GREMLIN Database
Q9HRH1 - Uncharacterized protein
UniProt: Q9HRH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 68 (62)
Sequences: 6457 (4709)
Seq/√Len: 598.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_D62_D2.6611.00
22_A59_A2.2801.00
3_K43_V2.1861.00
48_T51_D2.1541.00
4_T40_T2.1231.00
20_E24_A2.1131.00
4_T38_S2.0631.00
57_E62_D1.7811.00
12_C15_C1.7561.00
30_S44_D1.7371.00
23_L39_G1.6861.00
17_D21_N1.6861.00
10_M19_V1.6181.00
16_E34_A1.5611.00
26_V55_S1.4861.00
7_I10_M1.4731.00
7_I39_G1.4581.00
6_S64_E1.4131.00
53_L63_A1.4131.00
54_R58_L1.3561.00
18_I59_A1.3141.00
22_A55_S1.2721.00
30_S42_T1.2411.00
13_E35_D1.2311.00
5_L63_A1.1951.00
8_D64_E1.1821.00
11_G18_I1.1201.00
22_A26_V1.0961.00
13_E16_E1.0821.00
51_D54_R1.0721.00
56_V62_D1.0201.00
43_V47_A1.0071.00
54_R57_E0.9891.00
33_D36_H0.9611.00
50_D54_R0.9511.00
43_V48_T0.9511.00
3_K49_D0.9511.00
41_V52_L0.9351.00
32_V39_G0.9341.00
23_L52_L0.9251.00
49_D53_L0.9221.00
9_E62_D0.8981.00
29_V52_L0.8821.00
13_E17_D0.8771.00
6_S37_E0.8541.00
6_S63_A0.8531.00
8_D37_E0.8511.00
19_V59_A0.8451.00
55_S59_A0.8351.00
47_A52_L0.8211.00
50_D53_L0.7881.00
39_G56_V0.7671.00
14_G18_I0.7641.00
5_L56_V0.7391.00
18_I22_A0.7381.00
14_G17_D0.7381.00
9_E56_V0.7361.00
43_V52_L0.7171.00
5_L49_D0.7081.00
34_A37_E0.7001.00
51_D55_S0.6891.00
23_L55_S0.6861.00
28_A47_A0.6821.00
47_A51_D0.6721.00
19_V56_V0.6571.00
20_E31_D0.6431.00
16_E20_E0.6431.00
23_L41_V0.6391.00
53_L57_E0.6321.00
16_E39_G0.6251.00
14_G35_D0.6241.00
21_N24_A0.6221.00
5_L53_L0.6211.00
10_M34_A0.6031.00
11_G14_G0.6021.00
18_I61_Y0.6001.00
55_S58_L0.5991.00
5_L39_G0.5951.00
26_V47_A0.5891.00
11_G16_E0.5861.00
39_G63_A0.5831.00
53_L64_E0.5811.00
10_M32_V0.5761.00
31_D40_T0.5601.00
20_E32_V0.5400.99
57_E63_A0.5290.99
6_S40_T0.5170.99
13_E33_D0.5160.99
43_V49_D0.5130.99
29_V41_V0.5050.99
23_L26_V0.5040.99
5_L52_L0.5020.99
16_E32_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ropA 1 0.9706 99.2 0.283 Contact Map
3j09A 2 1 99.2 0.287 Contact Map
1q8lA 1 1 99.2 0.298 Contact Map
4umwA 1 0 99.2 0.299 Contact Map
1p6tA 1 1 99.2 0.299 Contact Map
2kt2A 1 0.9853 99.2 0.301 Contact Map
1aw0A 1 0.9853 99.2 0.303 Contact Map
4u9rA 1 0.8971 99.2 0.305 Contact Map
2ew9A 1 0.9853 99.2 0.305 Contact Map
1yg0A 1 0.9412 99.2 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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