GREMLIN Database
Q9HRG4 - Uncharacterized protein
UniProt: Q9HRG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (174)
Sequences: 1378 (1055)
Seq/√Len: 80.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A116_Y3.6351.00
65_D163_R3.4501.00
66_Y167_D3.2841.00
56_V93_L3.0971.00
89_R92_A2.9271.00
168_A176_E2.8181.00
41_V126_L2.7581.00
86_S89_R2.6381.00
20_S28_T2.6161.00
75_N106_R2.5641.00
41_V71_V2.3321.00
18_G32_A2.2701.00
55_K145_L2.1201.00
45_T73_G2.0901.00
144_R161_D2.0801.00
23_G29_H2.0261.00
79_A106_R2.0151.00
93_L97_G1.9971.00
9_E142_H1.9921.00
126_L166_I1.9451.00
93_L99_I1.8811.00
168_A173_D1.8811.00
134_D138_R1.8301.00
47_N104_Y1.8081.00
72_V105_L1.7921.00
58_T61_A1.7061.00
41_V69_V1.7061.00
159_G164_D1.6951.00
16_A31_L1.6841.00
140_A175_V1.6781.00
39_A69_V1.6371.00
47_N90_M1.6261.00
63_A71_V1.6031.00
61_A65_D1.5601.00
126_L162_M1.5550.99
66_Y170_L1.5440.99
34_F40_V1.5280.99
78_D190_T1.5090.99
29_H34_F1.4870.99
11_E14_A1.4770.99
15_P138_R1.4380.99
123_D142_H1.4370.99
38_D135_A1.4000.99
56_V97_G1.3850.99
167_D170_L1.3830.99
43_V59_L1.3790.99
43_V124_P1.3700.99
42_V72_V1.3650.99
144_R149_L1.3610.99
45_T52_A1.3580.99
148_A157_R1.3560.99
78_D82_Y1.3500.99
21_L105_L1.3450.99
134_D140_A1.3440.99
21_L112_T1.3320.98
62_I166_I1.3210.98
92_A96_D1.2850.98
34_F72_V1.2760.98
23_G87_M1.2690.98
169_V175_V1.2530.98
78_D81_E1.2520.98
10_L127_L1.2440.98
76_P113_A1.2300.97
140_A169_V1.2090.97
74_I112_T1.1970.97
56_V99_I1.1720.96
90_M104_Y1.1570.96
60_N100_Q1.1470.96
160_G163_R1.1200.95
23_G27_E1.1130.95
147_D157_R1.1060.95
16_A19_F1.1030.95
14_A127_L1.1030.95
58_T146_D1.0820.94
73_G101_Y1.0810.94
127_L139_V1.0730.94
57_D97_G1.0730.94
37_V70_A1.0660.94
20_S30_S1.0580.94
147_D158_D1.0460.93
124_P145_L1.0350.93
31_L116_Y1.0320.93
24_A94_V1.0310.93
91_Q95_A1.0210.93
60_N64_A1.0150.92
9_E12_V1.0060.92
147_D155_P1.0030.92
39_A126_L1.0030.92
29_H105_L1.0010.92
30_S33_S0.9900.91
48_H82_Y0.9820.91
60_N97_G0.9810.91
44_F116_Y0.9810.91
12_V179_F0.9680.90
147_D180_L0.9650.90
39_A169_V0.9600.90
160_G164_D0.9560.90
62_I145_L0.9550.90
111_A114_R0.9420.89
166_I169_V0.9380.89
24_A91_Q0.9350.89
39_A137_F0.9300.89
66_Y166_I0.9220.88
56_V60_N0.9210.88
34_F70_A0.9200.88
55_K59_L0.9190.88
31_L137_F0.9130.88
22_P26_G0.9080.87
84_A89_R0.8950.87
22_P28_T0.8920.86
85_D90_M0.8900.86
100_Q103_A0.8890.86
48_H84_A0.8840.86
64_A100_Q0.8810.86
48_H85_D0.8740.85
185_C188_K0.8720.85
40_V137_F0.8690.85
142_H179_F0.8500.84
77_N85_D0.8480.83
147_D159_G0.8470.83
36_D39_A0.8430.83
24_A87_M0.8410.83
113_A189_W0.8330.82
36_D137_F0.8270.82
69_V169_V0.8230.82
173_D176_E0.8170.81
58_T145_L0.8040.80
46_C90_M0.8040.80
126_L169_V0.8030.80
148_A152_D0.8000.80
114_R189_W0.7990.80
10_L14_A0.7960.79
163_R167_D0.7910.79
75_N104_Y0.7900.79
148_A154_D0.7850.78
75_N90_M0.7840.78
18_G31_L0.7790.78
40_V127_L0.7790.78
144_R180_L0.7670.77
120_C181_P0.7650.77
63_A100_Q0.7620.76
147_D160_G0.7610.76
69_V166_I0.7560.76
17_P116_Y0.7560.76
149_L161_D0.7530.76
75_N79_A0.7530.76
174_P178_A0.7510.75
119_T186_S0.7490.75
145_L166_I0.7430.75
25_D91_Q0.7400.74
77_N121_T0.7390.74
10_L17_P0.7310.73
148_A153_E0.7140.72
15_P127_L0.7140.72
67_D71_V0.7070.71
164_D168_A0.6990.70
54_A148_A0.6980.70
94_V101_Y0.6960.70
79_A89_R0.6950.70
55_K58_T0.6940.69
45_T99_I0.6910.69
58_T148_A0.6910.69
117_G125_F0.6900.69
41_V166_I0.6790.68
39_A166_I0.6790.68
51_Y149_L0.6790.68
153_E157_R0.6720.67
69_V126_L0.6680.67
120_C123_D0.6680.67
62_I163_R0.6670.66
45_T101_Y0.6660.66
51_Y82_Y0.6650.66
123_D182_S0.6650.66
89_R93_L0.6600.66
93_L96_D0.6580.65
25_D87_M0.6570.65
174_P177_T0.6560.65
35_T137_F0.6530.65
168_A178_A0.6500.64
31_L39_A0.6480.64
111_A115_A0.6480.64
25_D29_H0.6480.64
21_L74_I0.6470.64
35_T136_A0.6470.64
22_P108_A0.6470.64
71_V166_I0.6460.64
134_D137_F0.6410.63
34_F137_F0.6390.63
43_V52_A0.6370.63
32_A35_T0.6270.62
175_V178_A0.6260.62
58_T163_R0.6210.61
55_K123_D0.6170.60
66_Y163_R0.6100.60
55_K149_L0.6080.59
55_K146_D0.6050.59
153_E159_G0.6050.59
40_V72_V0.6040.59
38_D172_G0.6040.59
120_C186_S0.6020.59
77_N113_A0.6000.58
67_D100_Q0.6000.58
164_D177_T0.5990.58
94_V103_A0.5970.58
153_E156_T0.5930.57
57_D61_A0.5930.57
78_D83_P0.5920.57
53_K93_L0.5920.57
9_E14_A0.5880.57
17_P134_D0.5860.57
8_P119_T0.5790.56
87_M106_R0.5760.55
82_Y113_A0.5740.55
111_A171_A0.5740.55
26_G91_Q0.5740.55
126_L173_D0.5710.55
162_M166_I0.5700.54
120_C144_R0.5690.54
112_T116_Y0.5690.54
58_T157_R0.5660.54
44_F74_I0.5640.54
165_A169_V0.5630.54
34_F37_V0.5630.54
21_L170_L0.5590.53
92_A98_T0.5580.53
54_A149_L0.5540.52
61_A64_A0.5520.52
152_D158_D0.5500.52
57_D93_L0.5490.52
25_D94_V0.5410.51
168_A175_V0.5390.50
71_V100_Q0.5390.50
17_P115_A0.5380.50
19_F112_T0.5380.50
19_F74_I0.5370.50
28_T135_A0.5360.50
125_F139_V0.5310.49
20_S35_T0.5310.49
47_N85_D0.5310.49
68_R95_A0.5300.49
52_A59_L0.5300.49
168_A171_A0.5300.49
77_N83_P0.5270.49
27_E33_S0.5260.49
119_T123_D0.5230.48
27_E111_A0.5220.48
118_A187_I0.5220.48
51_Y110_Q0.5150.47
166_I170_L0.5150.47
154_D157_R0.5150.47
11_E179_F0.5150.47
40_V53_K0.5140.47
38_D71_V0.5100.47
46_C77_N0.5090.47
118_A121_T0.5070.46
27_E173_D0.5070.46
162_M165_A0.5060.46
31_L40_V0.5040.46
24_A56_V0.5030.46
47_N77_N0.5010.46
94_V97_G0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u5rE 1 0.943 100 0.463 Contact Map
2cvbA 1 0.9275 100 0.476 Contact Map
2ywiA 1 0.9585 100 0.482 Contact Map
3zl5A 3 0.7617 100 0.583 Contact Map
3tjjA 3 0.7668 100 0.584 Contact Map
4rqxA 3 0.7617 100 0.588 Contact Map
3qpmA 4 0.8342 100 0.59 Contact Map
3kebA 2 0.772 99.9 0.591 Contact Map
2pn8A 4 0.8083 99.9 0.597 Contact Map
1qmvA 3 0.8342 99.9 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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