Q9HRG5 - HALSA - GREMLIN Contacts

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Q9HRG5 - Uncharacterized protein

UniProt:	Q9HRG5	Sequences: MSTHTLPCVVHQFQLTNAAFEGRNSVYLLGVGDDAAPTTLVDTGIATPAVEAELRTALDDRGTSFAAIDRILLTHWHHDHAGLAGTIQADGDATVYVHEADAAMVAQDADAVSGMAATQAAYLDEWGMPADKQAELNDFLDTHDGLQGQPADVTPLSDGDTVQLGGLDAEVVHLPGHAAGLVAYVVERDGRREAFVGDAILPKYTPNVGGADVRVERPLQRYRDSLQRIEALDLDRAWPGHRGPVFAPAARARDIAAHHDERTERVLDVVRARGPVSAWTVSDALFGELHDIHVLHGPGEAYAHLDDLVHEGVLVESQPGEYALAASA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (276)
Sequences:	4366 (3383)
Seq/√Len:	203.6

ECOLI - YCBL GLO2 YJCS
BACSU - YQJP YYBB YFLN YOBT PKSB YQGX
HALSA - Q9HRG5 Q9HNJ9 Q9HSD1 Q9HSH2 Q9HQ50 Q9HNJ2
SULSO - Q97VU4 Q97VU0 Q97UV2 Q97WC2 Q7LYK3 Q97U88 Q97YZ2 Q97XZ1 Q97UR2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_Q	256_A	4.303	1.00
170_E	187_E	4.172	1.00
230_E	253_R	3.983	1.00
174_L	183_A	3.594	1.00
192_R	235_D	3.299	1.00
158_D	228_R	3.270	1.00
72_L	184_Y	3.159	1.00
37_P	69_D	3.157	1.00
41_V	74_T	3.104	1.00
277_S	280_T	2.936	1.00
161_T	168_D	2.873	1.00
230_E	256_A	2.788	1.00
73_L	84_A	2.719	1.00
161_T	170_E	2.690	1.00
186_V	189_D	2.576	1.00
41_V	195_F	2.572	1.00
181_L	197_G	2.532	1.00
307_D	311_E	2.524	1.00
39_T	70_R	2.499	1.00
171_V	182_V	2.493	1.00
74_T	197_G	2.477	1.00
163_Q	168_D	2.384	1.00
247_A	250_A	2.328	1.00
253_R	257_A	2.322	1.00
29_L	41_V	2.228	1.00
70_R	96_Y	2.211	1.00
196_V	237_A	2.030	1.00
53_E	57_A	2.010	1.00
94_T	154_T	2.001	1.00
168_D	188_R	2.000	1.00
70_R	94_T	1.974	1.00
99_E	157_S	1.970	1.00
96_Y	154_T	1.919	1.00
98_H	182_V	1.898	1.00
171_V	184_Y	1.890	1.00
174_L	181_L	1.815	1.00
55_R	90_D	1.794	1.00
98_H	173_H	1.771	1.00
52_A	56_T	1.770	1.00
227_Q	231_A	1.767	1.00
167_L	189_D	1.740	1.00
170_E	232_L	1.687	1.00
218_P	221_R	1.687	1.00
193_E	238_W	1.682	1.00
233_D	249_A	1.657	1.00
223_R	256_A	1.653	1.00
28_L	40_L	1.652	1.00
43_T	71_I	1.627	1.00
174_L	225_S	1.617	1.00
27_Y	195_F	1.610	1.00
57_A	60_D	1.604	1.00
56_T	60_D	1.542	1.00
55_R	59_D	1.513	1.00
37_P	67_A	1.498	1.00
185_V	194_A	1.486	1.00
154_T	160_D	1.480	1.00
157_S	160_D	1.467	1.00
230_E	249_A	1.462	1.00
228_R	231_A	1.460	1.00
51_E	86_T	1.460	1.00
260_D	264_E	1.440	1.00
169_A	186_V	1.437	1.00
251_R	255_I	1.437	1.00
236_R	246_F	1.419	1.00
194_A	232_L	1.403	1.00
227_Q	260_D	1.395	1.00
185_V	234_L	1.384	1.00
27_Y	238_W	1.378	1.00
192_R	233_D	1.364	1.00
96_Y	156_L	1.361	1.00
163_Q	166_G	1.345	1.00
276_V	284_A	1.342	1.00
227_Q	230_E	1.324	1.00
11_H	61_R	1.322	1.00
98_H	101_D	1.313	1.00
239_P	242_R	1.304	1.00
86_T	90_D	1.303	1.00
306_D	309_V	1.286	1.00
30_G	66_A	1.285	1.00
230_E	252_A	1.282	1.00
226_L	252_A	1.281	1.00
38_T	68_I	1.269	1.00
269_V	284_A	1.261	1.00
278_A	282_S	1.255	1.00
158_D	173_H	1.243	1.00
97_V	101_D	1.243	1.00
39_T	72_L	1.241	1.00
30_G	38_T	1.238	1.00
169_A	184_Y	1.237	1.00
71_I	87_I	1.237	1.00
39_T	169_A	1.235	1.00
167_L	186_V	1.217	1.00
250_A	254_D	1.207	1.00
205_T	255_I	1.167	1.00
156_L	171_V	1.161	1.00
37_P	70_R	1.159	1.00
161_T	187_E	1.159	1.00
51_E	55_R	1.148	1.00
56_T	59_D	1.147	1.00
185_V	192_R	1.141	1.00
189_D	192_R	1.135	1.00
256_A	260_D	1.134	1.00
187_E	192_R	1.130	1.00
55_R	58_L	1.128	1.00
26_V	40_L	1.126	1.00
170_E	185_V	1.123	1.00
251_R	254_D	1.121	1.00
38_T	63_T	1.121	1.00
220_Q	224_D	1.114	1.00
36_A	165_G	1.107	1.00
218_P	310_H	1.104	1.00
88_Q	153_V	1.099	1.00
27_Y	240_G	1.089	1.00
199_A	229_I	1.088	1.00
223_R	260_D	1.085	1.00
281_V	301_A	1.084	1.00
264_E	268_D	1.066	1.00
26_V	43_T	1.063	1.00
200_I	252_A	1.057	1.00
222_Y	226_L	1.053	1.00
217_R	307_D	1.040	1.00
129_P	279_W	1.035	1.00
28_L	38_T	1.032	1.00
176_G	225_S	1.029	1.00
206_P	209_G	1.019	1.00
9_V	189_D	1.016	1.00
173_H	182_V	1.011	1.00
54_L	58_L	1.006	1.00
195_F	238_W	0.997	1.00
72_L	182_V	0.995	1.00
183_A	199_A	0.994	1.00
107_Q	110_D	0.994	1.00
159_G	170_E	0.991	1.00
102_A	106_A	0.989	1.00
51_E	83_L	0.987	1.00
204_Y	207_N	0.963	0.99
59_D	65_F	0.962	0.99
172_V	185_V	0.961	0.99
26_V	54_L	0.960	0.99
54_L	57_A	0.960	0.99
225_S	228_R	0.958	0.99
234_L	237_A	0.956	0.99
223_R	227_Q	0.954	0.99
249_A	253_R	0.953	0.99
29_L	186_V	0.946	0.99
156_L	162_V	0.945	0.99
35_A	166_G	0.944	0.99
99_E	155_P	0.941	0.99
217_R	220_Q	0.940	0.99
265_R	268_D	0.939	0.99
101_D	180_G	0.937	0.99
237_A	245_V	0.932	0.99
269_V	281_V	0.931	0.99
40_L	87_I	0.927	0.99
293_H	296_H	0.925	0.99
257_A	261_E	0.917	0.99
26_V	44_G	0.916	0.99
237_A	248_P	0.914	0.99
34_D	37_P	0.905	0.99
70_R	154_T	0.900	0.99
102_A	155_P	0.896	0.99
169_A	195_F	0.890	0.99
199_A	225_S	0.889	0.99
42_D	75_H	0.888	0.99
10_V	29_L	0.888	0.99
185_V	232_L	0.887	0.99
54_L	61_R	0.885	0.99
84_A	95_V	0.884	0.99
268_D	271_R	0.880	0.99
94_T	153_V	0.880	0.99
189_D	193_E	0.877	0.99
101_D	104_M	0.877	0.99
183_A	194_A	0.873	0.99
75_H	198_D	0.868	0.99
258_H	262_R	0.868	0.99
233_D	236_R	0.867	0.99
150_P	153_V	0.866	0.99
101_D	178_A	0.866	0.99
209_G	299_G	0.861	0.99
71_I	84_A	0.860	0.99
208_V	212_D	0.857	0.99
210_G	213_V	0.856	0.99
193_E	236_R	0.854	0.99
76_W	101_D	0.847	0.99
50_V	54_L	0.846	0.99
40_L	68_I	0.842	0.99
25_S	240_G	0.842	0.99
177_H	198_D	0.835	0.99
289_L	294_V	0.829	0.98
204_Y	208_V	0.827	0.98
266_V	281_V	0.825	0.98
279_W	283_D	0.825	0.98
29_L	169_A	0.823	0.98
264_E	267_L	0.819	0.98
229_I	232_L	0.812	0.98
73_L	81_A	0.810	0.98
80_H	198_D	0.809	0.98
302_Y	306_D	0.805	0.98
88_Q	95_V	0.804	0.98
168_D	187_E	0.803	0.98
39_T	164_L	0.802	0.98
135_E	138_D	0.799	0.98
86_T	89_A	0.799	0.98
15_L	26_V	0.795	0.98
71_I	93_A	0.792	0.98
164_L	167_L	0.790	0.98
59_D	90_D	0.789	0.98
28_L	66_A	0.786	0.98
46_A	83_L	0.782	0.98
239_P	245_V	0.777	0.98
175_P	225_S	0.776	0.98
266_V	301_A	0.776	0.98
140_L	143_H	0.773	0.98
156_L	182_V	0.773	0.98
267_L	271_R	0.771	0.98
38_T	67_A	0.767	0.97
75_H	80_H	0.766	0.97
108_D	111_A	0.765	0.97
74_T	77_H	0.761	0.97
290_H	293_H	0.753	0.97
9_V	167_L	0.750	0.97
63_T	67_A	0.748	0.97
276_V	280_T	0.747	0.97
28_L	58_L	0.744	0.97
186_V	195_F	0.740	0.97
20_F	23_R	0.739	0.97
202_P	245_V	0.739	0.97
17_N	20_F	0.736	0.97
16_T	53_E	0.736	0.97
41_V	184_Y	0.733	0.97
41_V	169_A	0.730	0.97
286_F	289_L	0.729	0.97
47_T	52_A	0.722	0.96
269_V	285_L	0.722	0.96
257_A	260_D	0.719	0.96
236_R	244_P	0.718	0.96
25_S	242_R	0.718	0.96
265_R	269_V	0.716	0.96
152_D	155_P	0.715	0.96
266_V	304_H	0.714	0.96
259_H	304_H	0.713	0.96
280_T	284_A	0.712	0.96
172_V	183_A	0.710	0.96
292_I	296_H	0.706	0.96
57_A	61_R	0.706	0.96
259_H	263_T	0.706	0.96
69_D	94_T	0.704	0.96
8_C	11_H	0.698	0.96
85_G	89_A	0.698	0.96
205_T	209_G	0.698	0.96
30_G	34_D	0.698	0.96
259_H	262_R	0.694	0.95
172_V	228_R	0.694	0.95
40_L	43_T	0.694	0.95
10_V	186_V	0.693	0.95
226_L	256_A	0.691	0.95
7_P	189_D	0.689	0.95
79_D	241_H	0.686	0.95
220_Q	311_E	0.686	0.95
280_T	283_D	0.684	0.95
307_D	310_H	0.684	0.95
224_D	228_R	0.682	0.95
279_W	282_S	0.682	0.95
206_P	212_D	0.681	0.95
34_D	164_L	0.681	0.95
220_Q	307_D	0.680	0.95
274_G	284_A	0.679	0.95
41_V	186_V	0.676	0.95
104_M	107_Q	0.674	0.95
14_Q	17_N	0.673	0.95
80_H	241_H	0.671	0.95
36_A	69_D	0.671	0.95
222_Y	262_R	0.671	0.95
263_T	307_D	0.671	0.95
58_L	63_T	0.669	0.94
183_A	229_I	0.667	0.94
39_T	167_L	0.662	0.94
255_I	259_H	0.661	0.94
279_W	298_P	0.660	0.94
81_A	84_A	0.660	0.94
85_G	148_G	0.660	0.94
283_D	294_V	0.658	0.94
43_T	84_A	0.658	0.94
181_L	240_G	0.657	0.94
174_L	199_A	0.655	0.94
105_V	109_A	0.654	0.94
160_D	171_V	0.654	0.94
278_A	285_L	0.654	0.94
252_A	256_A	0.653	0.94
25_S	239_P	0.653	0.94
12_Q	15_L	0.650	0.94
36_A	66_A	0.650	0.94
263_T	267_L	0.648	0.93
221_R	224_D	0.647	0.93
136_L	139_F	0.645	0.93
269_V	276_V	0.643	0.93
274_G	277_S	0.642	0.93
141_D	146_L	0.640	0.93
275_P	281_V	0.637	0.93
134_A	138_D	0.633	0.93
278_A	302_Y	0.631	0.93
75_H	177_H	0.631	0.93
50_V	53_E	0.630	0.93
176_G	181_L	0.628	0.92
283_D	287_G	0.627	0.92
88_Q	150_P	0.626	0.92
52_A	55_R	0.624	0.92
183_A	196_V	0.623	0.92
206_P	255_I	0.623	0.92
24_N	240_G	0.622	0.92
297_G	300_E	0.619	0.92
300_E	304_H	0.619	0.92
222_Y	259_H	0.614	0.92
77_H	178_A	0.614	0.92
159_G	171_V	0.613	0.91
104_M	108_D	0.611	0.91
227_Q	253_R	0.609	0.91
282_S	301_A	0.608	0.91
97_V	105_V	0.607	0.91
72_L	169_A	0.606	0.91
219_L	222_Y	0.604	0.91
194_A	237_A	0.602	0.91
285_L	301_A	0.602	0.91
206_P	211_A	0.601	0.91
287_G	294_V	0.600	0.91
102_A	105_V	0.595	0.90
300_E	303_A	0.594	0.90
200_I	248_P	0.592	0.90
207_N	300_E	0.590	0.90
99_E	103_A	0.586	0.90
34_D	166_G	0.585	0.89
186_V	193_E	0.583	0.89
84_A	88_Q	0.579	0.89
98_H	105_V	0.579	0.89
73_L	95_V	0.578	0.89
7_P	10_V	0.578	0.89
13_F	28_L	0.578	0.89
218_P	306_D	0.577	0.89
19_A	23_R	0.576	0.89
296_H	299_G	0.576	0.89
82_G	85_G	0.575	0.89
137_N	141_D	0.574	0.89
291_D	294_V	0.573	0.89
77_H	80_H	0.572	0.88
156_L	184_Y	0.570	0.88
159_G	173_H	0.568	0.88
9_V	188_R	0.565	0.88
194_A	234_L	0.565	0.88
178_A	181_L	0.564	0.88
193_E	196_V	0.564	0.88
98_H	180_G	0.562	0.88
270_V	275_P	0.562	0.88
275_P	280_T	0.557	0.87
13_F	57_A	0.557	0.87
134_A	137_N	0.556	0.87
305_L	309_V	0.555	0.87
74_T	80_H	0.555	0.87
205_T	208_V	0.555	0.87
144_D	148_G	0.554	0.87
34_D	39_T	0.553	0.87
75_H	79_D	0.553	0.87
152_D	156_L	0.550	0.86
252_A	255_I	0.550	0.86
297_G	304_H	0.549	0.86
10_V	193_E	0.549	0.86
167_L	188_R	0.548	0.86
71_I	95_V	0.547	0.86
238_W	244_P	0.547	0.86
28_L	61_R	0.546	0.86
7_P	238_W	0.543	0.86
263_T	304_H	0.541	0.86
295_L	299_G	0.541	0.86
294_V	298_P	0.540	0.85
304_H	307_D	0.540	0.85
219_L	223_R	0.539	0.85
28_L	68_I	0.536	0.85
309_V	312_G	0.536	0.85
199_A	222_Y	0.534	0.85
196_V	239_P	0.533	0.85
71_I	88_Q	0.532	0.85
183_A	225_S	0.532	0.85
298_P	302_Y	0.532	0.85
299_G	302_Y	0.531	0.84
299_G	303_A	0.530	0.84
88_Q	93_A	0.530	0.84
277_S	281_V	0.529	0.84
151_A	155_P	0.529	0.84
76_W	180_G	0.528	0.84
83_L	86_T	0.528	0.84
98_H	103_A	0.526	0.84
251_R	259_H	0.524	0.84
88_Q	92_D	0.524	0.84
128_M	136_L	0.524	0.84
17_N	24_N	0.523	0.84
208_V	303_A	0.523	0.84
17_N	21_E	0.522	0.83
217_R	310_H	0.522	0.83
283_D	291_D	0.521	0.83
72_L	96_Y	0.520	0.83
181_L	199_A	0.519	0.83
156_L	159_G	0.518	0.83
50_V	57_A	0.514	0.83
282_S	298_P	0.514	0.83
74_T	198_D	0.511	0.82
223_R	307_D	0.511	0.82
14_Q	180_G	0.507	0.82
101_D	105_V	0.506	0.82
302_Y	309_V	0.505	0.81
47_T	50_V	0.502	0.81
77_H	225_S	0.502	0.81
39_T	69_D	0.501	0.81
143_H	146_L	0.501	0.81
53_E	56_T	0.500	0.81
107_Q	111_A	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zo4A	1	0.9146	100	0.247	Contact Map
4ad9A	4	0.8354	100	0.379	Contact Map
2yheA	3	0.9512	100	0.415	Contact Map
2cfuA	2	0.939	100	0.426	Contact Map
4nurA	2	0.9421	100	0.437	Contact Map
4pdxA	2	0.939	100	0.44	Contact Map
2fhxA	2	0.7134	100	0.466	Contact Map
2vw8A	2	0.8598	100	0.469	Contact Map
1k07A	1	0.7287	100	0.489	Contact Map
3vpeA	1	0.7134	100	0.491	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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