Q9HRH3 - HALSA - GREMLIN Contacts

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Q9HRH3 - Uncharacterized protein

UniProt:	Q9HRH3	Sequences: MPYDATGVLPRPLPQEIDDGTNLLVSGPAMSGTRTLLFELVARGEPDGEGAVLTTSTDPAETVIDDYEAIRGGDSAFRHVIDCVSTQSGSASPAPGVHHVSSPSDLTGIGIEFSGVAEAAEAAGVDRLRVGFDSLSPVLMYVDVQRLFRFLHVFTSQIQSQGWLGVFAIDPESQDDQTITTLSQLFDGVLEVRLHDGTQEVRLRGLADAPTDWLPVAGVRQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	221 (182)
Sequences:	269 (220)
Seq/√Len:	16.3

HALSA - Q9HRH3 Q9HRP1 Q9HMT0 Q9HS97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_N	167_F	4.511	1.00
148_F	152_H	4.023	1.00
20_G	129_R	3.699	1.00
17_I	23_L	3.308	0.99
22_N	155_T	2.954	0.98
54_T	113_F	2.950	0.98
37_L	168_A	2.856	0.98
151_L	155_T	2.790	0.97
107_T	141_Y	2.750	0.97
37_L	131_G	2.546	0.95
111_I	115_G	2.435	0.94
105_D	108_G	2.413	0.94
193_R	197_G	2.390	0.94
172_E	178_T	2.137	0.89
110_G	152_H	2.034	0.86
158_I	165_G	2.031	0.86
131_G	166_V	1.993	0.85
81_I	113_F	1.912	0.83
130_V	190_L	1.894	0.82
110_G	148_F	1.850	0.81
117_A	163_W	1.822	0.80
143_D	169_I	1.814	0.79
131_G	168_A	1.801	0.79
115_G	118_E	1.762	0.77
152_H	185_L	1.741	0.76
183_S	189_V	1.736	0.76
117_A	183_S	1.729	0.76
40_L	102_S	1.664	0.73
113_F	130_V	1.628	0.71
135_L	161_Q	1.614	0.70
90_S	93_P	1.605	0.70
149_R	152_H	1.564	0.68
87_Q	143_D	1.509	0.65
111_I	152_H	1.505	0.65
37_L	166_V	1.496	0.64
110_G	114_S	1.491	0.64
97_V	127_R	1.474	0.63
96_G	190_L	1.443	0.61
22_N	186_F	1.410	0.60
106_L	147_L	1.384	0.58
92_S	95_P	1.382	0.58
89_G	99_H	1.379	0.58
25_V	38_F	1.374	0.58
33_T	168_A	1.363	0.57
16_E	186_F	1.359	0.57
114_S	156_S	1.346	0.56
175_D	178_T	1.340	0.56
60_A	101_S	1.335	0.55
25_V	90_S	1.323	0.55
107_T	111_I	1.318	0.54
53_L	165_G	1.295	0.53
22_N	158_I	1.286	0.53
119_A	132_F	1.284	0.52
82_D	89_G	1.264	0.51
89_G	192_V	1.236	0.50
120_A	128_L	1.221	0.49
107_T	177_Q	1.209	0.48
42_A	49_E	1.201	0.48
139_L	152_H	1.198	0.47
111_I	173_S	1.182	0.46
136_S	174_Q	1.180	0.46
52_V	147_L	1.174	0.46
110_G	145_Q	1.167	0.46
129_R	165_G	1.151	0.45
148_F	181_T	1.148	0.44
113_F	135_L	1.146	0.44
115_G	143_D	1.127	0.43
153_V	181_T	1.123	0.43
151_L	167_F	1.119	0.43
117_A	194_L	1.117	0.43
32_G	81_I	1.116	0.43
98_H	140_M	1.116	0.43
85_S	99_H	1.115	0.43
127_R	164_L	1.113	0.42
31_S	132_F	1.105	0.42
131_G	163_W	1.100	0.42
133_D	192_V	1.095	0.41
193_R	196_D	1.083	0.41
94_A	97_V	1.076	0.40
56_S	82_D	1.064	0.40
44_G	129_R	1.064	0.40
132_F	192_V	1.062	0.40
50_G	120_A	1.059	0.39
21_T	103_P	1.052	0.39
55_T	60_A	1.048	0.39
65_D	80_V	1.044	0.39
75_S	135_L	1.020	0.37
50_G	128_L	1.020	0.37
23_L	41_V	1.012	0.37
24_L	170_D	0.999	0.36
165_G	188_G	0.999	0.36
82_D	134_S	0.992	0.36
139_L	147_L	0.987	0.35
103_P	141_Y	0.984	0.35
131_G	193_R	0.981	0.35
39_E	193_R	0.971	0.35
39_E	70_I	0.962	0.34
84_V	87_Q	0.956	0.34
52_V	183_S	0.951	0.34
106_L	179_I	0.947	0.33
152_H	184_Q	0.947	0.33
101_S	141_Y	0.944	0.33
149_R	181_T	0.938	0.33
148_F	186_F	0.935	0.33
42_A	170_D	0.910	0.31
81_I	175_D	0.909	0.31
136_S	148_F	0.903	0.31
149_R	185_L	0.890	0.30
29_A	197_G	0.885	0.30
139_L	185_L	0.885	0.30
17_I	49_E	0.883	0.30
166_V	190_L	0.882	0.30
25_V	40_L	0.880	0.30
156_S	183_S	0.878	0.30
148_F	180_T	0.877	0.30
44_G	48_G	0.877	0.30
34_R	52_V	0.873	0.30
153_V	157_Q	0.873	0.30
133_D	189_V	0.872	0.30
169_I	186_F	0.868	0.29
35_T	192_V	0.867	0.29
66_D	133_D	0.862	0.29
96_G	180_T	0.861	0.29
25_V	37_L	0.859	0.29
21_T	188_G	0.858	0.29
63_V	162_G	0.856	0.29
114_S	118_E	0.854	0.29
106_L	148_F	0.853	0.29
62_T	85_S	0.850	0.28
107_T	149_R	0.844	0.28
107_T	110_G	0.840	0.28
49_E	127_R	0.834	0.28
169_I	176_D	0.832	0.28
20_G	49_E	0.831	0.28
74_D	129_R	0.827	0.27
54_T	110_G	0.825	0.27
145_Q	185_L	0.823	0.27
148_F	153_V	0.823	0.27
114_S	160_S	0.822	0.27
22_N	149_R	0.819	0.27
130_V	151_L	0.807	0.26
108_G	141_Y	0.806	0.26
28_P	31_S	0.797	0.26
23_L	52_V	0.796	0.26
115_G	132_F	0.796	0.26
48_G	137_P	0.793	0.26
52_V	87_Q	0.791	0.26
99_H	138_V	0.791	0.26
75_S	92_S	0.788	0.26
114_S	153_V	0.784	0.25
61_E	180_T	0.782	0.25
46_P	72_G	0.782	0.25
157_Q	165_G	0.778	0.25
40_L	53_L	0.776	0.25
53_L	63_V	0.766	0.25
118_E	184_Q	0.760	0.24
138_V	163_W	0.757	0.24
25_V	34_R	0.754	0.24
59_P	87_Q	0.748	0.24
132_F	178_T	0.747	0.24
92_S	177_Q	0.744	0.24
25_V	182_L	0.743	0.24
81_I	137_P	0.743	0.24
54_T	75_S	0.741	0.24
152_H	157_Q	0.740	0.24
22_N	114_S	0.737	0.23
27_G	33_T	0.729	0.23
69_A	90_S	0.729	0.23
135_L	198_T	0.725	0.23
135_L	167_F	0.722	0.23
24_L	171_P	0.721	0.23
73_G	135_L	0.715	0.22
150_F	181_T	0.714	0.22
115_G	119_A	0.710	0.22
17_I	109_I	0.710	0.22
169_I	172_E	0.699	0.22
90_S	191_E	0.691	0.22
113_F	151_L	0.691	0.22
146_R	153_V	0.690	0.21
167_F	186_F	0.690	0.21
73_G	76_A	0.689	0.21
52_V	116_V	0.684	0.21
103_P	167_F	0.681	0.21
55_T	190_L	0.679	0.21
54_T	157_Q	0.676	0.21
146_R	160_S	0.673	0.21
163_W	193_R	0.669	0.21
27_G	193_R	0.669	0.21
107_T	114_S	0.665	0.21
76_A	185_L	0.663	0.20
117_A	133_D	0.660	0.20
158_I	163_W	0.654	0.20
32_G	141_Y	0.653	0.20
147_L	187_D	0.648	0.20
21_T	34_R	0.646	0.20
67_Y	184_Q	0.646	0.20
29_A	192_V	0.645	0.20
20_G	27_G	0.640	0.20
56_S	137_P	0.633	0.19
169_I	179_I	0.633	0.19
102_S	107_T	0.629	0.19
88_S	173_S	0.628	0.19
25_V	139_L	0.628	0.19
55_T	70_I	0.628	0.19
19_D	122_A	0.627	0.19
23_L	123_A	0.627	0.19
110_G	150_F	0.623	0.19
54_T	95_P	0.622	0.19
151_L	181_T	0.619	0.19
46_P	190_L	0.618	0.19
114_S	152_H	0.617	0.19
88_S	169_I	0.614	0.19
55_T	141_Y	0.606	0.18
107_T	140_M	0.604	0.18
133_D	188_G	0.598	0.18
154_F	176_D	0.592	0.18
68_E	72_G	0.589	0.18
82_D	85_S	0.588	0.18
34_R	131_G	0.587	0.18
129_R	163_W	0.586	0.18
108_G	146_R	0.586	0.18
100_V	105_D	0.582	0.18
115_G	138_V	0.582	0.18
102_S	155_T	0.579	0.17
87_Q	190_L	0.577	0.17
17_I	175_D	0.574	0.17
30_M	95_P	0.573	0.17
38_F	182_L	0.572	0.17
35_T	196_D	0.571	0.17
48_G	87_Q	0.570	0.17
175_D	194_L	0.568	0.17
20_G	23_L	0.568	0.17
49_E	164_L	0.565	0.17
152_H	181_T	0.565	0.17
91_A	106_L	0.563	0.17
20_G	164_L	0.561	0.17
48_G	160_S	0.561	0.17
59_P	109_I	0.558	0.17
127_R	182_L	0.556	0.17
75_S	147_L	0.556	0.17
81_I	117_A	0.553	0.17
147_L	186_F	0.551	0.16
183_S	190_L	0.551	0.16
56_S	129_R	0.551	0.16
88_S	123_A	0.550	0.16
97_V	100_V	0.545	0.16
108_G	184_Q	0.540	0.16
154_F	165_G	0.540	0.16
115_G	151_L	0.532	0.16
107_T	150_F	0.532	0.16
48_G	164_L	0.530	0.16
82_D	165_G	0.530	0.16
24_L	133_D	0.528	0.16
149_R	158_I	0.526	0.16
94_A	170_D	0.525	0.16
130_V	193_R	0.525	0.16
21_T	114_S	0.524	0.16
121_E	168_A	0.523	0.16
43_R	188_G	0.522	0.16
88_S	192_V	0.522	0.16
44_G	123_A	0.522	0.16
143_D	187_D	0.522	0.16
64_I	151_L	0.521	0.16
122_A	193_R	0.516	0.15
114_S	150_F	0.516	0.15
28_P	136_S	0.507	0.15
118_E	122_A	0.507	0.15
40_L	131_G	0.506	0.15
146_R	157_Q	0.505	0.15
162_G	193_R	0.504	0.15
18_D	106_L	0.504	0.15
155_T	158_I	0.503	0.15
19_D	58_D	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bs4A	1	0.9548	99.6	0.731	Contact Map
4a8jA	1	0.8959	99.5	0.76	Contact Map
4bwyA	3	0.733	98.4	0.843	Contact Map
2dr3A	3	0.9593	98.3	0.848	Contact Map
4blqA	3	0.7647	97.9	0.863	Contact Map
2w0mA	1	0.8824	97.6	0.871	Contact Map
2cvhA	1	0.8914	97.6	0.873	Contact Map
2ztsA	3	0.8869	97.2	0.881	Contact Map
1tf7A	3	0.9095	97	0.884	Contact Map
4ppfA	1	0.8462	96.5	0.891	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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