GREMLIN Database
ALF1 - Fructose-bisphosphate aldolase class 1
UniProt: Q9HRI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (240)
Sequences: 1112 (629)
Seq/√Len: 40.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_K221_D4.5391.00
220_I249_V4.3901.00
16_L250_V4.2561.00
214_E218_G4.1471.00
208_S211_D3.6371.00
175_I200_V3.2901.00
219_A224_A3.2441.00
134_A141_V3.2341.00
131_Q141_V3.0251.00
145_S168_A2.8881.00
14_K225_S2.8381.00
210_R214_E2.6791.00
229_V246_L2.5031.00
248_A252_E2.4691.00
162_A189_H2.4601.00
181_P186_A2.4321.00
54_A76_L2.3701.00
108_A140_P2.3291.00
227_L246_L2.2381.00
9_I12_D2.2251.00
53_S251_Y2.2141.00
111_F127_F2.0300.99
158_P162_A2.0250.99
183_S186_A2.0080.99
233_V246_L1.9440.99
180_Y187_M1.9300.99
110_G144_W1.9100.99
169_L196_P1.8750.98
99_D136_D1.8560.98
161_I181_P1.8500.98
102_A139_L1.8340.98
17_I200_V1.8200.98
216_V246_L1.8090.98
100_Y132_E1.7970.98
59_K100_Y1.7880.98
99_D133_A1.7590.98
127_F143_M1.7460.97
78_K144_W1.7270.97
213_L249_V1.6930.97
207_T212_F1.6550.96
14_K220_I1.6440.96
78_K110_G1.6420.96
76_L142_V1.6310.96
212_F242_F1.6240.96
209_D242_F1.6130.96
166_R170_E1.5890.95
99_D137_H1.5870.95
52_V243_L1.5520.95
39_D42_A1.5510.95
212_F229_V1.4990.94
109_V130_A1.4960.94
147_P164_A1.4840.93
189_H192_D1.4810.93
93_A134_A1.4740.93
78_K146_Y1.4610.93
181_P187_M1.4450.92
80_N144_W1.4420.92
23_G170_E1.4310.92
117_S123_M1.4290.92
92_S144_W1.4170.92
97_T132_E1.4050.91
112_T144_W1.4020.91
180_Y218_G1.3890.91
79_L130_A1.3840.91
115_G167_Q1.3820.91
206_K232_N1.3790.91
125_E129_D1.3550.90
96_W100_Y1.3490.90
212_F216_V1.3280.89
78_K114_Y1.3220.89
238_H241_A1.3170.88
217_K253_E1.2860.87
165_A178_V1.2810.87
16_L227_L1.2780.87
213_L245_G1.2730.87
78_K112_T1.2430.85
201_M219_A1.2300.85
24_L81_G1.2240.84
62_A75_L1.2200.84
92_S114_Y1.1980.83
77_A96_W1.1900.83
81_G95_N1.1840.82
92_S110_G1.1700.82
92_S112_T1.1530.81
15_V200_V1.1260.79
122_E125_E1.1150.78
237_E240_A1.0860.77
78_K163_Y1.0790.76
116_G149_G1.0710.75
147_P178_V1.0700.75
42_A46_V1.0680.75
211_D214_E1.0590.75
112_T146_Y1.0510.74
180_Y224_A1.0460.74
182_G186_A1.0460.74
191_V222_A1.0410.73
98_V139_L1.0310.73
110_G146_Y1.0300.73
78_K92_S1.0300.73
80_N110_G1.0270.72
94_V126_E1.0220.72
14_K253_E1.0220.72
93_A121_V1.0210.72
63_E135_R1.0140.71
107_D140_P1.0110.71
46_V240_A1.0040.71
92_S163_Y1.0040.71
56_A144_W1.0000.70
216_V229_V0.9970.70
144_W202_S0.9970.70
147_P228_A0.9820.69
25_E110_G0.9810.69
114_Y144_W0.9790.69
15_V53_S0.9770.69
232_N235_Q0.9770.69
8_P12_D0.9740.68
25_E78_K0.9710.68
220_I224_A0.9690.68
165_A175_I0.9680.68
109_V174_D0.9660.68
161_I178_V0.9590.67
155_D179_K0.9550.67
83_S120_E0.9420.66
94_V130_A0.9420.66
156_K205_S0.9410.66
80_N146_Y0.9380.65
24_L123_M0.9370.65
181_P190_A0.9300.65
17_I54_A0.9290.65
58_Q78_K0.9240.64
23_G166_R0.9230.64
137_H141_V0.9160.63
25_E92_S0.9150.63
45_D249_V0.9150.63
16_L243_L0.9110.63
154_N157_N0.9110.63
161_I190_A0.9080.63
57_A104_V0.9000.62
180_Y219_A0.8970.62
120_E124_A0.8960.62
80_N112_T0.8930.61
142_V228_A0.8920.61
18_L47_A0.8880.61
58_Q144_W0.8870.61
240_A249_V0.8770.60
207_T215_S0.8770.60
185_D188_S0.8760.60
110_G114_Y0.8750.60
80_N113_L0.8680.59
114_Y234_W0.8630.59
79_L98_V0.8560.58
41_E45_D0.8510.58
149_G152_L0.8500.58
37_T166_R0.8490.58
25_E144_W0.8460.57
47_A50_D0.8450.57
143_M168_A0.8410.57
62_A77_A0.8400.57
209_D236_R0.8390.57
56_A110_G0.8390.57
205_S208_S0.8370.56
133_A136_D0.8370.56
38_K189_H0.8360.56
23_G28_P0.8340.56
11_R252_E0.8130.54
96_W132_E0.8100.54
47_A243_L0.8080.54
79_L109_V0.8080.54
50_D243_L0.8070.54
118_N150_Q0.8050.54
136_D208_S0.7990.53
165_A194_A0.7920.52
213_L242_F0.7880.52
26_H117_S0.7820.51
103_D136_D0.7770.51
144_W163_Y0.7770.51
107_D174_D0.7770.51
143_M173_A0.7760.51
24_L80_N0.7750.51
200_V225_S0.7680.50
165_A190_A0.7680.50
108_A167_Q0.7640.50
119_S123_M0.7640.50
16_L247_E0.7540.49
239_P251_Y0.7510.49
109_V134_A0.7500.48
98_V137_H0.7490.48
114_Y163_Y0.7490.48
187_M190_A0.7460.48
245_G248_A0.7440.48
20_Y40_P0.7420.48
74_N107_D0.7410.48
88_G117_S0.7400.48
113_L216_V0.7400.48
25_E31_F0.7360.47
207_T211_D0.7300.47
188_S192_D0.7260.46
213_L232_N0.7240.46
204_G231_R0.7220.46
117_S228_A0.7200.46
17_I76_L0.7180.46
108_A221_D0.7150.45
187_M224_A0.7140.45
111_F131_Q0.7120.45
194_A200_V0.7080.45
107_D182_G0.7080.45
130_A136_D0.7040.44
203_G231_R0.7040.44
44_W104_V0.7040.44
82_T92_S0.7020.44
82_T234_W0.7010.44
100_Y103_D0.7010.44
152_L161_I0.7000.44
154_N164_A0.7000.44
146_Y202_S0.6980.44
19_A144_W0.6980.44
114_Y123_M0.6980.44
37_T170_E0.6930.43
49_H240_A0.6920.43
213_L233_V0.6920.43
169_L197_T0.6910.43
45_D49_H0.6900.43
44_W65_Y0.6890.43
175_I246_L0.6870.43
113_L133_A0.6870.43
91_D119_S0.6850.43
58_Q110_G0.6790.42
112_T173_A0.6780.42
125_E237_E0.6780.42
115_G164_A0.6750.42
14_K128_R0.6730.41
115_G202_S0.6730.41
214_E240_A0.6720.41
25_E112_T0.6710.41
44_W133_A0.6630.41
244_D249_V0.6630.41
98_V109_V0.6620.40
211_D218_G0.6530.40
25_E114_Y0.6520.40
113_L143_M0.6520.40
182_G185_D0.6500.39
201_M215_S0.6490.39
58_Q92_S0.6490.39
168_A176_A0.6490.39
48_T62_A0.6480.39
81_G85_L0.6480.39
80_N202_S0.6480.39
92_S234_W0.6440.39
117_S178_V0.6430.39
198_N251_Y0.6430.39
209_D245_G0.6420.39
28_P234_W0.6410.39
194_A249_V0.6400.39
44_W57_A0.6400.39
183_S218_G0.6380.38
207_T232_N0.6370.38
81_G114_Y0.6350.38
112_T123_M0.6340.38
112_T163_Y0.6340.38
18_L91_D0.6330.38
54_A107_D0.6310.38
213_L253_E0.6290.38
129_D244_D0.6290.38
42_A45_D0.6280.37
38_K197_T0.6270.37
158_P189_H0.6270.37
178_V190_A0.6240.37
210_R213_L0.6210.37
51_A74_N0.6210.37
31_F37_T0.6210.37
177_K231_R0.6210.37
19_A78_K0.6200.37
88_G246_L0.6180.37
19_A82_T0.6140.36
97_T133_A0.6140.36
77_A106_A0.6130.36
180_Y201_M0.6090.36
98_V130_A0.6080.36
220_I250_V0.6070.36
78_K202_S0.6060.36
140_P234_W0.6030.35
173_A198_N0.6030.35
126_E129_D0.6020.35
19_A114_Y0.6020.35
187_M191_V0.6010.35
81_G120_E0.5960.35
18_L52_V0.5940.35
26_H160_T0.5920.34
132_E135_R0.5910.34
208_S215_S0.5900.34
198_N225_S0.5880.34
161_I187_M0.5880.34
187_M201_M0.5870.34
115_G145_S0.5860.34
211_D215_S0.5840.34
63_E227_L0.5840.34
129_D237_E0.5830.34
58_Q146_Y0.5820.34
75_L106_A0.5800.33
14_K252_E0.5790.33
112_T234_W0.5770.33
184_T221_D0.5770.33
117_S148_R0.5750.33
218_G244_D0.5740.33
76_L152_L0.5730.33
82_T131_Q0.5710.33
78_K123_M0.5620.32
145_S197_T0.5620.32
148_R202_S0.5620.32
185_D199_V0.5610.32
40_P210_R0.5610.32
112_T148_R0.5610.32
98_V102_A0.5590.32
134_A137_H0.5580.32
144_W234_W0.5580.32
93_A104_V0.5570.32
178_V187_M0.5550.31
22_H198_N0.5540.31
148_R234_W0.5490.31
214_E217_K0.5490.31
152_L157_N0.5480.31
58_Q113_L0.5460.31
200_V246_L0.5430.30
53_S73_V0.5410.30
19_A92_S0.5410.30
184_T241_A0.5400.30
145_S229_V0.5380.30
49_H214_E0.5350.30
57_A62_A0.5340.30
100_Y118_N0.5330.30
17_I216_V0.5330.30
76_L102_A0.5310.30
156_K178_V0.5290.29
218_G224_A0.5280.29
64_A196_P0.5270.29
125_E188_S0.5250.29
59_K110_G0.5220.29
65_Y70_S0.5210.29
63_E197_T0.5200.29
139_L189_H0.5200.29
150_Q207_T0.5190.29
111_F171_L0.5190.29
48_T70_S0.5160.28
168_A172_G0.5140.28
82_T87_M0.5130.28
48_T61_I0.5130.28
116_G148_R0.5120.28
80_N92_S0.5120.28
191_V229_V0.5100.28
47_A138_D0.5090.28
197_T225_S0.5080.28
221_D249_V0.5080.28
66_Y70_S0.5060.28
111_F126_E0.5050.28
217_K220_I0.5040.27
135_R139_L0.5040.27
80_N126_E0.5040.27
23_G235_Q0.5040.27
239_P250_V0.5010.27
203_G226_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fokA 3 0.9087 100 0.332 Contact Map
4mozA 5 0.9962 100 0.394 Contact Map
3iv3A 2 0.981 100 0.408 Contact Map
1to3A 2 0.9772 100 0.436 Contact Map
3glcA 6 0.9354 100 0.519 Contact Map
1w8sA 4 0.9468 100 0.524 Contact Map
2qjgA 6 0.9772 100 0.569 Contact Map
3oa3A 2 0.8251 100 0.641 Contact Map
3r12A 2 0.8251 100 0.662 Contact Map
3ndoA 2 0.8023 100 0.663 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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