GREMLIN Database
F16PA - Fructose-1,6-bisphosphatase class 1
UniProt: Q9HRI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (280)
Sequences: 1648 (897)
Seq/√Len: 53.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_S255_D4.4681.00
163_D273_D4.3491.00
117_S252_S4.1461.00
247_S279_D3.9801.00
124_F204_N3.5851.00
245_A276_A3.3691.00
236_A246_S3.3381.00
12_I125_V3.1761.00
106_G119_L3.1321.00
245_A272_D3.0891.00
199_M267_T3.0831.00
114_A118_S2.8951.00
160_L239_V2.7831.00
143_E156_G2.7461.00
140_T241_T2.6351.00
245_A279_D2.6221.00
48_D69_R2.6021.00
248_D251_Q2.5491.00
203_V269_V2.5451.00
35_A38_D2.4901.00
99_N196_G2.4651.00
52_F69_R2.3511.00
105_V123_G2.2951.00
55_T84_V2.2851.00
136_A237_Y2.2771.00
15_A51_L2.2481.00
61_V84_V2.2031.00
51_L103_T2.1751.00
199_M203_V2.1711.00
212_V278_L2.1601.00
203_V239_V2.0961.00
12_I152_T2.0771.00
173_V185_R2.0061.00
65_A261_L1.9971.00
186_D281_A1.9751.00
240_E252_S1.9671.00
181_E185_R1.9251.00
235_I269_V1.9171.00
145_L155_L1.8730.99
162_A273_D1.8680.99
232_A267_T1.8380.99
186_D277_A1.8290.99
268_F275_I1.7940.99
272_D276_A1.7550.99
179_A282_L1.7330.99
99_N198_A1.7070.99
176_W184_V1.6940.99
138_D241_T1.6510.99
143_E158_V1.6460.98
136_A238_I1.6420.98
248_D256_V1.6220.98
178_P182_S1.6200.98
275_I278_L1.6140.98
268_F278_L1.6110.98
143_E157_P1.6030.98
40_Q45_V1.5990.98
69_R73_V1.5610.98
232_A265_T1.5460.98
97_S198_A1.5410.98
34_N37_G1.5140.97
168_G197_G1.4950.97
29_T39_T1.4780.97
52_F73_V1.4770.97
159_E162_A1.4730.97
259_T263_E1.4250.96
256_V263_E1.4090.96
228_A233_L1.3960.96
246_S252_S1.3770.95
252_S255_D1.3620.95
253_L256_V1.3480.95
48_D52_F1.3430.95
173_V181_E1.3350.95
165_T189_D1.3330.95
31_D39_T1.3300.94
276_A280_A1.3260.94
136_A241_T1.3240.94
20_R148_E1.2970.94
63_W83_A1.2970.94
63_W112_L1.2820.93
237_Y254_L1.2800.93
63_W72_V1.2800.93
162_A272_D1.2790.93
232_A253_L1.2770.93
228_A263_E1.2690.93
248_D268_F1.2690.93
182_S281_A1.2570.93
16_A131_T1.2470.92
85_A106_G1.2380.92
156_G208_V1.2200.91
68_E227_R1.2180.91
132_T143_E1.2150.91
67_E92_S1.2030.91
64_Y86_L1.1970.91
37_G40_Q1.1930.91
166_V209_Y1.1920.90
203_V267_T1.1880.90
29_T41_L1.1770.90
248_D253_L1.1750.90
100_P198_A1.1530.89
178_P181_E1.1400.88
164_P271_T1.1390.88
51_L86_L1.1330.88
4_V82_Y1.1330.88
172_R218_M1.1330.88
183_F187_V1.1190.87
171_G190_D1.1170.87
169_F214_G1.1110.87
6_D10_D1.1030.87
7_A58_I1.0990.87
34_N40_Q1.0970.86
239_V244_G1.0860.86
49_D53_D1.0800.86
8_V55_T1.0740.85
217_G221_A1.0680.85
8_V125_V1.0600.84
277_A280_A1.0510.84
76_G79_E1.0460.84
137_R142_R1.0450.84
233_L258_P1.0430.83
44_D68_E1.0340.83
202_D225_K1.0250.82
115_P118_S1.0240.82
138_D237_Y1.0220.82
136_A140_T1.0020.81
227_R231_E0.9940.80
108_Y233_L0.9930.80
44_D92_S0.9900.80
214_G268_F0.9870.80
8_V12_I0.9850.80
115_P257_A0.9740.79
68_E92_S0.9730.79
134_V143_E0.9700.79
97_S209_Y0.9680.79
171_G192_K0.9640.78
40_Q68_E0.9480.77
15_A47_A0.9480.77
169_F184_V0.9340.76
34_N44_D0.9330.76
30_R39_T0.9320.76
191_L274_V0.9290.76
13_A150_G0.9280.76
11_A50_L0.9250.75
28_A42_E0.9230.75
19_V101_C0.9220.75
100_P126_L0.9210.75
21_A149_T0.9210.75
92_S227_R0.9210.75
249_G268_F0.9210.75
132_T156_G0.9200.75
197_G202_D0.9160.75
163_D274_V0.9150.75
116_G258_P0.9150.75
177_T282_L0.9140.74
176_W218_M0.9140.74
224_G266_P0.9140.74
251_Q255_D0.9130.74
175_D219_E0.9080.74
180_F282_L0.9050.74
235_I267_T0.9040.74
95_V101_C0.9020.74
119_L233_L0.9010.73
278_L282_L0.9010.73
134_V238_I0.9010.73
170_G205_Q0.8930.73
214_G278_L0.8920.73
34_N68_E0.8910.73
65_A112_L0.8820.72
160_L244_G0.8640.70
160_L271_T0.8640.70
239_V269_V0.8600.70
111_P118_S0.8580.70
67_E227_R0.8580.70
215_Y224_G0.8560.70
16_A146_V0.8550.69
198_A201_A0.8540.69
33_Q39_T0.8530.69
87_D92_S0.8520.69
207_L239_V0.8510.69
122_A237_Y0.8490.69
30_R45_V0.8480.69
175_D190_D0.8440.68
61_V75_V0.8440.68
277_A281_A0.8390.68
247_S251_Q0.8380.68
236_A253_L0.8380.68
199_M269_V0.8320.67
174_P190_D0.8320.67
103_T127_Y0.8280.67
274_V277_A0.8230.66
253_L267_T0.8210.66
64_Y75_V0.8210.66
17_P149_T0.8200.66
134_V158_V0.8180.66
82_Y120_V0.8180.66
4_V13_A0.8100.65
44_D67_E0.8040.65
158_V208_V0.8040.65
65_A85_A0.7970.64
93_S104_V0.7970.64
85_A229_Q0.7920.64
177_T217_G0.7920.64
139_D241_T0.7900.63
140_T144_S0.7890.63
116_G254_L0.7880.63
143_E155_L0.7850.63
117_S254_L0.7850.63
40_Q227_R0.7810.62
48_D86_L0.7810.62
249_G266_P0.7800.62
42_E96_K0.7780.62
125_V155_L0.7720.62
187_V278_L0.7710.61
74_T80_G0.7700.61
166_V195_Y0.7700.61
273_D276_A0.7690.61
38_D264_R0.7650.61
4_V61_V0.7650.61
37_G68_E0.7640.61
10_D151_A0.7580.60
55_T61_V0.7530.60
170_G230_F0.7460.59
40_Q44_D0.7390.58
175_D220_S0.7320.57
223_D260_R0.7320.57
195_Y209_Y0.7310.57
206_V209_Y0.7290.57
247_S275_I0.7290.57
180_F268_F0.7280.57
68_E231_E0.7250.57
182_S186_D0.7230.56
203_V235_I0.7210.56
9_F133_M0.7180.56
167_Y193_L0.7170.56
164_P191_L0.7150.56
212_V268_F0.7140.56
14_D53_D0.7130.55
164_P195_Y0.7120.55
199_M213_F0.7080.55
56_E75_V0.7050.55
210_G216_P0.7050.55
228_A253_L0.7010.54
280_A283_P0.6990.54
7_A57_S0.6980.54
136_A254_L0.6970.54
14_D18_E0.6920.53
256_V265_T0.6920.53
183_F281_A0.6910.53
268_F279_D0.6910.53
192_K195_Y0.6910.53
34_N38_D0.6910.53
172_R220_S0.6910.53
14_D17_P0.6900.53
44_D227_R0.6900.53
72_V261_L0.6890.53
248_D279_D0.6880.53
87_D91_G0.6820.52
88_P91_G0.6810.52
99_N126_L0.6810.52
31_D34_N0.6790.52
15_A86_L0.6770.52
17_P148_E0.6770.52
196_G206_V0.6760.52
52_F56_E0.6750.51
59_E76_G0.6720.51
199_M239_V0.6690.51
44_D87_D0.6670.51
50_L54_R0.6620.50
217_G266_P0.6620.50
169_F201_A0.6590.50
117_S240_E0.6590.50
5_I137_R0.6560.49
40_Q274_V0.6550.49
55_T73_V0.6550.49
85_A112_L0.6550.49
86_L95_V0.6540.49
36_S264_R0.6540.49
83_A112_L0.6490.49
34_N227_R0.6470.48
229_Q233_L0.6450.48
38_D227_R0.6430.48
8_V103_T0.6420.48
101_C180_F0.6410.48
37_G44_D0.6400.48
186_D191_L0.6390.48
57_S76_G0.6390.48
203_V225_K0.6380.47
196_G201_A0.6370.47
89_L98_N0.6370.47
28_A96_K0.6360.47
67_E87_D0.6320.47
144_S228_A0.6300.47
75_V79_E0.6290.47
83_A108_Y0.6290.47
15_A19_V0.6260.46
233_L263_E0.6260.46
131_T146_V0.6250.46
182_S185_R0.6250.46
41_L209_Y0.6240.46
8_V51_L0.6230.46
121_A191_L0.6210.46
126_L201_A0.6190.45
129_P149_T0.6140.45
228_A232_A0.6120.45
251_Q268_F0.6120.45
268_F282_L0.6110.45
142_R154_D0.6080.44
109_D120_V0.6070.44
34_N67_E0.6070.44
107_I177_T0.6070.44
80_G120_V0.6060.44
183_F278_L0.6050.44
180_F214_G0.6050.44
228_A256_V0.6040.44
7_A151_A0.6030.44
186_D278_L0.6010.44
163_D277_A0.6010.44
66_S87_D0.5990.43
233_L253_L0.5980.43
85_A261_L0.5980.43
6_D58_I0.5970.43
117_S251_Q0.5950.43
142_R157_P0.5950.43
161_P271_T0.5940.43
117_S238_I0.5930.43
34_N213_F0.5870.42
179_A281_A0.5860.42
103_T240_E0.5850.42
9_F54_R0.5820.42
57_S61_V0.5810.42
55_T266_P0.5800.41
164_P208_V0.5790.41
164_P171_G0.5760.41
71_A74_T0.5760.41
21_A148_E0.5750.41
18_E50_L0.5750.41
54_R75_V0.5740.41
172_R187_V0.5740.41
72_V112_L0.5710.40
195_Y225_K0.5700.40
23_L26_H0.5700.40
29_T239_V0.5670.40
36_S48_D0.5670.40
144_S154_D0.5670.40
63_W85_A0.5660.40
103_T123_G0.5650.40
248_D265_T0.5650.40
87_D227_R0.5650.40
68_E93_S0.5640.40
41_L95_V0.5630.40
64_Y73_V0.5630.40
197_G281_A0.5630.40
213_F225_K0.5600.39
238_I271_T0.5590.39
115_P252_S0.5580.39
187_V274_V0.5570.39
197_G282_L0.5550.39
94_N170_G0.5550.39
68_E215_Y0.5540.39
177_T250_T0.5540.39
10_D54_R0.5530.39
97_S271_T0.5530.39
4_V64_Y0.5490.38
108_Y114_A0.5480.38
113_P258_P0.5460.38
171_G195_Y0.5420.38
116_G228_A0.5410.37
88_P227_R0.5410.37
7_A11_A0.5400.37
67_E226_L0.5400.37
175_D192_K0.5360.37
143_E208_V0.5360.37
245_A251_Q0.5340.37
59_E98_N0.5330.37
10_D13_A0.5320.37
171_G193_L0.5310.36
16_A20_R0.5310.36
35_A70_D0.5300.36
170_G262_H0.5290.36
130_T205_Q0.5290.36
19_V165_T0.5280.36
180_F278_L0.5260.36
38_D68_E0.5240.36
10_D17_P0.5220.36
166_V171_G0.5220.36
111_P250_T0.5220.36
237_Y241_T0.5220.36
94_N198_A0.5220.36
37_G92_S0.5210.35
3_D146_V0.5210.35
94_N262_H0.5210.35
158_V265_T0.5200.35
6_D9_F0.5190.35
10_D150_G0.5180.35
209_Y282_L0.5180.35
66_S92_S0.5170.35
37_G227_R0.5170.35
23_L153_T0.5150.35
98_N131_T0.5140.35
16_A176_W0.5140.35
19_V100_P0.5140.35
169_F180_F0.5120.35
169_F192_K0.5120.35
236_A279_D0.5120.35
35_A264_R0.5110.35
168_G192_K0.5110.35
37_G226_L0.5110.35
51_L65_A0.5110.35
89_L266_P0.5100.34
171_G268_F0.5090.34
98_N129_P0.5090.34
49_D208_V0.5080.34
66_S227_R0.5070.34
63_W74_T0.5070.34
7_A51_L0.5070.34
166_V192_K0.5040.34
157_P259_T0.5030.34
32_D45_V0.5020.34
43_A95_V0.5020.34
246_S253_L0.5010.34
112_L119_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dcuA 4 0.9582 100 0.337 Contact Map
2fhyA 4 0.9617 100 0.376 Contact Map
2gq1A 3 0.9268 100 0.426 Contact Map
1nuwA 3 0.9965 100 0.429 Contact Map
4ir8A 2 0.9791 100 0.436 Contact Map
2bjiA 2 0.8955 99.9 0.768 Contact Map
1lbvA 2 0.8606 99.9 0.77 Contact Map
4i3yA 2 0.8676 99.9 0.774 Contact Map
1xi6A 1 0.8014 99.9 0.778 Contact Map
2qflA 1 0.8815 99.9 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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