GREMLIN Database
Q9HRG9 - Uncharacterized protein
UniProt: Q9HRG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (101)
Sequences: 9751 (5811)
Seq/√Len: 578.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_S89_A2.7781.00
96_S110_Q2.7631.00
50_Q58_S2.7561.00
59_K63_E2.7541.00
81_E85_R2.5391.00
39_L98_E2.5161.00
77_T89_A2.4421.00
38_L74_V2.2801.00
75_S91_T2.2781.00
37_R52_E2.0791.00
79_V87_E1.9861.00
38_L49_L1.8001.00
93_L111_H1.7811.00
79_V85_R1.6951.00
103_S106_E1.6941.00
100_V103_S1.6741.00
43_P89_A1.6341.00
90_L94_G1.6161.00
99_P103_S1.6131.00
34_I64_S1.5891.00
44_L52_E1.5881.00
66_D69_E1.5831.00
60_V63_E1.5431.00
43_P87_E1.4981.00
31_H67_D1.4361.00
95_Q98_E1.4281.00
96_S107_W1.3981.00
76_R86_V1.3591.00
92_E95_Q1.3581.00
31_H64_S1.3551.00
22_T104_M1.3441.00
73_I94_G1.3301.00
93_L96_S1.2581.00
58_S62_S1.2441.00
25_L71_K1.2401.00
22_T108_G1.2381.00
28_K67_D1.2231.00
38_L44_L1.1771.00
78_I83_P1.1681.00
79_V83_P1.1681.00
44_L48_A1.1431.00
47_N51_E1.1191.00
28_K64_S1.1121.00
105_A109_H1.1041.00
69_E74_V1.0981.00
93_L114_P1.0781.00
35_I90_L1.0741.00
73_I97_L1.0671.00
77_T87_E1.0661.00
46_F62_S1.0541.00
21_T112_L1.0501.00
79_V84_V1.0351.00
28_K31_H1.0261.00
45_G87_E1.0231.00
96_S111_H0.9871.00
79_V82_K0.9861.00
31_H68_L0.9791.00
62_S66_D0.9751.00
80_S83_P0.9741.00
89_A95_Q0.9721.00
32_P101_V0.9611.00
98_E102_S0.9471.00
78_I84_V0.9431.00
60_V64_S0.9411.00
78_I86_V0.9331.00
25_L73_I0.9231.00
34_I53_V0.9131.00
39_L90_L0.9021.00
56_I61_L0.8811.00
57_S60_V0.8801.00
31_H71_K0.8741.00
106_E110_Q0.8731.00
99_P106_E0.8731.00
97_L107_W0.8701.00
48_A51_E0.8621.00
46_F58_S0.8511.00
102_S106_E0.8441.00
37_R49_L0.8331.00
72_Q93_L0.8281.00
20_T24_S0.8161.00
47_N50_Q0.8081.00
34_I56_I0.7911.00
18_S109_H0.7801.00
30_W56_I0.7601.00
39_L102_S0.7561.00
78_I82_K0.7561.00
53_V56_I0.7501.00
36_H105_A0.7481.00
67_D71_K0.7451.00
21_T111_H0.7381.00
100_V104_M0.7341.00
111_H114_P0.7221.00
44_L49_L0.7211.00
78_I81_E0.6921.00
15_S20_T0.6821.00
56_I86_V0.6821.00
82_K86_V0.6731.00
63_E67_D0.6621.00
97_L100_V0.6601.00
23_A97_L0.6571.00
23_A32_P0.6571.00
45_G79_V0.6561.00
23_A104_M0.6511.00
38_L43_P0.6381.00
42_G95_Q0.6351.00
106_E109_H0.6321.00
69_E78_I0.6301.00
36_H39_L0.6301.00
33_V37_R0.6211.00
102_S105_A0.6191.00
40_S44_L0.6171.00
15_S24_S0.6141.00
58_S64_S0.6081.00
108_G112_L0.6051.00
68_L73_I0.5981.00
40_S52_E0.5961.00
48_A52_E0.5941.00
38_L69_E0.5861.00
13_G19_I0.5811.00
81_E84_V0.5811.00
37_R44_L0.5771.00
69_E76_R0.5771.00
33_V53_V0.5751.00
19_I112_L0.5701.00
46_F50_Q0.5701.00
110_Q113_D0.5660.99
81_E86_V0.5660.99
81_E87_E0.5650.99
35_I97_L0.5650.99
45_G48_A0.5640.99
107_W111_H0.5540.99
83_P86_V0.5520.99
109_H112_L0.5510.99
20_T32_P0.5510.99
47_N58_S0.5460.99
15_S21_T0.5420.99
50_Q61_L0.5350.99
21_T24_S0.5330.99
43_P48_A0.5330.99
17_C46_F0.5300.99
93_L112_L0.5280.99
100_V108_G0.5260.99
99_P102_S0.5240.99
43_P49_L0.5210.99
82_K85_R0.5130.99
96_S99_P0.5080.99
35_I73_I0.5060.99
20_T54_D0.5050.99
26_V104_M0.5040.99
90_L95_Q0.5030.99
36_H46_F0.5030.99
92_E96_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.8455 99.9 0.417 Contact Map
4a5nA 2 0.8537 99.7 0.488 Contact Map
1yyvA 2 0.9106 99.7 0.503 Contact Map
2hztA 2 0.7724 99.7 0.52 Contact Map
1z7uA 2 0.9024 99.7 0.521 Contact Map
2fswA 2 0.8374 99.7 0.523 Contact Map
2f2eA 4 0.9024 99.6 0.532 Contact Map
4hw0A 2 0.7642 99.6 0.56 Contact Map
3df8A 2 0.8537 99.5 0.574 Contact Map
4hqeA 2 0.8699 99.4 0.594 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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