GREMLIN Database
Q9HRH9 - Uncharacterized protein
UniProt: Q9HRH9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (246)
Sequences: 533 (464)
Seq/√Len: 29.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_S262_R4.3211.00
208_R262_R4.0901.00
116_D119_L3.4761.00
64_L69_L3.3961.00
35_V78_L3.0031.00
21_L67_H2.6961.00
116_D256_R2.5951.00
225_S254_A2.4800.99
47_A54_R2.4600.99
60_A64_L2.4530.99
220_T258_T2.4010.99
35_V70_L2.3250.99
71_E77_S2.2830.99
208_R265_A2.2460.99
230_C234_Y2.1520.98
46_L62_R2.1280.98
155_S217_S2.1210.98
71_E79_T2.1060.98
43_K61_V2.0600.97
177_S258_T2.0150.97
43_K58_D2.0090.97
54_R57_V1.9870.97
124_T236_D1.9790.97
163_S167_E1.9680.97
92_F159_D1.9680.97
126_V139_A1.9340.96
18_P69_L1.8720.95
55_S60_A1.8240.95
155_S178_L1.8180.95
56_T59_R1.7650.94
19_D23_Q1.7500.93
230_C233_F1.7490.93
151_E255_D1.7060.93
73_A77_S1.7050.93
79_T145_A1.6680.92
50_L60_A1.6640.92
38_A41_T1.6460.91
221_L224_T1.6420.91
19_D25_L1.6270.91
109_V232_L1.6200.90
41_T45_E1.6190.90
122_D247_D1.6160.90
237_T263_A1.5970.90
169_I202_T1.5830.89
233_F240_T1.5780.89
123_A145_A1.5770.89
191_T256_R1.5490.88
53_S153_Y1.5140.87
114_R117_T1.4960.86
212_T265_A1.4750.86
144_L266_T1.4670.85
98_G157_V1.4630.85
181_H258_T1.4560.85
60_A63_E1.4540.85
166_R198_D1.4380.84
44_P47_A1.4350.84
145_A167_E1.4300.84
140_Y152_G1.4130.83
28_R32_M1.4090.83
237_T240_T1.3750.81
128_A136_A1.3690.81
234_Y238_G1.3680.81
25_L67_H1.3610.81
20_S24_L1.3530.80
140_Y161_V1.3480.80
55_S59_R1.3360.79
188_L208_R1.3350.79
221_L258_T1.3330.79
34_A41_T1.3280.79
243_V253_W1.3250.79
173_E204_A1.3030.78
50_L100_D1.3020.78
257_V261_L1.2980.77
206_T267_T1.2820.77
151_E177_S1.2700.76
76_V253_W1.2610.75
229_A233_F1.2540.75
36_R90_E1.2530.75
94_A121_R1.2450.74
36_R78_L1.2290.73
153_Y261_L1.2230.73
186_D207_L1.2110.72
70_L235_D1.2060.72
149_R175_Q1.2050.72
53_S141_R1.2040.72
109_V157_V1.1850.71
74_G213_T1.1780.70
248_A252_A1.1660.69
59_R133_P1.1570.69
37_D100_D1.1530.68
99_L104_A1.1520.68
87_R267_T1.1490.68
58_D78_L1.1460.68
115_M122_D1.1410.68
167_E172_G1.1390.68
79_T147_A1.1380.67
43_K105_A1.1360.67
27_Q50_L1.1280.67
48_D74_G1.1090.65
79_T259_A1.1010.65
45_E136_A1.1000.65
218_L222_D1.0990.65
37_D77_S1.0930.64
21_L50_L1.0890.64
151_E222_D1.0870.64
196_V268_L1.0820.63
153_Y221_L1.0750.63
135_R205_L1.0650.62
134_Q158_L1.0620.62
78_L152_G1.0590.62
186_D190_A1.0590.62
29_A69_L1.0580.62
63_E265_A1.0580.62
229_A238_G1.0570.62
169_I205_L1.0550.61
71_E166_R1.0490.61
70_L189_V1.0440.61
220_T254_A1.0430.61
79_T133_P1.0340.60
154_A217_S1.0340.60
31_L71_E1.0330.60
104_A183_D1.0300.60
68_T83_R1.0300.60
246_D265_A1.0290.59
54_R106_L1.0270.59
177_S208_R1.0230.59
25_L28_R1.0200.59
31_L52_V1.0170.59
144_L214_L1.0100.58
131_V244_H0.9910.57
37_D127_N0.9870.56
61_V99_L0.9850.56
105_A156_A0.9820.56
48_D83_R0.9800.56
70_L108_T0.9780.56
87_R263_A0.9770.55
164_T197_T0.9750.55
167_E215_P0.9750.55
70_L94_A0.9740.55
22_F69_L0.9730.55
207_L236_D0.9680.55
26_A29_A0.9680.55
38_A258_T0.9640.54
117_T243_V0.9620.54
109_V233_F0.9590.54
180_L195_S0.9560.54
170_R198_D0.9560.54
43_K98_G0.9450.53
172_G194_D0.9420.53
94_A167_E0.9380.52
56_T60_A0.9330.52
123_A177_S0.9330.52
19_D93_A0.9300.52
48_D175_Q0.9260.51
168_R174_L0.9260.51
212_T230_C0.9220.51
22_F59_R0.9210.51
53_S123_A0.9180.51
46_L90_E0.9180.51
117_T164_T0.9140.51
189_V196_V0.9090.50
236_D263_A0.9060.50
249_Q263_A0.9050.50
65_E169_I0.9030.50
113_A116_D0.9020.50
220_T236_D0.9020.50
198_D218_L0.8930.49
42_T45_E0.8880.48
122_D205_L0.8880.48
173_E252_A0.8830.48
61_V76_V0.8760.48
110_P113_A0.8750.47
81_K182_P0.8750.47
153_Y194_D0.8740.47
165_L244_H0.8740.47
54_R232_L0.8730.47
145_A190_A0.8720.47
146_D170_R0.8710.47
84_L107_A0.8700.47
233_F239_H0.8670.47
78_L126_V0.8650.47
69_L244_H0.8580.46
232_L258_T0.8570.46
120_F256_R0.8560.46
54_R58_D0.8560.46
172_G268_L0.8540.46
88_S159_D0.8530.46
78_L105_A0.8520.46
43_K102_A0.8520.46
207_L223_T0.8510.46
61_V140_Y0.8420.45
56_T133_P0.8420.45
139_A244_H0.8380.45
28_R55_S0.8360.44
182_P209_E0.8340.44
61_V159_D0.8260.44
83_R258_T0.8190.43
172_G186_D0.8180.43
104_A110_P0.8170.43
25_L245_T0.8170.43
85_A96_I0.8140.43
23_Q61_V0.8130.43
81_K134_Q0.8120.43
175_Q196_V0.7970.41
115_M198_D0.7960.41
47_A243_V0.7900.41
58_D64_L0.7870.41
47_A52_V0.7850.40
57_V216_Y0.7840.40
31_L131_V0.7810.40
32_M253_W0.7810.40
102_A125_V0.7800.40
137_T221_L0.7790.40
230_C243_V0.7740.40
160_S163_S0.7720.40
258_T262_R0.7620.39
155_S169_I0.7610.39
23_Q64_L0.7570.38
21_L241_S0.7560.38
27_Q61_V0.7550.38
109_V169_I0.7460.38
55_S135_R0.7430.37
140_Y176_V0.7400.37
25_L31_L0.7370.37
205_L262_R0.7350.37
147_A221_L0.7330.37
145_A172_G0.7290.36
34_A91_S0.7210.36
70_L255_D0.7190.36
42_T268_L0.7130.35
89_Y92_F0.7130.35
184_V205_L0.7130.35
75_Q83_R0.7110.35
42_T165_L0.7090.35
174_L178_L0.7060.35
149_R156_A0.7020.34
210_A265_A0.7010.34
134_Q159_D0.6980.34
114_R258_T0.6980.34
153_Y268_L0.6970.34
27_Q69_L0.6960.34
165_L176_V0.6950.34
131_V179_V0.6920.34
21_L69_L0.6900.34
179_V263_A0.6890.33
200_L204_A0.6840.33
64_L258_T0.6810.33
38_A94_A0.6780.33
194_D223_T0.6770.33
39_T127_N0.6760.33
150_I160_S0.6750.32
38_A198_D0.6720.32
153_Y162_V0.6690.32
136_A214_L0.6690.32
94_A188_L0.6670.32
94_A97_D0.6670.32
24_L88_S0.6660.32
37_D266_T0.6650.32
61_V67_H0.6640.32
37_D110_P0.6610.32
160_S169_I0.6600.31
46_L246_D0.6600.31
225_S231_G0.6570.31
225_S229_A0.6550.31
125_V191_T0.6540.31
101_A122_D0.6540.31
182_P245_T0.6540.31
94_A105_A0.6540.31
90_E258_T0.6520.31
262_R265_A0.6510.31
179_V241_S0.6480.31
31_L60_A0.6430.30
18_P50_L0.6390.30
50_L58_D0.6370.30
185_L196_V0.6370.30
120_F237_T0.6300.29
79_T225_S0.6290.29
101_A268_L0.6270.29
38_A118_V0.6240.29
52_V60_A0.6230.29
58_D61_V0.6180.29
55_S129_T0.6170.29
142_S188_L0.6160.29
170_R243_V0.6150.28
184_V218_L0.6150.28
25_L106_L0.6140.28
155_S219_F0.6140.28
25_L60_A0.6130.28
150_I207_L0.6130.28
177_S206_T0.6120.28
162_V169_I0.6110.28
63_E67_H0.6090.28
47_A232_L0.6090.28
45_E90_E0.6090.28
140_Y159_D0.6080.28
26_A188_L0.6080.28
229_A242_L0.6060.28
53_S60_A0.6040.28
70_L148_T0.6020.28
144_L179_V0.6020.28
79_T126_V0.5990.27
74_G104_A0.5990.27
173_E223_T0.5970.27
140_Y233_F0.5960.27
138_E213_T0.5920.27
50_L64_L0.5910.27
139_A143_L0.5860.27
51_P259_A0.5860.27
38_A148_T0.5830.26
248_A255_D0.5820.26
157_V218_L0.5810.26
25_L58_D0.5800.26
83_R165_L0.5790.26
179_V260_D0.5780.26
73_A256_R0.5780.26
179_V265_A0.5770.26
72_R267_T0.5760.26
77_S150_I0.5730.26
150_I216_Y0.5680.26
44_P85_A0.5660.25
128_A155_S0.5640.25
83_R248_A0.5600.25
46_L249_Q0.5570.25
174_L203_D0.5560.25
89_Y113_A0.5560.25
44_P266_T0.5540.25
56_T238_G0.5540.25
21_L25_L0.5530.25
145_A195_S0.5520.25
55_S155_S0.5520.25
54_R86_L0.5520.25
67_H203_D0.5480.24
161_V216_Y0.5470.24
21_L65_E0.5460.24
24_L63_E0.5450.24
162_V185_L0.5420.24
199_A205_L0.5410.24
79_T97_D0.5400.24
199_A217_S0.5370.24
217_S222_D0.5360.24
137_T257_V0.5330.24
75_Q168_R0.5320.23
26_A30_D0.5310.23
124_T254_A0.5300.23
26_A212_T0.5300.23
178_L233_F0.5300.23
80_L111_A0.5270.23
72_R76_V0.5260.23
33_R90_E0.5240.23
53_S63_E0.5220.23
50_L91_S0.5220.23
97_D148_T0.5220.23
240_T244_H0.5210.23
245_T250_A0.5210.23
97_D137_T0.5210.23
152_G156_A0.5190.23
102_A245_T0.5190.23
64_L106_L0.5170.23
105_A128_A0.5160.23
125_V134_Q0.5160.23
133_P156_A0.5100.22
78_L179_V0.5090.22
142_S190_A0.5080.22
151_E248_A0.5070.22
26_A60_A0.5050.22
209_E263_A0.5050.22
104_A266_T0.5040.22
178_L265_A0.5030.22
50_L192_H0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.8296 99.3 0.789 Contact Map
3df8A 2 0.3519 98.9 0.825 Contact Map
1z7uA 2 0.3741 98.6 0.84 Contact Map
4k2eA 2 0.3296 98.6 0.841 Contact Map
2fswA 2 0.3481 98.6 0.843 Contact Map
4a5nA 2 0.3556 98.5 0.843 Contact Map
4g6qA 4 0.563 98.5 0.845 Contact Map
3elkA 3 0.3333 98.5 0.845 Contact Map
3f6oA 2 0.3407 98.5 0.846 Contact Map
2f2eA 4 0.4889 98.5 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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