GREMLIN Database
Q9HRG7 - Uncharacterized protein
UniProt: Q9HRG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (177)
Sequences: 103 (69)
Seq/√Len: 5.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_T48_R3.2200.77
116_E120_T2.9800.71
43_A46_R2.9010.69
86_T138_D2.8710.68
143_E171_A2.7730.66
21_V73_S2.6530.62
170_E177_A2.6430.62
48_R135_S2.6000.60
30_G77_Y2.5980.60
147_S182_R2.5190.58
47_L51_L2.3770.53
137_E155_V2.1970.47
159_A162_A2.1050.44
147_S184_A2.0850.43
58_T74_F2.0470.42
62_D169_V2.0020.41
107_T184_A1.9550.39
118_A157_P1.9440.39
143_E150_L1.9310.39
97_P139_R1.9220.38
30_G39_T1.9140.38
41_S44_G1.8710.37
107_T147_S1.8440.36
22_I87_P1.8290.35
112_L168_Y1.7570.33
135_S169_V1.7010.32
59_T62_D1.6880.31
39_T135_S1.6710.31
128_A147_S1.6710.31
15_A99_F1.6160.29
114_V157_P1.5850.28
23_G114_V1.5690.28
16_N100_D1.5590.28
74_F116_E1.5510.28
128_A184_A1.5400.27
60_A173_R1.5060.26
126_C145_H1.4950.26
107_T128_A1.4710.25
155_V164_Q1.4600.25
107_T182_R1.4590.25
39_T77_Y1.3980.24
49_S165_E1.3940.24
58_T71_D1.3890.23
47_L142_T1.3800.23
41_S48_R1.3720.23
147_S183_Q1.3550.23
56_V175_V1.3500.23
69_D93_R1.3390.22
112_L172_L1.3380.22
80_P108_A1.3290.22
39_T46_R1.3110.22
19_I152_V1.3070.22
22_I164_Q1.3070.22
108_A151_V1.2740.21
75_F173_R1.2520.20
69_D152_V1.2460.20
142_T166_T1.2410.20
128_A182_R1.2310.20
43_A135_S1.2260.20
44_G48_R1.2200.20
95_L107_T1.2200.20
41_S52_R1.2060.19
44_G174_A1.1920.19
26_P106_I1.1890.19
25_H87_P1.1810.19
159_A170_E1.1740.19
88_T134_A1.1730.19
62_D69_D1.1620.19
43_A169_V1.1580.18
15_A85_G1.1490.18
71_D144_L1.1480.18
12_H126_C1.1440.18
21_V24_D1.1300.18
90_A93_R1.1260.18
121_H164_Q1.1210.18
32_T98_F1.1170.18
77_Y103_L1.1150.18
135_S164_Q1.0980.17
15_A93_R1.0950.17
74_F130_D1.0920.17
91_D174_A1.0910.17
58_T134_A1.0900.17
48_R52_R1.0880.17
47_L168_Y1.0470.16
36_T101_A1.0460.16
78_L87_P1.0440.16
119_T136_L1.0340.16
19_I110_V1.0170.16
107_T110_V1.0050.16
74_F78_L1.0050.16
51_L84_E0.9990.16
53_D170_E0.9890.15
136_L154_C0.9840.15
22_I175_V0.9750.15
80_P95_L0.9750.15
106_I118_A0.9720.15
42_A156_Q0.9720.15
149_W182_R0.9720.15
8_F183_Q0.9700.15
56_V187_G0.9690.15
6_E120_T0.9670.15
53_D93_R0.9590.15
15_A103_L0.9470.15
10_P183_Q0.9420.15
20_H103_L0.9380.14
78_L117_R0.9350.14
21_V75_F0.9260.14
56_V110_V0.9210.14
48_R136_L0.9170.14
96_E127_T0.9170.14
166_T177_A0.9140.14
27_G30_G0.9080.14
105_A150_L0.9030.14
180_Y184_A0.9010.14
62_D84_E0.8950.14
97_P132_A0.8940.14
50_A107_T0.8920.14
120_T156_Q0.8880.14
85_G170_E0.8830.14
74_F94_E0.8810.14
31_G108_A0.8700.13
16_N105_A0.8630.13
12_H80_P0.8610.13
49_S53_D0.8560.13
74_F157_P0.8550.13
20_H100_D0.8530.13
5_C10_P0.8520.13
8_F187_G0.8490.13
58_T173_R0.8420.13
92_Y136_L0.8420.13
83_P91_D0.8410.13
117_R161_S0.8400.13
32_T82_V0.8300.13
72_N107_T0.8220.13
104_R148_G0.8220.13
20_H136_L0.8190.13
45_D60_A0.8120.13
138_D178_T0.8090.12
145_H184_A0.8070.12
57_L70_P0.8040.12
107_T183_Q0.8030.12
28_V63_D0.7990.12
93_R141_A0.7980.12
89_P161_S0.7970.12
48_R61_A0.7970.12
16_N20_H0.7960.12
56_V69_D0.7900.12
31_G76_S0.7790.12
132_A180_Y0.7700.12
132_A144_L0.7660.12
53_D75_F0.7620.12
43_A174_A0.7620.12
100_D105_A0.7620.12
51_L73_S0.7600.12
46_R78_L0.7590.12
71_D142_T0.7570.12
101_A152_V0.7520.12
25_H116_E0.7500.12
34_T101_A0.7490.12
116_E137_E0.7420.12
143_E160_W0.7410.12
111_L135_S0.7410.12
110_V147_S0.7370.11
5_C182_R0.7360.11
98_F114_V0.7340.11
16_N160_W0.7340.11
5_C8_F0.7320.11
17_A118_A0.7320.11
24_D99_F0.7280.11
116_E136_L0.7270.11
47_L102_E0.7230.11
53_D175_V0.7230.11
24_D119_T0.7230.11
25_H92_Y0.7200.11
9_V36_T0.7190.11
89_P133_D0.7100.11
158_D175_V0.7010.11
34_T48_R0.6900.11
72_N180_Y0.6880.11
100_D109_H0.6850.11
94_E168_Y0.6840.11
54_A176_M0.6800.11
41_S142_T0.6780.11
30_G34_T0.6750.11
18_D71_D0.6690.11
15_A50_A0.6670.11
69_D144_L0.6670.11
53_D85_G0.6660.11
8_F182_R0.6650.11
41_S111_L0.6640.11
48_R166_T0.6620.11
107_T145_H0.6610.11
49_S125_T0.6590.10
109_H172_L0.6590.10
76_S108_A0.6550.10
97_P100_D0.6530.10
103_L136_L0.6500.10
55_G62_D0.6490.10
92_Y99_F0.6420.10
110_V182_R0.6410.10
149_W183_Q0.6350.10
31_G79_H0.6340.10
87_P164_Q0.6320.10
122_V143_E0.6260.10
88_T177_A0.6240.10
57_L73_S0.6240.10
145_H181_Q0.6210.10
81_C141_A0.6210.10
34_T177_A0.6200.10
92_Y119_T0.6200.10
60_A90_A0.6180.10
23_G73_S0.6130.10
80_P121_H0.6120.10
60_A63_D0.6110.10
89_P128_A0.6030.10
72_N145_H0.6020.10
110_V184_A0.5980.10
40_G178_T0.5920.10
95_L184_A0.5880.10
30_G38_F0.5860.10
25_H143_E0.5850.10
141_A165_E0.5800.10
104_R127_T0.5800.10
120_T141_A0.5750.09
16_N103_L0.5730.09
145_H149_W0.5700.09
156_Q173_R0.5690.09
5_C183_Q0.5680.09
160_W165_E0.5680.09
33_D136_L0.5660.09
74_F159_A0.5660.09
125_T162_A0.5660.09
17_A125_T0.5650.09
20_H76_S0.5640.09
76_S168_Y0.5600.09
34_T166_T0.5600.09
7_S114_V0.5600.09
105_A151_V0.5600.09
120_T170_E0.5570.09
75_F90_A0.5540.09
110_V128_A0.5540.09
21_V121_H0.5510.09
71_D134_A0.5500.09
177_A180_Y0.5480.09
52_R133_D0.5400.09
85_G91_D0.5350.09
50_A54_A0.5340.09
33_D163_A0.5320.09
83_P183_Q0.5300.09
39_T43_A0.5290.09
34_T39_T0.5280.09
20_H109_H0.5190.09
45_D63_D0.5190.09
50_A99_F0.5160.09
12_H181_Q0.5160.09
127_T148_G0.5150.09
10_P108_A0.5130.09
28_V36_T0.5120.09
43_A48_R0.5110.09
50_A98_F0.5110.09
56_V144_L0.5090.09
33_D53_D0.5080.09
133_D174_A0.5070.09
99_F119_T0.5070.09
22_I162_A0.5050.09
83_P107_T0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d3yA 1 0.9146 100 0.722 Contact Map
1vk2A 1 0.8291 99.9 0.734 Contact Map
1ui0A 1 0.8342 99.9 0.746 Contact Map
1oe4A 2 0.8241 99.9 0.768 Contact Map
3ikbA 1 0.7688 99.8 0.783 Contact Map
1wywA 1 0.9497 99.8 0.786 Contact Map
1mugA 1 0.7889 99.7 0.806 Contact Map
2c2qA 1 0.8543 99.4 0.85 Contact Map
2l3fA 1 0.7789 94.4 0.938 Contact Map
1wgxA 1 0.2513 14.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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