Q9HRH9 - HALSA - GREMLIN Contacts

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Q9HRH9 - Uncharacterized protein

UniProt:	Q9HRH9	Sequences: MWKTFSRNATSVETMPAPDSLFQLLAQRADLMRAVRDATTTTKPELADTLPVSRSTVDRAVRELEAHTLLERAGQVSLTLKGRLALRSYESFAADIDGLDAADAALATVPADARMDTVLFRDATVVNATSVAPQRATEAYRSLLADATRIEGYASAVLDSVVSTLRERIRAGELQVSLVLHPDVLDALVATHGDSVTDALRTDALTLREATTTLPYSLFTLDTTSTTYACGLFYDDTGHTSLVHTDDAQAVAWADRVTADLRADATTLPR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (246)
Sequences:	533 (464)
Seq/√Len:	29.6

HALSA - Q9HRH9 Q9HMF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_S	262_R	4.321	1.00
208_R	262_R	4.090	1.00
116_D	119_L	3.476	1.00
64_L	69_L	3.396	1.00
35_V	78_L	3.003	1.00
21_L	67_H	2.696	1.00
116_D	256_R	2.595	1.00
225_S	254_A	2.480	0.99
47_A	54_R	2.460	0.99
60_A	64_L	2.453	0.99
220_T	258_T	2.401	0.99
35_V	70_L	2.325	0.99
71_E	77_S	2.283	0.99
208_R	265_A	2.246	0.99
230_C	234_Y	2.152	0.98
46_L	62_R	2.128	0.98
155_S	217_S	2.121	0.98
71_E	79_T	2.106	0.98
43_K	61_V	2.060	0.97
177_S	258_T	2.015	0.97
43_K	58_D	2.009	0.97
54_R	57_V	1.987	0.97
124_T	236_D	1.979	0.97
163_S	167_E	1.968	0.97
92_F	159_D	1.968	0.97
126_V	139_A	1.934	0.96
18_P	69_L	1.872	0.95
55_S	60_A	1.824	0.95
155_S	178_L	1.818	0.95
56_T	59_R	1.765	0.94
19_D	23_Q	1.750	0.93
230_C	233_F	1.749	0.93
151_E	255_D	1.706	0.93
73_A	77_S	1.705	0.93
79_T	145_A	1.668	0.92
50_L	60_A	1.664	0.92
38_A	41_T	1.646	0.91
221_L	224_T	1.642	0.91
19_D	25_L	1.627	0.91
109_V	232_L	1.620	0.90
41_T	45_E	1.619	0.90
122_D	247_D	1.616	0.90
237_T	263_A	1.597	0.90
169_I	202_T	1.583	0.89
233_F	240_T	1.578	0.89
123_A	145_A	1.577	0.89
191_T	256_R	1.549	0.88
53_S	153_Y	1.514	0.87
114_R	117_T	1.496	0.86
212_T	265_A	1.475	0.86
144_L	266_T	1.467	0.85
98_G	157_V	1.463	0.85
181_H	258_T	1.456	0.85
60_A	63_E	1.454	0.85
166_R	198_D	1.438	0.84
44_P	47_A	1.435	0.84
145_A	167_E	1.430	0.84
140_Y	152_G	1.413	0.83
28_R	32_M	1.409	0.83
237_T	240_T	1.375	0.81
128_A	136_A	1.369	0.81
234_Y	238_G	1.368	0.81
25_L	67_H	1.361	0.81
20_S	24_L	1.353	0.80
140_Y	161_V	1.348	0.80
55_S	59_R	1.336	0.79
188_L	208_R	1.335	0.79
221_L	258_T	1.333	0.79
34_A	41_T	1.328	0.79
243_V	253_W	1.325	0.79
173_E	204_A	1.303	0.78
50_L	100_D	1.302	0.78
257_V	261_L	1.298	0.77
206_T	267_T	1.282	0.77
151_E	177_S	1.270	0.76
76_V	253_W	1.261	0.75
229_A	233_F	1.254	0.75
36_R	90_E	1.253	0.75
94_A	121_R	1.245	0.74
36_R	78_L	1.229	0.73
153_Y	261_L	1.223	0.73
186_D	207_L	1.211	0.72
70_L	235_D	1.206	0.72
149_R	175_Q	1.205	0.72
53_S	141_R	1.204	0.72
109_V	157_V	1.185	0.71
74_G	213_T	1.178	0.70
248_A	252_A	1.166	0.69
59_R	133_P	1.157	0.69
37_D	100_D	1.153	0.68
99_L	104_A	1.152	0.68
87_R	267_T	1.149	0.68
58_D	78_L	1.146	0.68
115_M	122_D	1.141	0.68
167_E	172_G	1.139	0.68
79_T	147_A	1.138	0.67
43_K	105_A	1.136	0.67
27_Q	50_L	1.128	0.67
48_D	74_G	1.109	0.65
79_T	259_A	1.101	0.65
45_E	136_A	1.100	0.65
218_L	222_D	1.099	0.65
37_D	77_S	1.093	0.64
21_L	50_L	1.089	0.64
151_E	222_D	1.087	0.64
196_V	268_L	1.082	0.63
153_Y	221_L	1.075	0.63
135_R	205_L	1.065	0.62
134_Q	158_L	1.062	0.62
78_L	152_G	1.059	0.62
186_D	190_A	1.059	0.62
29_A	69_L	1.058	0.62
63_E	265_A	1.058	0.62
229_A	238_G	1.057	0.62
169_I	205_L	1.055	0.61
71_E	166_R	1.049	0.61
70_L	189_V	1.044	0.61
220_T	254_A	1.043	0.61
79_T	133_P	1.034	0.60
154_A	217_S	1.034	0.60
31_L	71_E	1.033	0.60
104_A	183_D	1.030	0.60
68_T	83_R	1.030	0.60
246_D	265_A	1.029	0.59
54_R	106_L	1.027	0.59
177_S	208_R	1.023	0.59
25_L	28_R	1.020	0.59
31_L	52_V	1.017	0.59
144_L	214_L	1.010	0.58
131_V	244_H	0.991	0.57
37_D	127_N	0.987	0.56
61_V	99_L	0.985	0.56
105_A	156_A	0.982	0.56
48_D	83_R	0.980	0.56
70_L	108_T	0.978	0.56
87_R	263_A	0.977	0.55
164_T	197_T	0.975	0.55
167_E	215_P	0.975	0.55
70_L	94_A	0.974	0.55
22_F	69_L	0.973	0.55
207_L	236_D	0.968	0.55
26_A	29_A	0.968	0.55
38_A	258_T	0.964	0.54
117_T	243_V	0.962	0.54
109_V	233_F	0.959	0.54
180_L	195_S	0.956	0.54
170_R	198_D	0.956	0.54
43_K	98_G	0.945	0.53
172_G	194_D	0.942	0.53
94_A	167_E	0.938	0.52
56_T	60_A	0.933	0.52
123_A	177_S	0.933	0.52
19_D	93_A	0.930	0.52
48_D	175_Q	0.926	0.51
168_R	174_L	0.926	0.51
212_T	230_C	0.922	0.51
22_F	59_R	0.921	0.51
53_S	123_A	0.918	0.51
46_L	90_E	0.918	0.51
117_T	164_T	0.914	0.51
189_V	196_V	0.909	0.50
236_D	263_A	0.906	0.50
249_Q	263_A	0.905	0.50
65_E	169_I	0.903	0.50
113_A	116_D	0.902	0.50
220_T	236_D	0.902	0.50
198_D	218_L	0.893	0.49
42_T	45_E	0.888	0.48
122_D	205_L	0.888	0.48
173_E	252_A	0.883	0.48
61_V	76_V	0.876	0.48
110_P	113_A	0.875	0.47
81_K	182_P	0.875	0.47
153_Y	194_D	0.874	0.47
165_L	244_H	0.874	0.47
54_R	232_L	0.873	0.47
145_A	190_A	0.872	0.47
146_D	170_R	0.871	0.47
84_L	107_A	0.870	0.47
233_F	239_H	0.867	0.47
78_L	126_V	0.865	0.47
69_L	244_H	0.858	0.46
232_L	258_T	0.857	0.46
120_F	256_R	0.856	0.46
54_R	58_D	0.856	0.46
172_G	268_L	0.854	0.46
88_S	159_D	0.853	0.46
78_L	105_A	0.852	0.46
43_K	102_A	0.852	0.46
207_L	223_T	0.851	0.46
61_V	140_Y	0.842	0.45
56_T	133_P	0.842	0.45
139_A	244_H	0.838	0.45
28_R	55_S	0.836	0.44
182_P	209_E	0.834	0.44
61_V	159_D	0.826	0.44
83_R	258_T	0.819	0.43
172_G	186_D	0.818	0.43
104_A	110_P	0.817	0.43
25_L	245_T	0.817	0.43
85_A	96_I	0.814	0.43
23_Q	61_V	0.813	0.43
81_K	134_Q	0.812	0.43
175_Q	196_V	0.797	0.41
115_M	198_D	0.796	0.41
47_A	243_V	0.790	0.41
58_D	64_L	0.787	0.41
47_A	52_V	0.785	0.40
57_V	216_Y	0.784	0.40
31_L	131_V	0.781	0.40
32_M	253_W	0.781	0.40
102_A	125_V	0.780	0.40
137_T	221_L	0.779	0.40
230_C	243_V	0.774	0.40
160_S	163_S	0.772	0.40
258_T	262_R	0.762	0.39
155_S	169_I	0.761	0.39
23_Q	64_L	0.757	0.38
21_L	241_S	0.756	0.38
27_Q	61_V	0.755	0.38
109_V	169_I	0.746	0.38
55_S	135_R	0.743	0.37
140_Y	176_V	0.740	0.37
25_L	31_L	0.737	0.37
205_L	262_R	0.735	0.37
147_A	221_L	0.733	0.37
145_A	172_G	0.729	0.36
34_A	91_S	0.721	0.36
70_L	255_D	0.719	0.36
42_T	268_L	0.713	0.35
89_Y	92_F	0.713	0.35
184_V	205_L	0.713	0.35
75_Q	83_R	0.711	0.35
42_T	165_L	0.709	0.35
174_L	178_L	0.706	0.35
149_R	156_A	0.702	0.34
210_A	265_A	0.701	0.34
134_Q	159_D	0.698	0.34
114_R	258_T	0.698	0.34
153_Y	268_L	0.697	0.34
27_Q	69_L	0.696	0.34
165_L	176_V	0.695	0.34
131_V	179_V	0.692	0.34
21_L	69_L	0.690	0.34
179_V	263_A	0.689	0.33
200_L	204_A	0.684	0.33
64_L	258_T	0.681	0.33
38_A	94_A	0.678	0.33
194_D	223_T	0.677	0.33
39_T	127_N	0.676	0.33
150_I	160_S	0.675	0.32
38_A	198_D	0.672	0.32
153_Y	162_V	0.669	0.32
136_A	214_L	0.669	0.32
94_A	188_L	0.667	0.32
94_A	97_D	0.667	0.32
24_L	88_S	0.666	0.32
37_D	266_T	0.665	0.32
61_V	67_H	0.664	0.32
37_D	110_P	0.661	0.32
160_S	169_I	0.660	0.31
46_L	246_D	0.660	0.31
225_S	231_G	0.657	0.31
225_S	229_A	0.655	0.31
125_V	191_T	0.654	0.31
101_A	122_D	0.654	0.31
182_P	245_T	0.654	0.31
94_A	105_A	0.654	0.31
90_E	258_T	0.652	0.31
262_R	265_A	0.651	0.31
179_V	241_S	0.648	0.31
31_L	60_A	0.643	0.30
18_P	50_L	0.639	0.30
50_L	58_D	0.637	0.30
185_L	196_V	0.637	0.30
120_F	237_T	0.630	0.29
79_T	225_S	0.629	0.29
101_A	268_L	0.627	0.29
38_A	118_V	0.624	0.29
52_V	60_A	0.623	0.29
58_D	61_V	0.618	0.29
55_S	129_T	0.617	0.29
142_S	188_L	0.616	0.29
170_R	243_V	0.615	0.28
184_V	218_L	0.615	0.28
25_L	106_L	0.614	0.28
155_S	219_F	0.614	0.28
25_L	60_A	0.613	0.28
150_I	207_L	0.613	0.28
177_S	206_T	0.612	0.28
162_V	169_I	0.611	0.28
63_E	67_H	0.609	0.28
47_A	232_L	0.609	0.28
45_E	90_E	0.609	0.28
140_Y	159_D	0.608	0.28
26_A	188_L	0.608	0.28
229_A	242_L	0.606	0.28
53_S	60_A	0.604	0.28
70_L	148_T	0.602	0.28
144_L	179_V	0.602	0.28
79_T	126_V	0.599	0.27
74_G	104_A	0.599	0.27
173_E	223_T	0.597	0.27
140_Y	233_F	0.596	0.27
138_E	213_T	0.592	0.27
50_L	64_L	0.591	0.27
139_A	143_L	0.586	0.27
51_P	259_A	0.586	0.27
38_A	148_T	0.583	0.26
248_A	255_D	0.582	0.26
157_V	218_L	0.581	0.26
25_L	58_D	0.580	0.26
83_R	165_L	0.579	0.26
179_V	260_D	0.578	0.26
73_A	256_R	0.578	0.26
179_V	265_A	0.577	0.26
72_R	267_T	0.576	0.26
77_S	150_I	0.573	0.26
150_I	216_Y	0.568	0.26
44_P	85_A	0.566	0.25
128_A	155_S	0.564	0.25
83_R	248_A	0.560	0.25
46_L	249_Q	0.557	0.25
174_L	203_D	0.556	0.25
89_Y	113_A	0.556	0.25
44_P	266_T	0.554	0.25
56_T	238_G	0.554	0.25
21_L	25_L	0.553	0.25
145_A	195_S	0.552	0.25
55_S	155_S	0.552	0.25
54_R	86_L	0.552	0.25
67_H	203_D	0.548	0.24
161_V	216_Y	0.547	0.24
21_L	65_E	0.546	0.24
24_L	63_E	0.545	0.24
162_V	185_L	0.542	0.24
199_A	205_L	0.541	0.24
79_T	97_D	0.540	0.24
199_A	217_S	0.537	0.24
217_S	222_D	0.536	0.24
137_T	257_V	0.533	0.24
75_Q	168_R	0.532	0.23
26_A	30_D	0.531	0.23
124_T	254_A	0.530	0.23
26_A	212_T	0.530	0.23
178_L	233_F	0.530	0.23
80_L	111_A	0.527	0.23
72_R	76_V	0.526	0.23
33_R	90_E	0.524	0.23
53_S	63_E	0.522	0.23
50_L	91_S	0.522	0.23
97_D	148_T	0.522	0.23
240_T	244_H	0.521	0.23
245_T	250_A	0.521	0.23
97_D	137_T	0.521	0.23
152_G	156_A	0.519	0.23
102_A	245_T	0.519	0.23
64_L	106_L	0.517	0.23
105_A	128_A	0.516	0.23
125_V	134_Q	0.516	0.23
133_P	156_A	0.510	0.22
78_L	179_V	0.509	0.22
142_S	190_A	0.508	0.22
151_E	248_A	0.507	0.22
26_A	60_A	0.505	0.22
209_E	263_A	0.505	0.22
104_A	266_T	0.504	0.22
178_L	265_A	0.503	0.22
50_L	192_H	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qphA	2	0.8296	99.3	0.789	Contact Map
3df8A	2	0.3519	98.9	0.825	Contact Map
1z7uA	2	0.3741	98.6	0.84	Contact Map
4k2eA	2	0.3296	98.6	0.841	Contact Map
2fswA	2	0.3481	98.6	0.843	Contact Map
4a5nA	2	0.3556	98.5	0.843	Contact Map
4g6qA	4	0.563	98.5	0.845	Contact Map
3elkA	3	0.3333	98.5	0.845	Contact Map
3f6oA	2	0.3407	98.5	0.846	Contact Map
2f2eA	4	0.4889	98.5	0.847	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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