49
121_L161_F0.8170.49
337_T355_K0.8150.49
90_Y246_L0.8120.48
303_R339_R0.8110.48
94_R215_V0.8110.48
153_N156_R0.8100.48
179_M257_P0.8090.48
102_A110_Q0.8080.48
182_G215_V0.8080.48
371_D375_S0.8070.48
213_G251_V0.8020.48
213_G243_A0.8020.48
336_G356_V0.8020.48
88_V163_S0.8000.47
72_A75_I0.7980.47
64_V211_V0.7960.47
367_L372_F0.7940.47
256_R353_D0.7910.47
94_R247_Q0.7810.46
272_L294_V0.7790.46
323_T327_W0.7790.46
312_W334_A0.7780.45
207_Y247_Q0.7760.45
62_S289_G0.7730.45
98_T337_T0.7720.45
200_S375_S0.7680.45
79_E159_S0.7670.45
250_N254_D0.7640.44
209_W214_T0.7620.44
317_P323_T0.7610.44
312_W326_A0.7600.44
370_D373_D0.7590.44
180_A184_A0.7590.44
121_L154_T0.7560.44
99_V114_L0.7550.44
200_S270_E0.7520.43
71_F213_G0.7500.43
269_Q273_D0.7500.43
202_T205_E0.7500.43
48_Q53_T0.7490.43
50_H341_L0.7480.43
301_R347_D0.7440.43
64_V326_A0.7440.43
220_T233_A0.7420.42
201_P298_V0.7320.42
186_F266_Y0.7310.42
98_T334_A0.7290.41
79_E318_T0.7270.41
368_V372_F0.7260.41
291_V348_V0.7200.41
259_Y373_D0.7200.41
367_L373_D0.7180.40
91_L98_T0.7160.40
90_Y266_Y0.7150.40
70_T250_N0.7140.40
179_M251_V0.7100.40
100_E183_M0.7090.40
181_T185_S0.7060.39
288_A345_P0.7030.39
48_Q52_P0.7020.39
81_P177_R0.7000.39
267_L348_V0.6980.39
56_D126_G0.6970.39
68_S94_R0.6960.39
68_S216_G0.6950.39
55_S285_P0.6940.38
71_F247_Q0.6900.38
114_L264_N0.6890.38
197_R263_N0.6890.38
75_I326_A0.6870.38
179_M218_L0.6810.37
179_M208_C0.6810.37
68_S90_Y0.6810.37
90_Y207_Y0.6810.37
212_A266_Y0.6800.37
94_R207_Y0.6800.37
97_D250_N0.6750.37
94_R183_M0.6730.37
103_T153_N0.6720.37
99_V125_C0.6720.37
127_T152_A0.6710.37
156_R159_S0.6690.36
198_I265_V0.6690.36
289_G343_N0.6680.36
50_H170_A0.6680.36
127_T155_T0.6680.36
250_N258_D0.6610.36
226_D239_A0.6610.36
201_P297_R0.6590.36
312_W330_P0.6560.35
88_V160_A0.6550.35
69_R214_T0.6550.35
90_Y183_M0.6550.35
103_T126_G0.6540.35
179_M246_L0.6540.35
46_G51_Q0.6530.35
69_R337_T0.6520.35
91_L326_A0.6510.35
250_N334_A0.6500.35
127_T153_N0.6490.35
99_V113_L0.6470.35
90_Y215_V0.6470.35
108_T112_Q0.6460.35
75_I100_E0.6460.35
347_D354_V0.6450.35
332_L357_D0.6440.35
184_A187_V0.6430.34
372_F375_S0.6310.34
76_D322_N0.6310.34
329_V333_L0.6300.33
182_G208_C0.6270.33
88_V161_F0.6210.33
159_S316_M0.6200.33
243_A251_V0.6180.33
260_E351_E0.6170.32
120_A158_V0.6160.32
75_I251_V0.6150.32
340_E360_E0.6140.32
119_A284_D0.6130.32
315_V365_I0.6110.32
162_E357_D0.6100.32
324_L330_P0.6070.32
96_A183_M0.6070.32
70_T183_M0.6020.31
94_R266_Y0.6000.31
270_E364_V0.5990.31
292_A341_L0.5980.31
46_G55_S0.5980.31
206_E210_Y0.5980.31
75_I183_M0.5970.31
160_A353_D0.5970.31
86_I183_M0.5960.31
366_G370_D0.5960.31
100_E208_C0.5950.31
243_A334_A0.5940.31
107_P302_A0.5910.31
211_V216_G0.5900.30
69_R250_N0.5890.30
74_T242_F0.5890.30
68_S330_P0.5880.30
180_A333_L0.5880.30
242_F253_K0.5880.30
259_Y282_V0.5870.30
108_T284_D0.5870.30
63_A67_V0.5860.30
323_T326_A0.5860.30
183_M212_A0.5840.30
168_A299_T0.5830.30
179_M211_V0.5830.30
203_E323_T0.5820.30
277_L290_R0.5820.30
47_R51_Q0.5770.30
93_C211_V0.5770.30
305_Y309_A0.5770.30
178_E316_M0.5760.29
179_M182_G0.5760.29
211_V253_K0.5720.29
53_T163_S0.5700.29
104_A140_V0.5670.29
208_C298_V0.5670.29
250_N253_K0.5650.29
255_V360_E0.5650.29
265_V279_P0.5640.29
177_R181_T0.5620.28
91_L183_M0.5620.28
208_C215_V0.5600.28
100_E312_W0.5580.28
182_G210_Y0.5580.28
344_R354_V0.5560.28
244_L256_R0.5560.28
215_V251_V0.5550.28
100_E179_M0.5550.28
50_H317_P0.5540.28
215_V247_Q0.5530.28
102_A219_V0.5530.28
213_G244_L0.5520.28
107_P265_V0.5500.28
201_P270_E0.5480.27
336_G360_E0.5460.27
118_D181_T0.5460.27
323_T330_P0.5440.27
205_E305_Y0.5420.27
276_D311_R0.5420.27
107_P188_Q0.5410.27
271_W301_R0.5400.27
47_R368_V0.5400.27
98_T219_V0.5360.27
326_A334_A0.5360.27
189_R197_R0.5350.27
211_V250_N0.5320.26
172_I330_P0.5320.26
242_F361_V0.5310.26
247_Q251_V0.5300.26
81_P168_A0.5300.26
97_D211_V0.5290.26
55_S119_A0.5280.26
89_G253_K0.5260.26
158_V179_M0.5260.26
334_A361_V0.5260.26
74_T330_P0.5250.26
183_M216_G0.5250.26
357_D370_D0.5240.26
83_A371_D0.5240.26
298_V301_R0.5240.26
81_P205_E0.5230.26
93_C248_L0.5220.26
179_M210_Y0.5200.26
197_R265_V0.5200.26
83_A253_K0.5200.26
100_E337_T0.5190.26
86_I171_A0.5180.25
175_T218_L0.5170.25
350_R354_V0.5160.25
242_F264_N0.5160.25
67_V73_L0.5160.25
205_E255_V0.5160.25
367_L371_D0.5150.25
244_L340_E0.5140.25
101_D207_Y0.5130.25
249_V263_N0.5110.25
68_S247_Q0.5100.25
62_S307_A0.5100.25
101_D247_Q0.5090.25
207_Y216_G0.5090.25
325_A329_V0.5090.25
91_L172_I0.5080.25
69_R330_P0.5080.25
88_V164_L0.5070.25
140_V151_V0.5070.25
67_V98_T0.5060.25
105_M140_V0.5060.25
247_Q264_N0.5050.25
114_L176_V0.5050.25
61_H84_T0.5040.25
211_V247_Q0.5030.25
336_G340_E0.5020.24
220_T223_L0.5020.24
59_W156_R0.5000.24
62_S363_A0.5000.24
98_T330_P0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vj8A 1 0.8077 100 0.324 Contact Map
4hd1A 1 0.6744 100 0.339 Contact Map
3wcaA 1 0.7872 100 0.342 Contact Map
3acxA 1 0.7282 100 0.357 Contact Map
3we9A 1 0.6333 100 0.374 Contact Map
3lmdA 2 0.7077 96.9 0.923 Contact Map
3oyrA 2 0.7333 96.5 0.926 Contact Map
3rmgA 2 0.6897 96.3 0.928 Contact Map
1wy0A 2 0.7231 96.3 0.928 Contact Map
3mzvA 2 0.7308 96.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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