GREMLIN Database
Q9HRG5 - Uncharacterized protein
UniProt: Q9HRG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (276)
Sequences: 4366 (3383)
Seq/√Len: 203.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_Q256_A4.3031.00
170_E187_E4.1721.00
230_E253_R3.9831.00
174_L183_A3.5941.00
192_R235_D3.2991.00
158_D228_R3.2701.00
72_L184_Y3.1591.00
37_P69_D3.1571.00
41_V74_T3.1041.00
277_S280_T2.9361.00
161_T168_D2.8731.00
230_E256_A2.7881.00
73_L84_A2.7191.00
161_T170_E2.6901.00
186_V189_D2.5761.00
41_V195_F2.5721.00
181_L197_G2.5321.00
307_D311_E2.5241.00
39_T70_R2.4991.00
171_V182_V2.4931.00
74_T197_G2.4771.00
163_Q168_D2.3841.00
247_A250_A2.3281.00
253_R257_A2.3221.00
29_L41_V2.2281.00
70_R96_Y2.2111.00
196_V237_A2.0301.00
53_E57_A2.0101.00
94_T154_T2.0011.00
168_D188_R2.0001.00
70_R94_T1.9741.00
99_E157_S1.9701.00
96_Y154_T1.9191.00
98_H182_V1.8981.00
171_V184_Y1.8901.00
174_L181_L1.8151.00
55_R90_D1.7941.00
98_H173_H1.7711.00
52_A56_T1.7701.00
227_Q231_A1.7671.00
167_L189_D1.7401.00
170_E232_L1.6871.00
218_P221_R1.6871.00
193_E238_W1.6821.00
233_D249_A1.6571.00
223_R256_A1.6531.00
28_L40_L1.6521.00
43_T71_I1.6271.00
174_L225_S1.6171.00
27_Y195_F1.6101.00
57_A60_D1.6041.00
56_T60_D1.5421.00
55_R59_D1.5131.00
37_P67_A1.4981.00
185_V194_A1.4861.00
154_T160_D1.4801.00
157_S160_D1.4671.00
230_E249_A1.4621.00
228_R231_A1.4601.00
51_E86_T1.4601.00
260_D264_E1.4401.00
169_A186_V1.4371.00
251_R255_I1.4371.00
236_R246_F1.4191.00
194_A232_L1.4031.00
227_Q260_D1.3951.00
185_V234_L1.3841.00
27_Y238_W1.3781.00
192_R233_D1.3641.00
96_Y156_L1.3611.00
163_Q166_G1.3451.00
276_V284_A1.3421.00
227_Q230_E1.3241.00
11_H61_R1.3221.00
98_H101_D1.3131.00
239_P242_R1.3041.00
86_T90_D1.3031.00
306_D309_V1.2861.00
30_G66_A1.2851.00
230_E252_A1.2821.00
226_L252_A1.2811.00
38_T68_I1.2691.00
269_V284_A1.2611.00
278_A282_S1.2551.00
158_D173_H1.2431.00
97_V101_D1.2431.00
39_T72_L1.2411.00
30_G38_T1.2381.00
169_A184_Y1.2371.00
71_I87_I1.2371.00
39_T169_A1.2351.00
167_L186_V1.2171.00
250_A254_D1.2071.00
205_T255_I1.1671.00
156_L171_V1.1611.00
37_P70_R1.1591.00
161_T187_E1.1591.00
51_E55_R1.1481.00
56_T59_D1.1471.00
185_V192_R1.1411.00
189_D192_R1.1351.00
256_A260_D1.1341.00
187_E192_R1.1301.00
55_R58_L1.1281.00
26_V40_L1.1261.00
170_E185_V1.1231.00
251_R254_D1.1211.00
38_T63_T1.1211.00
220_Q224_D1.1141.00
36_A165_G1.1071.00
218_P310_H1.1041.00
88_Q153_V1.0991.00
27_Y240_G1.0891.00
199_A229_I1.0881.00
223_R260_D1.0851.00
281_V301_A1.0841.00
264_E268_D1.0661.00
26_V43_T1.0631.00
200_I252_A1.0571.00
222_Y226_L1.0531.00
217_R307_D1.0401.00
129_P279_W1.0351.00
28_L38_T1.0321.00
176_G225_S1.0291.00
206_P209_G1.0191.00
9_V189_D1.0161.00
173_H182_V1.0111.00
54_L58_L1.0061.00
195_F238_W0.9971.00
72_L182_V0.9951.00
183_A199_A0.9941.00
107_Q110_D0.9941.00
159_G170_E0.9911.00
102_A106_A0.9891.00
51_E83_L0.9871.00
204_Y207_N0.9630.99
59_D65_F0.9620.99
172_V185_V0.9610.99
26_V54_L0.9600.99
54_L57_A0.9600.99
225_S228_R0.9580.99
234_L237_A0.9560.99
223_R227_Q0.9540.99
249_A253_R0.9530.99
29_L186_V0.9460.99
156_L162_V0.9450.99
35_A166_G0.9440.99
99_E155_P0.9410.99
217_R220_Q0.9400.99
265_R268_D0.9390.99
101_D180_G0.9370.99
237_A245_V0.9320.99
269_V281_V0.9310.99
40_L87_I0.9270.99
293_H296_H0.9250.99
257_A261_E0.9170.99
26_V44_G0.9160.99
237_A248_P0.9140.99
34_D37_P0.9050.99
70_R154_T0.9000.99
102_A155_P0.8960.99
169_A195_F0.8900.99
199_A225_S0.8890.99
42_D75_H0.8880.99
10_V29_L0.8880.99
185_V232_L0.8870.99
54_L61_R0.8850.99
84_A95_V0.8840.99
268_D271_R0.8800.99
94_T153_V0.8800.99
189_D193_E0.8770.99
101_D104_M0.8770.99
183_A194_A0.8730.99
75_H198_D0.8680.99
258_H262_R0.8680.99
233_D236_R0.8670.99
150_P153_V0.8660.99
101_D178_A0.8660.99
209_G299_G0.8610.99
71_I84_A0.8600.99
208_V212_D0.8570.99
210_G213_V0.8560.99
193_E236_R0.8540.99
76_W101_D0.8470.99
50_V54_L0.8460.99
40_L68_I0.8420.99
25_S240_G0.8420.99
177_H198_D0.8350.99
289_L294_V0.8290.98
204_Y208_V0.8270.98
266_V281_V0.8250.98
279_W283_D0.8250.98
29_L169_A0.8230.98
264_E267_L0.8190.98
229_I232_L0.8120.98
73_L81_A0.8100.98
80_H198_D0.8090.98
302_Y306_D0.8050.98
88_Q95_V0.8040.98
168_D187_E0.8030.98
39_T164_L0.8020.98
135_E138_D0.7990.98
86_T89_A0.7990.98
15_L26_V0.7950.98
71_I93_A0.7920.98
164_L167_L0.7900.98
59_D90_D0.7890.98
28_L66_A0.7860.98
46_A83_L0.7820.98
239_P245_V0.7770.98
175_P225_S0.7760.98
266_V301_A0.7760.98
140_L143_H0.7730.98
156_L182_V0.7730.98
267_L271_R0.7710.98
38_T67_A0.7670.97
75_H80_H0.7660.97
108_D111_A0.7650.97
74_T77_H0.7610.97
290_H293_H0.7530.97
9_V167_L0.7500.97
63_T67_A0.7480.97
276_V280_T0.7470.97
28_L58_L0.7440.97
186_V195_F0.7400.97
20_F23_R0.7390.97
202_P245_V0.7390.97
17_N20_F0.7360.97
16_T53_E0.7360.97
41_V184_Y0.7330.97
41_V169_A0.7300.97
286_F289_L0.7290.97
47_T52_A0.7220.96
269_V285_L0.7220.96
257_A260_D0.7190.96
236_R244_P0.7180.96
25_S242_R0.7180.96
265_R269_V0.7160.96
152_D155_P0.7150.96
266_V304_H0.7140.96
259_H304_H0.7130.96
280_T284_A0.7120.96
172_V183_A0.7100.96
292_I296_H0.7060.96
57_A61_R0.7060.96
259_H263_T0.7060.96
69_D94_T0.7040.96
8_C11_H0.6980.96
85_G89_A0.6980.96
205_T209_G0.6980.96
30_G34_D0.6980.96
259_H262_R0.6940.95
172_V228_R0.6940.95
40_L43_T0.6940.95
10_V186_V0.6930.95
226_L256_A0.6910.95
7_P189_D0.6890.95
79_D241_H0.6860.95
220_Q311_E0.6860.95
280_T283_D0.6840.95
307_D310_H0.6840.95
224_D228_R0.6820.95
279_W282_S0.6820.95
206_P212_D0.6810.95
34_D164_L0.6810.95
220_Q307_D0.6800.95
274_G284_A0.6790.95
41_V186_V0.6760.95
104_M107_Q0.6740.95
14_Q17_N0.6730.95
80_H241_H0.6710.95
36_A69_D0.6710.95
222_Y262_R0.6710.95
263_T307_D0.6710.95
58_L63_T0.6690.94
183_A229_I0.6670.94
39_T167_L0.6620.94
255_I259_H0.6610.94
279_W298_P0.6600.94
81_A84_A0.6600.94
85_G148_G0.6600.94
283_D294_V0.6580.94
43_T84_A0.6580.94
181_L240_G0.6570.94
174_L199_A0.6550.94
105_V109_A0.6540.94
160_D171_V0.6540.94
278_A285_L0.6540.94
252_A256_A0.6530.94
25_S239_P0.6530.94
12_Q15_L0.6500.94
36_A66_A0.6500.94
263_T267_L0.6480.93
221_R224_D0.6470.93
136_L139_F0.6450.93
269_V276_V0.6430.93
274_G277_S0.6420.93
141_D146_L0.6400.93
275_P281_V0.6370.93
134_A138_D0.6330.93
278_A302_Y0.6310.93
75_H177_H0.6310.93
50_V53_E0.6300.93
176_G181_L0.6280.92
283_D287_G0.6270.92
88_Q150_P0.6260.92
52_A55_R0.6240.92
183_A196_V0.6230.92
206_P255_I0.6230.92
24_N240_G0.6220.92
297_G300_E0.6190.92
300_E304_H0.6190.92
222_Y259_H0.6140.92
77_H178_A0.6140.92
159_G171_V0.6130.91
104_M108_D0.6110.91
227_Q253_R0.6090.91
282_S301_A0.6080.91
97_V105_V0.6070.91
72_L169_A0.6060.91
219_L222_Y0.6040.91
194_A237_A0.6020.91
285_L301_A0.6020.91
206_P211_A0.6010.91
287_G294_V0.6000.91
102_A105_V0.5950.90
300_E303_A0.5940.90
200_I248_P0.5920.90
207_N300_E0.5900.90
99_E103_A0.5860.90
34_D166_G0.5850.89
186_V193_E0.5830.89
84_A88_Q0.5790.89
98_H105_V0.5790.89
73_L95_V0.5780.89
7_P10_V0.5780.89
13_F28_L0.5780.89
218_P306_D0.5770.89
19_A23_R0.5760.89
296_H299_G0.5760.89
82_G85_G0.5750.89
137_N141_D0.5740.89
291_D294_V0.5730.89
77_H80_H0.5720.88
156_L184_Y0.5700.88
159_G173_H0.5680.88
9_V188_R0.5650.88
194_A234_L0.5650.88
178_A181_L0.5640.88
193_E196_V0.5640.88
98_H180_G0.5620.88
270_V275_P0.5620.88
275_P280_T0.5570.87
13_F57_A0.5570.87
134_A137_N0.5560.87
305_L309_V0.5550.87
74_T80_H0.5550.87
205_T208_V0.5550.87
144_D148_G0.5540.87
34_D39_T0.5530.87
75_H79_D0.5530.87
152_D156_L0.5500.86
252_A255_I0.5500.86
297_G304_H0.5490.86
10_V193_E0.5490.86
167_L188_R0.5480.86
71_I95_V0.5470.86
238_W244_P0.5470.86
28_L61_R0.5460.86
7_P238_W0.5430.86
263_T304_H0.5410.86
295_L299_G0.5410.86
294_V298_P0.5400.85
304_H307_D0.5400.85
219_L223_R0.5390.85
28_L68_I0.5360.85
309_V312_G0.5360.85
199_A222_Y0.5340.85
196_V239_P0.5330.85
71_I88_Q0.5320.85
183_A225_S0.5320.85
298_P302_Y0.5320.85
299_G302_Y0.5310.84
299_G303_A0.5300.84
88_Q93_A0.5300.84
277_S281_V0.5290.84
151_A155_P0.5290.84
76_W180_G0.5280.84
83_L86_T0.5280.84
98_H103_A0.5260.84
251_R259_H0.5240.84
88_Q92_D0.5240.84
128_M136_L0.5240.84
17_N24_N0.5230.84
208_V303_A0.5230.84
17_N21_E0.5220.83
217_R310_H0.5220.83
283_D291_D0.5210.83
72_L96_Y0.5200.83
181_L199_A0.5190.83
156_L159_G0.5180.83
50_V57_A0.5140.83
282_S298_P0.5140.83
74_T198_D0.5110.82
223_R307_D0.5110.82
14_Q180_G0.5070.82
101_D105_V0.5060.82
302_Y309_V0.5050.81
47_T50_V0.5020.81
77_H225_S0.5020.81
39_T69_D0.5010.81
143_H146_L0.5010.81
53_E56_T0.5000.81
107_Q111_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9146 100 0.247 Contact Map
4ad9A 4 0.8354 100 0.379 Contact Map
2yheA 3 0.9512 100 0.415 Contact Map
2cfuA 2 0.939 100 0.426 Contact Map
4nurA 2 0.9421 100 0.437 Contact Map
4pdxA 2 0.939 100 0.44 Contact Map
2fhxA 2 0.7134 100 0.466 Contact Map
2vw8A 2 0.8598 100 0.469 Contact Map
1k07A 1 0.7287 100 0.489 Contact Map
3vpeA 1 0.7134 100 0.491 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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