Q9HRG3 - HALSA - GREMLIN Contacts

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Q9HRG3 - Uncharacterized protein

UniProt:	Q9HRG3	Sequences: MGRLLDTDITALLTAGHAEPSPLLAEMAAHGEDRSFPTVGPDVGRFLRVLATLSDAERVFEFGSGFGYSAAWMLPVLPADGELVLTDHDSDRLADARSFLDRADADATAVFEAGDALDTVTDYEGPFDVVFIDHDKARYPAAFEHAVDVLAPGGLIVADNVMAGPVTAPAVTDAVRDGGGAADDATAGVAAYVRRVRDASGFETALVPLGEGIAVSAATDDTEPPSEPTDG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (203)
Sequences:	3857 (2677)
Seq/√Len:	187.9

BACSU - YRRM
HALSA - Q9HRG3
SULSO - Q97UA9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_E	102_R	3.879	1.00
86_T	119_T	3.698	1.00
101_D	106_D	3.234	1.00
21_S	75_P	3.209	1.00
82_E	110_V	3.200	1.00
140_P	195_R	2.824	1.00
158_A	192_Y	2.806	1.00
84_V	127_F	2.524	1.00
59_V	73_M	2.520	1.00
150_L	154_G	2.514	1.00
57_E	80_D	2.478	1.00
51_A	73_M	2.380	1.00
121_T	145_H	2.361	1.00
64_S	85_L	2.349	1.00
143_F	202_F	2.331	1.00
138_R	141_A	2.151	1.00
117_L	141_A	2.150	1.00
44_G	72_W	2.135	1.00
84_V	112_E	2.122	1.00
90_S	94_A	2.120	1.00
147_V	202_F	2.009	1.00
129_V	157_V	1.980	1.00
194_R	198_D	1.945	1.00
93_L	113_A	1.942	1.00
145_H	148_D	1.895	1.00
29_A	33_D	1.838	1.00
135_D	138_R	1.801	1.00
157_V	215_V	1.772	1.00
58_R	82_E	1.768	1.00
60_F	127_F	1.743	1.00
52_T	203_E	1.694	1.00
130_V	150_L	1.665	1.00
144_E	195_R	1.649	1.00
20_P	28_A	1.634	1.00
130_V	146_A	1.591	1.00
134_H	142_A	1.579	1.00
77_L	83_L	1.573	1.00
115_D	118_D	1.566	1.00
112_E	119_T	1.558	1.00
89_D	92_R	1.551	1.00
30_H	98_S	1.546	1.00
11_A	15_A	1.532	1.00
31_G	38_T	1.474	1.00
158_A	216_S	1.468	1.00
147_V	201_G	1.468	1.00
77_L	81_G	1.456	1.00
93_L	111_F	1.441	1.00
71_A	105_A	1.424	1.00
23_L	103_A	1.414	1.00
114_G	119_T	1.412	1.00
160_N	211_E	1.411	1.00
48_R	76_V	1.405	1.00
51_A	129_V	1.388	1.00
192_Y	216_S	1.365	1.00
87_D	93_L	1.353	1.00
204_T	216_S	1.346	1.00
70_A	83_L	1.324	1.00
137_A	185_A	1.321	1.00
22_P	25_A	1.315	1.00
53_L	155_L	1.281	1.00
117_L	138_R	1.279	1.00
100_L	109_A	1.273	1.00
52_T	217_A	1.269	1.00
163_A	186_T	1.247	1.00
143_F	158_A	1.240	1.00
132_I	156_I	1.238	1.00
147_V	199_A	1.237	1.00
31_G	66_F	1.199	1.00
58_R	125_G	1.189	1.00
203_E	217_A	1.177	1.00
150_L	218_A	1.168	1.00
161_V	214_A	1.165	1.00
28_A	41_P	1.161	1.00
14_T	42_D	1.160	1.00
59_V	83_L	1.159	1.00
73_M	83_L	1.127	1.00
98_S	102_R	1.126	1.00
97_R	113_A	1.119	1.00
16_G	194_R	1.111	1.00
46_F	215_V	1.108	1.00
196_V	204_T	1.107	1.00
158_A	196_V	1.097	1.00
50_L	157_V	1.092	1.00
196_V	214_A	1.091	1.00
204_T	214_A	1.090	1.00
140_P	191_A	1.078	1.00
126_P	151_A	1.075	1.00
25_A	29_A	1.071	1.00
154_G	218_A	1.070	1.00
192_Y	214_A	1.067	1.00
100_L	105_A	1.064	1.00
139_Y	158_A	1.059	1.00
10_T	14_T	1.059	1.00
157_V	213_I	1.056	1.00
190_A	194_R	1.048	1.00
70_A	73_M	1.033	1.00
84_V	110_V	1.026	1.00
48_R	72_W	1.025	1.00
98_S	101_D	1.011	1.00
39_V	69_S	1.010	1.00
140_P	144_E	0.996	0.99
79_A	108_T	0.992	0.99
71_A	100_L	0.992	0.99
43_V	213_I	0.983	0.99
196_V	216_S	0.981	0.99
70_A	100_L	0.978	0.99
191_A	194_R	0.972	0.99
93_L	97_R	0.957	0.99
115_D	119_T	0.956	0.99
199_A	202_F	0.951	0.99
26_E	30_H	0.950	0.99
80_D	108_T	0.947	0.99
30_H	34_R	0.944	0.99
49_V	217_A	0.941	0.99
48_R	52_T	0.939	0.99
12_L	193_V	0.931	0.99
22_P	26_E	0.929	0.99
90_S	113_A	0.927	0.99
23_L	99_F	0.927	0.99
71_A	103_A	0.918	0.99
195_R	199_A	0.904	0.99
130_V	154_G	0.899	0.99
39_V	44_G	0.893	0.99
191_A	195_R	0.893	0.99
97_R	101_D	0.892	0.99
183_D	186_T	0.885	0.99
29_A	32_E	0.884	0.99
166_V	169_P	0.883	0.99
51_A	76_V	0.883	0.99
51_A	59_V	0.877	0.99
132_I	158_A	0.868	0.99
13_L	206_L	0.861	0.98
24_L	75_P	0.861	0.98
24_L	71_A	0.858	0.98
56_A	81_G	0.851	0.98
139_Y	189_V	0.850	0.98
47_L	157_V	0.847	0.98
196_V	202_F	0.846	0.98
137_A	188_G	0.841	0.98
94_A	98_S	0.841	0.98
128_D	151_A	0.838	0.98
187_A	190_A	0.836	0.98
143_F	199_A	0.836	0.98
184_D	188_G	0.834	0.98
42_D	210_G	0.831	0.98
61_E	83_L	0.830	0.98
141_A	144_E	0.830	0.98
58_R	84_V	0.827	0.98
100_L	111_F	0.824	0.98
136_K	159_D	0.824	0.98
49_V	205_A	0.819	0.98
88_H	115_D	0.817	0.98
86_T	115_D	0.816	0.98
30_H	95_D	0.812	0.98
45_R	48_R	0.810	0.98
118_D	122_D	0.810	0.98
20_P	68_Y	0.802	0.98
136_K	139_Y	0.796	0.97
103_A	106_D	0.792	0.97
30_H	33_D	0.790	0.97
39_V	43_V	0.787	0.97
112_E	122_D	0.784	0.97
114_G	118_D	0.784	0.97
50_L	53_L	0.783	0.97
27_M	71_A	0.782	0.97
23_L	71_A	0.779	0.97
37_P	65_G	0.779	0.97
74_L	109_A	0.773	0.97
62_F	116_A	0.772	0.97
20_P	25_A	0.772	0.97
13_L	208_P	0.768	0.97
144_E	191_A	0.764	0.97
105_A	108_T	0.762	0.97
44_G	68_Y	0.761	0.97
78_P	108_T	0.758	0.97
169_P	190_A	0.757	0.96
48_R	75_P	0.755	0.96
162_M	167_T	0.752	0.96
49_V	155_L	0.749	0.96
193_V	214_A	0.742	0.96
85_L	109_A	0.741	0.96
58_R	126_P	0.741	0.96
143_F	147_V	0.738	0.96
54_S	151_A	0.738	0.96
58_R	127_F	0.734	0.96
49_V	53_L	0.729	0.96
206_L	214_A	0.726	0.96
30_H	99_F	0.724	0.95
24_L	68_Y	0.716	0.95
119_T	122_D	0.714	0.95
69_S	133_D	0.714	0.95
51_A	54_S	0.713	0.95
95_D	98_S	0.713	0.95
69_S	131_F	0.711	0.95
30_H	66_F	0.710	0.95
150_L	156_I	0.700	0.95
30_H	102_R	0.694	0.94
44_G	76_V	0.694	0.94
36_F	65_G	0.691	0.94
62_F	86_T	0.689	0.94
132_I	142_A	0.689	0.94
151_A	154_G	0.685	0.94
23_L	27_M	0.682	0.94
51_A	56_A	0.681	0.94
46_F	50_L	0.680	0.94
74_L	105_A	0.680	0.94
117_L	142_A	0.675	0.93
136_K	160_N	0.671	0.93
117_L	145_H	0.671	0.93
167_T	193_V	0.669	0.93
43_V	47_L	0.669	0.93
64_S	70_A	0.667	0.93
39_V	131_F	0.666	0.93
47_L	51_A	0.664	0.93
12_L	16_G	0.663	0.93
87_D	99_F	0.661	0.93
184_D	187_A	0.657	0.93
27_M	31_G	0.655	0.92
187_A	191_A	0.653	0.92
152_P	218_A	0.651	0.92
59_V	77_L	0.646	0.92
99_F	102_R	0.644	0.92
20_P	41_P	0.642	0.92
31_G	36_F	0.637	0.91
74_L	83_L	0.636	0.91
28_A	38_T	0.635	0.91
23_L	26_E	0.631	0.91
31_G	65_G	0.627	0.91
46_F	213_I	0.625	0.91
115_D	138_R	0.622	0.90
73_M	129_V	0.618	0.90
126_P	152_P	0.611	0.90
56_A	59_V	0.608	0.89
23_L	102_R	0.605	0.89
193_V	197_R	0.605	0.89
202_F	216_S	0.603	0.89
43_V	210_G	0.600	0.89
97_R	106_D	0.597	0.88
44_G	47_L	0.594	0.88
86_T	116_A	0.594	0.88
64_S	111_F	0.594	0.88
137_A	184_D	0.590	0.88
47_L	73_M	0.584	0.87
144_E	148_D	0.584	0.87
72_W	76_V	0.580	0.87
129_V	154_G	0.578	0.87
143_F	192_Y	0.577	0.87
19_E	25_A	0.572	0.86
159_D	211_E	0.572	0.86
124_E	148_D	0.572	0.86
11_A	14_T	0.567	0.86
135_D	142_A	0.566	0.86
207_V	215_V	0.565	0.86
8_D	11_A	0.563	0.85
163_A	189_V	0.561	0.85
94_A	97_R	0.561	0.85
134_H	138_R	0.561	0.85
161_V	206_L	0.560	0.85
48_R	51_A	0.560	0.85
62_F	120_V	0.560	0.85
163_A	183_D	0.560	0.85
73_M	85_L	0.558	0.85
146_A	150_L	0.557	0.85
64_S	100_L	0.556	0.85
131_F	159_D	0.556	0.85
120_V	146_A	0.555	0.85
148_D	152_P	0.554	0.85
181_A	185_A	0.552	0.84
46_F	207_V	0.551	0.84
9_I	168_A	0.551	0.84
54_S	129_V	0.547	0.84
163_A	211_E	0.544	0.83
185_A	189_V	0.543	0.83
86_T	112_E	0.542	0.83
163_A	185_A	0.539	0.83
59_V	129_V	0.537	0.83
85_L	100_L	0.537	0.83
73_M	76_V	0.536	0.83
201_G	218_A	0.534	0.82
7_T	11_A	0.530	0.82
46_F	209_L	0.528	0.82
27_M	99_F	0.528	0.82
136_K	211_E	0.528	0.82
138_R	142_A	0.527	0.82
49_V	215_V	0.527	0.82
144_E	199_A	0.525	0.81
38_T	65_G	0.525	0.81
118_D	121_T	0.523	0.81
50_L	155_L	0.521	0.81
182_A	187_A	0.520	0.81
153_G	217_A	0.519	0.81
207_V	213_I	0.517	0.80
205_A	217_A	0.517	0.80
124_E	149_V	0.516	0.80
27_M	66_F	0.513	0.80
28_A	32_E	0.512	0.80
143_F	156_I	0.511	0.80
60_F	146_A	0.510	0.79
158_A	214_A	0.510	0.79
59_V	85_L	0.507	0.79
166_V	186_T	0.506	0.79
151_A	155_L	0.502	0.78
192_Y	196_V	0.500	0.78
16_G	193_V	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tr6A	2	0.9134	100	0.447	Contact Map
3dr5A	2	0.9134	100	0.472	Contact Map
3tosA	5	0.8528	100	0.474	Contact Map
1suiA	2	0.9307	100	0.485	Contact Map
3cbgA	2	0.9091	100	0.49	Contact Map
3c3yA	2	0.9307	100	0.491	Contact Map
4ymhA	2	0.974	100	0.495	Contact Map
2hnkA	2	0.9177	100	0.504	Contact Map
2gpyA	2	0.8009	100	0.504	Contact Map
3ntvA	2	0.9048	100	0.509	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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