GREMLIN Database
Q9HRI4 - 3-hydroxyacyl-CoA dehydrogenase
UniProt: Q9HRI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (279)
Sequences: 8949 (5413)
Seq/√Len: 324.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_D107_D3.1771.00
273_D280_A2.9041.00
40_Q44_D2.7391.00
223_K234_E2.6831.00
11_G84_L2.4951.00
94_A104_I2.4641.00
80_D83_E2.4271.00
280_A284_T2.4261.00
214_S217_D2.3361.00
9_T32_T2.2841.00
95_V100_I2.2501.00
109_D135_D2.2171.00
138_S164_D2.2041.00
141_V171_A2.1861.00
172_H184_E2.1771.00
165_A169_A2.1591.00
27_A75_I2.1541.00
10_I26_A2.1221.00
65_E69_D2.1001.00
136_R139_R2.0821.00
249_E266_Q2.0371.00
47_F77_G2.0251.00
109_D134_T2.0171.00
11_G87_C2.0091.00
155_V175_A1.9811.00
208_F218_I1.9501.00
9_T86_D1.9211.00
98_M129_T1.9011.00
88_D113_P1.8961.00
268_K273_D1.8931.00
94_A100_I1.8821.00
274_L278_T1.8731.00
164_D167_V1.8591.00
26_A174_L1.8561.00
102_Q133_V1.8471.00
58_V68_A1.8051.00
159_V165_A1.7981.00
157_V172_H1.7871.00
107_D110_D1.7781.00
90_V112_L1.7591.00
172_H176_E1.7331.00
9_T34_V1.6941.00
55_D59_S1.6911.00
267_R271_A1.6831.00
115_D139_R1.6701.00
43_V77_G1.6481.00
31_Y177_D1.6421.00
143_L175_A1.6391.00
26_A178_L1.6381.00
120_T127_I1.6331.00
51_E72_V1.6141.00
32_T74_R1.6051.00
112_L116_V1.5931.00
137_A162_K1.5851.00
70_A74_R1.5651.00
143_L171_A1.5561.00
78_T83_E1.5531.00
51_E55_D1.5281.00
242_D277_K1.5271.00
17_T243_V1.5271.00
64_S67_D1.5181.00
47_F51_E1.5121.00
10_I31_Y1.5051.00
67_D70_A1.5041.00
15_A35_M1.4951.00
159_V168_V1.4921.00
181_E220_T1.4851.00
168_V184_E1.4701.00
128_T161_E1.4661.00
213_A218_I1.4601.00
89_V171_A1.4401.00
106_R133_V1.4371.00
105_F118_L1.4231.00
24_Q53_S1.4131.00
245_L266_Q1.4071.00
20_A49_S1.4011.00
55_D68_A1.3961.00
15_A37_D1.3841.00
236_A244_C1.3841.00
39_E42_Y1.3821.00
99_E102_Q1.3731.00
34_V78_T1.3721.00
98_M125_L1.3651.00
44_D48_D1.3631.00
99_E103_D1.3561.00
134_T140_V1.3451.00
112_L118_L1.3441.00
173_A177_D1.3411.00
185_S192_V1.3381.00
103_D106_R1.3371.00
24_Q28_T1.3341.00
245_L249_E1.3181.00
48_D52_S1.3151.00
173_A176_E1.3131.00
169_A173_A1.3061.00
69_D73_D1.3051.00
110_D135_D1.3031.00
36_R81_L1.2961.00
128_T187_D1.2831.00
32_T76_T1.2781.00
28_T71_I1.2781.00
40_Q79_T1.2681.00
82_A107_D1.2581.00
266_Q270_D1.2521.00
208_F215_K1.2511.00
54_L71_I1.2481.00
113_P116_V1.2431.00
175_A182_T1.2401.00
129_T132_S1.2331.00
23_A35_M1.2311.00
105_F108_L1.2251.00
34_V76_T1.2151.00
98_M102_Q1.2151.00
89_V174_L1.2061.00
160_G163_T1.2041.00
106_R110_D1.2011.00
263_Y267_R1.2001.00
102_Q106_R1.1961.00
65_E68_A1.1951.00
245_L269_V1.1921.00
82_A111_A1.1781.00
130_I140_V1.1671.00
58_V63_L1.1591.00
68_A72_V1.1561.00
42_Y45_A1.1541.00
117_V167_V1.1511.00
249_E253_E1.1481.00
41_E44_D1.1271.00
100_I103_D1.1231.00
109_D136_R1.1211.00
43_V79_T1.1191.00
86_D113_P1.1171.00
45_A49_S1.1141.00
141_V167_V1.1131.00
207_A212_V1.1071.00
209_D262_A1.1041.00
119_A141_V1.0961.00
142_G158_V1.0831.00
15_A46_G1.0801.00
127_I142_G1.0761.00
44_D47_F1.0741.00
183_W221_G1.0711.00
105_F130_I1.0631.00
206_R210_E1.0561.00
107_D111_A1.0461.00
36_R78_T1.0281.00
222_M226_T1.0231.00
81_L111_A1.0131.00
13_V104_I1.0081.00
10_I89_V1.0071.00
88_D115_D1.0041.00
128_T160_G1.0031.00
26_A91_I1.0031.00
7_T170_F1.0011.00
51_E68_A1.0001.00
89_V143_L1.0001.00
76_T83_E0.9991.00
35_M46_G0.9981.00
176_E182_T0.9911.00
66_A70_A0.9841.00
56_R59_S0.9731.00
126_S129_T0.9691.00
215_K233_L0.9671.00
205_V282_F0.9641.00
167_V170_F0.9601.00
222_M232_P0.9571.00
36_R107_D0.9541.00
81_L107_D0.9531.00
119_A143_L0.9451.00
49_S52_S0.9431.00
48_D51_E0.9361.00
162_K273_D0.9291.00
124_T247_A0.9261.00
51_E69_D0.9261.00
200_W228_V0.9251.00
13_V108_L0.9231.00
159_V184_E0.9171.00
54_L68_A0.9151.00
141_V157_V0.9071.00
120_T142_G0.8921.00
120_T130_I0.8901.00
138_S162_K0.8901.00
274_L277_K0.8821.00
34_V86_D0.8791.00
43_V47_F0.8751.00
89_V119_A0.8731.00
166_D170_F0.8701.00
102_Q130_I0.8661.00
37_D42_Y0.8621.00
193_T221_G0.8621.00
49_S53_S0.8601.00
27_A71_I0.8581.00
35_M77_G0.8571.00
13_V36_R0.8511.00
55_D58_V0.8471.00
97_D246_D0.8451.00
153_T181_E0.8431.00
234_E238_H0.8401.00
98_M130_I0.8391.00
229_P235_L0.8291.00
82_A85_A0.8251.00
114_E135_D0.8231.00
207_A218_I0.8221.00
131_A140_V0.8211.00
11_G34_V0.8191.00
108_L112_L0.8161.00
196_I200_W0.8151.00
202_N262_A0.8131.00
31_Y174_L0.8101.00
53_S57_F0.8101.00
7_T10_I0.8081.00
169_A172_H0.8071.00
117_V141_V0.8051.00
264_L282_F0.8031.00
220_T223_K0.8021.00
84_L87_C0.8011.00
100_I104_I0.8001.00
71_I74_R0.7981.00
206_R209_D0.7941.00
25_V29_A0.7911.00
171_A175_A0.7871.00
20_A46_G0.7861.00
203_E210_E0.7861.00
145_F178_L0.7831.00
8_E88_D0.7821.00
81_L84_L0.7741.00
24_Q150_P0.7721.00
125_L129_T0.7711.00
105_F134_T0.7681.00
201_I236_A0.7661.00
181_E224_L0.7641.00
7_T88_D0.7610.99
67_D74_R0.7610.99
236_A241_L0.7590.99
252_H256_G0.7580.99
25_V178_L0.7570.99
12_V23_A0.7570.99
206_R262_A0.7570.99
57_F151_I0.7560.99
9_T87_C0.7550.99
38_I42_Y0.7520.99
34_V83_E0.7500.99
146_M193_T0.7470.99
241_L244_C0.7460.99
249_E261_P0.7440.99
57_F63_L0.7430.99
154_G183_W0.7430.99
68_A71_I0.7410.99
172_H182_T0.7380.99
272_G278_T0.7370.99
89_V117_V0.7370.99
183_W192_V0.7330.99
230_M238_H0.7300.99
102_Q132_S0.7290.99
169_A184_E0.7290.99
139_R164_D0.7270.99
241_L269_V0.7250.99
163_T167_V0.7180.99
143_L174_L0.7160.99
143_L157_V0.7150.99
122_T142_G0.7150.99
193_T226_T0.7140.99
102_Q129_T0.7130.99
174_L178_L0.7110.99
198_M244_C0.7080.99
97_D100_I0.7080.99
215_K283_Y0.7080.99
10_I174_L0.7040.99
21_G150_P0.7010.99
52_S55_D0.7000.99
97_D103_D0.6990.99
38_I95_V0.6960.99
50_I75_I0.6940.99
25_V180_K0.6940.99
55_D65_E0.6930.99
217_D220_T0.6930.99
34_V87_C0.6930.99
168_V172_H0.6900.99
157_V182_T0.6900.99
20_A45_A0.6890.99
29_A179_D0.6870.99
57_F62_D0.6870.99
245_L270_D0.6860.99
109_D140_V0.6850.99
81_L104_I0.6800.99
80_D107_D0.6800.99
46_G50_I0.6780.99
165_A184_E0.6760.99
230_M234_E0.6760.99
146_M154_G0.6760.99
216_D220_T0.6750.99
239_I244_C0.6740.99
204_G233_L0.6680.99
195_R203_E0.6680.99
79_T83_E0.6660.99
246_D250_T0.6630.99
126_S187_D0.6620.99
18_M121_N0.6620.99
7_T117_V0.6620.99
7_T31_Y0.6600.99
202_N206_R0.6590.99
18_M22_I0.6570.99
243_V247_A0.6560.99
166_D169_A0.6560.99
220_T224_L0.6540.98
90_V108_L0.6520.98
170_F177_D0.6510.98
267_R270_D0.6490.98
13_V84_L0.6480.98
208_F233_L0.6450.98
197_L201_I0.6450.98
41_E45_A0.6420.98
67_D71_I0.6420.98
154_G221_G0.6390.98
269_V274_L0.6370.98
131_A160_G0.6370.98
70_A73_D0.6360.98
253_E256_G0.6310.98
238_H276_K0.6290.98
132_S162_K0.6270.98
28_T57_F0.6270.98
46_G77_G0.6260.98
205_V236_A0.6240.98
221_G226_T0.6240.98
157_V175_A0.6240.98
50_I53_S0.6190.98
199_P202_N0.6190.98
127_I187_D0.6170.98
273_D278_T0.6120.98
36_R84_L0.6120.98
58_V65_E0.6110.98
209_D263_Y0.6090.98
198_M201_I0.6090.98
147_N239_I0.6090.98
205_V264_L0.6080.98
142_G187_D0.6050.97
22_I93_A0.6040.97
57_F60_N0.6040.97
264_L268_K0.6020.97
58_V61_D0.5990.97
25_V149_V0.5980.97
17_T147_N0.5940.97
233_L282_F0.5890.97
38_I94_A0.5880.97
201_I244_C0.5860.97
8_E177_D0.5860.97
209_D264_L0.5850.97
114_E136_R0.5850.97
11_G36_R0.5840.97
110_D113_P0.5800.97
170_F173_A0.5790.97
123_S194_N0.5780.97
208_F264_L0.5740.97
206_R260_K0.5720.96
249_E252_H0.5710.96
134_T137_A0.5700.96
235_L239_I0.5680.96
15_A23_A0.5670.96
147_N235_L0.5660.96
45_A48_D0.5660.96
108_L111_A0.5660.96
117_V170_F0.5660.96
263_Y266_Q0.5650.96
197_L239_I0.5650.96
213_A217_D0.5650.96
276_K285_Y0.5630.96
119_A171_A0.5620.96
118_L140_V0.5610.96
242_D274_L0.5570.96
113_P139_R0.5550.96
200_W222_M0.5540.96
11_G90_V0.5530.96
252_H260_K0.5520.96
158_V191_F0.5510.96
37_D43_V0.5510.96
202_N248_S0.5510.96
252_H261_P0.5500.96
194_N199_P0.5480.96
246_D249_E0.5460.95
24_Q57_F0.5450.95
82_A110_D0.5420.95
241_L268_K0.5350.95
174_L177_D0.5340.95
176_E181_E0.5320.95
39_E45_A0.5310.95
7_T89_V0.5300.95
59_S65_E0.5260.94
26_A31_Y0.5250.94
118_L136_R0.5240.94
50_I77_G0.5240.94
9_T88_D0.5240.94
108_L118_L0.5230.94
201_I205_V0.5220.94
69_D72_V0.5190.94
217_D225_G0.5190.94
97_D102_Q0.5190.94
118_L134_T0.5190.94
10_I91_I0.5180.94
8_E31_Y0.5180.94
55_D72_V0.5180.94
105_F140_V0.5160.94
53_S56_R0.5160.94
250_T253_E0.5150.94
175_A178_L0.5150.94
240_G277_K0.5140.94
66_A69_D0.5140.94
151_I229_P0.5100.93
11_G78_T0.5100.93
84_L108_L0.5090.93
197_L229_P0.5080.93
139_R166_D0.5070.93
25_V150_P0.5050.93
137_A160_G0.5050.93
240_G243_V0.5030.93
189_P250_T0.5030.93
28_T54_L0.5010.93
193_T199_P0.5000.93
192_V213_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkA 2 0.993 100 0.229 Contact Map
2wtbA 1 0.9301 100 0.238 Contact Map
4b3hA 1 0.993 100 0.243 Contact Map
3zwcA 1 0.986 100 0.257 Contact Map
3k6jA 1 0.9615 100 0.265 Contact Map
1zcjA 1 0.986 100 0.267 Contact Map
4j0eA 2 0.9965 100 0.274 Contact Map
1f0yA 2 0.9895 100 0.291 Contact Map
4r1nA 2 0.979 100 0.298 Contact Map
3mogA 3 0.986 100 0.32 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.