F16PA - HALSA - GREMLIN Contacts

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F16PA - Fructose-1,6-bisphosphatase class 1

UniProt:	Q9HRI1	Sequences: MADVIDAVFDAIADAAPEVRAGLPDHRATRDDQNASGDTQLEADVWADDLLFDRTESIEGVNWYASEERDAVVTVGDAEGGYAVALDPLDGSSNVKSNNPCGTVVGIYDQPLPAPGSSLVAAGFVLYGPTTTMVVARDDTVRESLVSETGATTDLGPVELPADPTVYGFGGRVPDWTPAFESFVRDVEDDLKLRYGGAMIADVNQVLVYGGVFGYPGMESAPDGKLRAQFEALPIAYIVETAGGASSDGTQSLLDVAPTRLHERTPTFVGTDDVIAALDAALPDHTN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	287 (280)
Sequences:	1648 (897)
Seq/√Len:	53.6

ECOLI - F16PA
HALSA - F16PA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
117_S	255_D	4.468	1.00
163_D	273_D	4.349	1.00
117_S	252_S	4.146	1.00
247_S	279_D	3.980	1.00
124_F	204_N	3.585	1.00
245_A	276_A	3.369	1.00
236_A	246_S	3.338	1.00
12_I	125_V	3.176	1.00
106_G	119_L	3.132	1.00
245_A	272_D	3.089	1.00
199_M	267_T	3.083	1.00
114_A	118_S	2.895	1.00
160_L	239_V	2.783	1.00
143_E	156_G	2.746	1.00
140_T	241_T	2.635	1.00
245_A	279_D	2.622	1.00
48_D	69_R	2.602	1.00
248_D	251_Q	2.549	1.00
203_V	269_V	2.545	1.00
35_A	38_D	2.490	1.00
99_N	196_G	2.465	1.00
52_F	69_R	2.351	1.00
105_V	123_G	2.295	1.00
55_T	84_V	2.285	1.00
136_A	237_Y	2.277	1.00
15_A	51_L	2.248	1.00
61_V	84_V	2.203	1.00
51_L	103_T	2.175	1.00
199_M	203_V	2.171	1.00
212_V	278_L	2.160	1.00
203_V	239_V	2.096	1.00
12_I	152_T	2.077	1.00
173_V	185_R	2.006	1.00
65_A	261_L	1.997	1.00
186_D	281_A	1.975	1.00
240_E	252_S	1.967	1.00
181_E	185_R	1.925	1.00
235_I	269_V	1.917	1.00
145_L	155_L	1.873	0.99
162_A	273_D	1.868	0.99
232_A	267_T	1.838	0.99
186_D	277_A	1.829	0.99
268_F	275_I	1.794	0.99
272_D	276_A	1.755	0.99
179_A	282_L	1.733	0.99
99_N	198_A	1.707	0.99
176_W	184_V	1.694	0.99
138_D	241_T	1.651	0.99
143_E	158_V	1.646	0.98
136_A	238_I	1.642	0.98
248_D	256_V	1.622	0.98
178_P	182_S	1.620	0.98
275_I	278_L	1.614	0.98
268_F	278_L	1.611	0.98
143_E	157_P	1.603	0.98
40_Q	45_V	1.599	0.98
69_R	73_V	1.561	0.98
232_A	265_T	1.546	0.98
97_S	198_A	1.541	0.98
34_N	37_G	1.514	0.97
168_G	197_G	1.495	0.97
29_T	39_T	1.478	0.97
52_F	73_V	1.477	0.97
159_E	162_A	1.473	0.97
259_T	263_E	1.425	0.96
256_V	263_E	1.409	0.96
228_A	233_L	1.396	0.96
246_S	252_S	1.377	0.95
252_S	255_D	1.362	0.95
253_L	256_V	1.348	0.95
48_D	52_F	1.343	0.95
173_V	181_E	1.335	0.95
165_T	189_D	1.333	0.95
31_D	39_T	1.330	0.94
276_A	280_A	1.326	0.94
136_A	241_T	1.324	0.94
20_R	148_E	1.297	0.94
63_W	83_A	1.297	0.94
63_W	112_L	1.282	0.93
237_Y	254_L	1.280	0.93
63_W	72_V	1.280	0.93
162_A	272_D	1.279	0.93
232_A	253_L	1.277	0.93
228_A	263_E	1.269	0.93
248_D	268_F	1.269	0.93
182_S	281_A	1.257	0.93
16_A	131_T	1.247	0.92
85_A	106_G	1.238	0.92
156_G	208_V	1.220	0.91
68_E	227_R	1.218	0.91
132_T	143_E	1.215	0.91
67_E	92_S	1.203	0.91
64_Y	86_L	1.197	0.91
37_G	40_Q	1.193	0.91
166_V	209_Y	1.192	0.90
203_V	267_T	1.188	0.90
29_T	41_L	1.177	0.90
248_D	253_L	1.175	0.90
100_P	198_A	1.153	0.89
178_P	181_E	1.140	0.88
164_P	271_T	1.139	0.88
51_L	86_L	1.133	0.88
4_V	82_Y	1.133	0.88
172_R	218_M	1.133	0.88
183_F	187_V	1.119	0.87
171_G	190_D	1.117	0.87
169_F	214_G	1.111	0.87
6_D	10_D	1.103	0.87
7_A	58_I	1.099	0.87
34_N	40_Q	1.097	0.86
239_V	244_G	1.086	0.86
49_D	53_D	1.080	0.86
8_V	55_T	1.074	0.85
217_G	221_A	1.068	0.85
8_V	125_V	1.060	0.84
277_A	280_A	1.051	0.84
76_G	79_E	1.046	0.84
137_R	142_R	1.045	0.84
233_L	258_P	1.043	0.83
44_D	68_E	1.034	0.83
202_D	225_K	1.025	0.82
115_P	118_S	1.024	0.82
138_D	237_Y	1.022	0.82
136_A	140_T	1.002	0.81
227_R	231_E	0.994	0.80
108_Y	233_L	0.993	0.80
44_D	92_S	0.990	0.80
214_G	268_F	0.987	0.80
8_V	12_I	0.985	0.80
115_P	257_A	0.974	0.79
68_E	92_S	0.973	0.79
134_V	143_E	0.970	0.79
97_S	209_Y	0.968	0.79
171_G	192_K	0.964	0.78
40_Q	68_E	0.948	0.77
15_A	47_A	0.948	0.77
169_F	184_V	0.934	0.76
34_N	44_D	0.933	0.76
30_R	39_T	0.932	0.76
191_L	274_V	0.929	0.76
13_A	150_G	0.928	0.76
11_A	50_L	0.925	0.75
28_A	42_E	0.923	0.75
19_V	101_C	0.922	0.75
100_P	126_L	0.921	0.75
21_A	149_T	0.921	0.75
92_S	227_R	0.921	0.75
249_G	268_F	0.921	0.75
132_T	156_G	0.920	0.75
197_G	202_D	0.916	0.75
163_D	274_V	0.915	0.75
116_G	258_P	0.915	0.75
177_T	282_L	0.914	0.74
176_W	218_M	0.914	0.74
224_G	266_P	0.914	0.74
251_Q	255_D	0.913	0.74
175_D	219_E	0.908	0.74
180_F	282_L	0.905	0.74
235_I	267_T	0.904	0.74
95_V	101_C	0.902	0.74
119_L	233_L	0.901	0.73
278_L	282_L	0.901	0.73
134_V	238_I	0.901	0.73
170_G	205_Q	0.893	0.73
214_G	278_L	0.892	0.73
34_N	68_E	0.891	0.73
65_A	112_L	0.882	0.72
160_L	244_G	0.864	0.70
160_L	271_T	0.864	0.70
239_V	269_V	0.860	0.70
111_P	118_S	0.858	0.70
67_E	227_R	0.858	0.70
215_Y	224_G	0.856	0.70
16_A	146_V	0.855	0.69
198_A	201_A	0.854	0.69
33_Q	39_T	0.853	0.69
87_D	92_S	0.852	0.69
207_L	239_V	0.851	0.69
122_A	237_Y	0.849	0.69
30_R	45_V	0.848	0.69
175_D	190_D	0.844	0.68
61_V	75_V	0.844	0.68
277_A	281_A	0.839	0.68
247_S	251_Q	0.838	0.68
236_A	253_L	0.838	0.68
199_M	269_V	0.832	0.67
174_P	190_D	0.832	0.67
103_T	127_Y	0.828	0.67
274_V	277_A	0.823	0.66
253_L	267_T	0.821	0.66
64_Y	75_V	0.821	0.66
17_P	149_T	0.820	0.66
134_V	158_V	0.818	0.66
82_Y	120_V	0.818	0.66
4_V	13_A	0.810	0.65
44_D	67_E	0.804	0.65
158_V	208_V	0.804	0.65
65_A	85_A	0.797	0.64
93_S	104_V	0.797	0.64
85_A	229_Q	0.792	0.64
177_T	217_G	0.792	0.64
139_D	241_T	0.790	0.63
140_T	144_S	0.789	0.63
116_G	254_L	0.788	0.63
143_E	155_L	0.785	0.63
117_S	254_L	0.785	0.63
40_Q	227_R	0.781	0.62
48_D	86_L	0.781	0.62
249_G	266_P	0.780	0.62
42_E	96_K	0.778	0.62
125_V	155_L	0.772	0.62
187_V	278_L	0.771	0.61
74_T	80_G	0.770	0.61
166_V	195_Y	0.770	0.61
273_D	276_A	0.769	0.61
38_D	264_R	0.765	0.61
4_V	61_V	0.765	0.61
37_G	68_E	0.764	0.61
10_D	151_A	0.758	0.60
55_T	61_V	0.753	0.60
170_G	230_F	0.746	0.59
40_Q	44_D	0.739	0.58
175_D	220_S	0.732	0.57
223_D	260_R	0.732	0.57
195_Y	209_Y	0.731	0.57
206_V	209_Y	0.729	0.57
247_S	275_I	0.729	0.57
180_F	268_F	0.728	0.57
68_E	231_E	0.725	0.57
182_S	186_D	0.723	0.56
203_V	235_I	0.721	0.56
9_F	133_M	0.718	0.56
167_Y	193_L	0.717	0.56
164_P	191_L	0.715	0.56
212_V	268_F	0.714	0.56
14_D	53_D	0.713	0.55
164_P	195_Y	0.712	0.55
199_M	213_F	0.708	0.55
56_E	75_V	0.705	0.55
210_G	216_P	0.705	0.55
228_A	253_L	0.701	0.54
280_A	283_P	0.699	0.54
7_A	57_S	0.698	0.54
136_A	254_L	0.697	0.54
14_D	18_E	0.692	0.53
256_V	265_T	0.692	0.53
183_F	281_A	0.691	0.53
268_F	279_D	0.691	0.53
192_K	195_Y	0.691	0.53
34_N	38_D	0.691	0.53
172_R	220_S	0.691	0.53
14_D	17_P	0.690	0.53
44_D	227_R	0.690	0.53
72_V	261_L	0.689	0.53
248_D	279_D	0.688	0.53
87_D	91_G	0.682	0.52
88_P	91_G	0.681	0.52
99_N	126_L	0.681	0.52
31_D	34_N	0.679	0.52
15_A	86_L	0.677	0.52
17_P	148_E	0.677	0.52
196_G	206_V	0.676	0.52
52_F	56_E	0.675	0.51
59_E	76_G	0.672	0.51
199_M	239_V	0.669	0.51
44_D	87_D	0.667	0.51
50_L	54_R	0.662	0.50
217_G	266_P	0.662	0.50
169_F	201_A	0.659	0.50
117_S	240_E	0.659	0.50
5_I	137_R	0.656	0.49
40_Q	274_V	0.655	0.49
55_T	73_V	0.655	0.49
85_A	112_L	0.655	0.49
86_L	95_V	0.654	0.49
36_S	264_R	0.654	0.49
83_A	112_L	0.649	0.49
34_N	227_R	0.647	0.48
229_Q	233_L	0.645	0.48
38_D	227_R	0.643	0.48
8_V	103_T	0.642	0.48
101_C	180_F	0.641	0.48
37_G	44_D	0.640	0.48
186_D	191_L	0.639	0.48
57_S	76_G	0.639	0.48
203_V	225_K	0.638	0.47
196_G	201_A	0.637	0.47
89_L	98_N	0.637	0.47
28_A	96_K	0.636	0.47
67_E	87_D	0.632	0.47
144_S	228_A	0.630	0.47
75_V	79_E	0.629	0.47
83_A	108_Y	0.629	0.47
15_A	19_V	0.626	0.46
233_L	263_E	0.626	0.46
131_T	146_V	0.625	0.46
182_S	185_R	0.625	0.46
41_L	209_Y	0.624	0.46
8_V	51_L	0.623	0.46
121_A	191_L	0.621	0.46
126_L	201_A	0.619	0.45
129_P	149_T	0.614	0.45
228_A	232_A	0.612	0.45
251_Q	268_F	0.612	0.45
268_F	282_L	0.611	0.45
142_R	154_D	0.608	0.44
109_D	120_V	0.607	0.44
34_N	67_E	0.607	0.44
107_I	177_T	0.607	0.44
80_G	120_V	0.606	0.44
183_F	278_L	0.605	0.44
180_F	214_G	0.605	0.44
228_A	256_V	0.604	0.44
7_A	151_A	0.603	0.44
186_D	278_L	0.601	0.44
163_D	277_A	0.601	0.44
66_S	87_D	0.599	0.43
233_L	253_L	0.598	0.43
85_A	261_L	0.598	0.43
6_D	58_I	0.597	0.43
117_S	251_Q	0.595	0.43
142_R	157_P	0.595	0.43
161_P	271_T	0.594	0.43
117_S	238_I	0.593	0.43
34_N	213_F	0.587	0.42
179_A	281_A	0.586	0.42
103_T	240_E	0.585	0.42
9_F	54_R	0.582	0.42
57_S	61_V	0.581	0.42
55_T	266_P	0.580	0.41
164_P	208_V	0.579	0.41
164_P	171_G	0.576	0.41
71_A	74_T	0.576	0.41
21_A	148_E	0.575	0.41
18_E	50_L	0.575	0.41
54_R	75_V	0.574	0.41
172_R	187_V	0.574	0.41
72_V	112_L	0.571	0.40
195_Y	225_K	0.570	0.40
23_L	26_H	0.570	0.40
29_T	239_V	0.567	0.40
36_S	48_D	0.567	0.40
144_S	154_D	0.567	0.40
63_W	85_A	0.566	0.40
103_T	123_G	0.565	0.40
248_D	265_T	0.565	0.40
87_D	227_R	0.565	0.40
68_E	93_S	0.564	0.40
41_L	95_V	0.563	0.40
64_Y	73_V	0.563	0.40
197_G	281_A	0.563	0.40
213_F	225_K	0.560	0.39
238_I	271_T	0.559	0.39
115_P	252_S	0.558	0.39
187_V	274_V	0.557	0.39
197_G	282_L	0.555	0.39
94_N	170_G	0.555	0.39
68_E	215_Y	0.554	0.39
177_T	250_T	0.554	0.39
10_D	54_R	0.553	0.39
97_S	271_T	0.553	0.39
4_V	64_Y	0.549	0.38
108_Y	114_A	0.548	0.38
113_P	258_P	0.546	0.38
171_G	195_Y	0.542	0.38
116_G	228_A	0.541	0.37
88_P	227_R	0.541	0.37
7_A	11_A	0.540	0.37
67_E	226_L	0.540	0.37
175_D	192_K	0.536	0.37
143_E	208_V	0.536	0.37
245_A	251_Q	0.534	0.37
59_E	98_N	0.533	0.37
10_D	13_A	0.532	0.37
171_G	193_L	0.531	0.36
16_A	20_R	0.531	0.36
35_A	70_D	0.530	0.36
170_G	262_H	0.529	0.36
130_T	205_Q	0.529	0.36
19_V	165_T	0.528	0.36
180_F	278_L	0.526	0.36
38_D	68_E	0.524	0.36
10_D	17_P	0.522	0.36
166_V	171_G	0.522	0.36
111_P	250_T	0.522	0.36
237_Y	241_T	0.522	0.36
94_N	198_A	0.522	0.36
37_G	92_S	0.521	0.35
3_D	146_V	0.521	0.35
94_N	262_H	0.521	0.35
158_V	265_T	0.520	0.35
6_D	9_F	0.519	0.35
10_D	150_G	0.518	0.35
209_Y	282_L	0.518	0.35
66_S	92_S	0.517	0.35
37_G	227_R	0.517	0.35
23_L	153_T	0.515	0.35
98_N	131_T	0.514	0.35
16_A	176_W	0.514	0.35
19_V	100_P	0.514	0.35
169_F	180_F	0.512	0.35
169_F	192_K	0.512	0.35
236_A	279_D	0.512	0.35
35_A	264_R	0.511	0.35
168_G	192_K	0.511	0.35
37_G	226_L	0.511	0.35
51_L	65_A	0.511	0.35
89_L	266_P	0.510	0.34
171_G	268_F	0.509	0.34
98_N	129_P	0.509	0.34
49_D	208_V	0.508	0.34
66_S	227_R	0.507	0.34
63_W	74_T	0.507	0.34
7_A	51_L	0.507	0.34
166_V	192_K	0.504	0.34
157_P	259_T	0.503	0.34
32_D	45_V	0.502	0.34
43_A	95_V	0.502	0.34
246_S	253_L	0.501	0.34
112_L	119_L	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1dcuA	4	0.9582	100	0.337	Contact Map
2fhyA	4	0.9617	100	0.376	Contact Map
2gq1A	3	0.9268	100	0.426	Contact Map
1nuwA	3	0.9965	100	0.429	Contact Map
4ir8A	2	0.9791	100	0.436	Contact Map
2bjiA	2	0.8955	99.9	0.768	Contact Map
1lbvA	2	0.8606	99.9	0.77	Contact Map
4i3yA	2	0.8676	99.9	0.774	Contact Map
1xi6A	1	0.8014	99.9	0.778	Contact Map
2qflA	1	0.8815	99.9	0.782	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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