Q9HRI0 - HALSA - GREMLIN Contacts

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Q9HRI0 - Uncharacterized protein

UniProt:	Q9HRI0	Sequences: MCGRYALFSTPETLRETFGLTTAPVEPTYNAAPSQSLPVILDTEPTETVRARWGLVPSWSDGPQSAPDPINARAETLTETRHFQAAYEHRRCLVPVDGFYEWRDEDGATVPYFVSRTDGAPFLLAGLWETWTPEQTQTGLGEFTGDDGPSRDPETVRSFTVVTTQPNAFLADYHHRMAVVLTPAQGQRWLTDDDPTDLFTPGAFDLQAWRVSTAVNDPTVDRPALVEPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	229 (207)
Sequences:	3262 (2333)
Seq/√Len:	162.2

ECOLI - YEDK
BACSU - YOBE YOAM YOQW
HALSA - Q9HRI0 O51976

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
37_L	159_F	4.377	1.00
96_V	124_L	4.267	1.00
77_L	162_V	4.172	1.00
39_V	51_A	4.030	1.00
127_L	160_T	3.874	1.00
28_T	221_D	3.548	1.00
18_F	123_L	3.501	1.00
93_L	186_G	3.387	1.00
214_A	222_R	2.707	1.00
98_G	113_F	2.653	1.00
182_T	185_Q	2.619	1.00
110_V	210_R	2.583	1.00
92_C	126_G	2.426	1.00
86_A	129_E	2.421	1.00
41_L	49_V	2.339	1.00
74_A	162_V	2.332	1.00
115_S	207_Q	2.258	1.00
124_L	161_V	2.188	1.00
115_S	209_W	2.084	1.00
81_R	84_Q	2.017	1.00
114_V	173_Y	1.881	1.00
130_T	157_R	1.862	1.00
93_L	123_L	1.861	1.00
71_N	174_H	1.828	1.00
101_E	174_H	1.789	1.00
90_R	129_E	1.769	1.00
123_L	186_G	1.734	1.00
17_T	186_G	1.716	1.00
69_P	82_H	1.703	1.00
78_T	87_Y	1.693	1.00
185_Q	188_R	1.652	1.00
94_V	159_F	1.630	1.00
5_Y	37_L	1.612	1.00
167_N	177_M	1.603	1.00
31_A	37_L	1.589	1.00
46_T	187_Q	1.583	1.00
99_F	170_L	1.581	1.00
214_A	224_A	1.548	1.00
6_A	113_F	1.548	1.00
72_A	160_T	1.545	1.00
105_E	108_A	1.537	1.00
9_S	97_D	1.518	1.00
12_E	16_E	1.512	1.00
212_S	216_N	1.473	1.00
114_V	170_L	1.468	1.00
56_V	156_V	1.456	1.00
180_V	206_L	1.442	1.00
202_G	206_L	1.438	1.00
94_V	161_V	1.425	1.00
74_A	199_F	1.425	1.00
77_L	87_Y	1.416	1.00
39_V	159_F	1.416	1.00
28_T	35_Q	1.414	1.00
130_T	155_T	1.401	1.00
116_R	120_A	1.390	1.00
10_T	13_T	1.383	1.00
122_F	206_L	1.329	1.00
168_A	171_A	1.328	1.00
169_F	204_F	1.304	1.00
78_T	196_T	1.300	1.00
102_W	109_T	1.289	1.00
132_T	155_T	1.275	1.00
183_P	186_G	1.272	1.00
5_Y	96_V	1.256	1.00
7_L	31_A	1.253	1.00
41_L	128_W	1.248	1.00
213_T	216_N	1.204	1.00
28_T	31_A	1.198	1.00
116_R	122_F	1.191	1.00
30_N	111_P	1.174	1.00
181_L	185_Q	1.170	1.00
39_V	92_C	1.153	1.00
131_W	134_E	1.151	1.00
76_T	80_T	1.148	1.00
164_T	201_P	1.137	1.00
164_T	179_V	1.126	1.00
108_A	213_T	1.114	1.00
39_V	94_V	1.114	1.00
85_A	88_E	1.109	1.00
203_A	206_L	1.106	1.00
114_V	208_A	1.105	1.00
41_L	47_E	1.088	1.00
133_P	154_E	1.084	0.99
94_V	126_G	1.081	0.99
112_Y	210_R	1.073	0.99
113_F	209_W	1.070	0.99
3_G	70_I	1.069	0.99
169_F	206_L	1.068	0.99
125_A	179_V	1.056	0.99
20_L	48_T	1.052	0.99
93_L	181_L	1.046	0.99
85_A	89_H	1.043	0.99
165_Q	175_H	1.042	0.99
34_S	52_R	1.040	0.99
122_F	186_G	1.036	0.99
90_R	128_W	1.036	0.99
76_T	83_F	1.033	0.99
71_N	101_E	1.030	0.99
103_R	112_Y	1.029	0.99
86_A	90_R	1.023	0.99
60_S	65_S	1.013	0.99
75_E	176_R	1.006	0.99
117_T	207_Q	1.005	0.99
11_P	15_R	1.003	0.99
9_S	121_P	1.001	0.99
135_Q	154_E	0.989	0.99
38_P	48_T	0.985	0.99
87_Y	195_P	0.984	0.99
134_E	153_P	0.984	0.99
8_F	97_D	0.972	0.99
37_L	94_V	0.972	0.99
56_V	158_S	0.962	0.99
168_A	172_D	0.940	0.99
104_D	109_T	0.931	0.98
4_R	30_N	0.931	0.98
132_T	154_E	0.926	0.98
34_S	67_P	0.922	0.98
52_R	63_P	0.899	0.98
49_V	157_R	0.890	0.98
42_D	46_T	0.887	0.98
220_V	224_A	0.885	0.98
188_R	194_D	0.875	0.98
164_T	167_N	0.862	0.97
188_R	197_D	0.862	0.97
56_V	69_P	0.858	0.97
69_P	83_F	0.855	0.97
92_C	128_W	0.851	0.97
77_L	127_L	0.841	0.97
169_F	208_A	0.835	0.97
116_R	182_T	0.833	0.97
164_T	177_M	0.833	0.97
2_C	71_N	0.831	0.97
55_L	158_S	0.830	0.97
169_F	172_D	0.829	0.97
4_R	102_W	0.828	0.97
99_F	180_V	0.827	0.97
40_I	46_T	0.827	0.97
55_L	129_E	0.813	0.96
179_V	201_P	0.813	0.96
62_G	66_A	0.811	0.96
51_A	157_R	0.807	0.96
80_T	83_F	0.797	0.96
166_P	175_H	0.794	0.96
65_S	68_D	0.792	0.96
161_V	178_A	0.791	0.96
194_D	197_D	0.789	0.96
74_A	164_T	0.788	0.96
120_A	183_P	0.786	0.96
185_Q	200_T	0.783	0.96
103_R	106_D	0.781	0.95
58_S	129_E	0.780	0.95
57_P	60_S	0.777	0.95
102_W	111_P	0.772	0.95
99_F	172_D	0.771	0.95
214_A	220_V	0.770	0.95
18_F	186_G	0.769	0.95
115_S	119_G	0.765	0.95
54_G	70_I	0.756	0.95
212_S	215_V	0.756	0.95
99_F	167_N	0.752	0.94
167_N	172_D	0.749	0.94
36_S	50_R	0.748	0.94
166_P	171_A	0.747	0.94
182_T	205_D	0.747	0.94
5_Y	38_P	0.746	0.94
2_C	174_H	0.746	0.94
192_D	195_P	0.746	0.94
7_L	38_P	0.745	0.94
188_R	191_T	0.743	0.94
62_G	65_S	0.734	0.94
41_L	157_R	0.733	0.94
135_Q	153_P	0.731	0.94
5_Y	31_A	0.730	0.94
30_N	102_W	0.729	0.93
17_T	120_A	0.726	0.93
105_E	110_V	0.720	0.93
116_R	206_L	0.717	0.93
122_F	180_V	0.715	0.93
62_G	68_D	0.714	0.93
116_R	205_D	0.711	0.93
42_D	45_P	0.709	0.93
198_L	201_P	0.706	0.92
53_W	178_A	0.706	0.92
103_R	172_D	0.706	0.92
5_Y	95_P	0.705	0.92
38_P	50_R	0.705	0.92
162_V	179_V	0.703	0.92
70_I	218_P	0.701	0.92
58_S	85_A	0.700	0.92
126_G	160_T	0.694	0.92
66_A	69_P	0.691	0.92
15_R	22_T	0.686	0.91
43_T	47_E	0.683	0.91
55_L	69_P	0.679	0.91
104_D	107_G	0.673	0.90
32_A	35_Q	0.671	0.90
9_S	13_T	0.668	0.90
96_V	161_V	0.666	0.90
187_Q	191_T	0.666	0.90
2_C	101_E	0.665	0.90
97_D	113_F	0.663	0.90
13_T	16_E	0.663	0.90
37_L	53_W	0.662	0.90
5_Y	94_V	0.658	0.89
98_G	115_S	0.657	0.89
6_A	98_G	0.655	0.89
211_V	215_V	0.654	0.89
25_V	38_P	0.653	0.89
179_V	202_G	0.653	0.89
40_I	95_P	0.652	0.89
185_Q	198_L	0.649	0.89
72_A	83_F	0.643	0.88
26_E	221_D	0.642	0.88
38_P	159_F	0.640	0.88
60_S	66_A	0.640	0.88
54_G	66_A	0.639	0.88
85_A	129_E	0.637	0.88
55_L	82_H	0.633	0.88
53_W	91_R	0.632	0.88
14_L	22_T	0.632	0.88
12_E	21_T	0.632	0.88
60_S	64_Q	0.631	0.87
179_V	199_F	0.627	0.87
19_G	187_Q	0.626	0.87
32_A	102_W	0.626	0.87
32_A	215_V	0.625	0.87
162_V	199_F	0.624	0.87
180_V	202_G	0.621	0.87
3_G	33_P	0.614	0.86
114_V	175_H	0.610	0.86
165_Q	171_A	0.608	0.85
104_D	108_A	0.607	0.85
69_P	160_T	0.606	0.85
76_T	79_E	0.605	0.85
11_P	24_P	0.604	0.85
73_R	174_H	0.603	0.85
70_I	160_T	0.596	0.84
30_N	98_G	0.596	0.84
73_R	101_E	0.594	0.84
17_T	183_P	0.592	0.84
116_R	119_G	0.590	0.84
195_P	199_F	0.589	0.84
51_A	159_F	0.587	0.83
7_L	14_L	0.587	0.83
217_D	220_V	0.586	0.83
166_P	169_F	0.586	0.83
63_P	156_V	0.582	0.83
132_T	153_P	0.582	0.83
3_G	102_W	0.578	0.82
9_S	14_L	0.577	0.82
56_V	62_G	0.576	0.82
215_V	220_V	0.571	0.82
165_Q	168_A	0.571	0.82
84_Q	88_E	0.569	0.82
74_A	179_V	0.569	0.82
33_P	70_I	0.565	0.81
170_L	173_Y	0.564	0.81
5_Y	32_A	0.563	0.81
5_Y	126_G	0.562	0.81
15_R	20_L	0.562	0.81
177_M	201_P	0.561	0.81
167_N	180_V	0.561	0.81
116_R	121_P	0.561	0.81
11_P	25_V	0.560	0.80
34_S	218_P	0.557	0.80
89_H	129_E	0.555	0.80
124_L	178_A	0.554	0.80
65_S	69_P	0.553	0.80
202_G	205_D	0.551	0.79
173_Y	177_M	0.550	0.79
55_L	67_P	0.549	0.79
9_S	12_E	0.548	0.79
180_V	201_P	0.548	0.79
32_A	111_P	0.540	0.78
41_L	45_P	0.540	0.78
181_L	198_L	0.539	0.78
5_Y	159_F	0.539	0.78
61_D	81_R	0.539	0.78
100_Y	211_V	0.537	0.78
64_Q	67_P	0.535	0.77
101_E	176_R	0.534	0.77
100_Y	111_P	0.534	0.77
72_A	77_L	0.533	0.77
24_P	50_R	0.533	0.77
169_F	205_D	0.533	0.77
212_S	220_V	0.531	0.77
81_R	86_A	0.531	0.77
124_L	180_V	0.528	0.77
99_F	206_L	0.526	0.76
7_L	97_D	0.525	0.76
41_L	51_A	0.525	0.76
220_V	223_P	0.523	0.76
6_A	97_D	0.523	0.76
52_R	156_V	0.521	0.76
60_S	67_P	0.520	0.75
29_Y	111_P	0.520	0.75
197_D	200_T	0.518	0.75
69_P	80_T	0.517	0.75
46_T	192_D	0.515	0.75
57_P	82_H	0.515	0.75
57_P	61_D	0.515	0.75
57_P	158_S	0.515	0.75
105_E	112_Y	0.512	0.74
117_T	205_D	0.510	0.74
18_F	190_L	0.508	0.74
169_F	203_A	0.507	0.74
75_E	165_Q	0.506	0.73
133_P	153_P	0.504	0.73
75_E	162_V	0.502	0.73
131_W	158_S	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2f20A	1	0.917	100	0.119	Contact Map
2icuA	1	0.8603	100	0.12	Contact Map
2bdvA	1	0.869	100	0.127	Contact Map
2aegA	1	0.8734	100	0.169	Contact Map
1zn6A	1	0.8472	100	0.184	Contact Map
2gs0B	1	0.048	8.1	0.964	Contact Map
2b3gB	2	0.1048	7.6	0.964	Contact Map
5c6gA	1	0.3013	4.7	0.968	Contact Map
3aj1A	5	0.607	4.6	0.968	Contact Map
3bsuA	1	0.214	4	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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