Q9HRG7 - HALSA - GREMLIN Contacts

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Q9HRG7 - Uncharacterized protein

UniProt:	Q9HRG7	Sequences: MQPPCESFVPGHGDANADIHVIGDHPGVHGGTDTGTPFTGSAAGDRLRSALRDAGVLTTAADDTPPIDDPDNSFFSYLHPCVPEGTPTPADYRELEPFFDAELRAITAHVLLPVGERATTHVLETCTAIDPADASLEDRHATELHGSGWLVVPCVQPDAWSAAQETAYVEALRAVMATDYQRQADLGRFLVGPEPYTVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	199 (177)
Sequences:	103 (69)
Seq/√Len:	5.2

HALSA - Q9HRG7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_T	48_R	3.220	0.77
116_E	120_T	2.980	0.71
43_A	46_R	2.901	0.69
86_T	138_D	2.871	0.68
143_E	171_A	2.773	0.66
21_V	73_S	2.653	0.62
170_E	177_A	2.643	0.62
48_R	135_S	2.600	0.60
30_G	77_Y	2.598	0.60
147_S	182_R	2.519	0.58
47_L	51_L	2.377	0.53
137_E	155_V	2.197	0.47
159_A	162_A	2.105	0.44
147_S	184_A	2.085	0.43
58_T	74_F	2.047	0.42
62_D	169_V	2.002	0.41
107_T	184_A	1.955	0.39
118_A	157_P	1.944	0.39
143_E	150_L	1.931	0.39
97_P	139_R	1.922	0.38
30_G	39_T	1.914	0.38
41_S	44_G	1.871	0.37
107_T	147_S	1.844	0.36
22_I	87_P	1.829	0.35
112_L	168_Y	1.757	0.33
135_S	169_V	1.701	0.32
59_T	62_D	1.688	0.31
39_T	135_S	1.671	0.31
128_A	147_S	1.671	0.31
15_A	99_F	1.616	0.29
114_V	157_P	1.585	0.28
23_G	114_V	1.569	0.28
16_N	100_D	1.559	0.28
74_F	116_E	1.551	0.28
128_A	184_A	1.540	0.27
60_A	173_R	1.506	0.26
126_C	145_H	1.495	0.26
107_T	128_A	1.471	0.25
155_V	164_Q	1.460	0.25
107_T	182_R	1.459	0.25
39_T	77_Y	1.398	0.24
49_S	165_E	1.394	0.24
58_T	71_D	1.389	0.23
47_L	142_T	1.380	0.23
41_S	48_R	1.372	0.23
147_S	183_Q	1.355	0.23
56_V	175_V	1.350	0.23
69_D	93_R	1.339	0.22
112_L	172_L	1.338	0.22
80_P	108_A	1.329	0.22
39_T	46_R	1.311	0.22
19_I	152_V	1.307	0.22
22_I	164_Q	1.307	0.22
108_A	151_V	1.274	0.21
75_F	173_R	1.252	0.20
69_D	152_V	1.246	0.20
142_T	166_T	1.241	0.20
128_A	182_R	1.231	0.20
43_A	135_S	1.226	0.20
44_G	48_R	1.220	0.20
95_L	107_T	1.220	0.20
41_S	52_R	1.206	0.19
44_G	174_A	1.192	0.19
26_P	106_I	1.189	0.19
25_H	87_P	1.181	0.19
159_A	170_E	1.174	0.19
88_T	134_A	1.173	0.19
62_D	69_D	1.162	0.19
43_A	169_V	1.158	0.18
15_A	85_G	1.149	0.18
71_D	144_L	1.148	0.18
12_H	126_C	1.144	0.18
21_V	24_D	1.130	0.18
90_A	93_R	1.126	0.18
121_H	164_Q	1.121	0.18
32_T	98_F	1.117	0.18
77_Y	103_L	1.115	0.18
135_S	164_Q	1.098	0.17
15_A	93_R	1.095	0.17
74_F	130_D	1.092	0.17
91_D	174_A	1.091	0.17
58_T	134_A	1.090	0.17
48_R	52_R	1.088	0.17
47_L	168_Y	1.047	0.16
36_T	101_A	1.046	0.16
78_L	87_P	1.044	0.16
119_T	136_L	1.034	0.16
19_I	110_V	1.017	0.16
107_T	110_V	1.005	0.16
74_F	78_L	1.005	0.16
51_L	84_E	0.999	0.16
53_D	170_E	0.989	0.15
136_L	154_C	0.984	0.15
22_I	175_V	0.975	0.15
80_P	95_L	0.975	0.15
106_I	118_A	0.972	0.15
42_A	156_Q	0.972	0.15
149_W	182_R	0.972	0.15
8_F	183_Q	0.970	0.15
56_V	187_G	0.969	0.15
6_E	120_T	0.967	0.15
53_D	93_R	0.959	0.15
15_A	103_L	0.947	0.15
10_P	183_Q	0.942	0.15
20_H	103_L	0.938	0.14
78_L	117_R	0.935	0.14
21_V	75_F	0.926	0.14
56_V	110_V	0.921	0.14
48_R	136_L	0.917	0.14
96_E	127_T	0.917	0.14
166_T	177_A	0.914	0.14
27_G	30_G	0.908	0.14
105_A	150_L	0.903	0.14
180_Y	184_A	0.901	0.14
62_D	84_E	0.895	0.14
97_P	132_A	0.894	0.14
50_A	107_T	0.892	0.14
120_T	156_Q	0.888	0.14
85_G	170_E	0.883	0.14
74_F	94_E	0.881	0.14
31_G	108_A	0.870	0.13
16_N	105_A	0.863	0.13
12_H	80_P	0.861	0.13
49_S	53_D	0.856	0.13
74_F	157_P	0.855	0.13
20_H	100_D	0.853	0.13
5_C	10_P	0.852	0.13
8_F	187_G	0.849	0.13
58_T	173_R	0.842	0.13
92_Y	136_L	0.842	0.13
83_P	91_D	0.841	0.13
117_R	161_S	0.840	0.13
32_T	82_V	0.830	0.13
72_N	107_T	0.822	0.13
104_R	148_G	0.822	0.13
20_H	136_L	0.819	0.13
45_D	60_A	0.812	0.13
138_D	178_T	0.809	0.12
145_H	184_A	0.807	0.12
57_L	70_P	0.804	0.12
107_T	183_Q	0.803	0.12
28_V	63_D	0.799	0.12
93_R	141_A	0.798	0.12
89_P	161_S	0.797	0.12
48_R	61_A	0.797	0.12
16_N	20_H	0.796	0.12
56_V	69_D	0.790	0.12
31_G	76_S	0.779	0.12
132_A	180_Y	0.770	0.12
132_A	144_L	0.766	0.12
53_D	75_F	0.762	0.12
43_A	174_A	0.762	0.12
100_D	105_A	0.762	0.12
51_L	73_S	0.760	0.12
46_R	78_L	0.759	0.12
71_D	142_T	0.757	0.12
101_A	152_V	0.752	0.12
25_H	116_E	0.750	0.12
34_T	101_A	0.749	0.12
116_E	137_E	0.742	0.12
143_E	160_W	0.741	0.12
111_L	135_S	0.741	0.12
110_V	147_S	0.737	0.11
5_C	182_R	0.736	0.11
98_F	114_V	0.734	0.11
16_N	160_W	0.734	0.11
5_C	8_F	0.732	0.11
17_A	118_A	0.732	0.11
24_D	99_F	0.728	0.11
116_E	136_L	0.727	0.11
47_L	102_E	0.723	0.11
53_D	175_V	0.723	0.11
24_D	119_T	0.723	0.11
25_H	92_Y	0.720	0.11
9_V	36_T	0.719	0.11
89_P	133_D	0.710	0.11
158_D	175_V	0.701	0.11
34_T	48_R	0.690	0.11
72_N	180_Y	0.688	0.11
100_D	109_H	0.685	0.11
94_E	168_Y	0.684	0.11
54_A	176_M	0.680	0.11
41_S	142_T	0.678	0.11
30_G	34_T	0.675	0.11
18_D	71_D	0.669	0.11
15_A	50_A	0.667	0.11
69_D	144_L	0.667	0.11
53_D	85_G	0.666	0.11
8_F	182_R	0.665	0.11
41_S	111_L	0.664	0.11
48_R	166_T	0.662	0.11
107_T	145_H	0.661	0.11
49_S	125_T	0.659	0.10
109_H	172_L	0.659	0.10
76_S	108_A	0.655	0.10
97_P	100_D	0.653	0.10
103_L	136_L	0.650	0.10
55_G	62_D	0.649	0.10
92_Y	99_F	0.642	0.10
110_V	182_R	0.641	0.10
149_W	183_Q	0.635	0.10
31_G	79_H	0.634	0.10
87_P	164_Q	0.632	0.10
122_V	143_E	0.626	0.10
88_T	177_A	0.624	0.10
57_L	73_S	0.624	0.10
145_H	181_Q	0.621	0.10
81_C	141_A	0.621	0.10
34_T	177_A	0.620	0.10
92_Y	119_T	0.620	0.10
60_A	90_A	0.618	0.10
23_G	73_S	0.613	0.10
80_P	121_H	0.612	0.10
60_A	63_D	0.611	0.10
89_P	128_A	0.603	0.10
72_N	145_H	0.602	0.10
110_V	184_A	0.598	0.10
40_G	178_T	0.592	0.10
95_L	184_A	0.588	0.10
30_G	38_F	0.586	0.10
25_H	143_E	0.585	0.10
141_A	165_E	0.580	0.10
104_R	127_T	0.580	0.10
120_T	141_A	0.575	0.09
16_N	103_L	0.573	0.09
145_H	149_W	0.570	0.09
156_Q	173_R	0.569	0.09
5_C	183_Q	0.568	0.09
160_W	165_E	0.568	0.09
33_D	136_L	0.566	0.09
74_F	159_A	0.566	0.09
125_T	162_A	0.566	0.09
17_A	125_T	0.565	0.09
20_H	76_S	0.564	0.09
76_S	168_Y	0.560	0.09
34_T	166_T	0.560	0.09
7_S	114_V	0.560	0.09
105_A	151_V	0.560	0.09
120_T	170_E	0.557	0.09
75_F	90_A	0.554	0.09
110_V	128_A	0.554	0.09
21_V	121_H	0.551	0.09
71_D	134_A	0.550	0.09
177_A	180_Y	0.548	0.09
52_R	133_D	0.540	0.09
85_G	91_D	0.535	0.09
50_A	54_A	0.534	0.09
33_D	163_A	0.532	0.09
83_P	183_Q	0.530	0.09
39_T	43_A	0.529	0.09
34_T	39_T	0.528	0.09
20_H	109_H	0.519	0.09
45_D	63_D	0.519	0.09
50_A	99_F	0.516	0.09
12_H	181_Q	0.516	0.09
127_T	148_G	0.515	0.09
10_P	108_A	0.513	0.09
28_V	36_T	0.512	0.09
43_A	48_R	0.511	0.09
50_A	98_F	0.511	0.09
56_V	144_L	0.509	0.09
33_D	53_D	0.508	0.09
133_D	174_A	0.507	0.09
99_F	119_T	0.507	0.09
22_I	162_A	0.505	0.09
83_P	107_T	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2d3yA	1	0.9146	100	0.722	Contact Map
1vk2A	1	0.8291	99.9	0.734	Contact Map
1ui0A	1	0.8342	99.9	0.746	Contact Map
1oe4A	2	0.8241	99.9	0.768	Contact Map
3ikbA	1	0.7688	99.8	0.783	Contact Map
1wywA	1	0.9497	99.8	0.786	Contact Map
1mugA	1	0.7889	99.7	0.806	Contact Map
2c2qA	1	0.8543	99.4	0.85	Contact Map
2l3fA	1	0.7789	94.4	0.938	Contact Map
1wgxA	1	0.2513	14.9	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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