GREMLIN Database
Q9HRI0 - Uncharacterized protein
UniProt: Q9HRI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (207)
Sequences: 3262 (2333)
Seq/√Len: 162.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_L159_F4.3771.00
96_V124_L4.2671.00
77_L162_V4.1721.00
39_V51_A4.0301.00
127_L160_T3.8741.00
28_T221_D3.5481.00
18_F123_L3.5011.00
93_L186_G3.3871.00
214_A222_R2.7071.00
98_G113_F2.6531.00
182_T185_Q2.6191.00
110_V210_R2.5831.00
92_C126_G2.4261.00
86_A129_E2.4211.00
41_L49_V2.3391.00
74_A162_V2.3321.00
115_S207_Q2.2581.00
124_L161_V2.1881.00
115_S209_W2.0841.00
81_R84_Q2.0171.00
114_V173_Y1.8811.00
130_T157_R1.8621.00
93_L123_L1.8611.00
71_N174_H1.8281.00
101_E174_H1.7891.00
90_R129_E1.7691.00
123_L186_G1.7341.00
17_T186_G1.7161.00
69_P82_H1.7031.00
78_T87_Y1.6931.00
185_Q188_R1.6521.00
94_V159_F1.6301.00
5_Y37_L1.6121.00
167_N177_M1.6031.00
31_A37_L1.5891.00
46_T187_Q1.5831.00
99_F170_L1.5811.00
214_A224_A1.5481.00
6_A113_F1.5481.00
72_A160_T1.5451.00
105_E108_A1.5371.00
9_S97_D1.5181.00
12_E16_E1.5121.00
212_S216_N1.4731.00
114_V170_L1.4681.00
56_V156_V1.4561.00
180_V206_L1.4421.00
202_G206_L1.4381.00
94_V161_V1.4251.00
74_A199_F1.4251.00
77_L87_Y1.4161.00
39_V159_F1.4161.00
28_T35_Q1.4141.00
130_T155_T1.4011.00
116_R120_A1.3901.00
10_T13_T1.3831.00
122_F206_L1.3291.00
168_A171_A1.3281.00
169_F204_F1.3041.00
78_T196_T1.3001.00
102_W109_T1.2891.00
132_T155_T1.2751.00
183_P186_G1.2721.00
5_Y96_V1.2561.00
7_L31_A1.2531.00
41_L128_W1.2481.00
213_T216_N1.2041.00
28_T31_A1.1981.00
116_R122_F1.1911.00
30_N111_P1.1741.00
181_L185_Q1.1701.00
39_V92_C1.1531.00
131_W134_E1.1511.00
76_T80_T1.1481.00
164_T201_P1.1371.00
164_T179_V1.1261.00
108_A213_T1.1141.00
39_V94_V1.1141.00
85_A88_E1.1091.00
203_A206_L1.1061.00
114_V208_A1.1051.00
41_L47_E1.0881.00
133_P154_E1.0840.99
94_V126_G1.0810.99
112_Y210_R1.0730.99
113_F209_W1.0700.99
3_G70_I1.0690.99
169_F206_L1.0680.99
125_A179_V1.0560.99
20_L48_T1.0520.99
93_L181_L1.0460.99
85_A89_H1.0430.99
165_Q175_H1.0420.99
34_S52_R1.0400.99
122_F186_G1.0360.99
90_R128_W1.0360.99
76_T83_F1.0330.99
71_N101_E1.0300.99
103_R112_Y1.0290.99
86_A90_R1.0230.99
60_S65_S1.0130.99
75_E176_R1.0060.99
117_T207_Q1.0050.99
11_P15_R1.0030.99
9_S121_P1.0010.99
135_Q154_E0.9890.99
38_P48_T0.9850.99
87_Y195_P0.9840.99
134_E153_P0.9840.99
8_F97_D0.9720.99
37_L94_V0.9720.99
56_V158_S0.9620.99
168_A172_D0.9400.99
104_D109_T0.9310.98
4_R30_N0.9310.98
132_T154_E0.9260.98
34_S67_P0.9220.98
52_R63_P0.8990.98
49_V157_R0.8900.98
42_D46_T0.8870.98
220_V224_A0.8850.98
188_R194_D0.8750.98
164_T167_N0.8620.97
188_R197_D0.8620.97
56_V69_P0.8580.97
69_P83_F0.8550.97
92_C128_W0.8510.97
77_L127_L0.8410.97
169_F208_A0.8350.97
116_R182_T0.8330.97
164_T177_M0.8330.97
2_C71_N0.8310.97
55_L158_S0.8300.97
169_F172_D0.8290.97
4_R102_W0.8280.97
99_F180_V0.8270.97
40_I46_T0.8270.97
55_L129_E0.8130.96
179_V201_P0.8130.96
62_G66_A0.8110.96
51_A157_R0.8070.96
80_T83_F0.7970.96
166_P175_H0.7940.96
65_S68_D0.7920.96
161_V178_A0.7910.96
194_D197_D0.7890.96
74_A164_T0.7880.96
120_A183_P0.7860.96
185_Q200_T0.7830.96
103_R106_D0.7810.95
58_S129_E0.7800.95
57_P60_S0.7770.95
102_W111_P0.7720.95
99_F172_D0.7710.95
214_A220_V0.7700.95
18_F186_G0.7690.95
115_S119_G0.7650.95
54_G70_I0.7560.95
212_S215_V0.7560.95
99_F167_N0.7520.94
167_N172_D0.7490.94
36_S50_R0.7480.94
166_P171_A0.7470.94
182_T205_D0.7470.94
5_Y38_P0.7460.94
2_C174_H0.7460.94
192_D195_P0.7460.94
7_L38_P0.7450.94
188_R191_T0.7430.94
62_G65_S0.7340.94
41_L157_R0.7330.94
135_Q153_P0.7310.94
5_Y31_A0.7300.94
30_N102_W0.7290.93
17_T120_A0.7260.93
105_E110_V0.7200.93
116_R206_L0.7170.93
122_F180_V0.7150.93
62_G68_D0.7140.93
116_R205_D0.7110.93
42_D45_P0.7090.93
198_L201_P0.7060.92
53_W178_A0.7060.92
103_R172_D0.7060.92
5_Y95_P0.7050.92
38_P50_R0.7050.92
162_V179_V0.7030.92
70_I218_P0.7010.92
58_S85_A0.7000.92
126_G160_T0.6940.92
66_A69_P0.6910.92
15_R22_T0.6860.91
43_T47_E0.6830.91
55_L69_P0.6790.91
104_D107_G0.6730.90
32_A35_Q0.6710.90
9_S13_T0.6680.90
96_V161_V0.6660.90
187_Q191_T0.6660.90
2_C101_E0.6650.90
97_D113_F0.6630.90
13_T16_E0.6630.90
37_L53_W0.6620.90
5_Y94_V0.6580.89
98_G115_S0.6570.89
6_A98_G0.6550.89
211_V215_V0.6540.89
25_V38_P0.6530.89
179_V202_G0.6530.89
40_I95_P0.6520.89
185_Q198_L0.6490.89
72_A83_F0.6430.88
26_E221_D0.6420.88
38_P159_F0.6400.88
60_S66_A0.6400.88
54_G66_A0.6390.88
85_A129_E0.6370.88
55_L82_H0.6330.88
53_W91_R0.6320.88
14_L22_T0.6320.88
12_E21_T0.6320.88
60_S64_Q0.6310.87
179_V199_F0.6270.87
19_G187_Q0.6260.87
32_A102_W0.6260.87
32_A215_V0.6250.87
162_V199_F0.6240.87
180_V202_G0.6210.87
3_G33_P0.6140.86
114_V175_H0.6100.86
165_Q171_A0.6080.85
104_D108_A0.6070.85
69_P160_T0.6060.85
76_T79_E0.6050.85
11_P24_P0.6040.85
73_R174_H0.6030.85
70_I160_T0.5960.84
30_N98_G0.5960.84
73_R101_E0.5940.84
17_T183_P0.5920.84
116_R119_G0.5900.84
195_P199_F0.5890.84
51_A159_F0.5870.83
7_L14_L0.5870.83
217_D220_V0.5860.83
166_P169_F0.5860.83
63_P156_V0.5820.83
132_T153_P0.5820.83
3_G102_W0.5780.82
9_S14_L0.5770.82
56_V62_G0.5760.82
215_V220_V0.5710.82
165_Q168_A0.5710.82
84_Q88_E0.5690.82
74_A179_V0.5690.82
33_P70_I0.5650.81
170_L173_Y0.5640.81
5_Y32_A0.5630.81
5_Y126_G0.5620.81
15_R20_L0.5620.81
177_M201_P0.5610.81
167_N180_V0.5610.81
116_R121_P0.5610.81
11_P25_V0.5600.80
34_S218_P0.5570.80
89_H129_E0.5550.80
124_L178_A0.5540.80
65_S69_P0.5530.80
202_G205_D0.5510.79
173_Y177_M0.5500.79
55_L67_P0.5490.79
9_S12_E0.5480.79
180_V201_P0.5480.79
32_A111_P0.5400.78
41_L45_P0.5400.78
181_L198_L0.5390.78
5_Y159_F0.5390.78
61_D81_R0.5390.78
100_Y211_V0.5370.78
64_Q67_P0.5350.77
101_E176_R0.5340.77
100_Y111_P0.5340.77
72_A77_L0.5330.77
24_P50_R0.5330.77
169_F205_D0.5330.77
212_S220_V0.5310.77
81_R86_A0.5310.77
124_L180_V0.5280.77
99_F206_L0.5260.76
7_L97_D0.5250.76
41_L51_A0.5250.76
220_V223_P0.5230.76
6_A97_D0.5230.76
52_R156_V0.5210.76
60_S67_P0.5200.75
29_Y111_P0.5200.75
197_D200_T0.5180.75
69_P80_T0.5170.75
46_T192_D0.5150.75
57_P82_H0.5150.75
57_P61_D0.5150.75
57_P158_S0.5150.75
105_E112_Y0.5120.74
117_T205_D0.5100.74
18_F190_L0.5080.74
169_F203_A0.5070.74
75_E165_Q0.5060.73
133_P153_P0.5040.73
75_E162_V0.5020.73
131_W158_S0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f20A 1 0.917 100 0.119 Contact Map
2icuA 1 0.8603 100 0.12 Contact Map
2bdvA 1 0.869 100 0.127 Contact Map
2aegA 1 0.8734 100 0.169 Contact Map
1zn6A 1 0.8472 100 0.184 Contact Map
2gs0B 1 0.048 8.1 0.964 Contact Map
2b3gB 2 0.1048 7.6 0.964 Contact Map
5c6gA 1 0.3013 4.7 0.968 Contact Map
3aj1A 5 0.607 4.6 0.968 Contact Map
3bsuA 1 0.214 4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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