GREMLIN Database
Q9HRH5 - Endonuclease III
UniProt: Q9HRH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (116)
Sequences: 300 (261)
Seq/√Len: 24.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_C113_C4.8751.00
90_C111_C4.5611.00
10_V70_L4.1241.00
7_T34_A4.0881.00
93_A118_V3.8461.00
41_G44_G2.8500.99
7_T36_T2.3460.98
41_G45_L2.2600.97
36_T118_V2.0840.96
62_R71_G2.0760.95
21_G24_G2.0460.95
8_L66_I2.0440.95
20_F24_G2.0340.95
113_C116_H2.0160.95
15_A30_A1.9990.94
106_L117_L1.9160.93
24_G28_L1.8980.93
12_L16_P1.8440.92
111_C116_H1.8220.91
66_I70_L1.7840.90
49_Q53_E1.7530.89
20_F23_A1.7350.89
21_G28_L1.6340.86
40_F44_G1.6020.84
12_L28_L1.5790.84
8_L70_L1.5650.83
20_F28_L1.5060.81
21_G68_Y1.4430.78
53_E59_R1.4350.77
90_C116_H1.4260.77
5_T40_F1.4170.76
15_A27_S1.3550.73
40_F87_D1.3170.71
69_L117_L1.2890.69
92_T100_A1.2290.65
19_T22_A1.1960.63
96_L118_V1.1900.63
40_F43_G1.1660.61
23_A105_G1.1510.60
4_G40_F1.1170.58
50_R90_C1.1080.57
9_L32_W1.0850.55
22_A101_T1.0760.55
76_S79_A1.0640.54
13_D33_Y1.0510.53
17_S25_T1.0290.51
52_R79_A1.0180.51
20_F26_R1.0060.50
102_P108_A0.9830.48
23_A28_L0.9790.48
23_A108_A0.9750.48
29_D102_P0.9710.47
106_L115_T0.9710.47
36_T93_A0.9670.47
14_D92_T0.9320.45
30_A94_R0.9160.43
5_T92_T0.9110.43
3_P96_L0.8980.42
11_A32_W0.8860.41
3_P41_G0.8680.40
104_P108_A0.8670.40
21_G113_C0.8580.39
13_D16_P0.8580.39
36_T40_F0.8550.39
23_A26_R0.8540.39
49_Q72_H0.8370.38
4_G43_G0.8240.37
23_A109_S0.8230.37
7_T83_T0.8230.37
11_A104_P0.8210.37
26_R103_V0.8120.36
59_R92_T0.7980.35
98_D102_P0.7950.35
48_V68_Y0.7930.35
88_V92_T0.7880.35
76_S95_L0.7810.34
5_T8_L0.7810.34
14_D94_R0.7740.34
16_P72_H0.7740.34
74_A77_V0.7720.34
9_L16_P0.7690.34
21_G109_S0.7600.33
8_L39_A0.7600.33
52_R70_L0.7550.33
83_T116_H0.7540.33
11_A78_D0.7460.32
45_L48_V0.7430.32
86_D98_D0.7400.32
10_V66_I0.7370.32
4_G41_G0.7350.31
12_L72_H0.7310.31
76_S80_V0.7300.31
9_L18_I0.7250.31
32_W120_A0.7230.31
77_V108_A0.7220.31
39_A44_G0.7170.30
48_V105_G0.7160.30
36_T96_L0.7150.30
69_L105_G0.7140.30
24_G68_Y0.7120.30
21_G111_C0.7060.30
24_G109_S0.6980.29
101_T108_A0.6960.29
41_G63_H0.6940.29
28_L68_Y0.6930.29
5_T36_T0.6910.29
3_P13_D0.6870.29
93_A116_H0.6860.29
3_P43_G0.6850.28
73_P80_V0.6800.28
14_D114_E0.6790.28
20_F68_Y0.6520.27
36_T70_L0.6490.26
19_T112_T0.6460.26
49_Q85_H0.6450.26
7_T96_L0.6400.26
4_G44_G0.6400.26
45_L120_A0.6400.26
39_A58_E0.6370.26
8_L48_V0.6360.26
13_D95_L0.6350.26
7_T16_P0.6330.26
10_V90_C0.6240.25
5_T87_D0.6170.25
58_E63_H0.6120.24
80_V92_T0.6120.24
21_G116_H0.6120.24
20_F95_L0.6090.24
34_A120_A0.6050.24
36_T94_R0.5950.24
13_D74_A0.5930.23
10_V124_D0.5920.23
28_L90_C0.5880.23
28_L116_H0.5850.23
96_L102_P0.5750.23
13_D76_S0.5740.22
85_H96_L0.5740.22
46_T109_S0.5690.22
84_T88_V0.5650.22
50_R92_T0.5410.21
18_I59_R0.5400.21
4_G93_A0.5390.21
30_A80_V0.5390.21
77_V121_P0.5370.21
34_A60_D0.5370.21
95_L98_D0.5360.21
78_D91_A0.5330.20
10_V18_I0.5240.20
4_G8_L0.5220.20
14_D27_S0.5180.20
18_I119_F0.5160.20
29_D112_T0.5130.20
20_F93_A0.5120.20
29_D79_A0.5090.19
3_P7_T0.5090.19
13_D91_A0.5080.19
63_H95_L0.5080.19
15_A29_D0.5060.19
61_A66_I0.5040.19
67_D89_E0.5000.19
67_D107_G0.5000.19
67_D110_D0.5000.19
89_E107_G0.5000.19
89_E110_D0.5000.19
107_G110_D0.5000.19
37_G110_D0.5000.19
35_Y107_G0.5000.19
35_Y110_D0.5000.19
47_R110_D0.5000.19
47_R107_G0.5000.19
47_R89_E0.5000.19
47_R67_D0.5000.19
47_R65_H0.5000.19
37_G47_R0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yd0A 1 0.529 67.4 0.923 Contact Map
1mk0A 1 0.6232 58.1 0.927 Contact Map
1yd6A 5 0.6594 50.8 0.93 Contact Map
3mx1A 2 0.913 18.8 0.944 Contact Map
3clwA 1 0.3623 16.5 0.946 Contact Map
3zzpA 1 0.5362 9.3 0.952 Contact Map
2ovsA 2 0.7319 8.9 0.952 Contact Map
3og6A 1 0.3043 7.8 0.953 Contact Map
2idcA 1 0.5797 7.8 0.953 Contact Map
2fzpA 1 0.3986 7.3 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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