GREMLIN Database
Q9HRH3 - Uncharacterized protein
UniProt: Q9HRH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (182)
Sequences: 269 (220)
Seq/√Len: 16.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_N167_F4.5111.00
148_F152_H4.0231.00
20_G129_R3.6991.00
17_I23_L3.3080.99
22_N155_T2.9540.98
54_T113_F2.9500.98
37_L168_A2.8560.98
151_L155_T2.7900.97
107_T141_Y2.7500.97
37_L131_G2.5460.95
111_I115_G2.4350.94
105_D108_G2.4130.94
193_R197_G2.3900.94
172_E178_T2.1370.89
110_G152_H2.0340.86
158_I165_G2.0310.86
131_G166_V1.9930.85
81_I113_F1.9120.83
130_V190_L1.8940.82
110_G148_F1.8500.81
117_A163_W1.8220.80
143_D169_I1.8140.79
131_G168_A1.8010.79
115_G118_E1.7620.77
152_H185_L1.7410.76
183_S189_V1.7360.76
117_A183_S1.7290.76
40_L102_S1.6640.73
113_F130_V1.6280.71
135_L161_Q1.6140.70
90_S93_P1.6050.70
149_R152_H1.5640.68
87_Q143_D1.5090.65
111_I152_H1.5050.65
37_L166_V1.4960.64
110_G114_S1.4910.64
97_V127_R1.4740.63
96_G190_L1.4430.61
22_N186_F1.4100.60
106_L147_L1.3840.58
92_S95_P1.3820.58
89_G99_H1.3790.58
25_V38_F1.3740.58
33_T168_A1.3630.57
16_E186_F1.3590.57
114_S156_S1.3460.56
175_D178_T1.3400.56
60_A101_S1.3350.55
25_V90_S1.3230.55
107_T111_I1.3180.54
53_L165_G1.2950.53
22_N158_I1.2860.53
119_A132_F1.2840.52
82_D89_G1.2640.51
89_G192_V1.2360.50
120_A128_L1.2210.49
107_T177_Q1.2090.48
42_A49_E1.2010.48
139_L152_H1.1980.47
111_I173_S1.1820.46
136_S174_Q1.1800.46
52_V147_L1.1740.46
110_G145_Q1.1670.46
129_R165_G1.1510.45
148_F181_T1.1480.44
113_F135_L1.1460.44
115_G143_D1.1270.43
153_V181_T1.1230.43
151_L167_F1.1190.43
117_A194_L1.1170.43
32_G81_I1.1160.43
98_H140_M1.1160.43
85_S99_H1.1150.43
127_R164_L1.1130.42
31_S132_F1.1050.42
131_G163_W1.1000.42
133_D192_V1.0950.41
193_R196_D1.0830.41
94_A97_V1.0760.40
56_S82_D1.0640.40
44_G129_R1.0640.40
132_F192_V1.0620.40
50_G120_A1.0590.39
21_T103_P1.0520.39
55_T60_A1.0480.39
65_D80_V1.0440.39
75_S135_L1.0200.37
50_G128_L1.0200.37
23_L41_V1.0120.37
24_L170_D0.9990.36
165_G188_G0.9990.36
82_D134_S0.9920.36
139_L147_L0.9870.35
103_P141_Y0.9840.35
131_G193_R0.9810.35
39_E193_R0.9710.35
39_E70_I0.9620.34
84_V87_Q0.9560.34
52_V183_S0.9510.34
106_L179_I0.9470.33
152_H184_Q0.9470.33
101_S141_Y0.9440.33
149_R181_T0.9380.33
148_F186_F0.9350.33
42_A170_D0.9100.31
81_I175_D0.9090.31
136_S148_F0.9030.31
149_R185_L0.8900.30
29_A197_G0.8850.30
139_L185_L0.8850.30
17_I49_E0.8830.30
166_V190_L0.8820.30
25_V40_L0.8800.30
156_S183_S0.8780.30
148_F180_T0.8770.30
44_G48_G0.8770.30
34_R52_V0.8730.30
153_V157_Q0.8730.30
133_D189_V0.8720.30
169_I186_F0.8680.29
35_T192_V0.8670.29
66_D133_D0.8620.29
96_G180_T0.8610.29
25_V37_L0.8590.29
21_T188_G0.8580.29
63_V162_G0.8560.29
114_S118_E0.8540.29
106_L148_F0.8530.29
62_T85_S0.8500.28
107_T149_R0.8440.28
107_T110_G0.8400.28
49_E127_R0.8340.28
169_I176_D0.8320.28
20_G49_E0.8310.28
74_D129_R0.8270.27
54_T110_G0.8250.27
145_Q185_L0.8230.27
148_F153_V0.8230.27
114_S160_S0.8220.27
22_N149_R0.8190.27
130_V151_L0.8070.26
108_G141_Y0.8060.26
28_P31_S0.7970.26
23_L52_V0.7960.26
115_G132_F0.7960.26
48_G137_P0.7930.26
52_V87_Q0.7910.26
99_H138_V0.7910.26
75_S92_S0.7880.26
114_S153_V0.7840.25
61_E180_T0.7820.25
46_P72_G0.7820.25
157_Q165_G0.7780.25
40_L53_L0.7760.25
53_L63_V0.7660.25
118_E184_Q0.7600.24
138_V163_W0.7570.24
25_V34_R0.7540.24
59_P87_Q0.7480.24
132_F178_T0.7470.24
92_S177_Q0.7440.24
25_V182_L0.7430.24
81_I137_P0.7430.24
54_T75_S0.7410.24
152_H157_Q0.7400.24
22_N114_S0.7370.23
27_G33_T0.7290.23
69_A90_S0.7290.23
135_L198_T0.7250.23
135_L167_F0.7220.23
24_L171_P0.7210.23
73_G135_L0.7150.22
150_F181_T0.7140.22
115_G119_A0.7100.22
17_I109_I0.7100.22
169_I172_E0.6990.22
90_S191_E0.6910.22
113_F151_L0.6910.22
146_R153_V0.6900.21
167_F186_F0.6900.21
73_G76_A0.6890.21
52_V116_V0.6840.21
103_P167_F0.6810.21
55_T190_L0.6790.21
54_T157_Q0.6760.21
146_R160_S0.6730.21
163_W193_R0.6690.21
27_G193_R0.6690.21
107_T114_S0.6650.21
76_A185_L0.6630.20
117_A133_D0.6600.20
158_I163_W0.6540.20
32_G141_Y0.6530.20
147_L187_D0.6480.20
21_T34_R0.6460.20
67_Y184_Q0.6460.20
29_A192_V0.6450.20
20_G27_G0.6400.20
56_S137_P0.6330.19
169_I179_I0.6330.19
102_S107_T0.6290.19
88_S173_S0.6280.19
25_V139_L0.6280.19
55_T70_I0.6280.19
19_D122_A0.6270.19
23_L123_A0.6270.19
110_G150_F0.6230.19
54_T95_P0.6220.19
151_L181_T0.6190.19
46_P190_L0.6180.19
114_S152_H0.6170.19
88_S169_I0.6140.19
55_T141_Y0.6060.18
107_T140_M0.6040.18
133_D188_G0.5980.18
154_F176_D0.5920.18
68_E72_G0.5890.18
82_D85_S0.5880.18
34_R131_G0.5870.18
129_R163_W0.5860.18
108_G146_R0.5860.18
100_V105_D0.5820.18
115_G138_V0.5820.18
102_S155_T0.5790.17
87_Q190_L0.5770.17
17_I175_D0.5740.17
30_M95_P0.5730.17
38_F182_L0.5720.17
35_T196_D0.5710.17
48_G87_Q0.5700.17
175_D194_L0.5680.17
20_G23_L0.5680.17
49_E164_L0.5650.17
152_H181_T0.5650.17
91_A106_L0.5630.17
20_G164_L0.5610.17
48_G160_S0.5610.17
59_P109_I0.5580.17
127_R182_L0.5560.17
75_S147_L0.5560.17
81_I117_A0.5530.17
147_L186_F0.5510.16
183_S190_L0.5510.16
56_S129_R0.5510.16
88_S123_A0.5500.16
97_V100_V0.5450.16
108_G184_Q0.5400.16
154_F165_G0.5400.16
115_G151_L0.5320.16
107_T150_F0.5320.16
48_G164_L0.5300.16
82_D165_G0.5300.16
24_L133_D0.5280.16
149_R158_I0.5260.16
94_A170_D0.5250.16
130_V193_R0.5250.16
21_T114_S0.5240.16
121_E168_A0.5230.16
43_R188_G0.5220.16
88_S192_V0.5220.16
44_G123_A0.5220.16
143_D187_D0.5220.16
64_I151_L0.5210.16
122_A193_R0.5160.15
114_S150_F0.5160.15
28_P136_S0.5070.15
118_E122_A0.5070.15
40_L131_G0.5060.15
146_R157_Q0.5050.15
162_G193_R0.5040.15
18_D106_L0.5040.15
155_T158_I0.5030.15
19_D58_D0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.9548 99.6 0.731 Contact Map
4a8jA 1 0.8959 99.5 0.76 Contact Map
4bwyA 3 0.733 98.4 0.843 Contact Map
2dr3A 3 0.9593 98.3 0.848 Contact Map
4blqA 3 0.7647 97.9 0.863 Contact Map
2w0mA 1 0.8824 97.6 0.871 Contact Map
2cvhA 1 0.8914 97.6 0.873 Contact Map
2ztsA 3 0.8869 97.2 0.881 Contact Map
1tf7A 3 0.9095 97 0.884 Contact Map
4ppfA 1 0.8462 96.5 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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