GREMLIN Database
Q9HRG3 - Uncharacterized protein
UniProt: Q9HRG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (203)
Sequences: 3857 (2677)
Seq/√Len: 187.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E102_R3.8791.00
86_T119_T3.6981.00
101_D106_D3.2341.00
21_S75_P3.2091.00
82_E110_V3.2001.00
140_P195_R2.8241.00
158_A192_Y2.8061.00
84_V127_F2.5241.00
59_V73_M2.5201.00
150_L154_G2.5141.00
57_E80_D2.4781.00
51_A73_M2.3801.00
121_T145_H2.3611.00
64_S85_L2.3491.00
143_F202_F2.3311.00
138_R141_A2.1511.00
117_L141_A2.1501.00
44_G72_W2.1351.00
84_V112_E2.1221.00
90_S94_A2.1201.00
147_V202_F2.0091.00
129_V157_V1.9801.00
194_R198_D1.9451.00
93_L113_A1.9421.00
145_H148_D1.8951.00
29_A33_D1.8381.00
135_D138_R1.8011.00
157_V215_V1.7721.00
58_R82_E1.7681.00
60_F127_F1.7431.00
52_T203_E1.6941.00
130_V150_L1.6651.00
144_E195_R1.6491.00
20_P28_A1.6341.00
130_V146_A1.5911.00
134_H142_A1.5791.00
77_L83_L1.5731.00
115_D118_D1.5661.00
112_E119_T1.5581.00
89_D92_R1.5511.00
30_H98_S1.5461.00
11_A15_A1.5321.00
31_G38_T1.4741.00
158_A216_S1.4681.00
147_V201_G1.4681.00
77_L81_G1.4561.00
93_L111_F1.4411.00
71_A105_A1.4241.00
23_L103_A1.4141.00
114_G119_T1.4121.00
160_N211_E1.4111.00
48_R76_V1.4051.00
51_A129_V1.3881.00
192_Y216_S1.3651.00
87_D93_L1.3531.00
204_T216_S1.3461.00
70_A83_L1.3241.00
137_A185_A1.3211.00
22_P25_A1.3151.00
53_L155_L1.2811.00
117_L138_R1.2791.00
100_L109_A1.2731.00
52_T217_A1.2691.00
163_A186_T1.2471.00
143_F158_A1.2401.00
132_I156_I1.2381.00
147_V199_A1.2371.00
31_G66_F1.1991.00
58_R125_G1.1891.00
203_E217_A1.1771.00
150_L218_A1.1681.00
161_V214_A1.1651.00
28_A41_P1.1611.00
14_T42_D1.1601.00
59_V83_L1.1591.00
73_M83_L1.1271.00
98_S102_R1.1261.00
97_R113_A1.1191.00
16_G194_R1.1111.00
46_F215_V1.1081.00
196_V204_T1.1071.00
158_A196_V1.0971.00
50_L157_V1.0921.00
196_V214_A1.0911.00
204_T214_A1.0901.00
140_P191_A1.0781.00
126_P151_A1.0751.00
25_A29_A1.0711.00
154_G218_A1.0701.00
192_Y214_A1.0671.00
100_L105_A1.0641.00
139_Y158_A1.0591.00
10_T14_T1.0591.00
157_V213_I1.0561.00
190_A194_R1.0481.00
70_A73_M1.0331.00
84_V110_V1.0261.00
48_R72_W1.0251.00
98_S101_D1.0111.00
39_V69_S1.0101.00
140_P144_E0.9960.99
79_A108_T0.9920.99
71_A100_L0.9920.99
43_V213_I0.9830.99
196_V216_S0.9810.99
70_A100_L0.9780.99
191_A194_R0.9720.99
93_L97_R0.9570.99
115_D119_T0.9560.99
199_A202_F0.9510.99
26_E30_H0.9500.99
80_D108_T0.9470.99
30_H34_R0.9440.99
49_V217_A0.9410.99
48_R52_T0.9390.99
12_L193_V0.9310.99
22_P26_E0.9290.99
90_S113_A0.9270.99
23_L99_F0.9270.99
71_A103_A0.9180.99
195_R199_A0.9040.99
130_V154_G0.8990.99
39_V44_G0.8930.99
191_A195_R0.8930.99
97_R101_D0.8920.99
183_D186_T0.8850.99
29_A32_E0.8840.99
166_V169_P0.8830.99
51_A76_V0.8830.99
51_A59_V0.8770.99
132_I158_A0.8680.99
13_L206_L0.8610.98
24_L75_P0.8610.98
24_L71_A0.8580.98
56_A81_G0.8510.98
139_Y189_V0.8500.98
47_L157_V0.8470.98
196_V202_F0.8460.98
137_A188_G0.8410.98
94_A98_S0.8410.98
128_D151_A0.8380.98
187_A190_A0.8360.98
143_F199_A0.8360.98
184_D188_G0.8340.98
42_D210_G0.8310.98
61_E83_L0.8300.98
141_A144_E0.8300.98
58_R84_V0.8270.98
100_L111_F0.8240.98
136_K159_D0.8240.98
49_V205_A0.8190.98
88_H115_D0.8170.98
86_T115_D0.8160.98
30_H95_D0.8120.98
45_R48_R0.8100.98
118_D122_D0.8100.98
20_P68_Y0.8020.98
136_K139_Y0.7960.97
103_A106_D0.7920.97
30_H33_D0.7900.97
39_V43_V0.7870.97
112_E122_D0.7840.97
114_G118_D0.7840.97
50_L53_L0.7830.97
27_M71_A0.7820.97
23_L71_A0.7790.97
37_P65_G0.7790.97
74_L109_A0.7730.97
62_F116_A0.7720.97
20_P25_A0.7720.97
13_L208_P0.7680.97
144_E191_A0.7640.97
105_A108_T0.7620.97
44_G68_Y0.7610.97
78_P108_T0.7580.97
169_P190_A0.7570.96
48_R75_P0.7550.96
162_M167_T0.7520.96
49_V155_L0.7490.96
193_V214_A0.7420.96
85_L109_A0.7410.96
58_R126_P0.7410.96
143_F147_V0.7380.96
54_S151_A0.7380.96
58_R127_F0.7340.96
49_V53_L0.7290.96
206_L214_A0.7260.96
30_H99_F0.7240.95
24_L68_Y0.7160.95
119_T122_D0.7140.95
69_S133_D0.7140.95
51_A54_S0.7130.95
95_D98_S0.7130.95
69_S131_F0.7110.95
30_H66_F0.7100.95
150_L156_I0.7000.95
30_H102_R0.6940.94
44_G76_V0.6940.94
36_F65_G0.6910.94
62_F86_T0.6890.94
132_I142_A0.6890.94
151_A154_G0.6850.94
23_L27_M0.6820.94
51_A56_A0.6810.94
46_F50_L0.6800.94
74_L105_A0.6800.94
117_L142_A0.6750.93
136_K160_N0.6710.93
117_L145_H0.6710.93
167_T193_V0.6690.93
43_V47_L0.6690.93
64_S70_A0.6670.93
39_V131_F0.6660.93
47_L51_A0.6640.93
12_L16_G0.6630.93
87_D99_F0.6610.93
184_D187_A0.6570.93
27_M31_G0.6550.92
187_A191_A0.6530.92
152_P218_A0.6510.92
59_V77_L0.6460.92
99_F102_R0.6440.92
20_P41_P0.6420.92
31_G36_F0.6370.91
74_L83_L0.6360.91
28_A38_T0.6350.91
23_L26_E0.6310.91
31_G65_G0.6270.91
46_F213_I0.6250.91
115_D138_R0.6220.90
73_M129_V0.6180.90
126_P152_P0.6110.90
56_A59_V0.6080.89
23_L102_R0.6050.89
193_V197_R0.6050.89
202_F216_S0.6030.89
43_V210_G0.6000.89
97_R106_D0.5970.88
44_G47_L0.5940.88
86_T116_A0.5940.88
64_S111_F0.5940.88
137_A184_D0.5900.88
47_L73_M0.5840.87
144_E148_D0.5840.87
72_W76_V0.5800.87
129_V154_G0.5780.87
143_F192_Y0.5770.87
19_E25_A0.5720.86
159_D211_E0.5720.86
124_E148_D0.5720.86
11_A14_T0.5670.86
135_D142_A0.5660.86
207_V215_V0.5650.86
8_D11_A0.5630.85
163_A189_V0.5610.85
94_A97_R0.5610.85
134_H138_R0.5610.85
161_V206_L0.5600.85
48_R51_A0.5600.85
62_F120_V0.5600.85
163_A183_D0.5600.85
73_M85_L0.5580.85
146_A150_L0.5570.85
64_S100_L0.5560.85
131_F159_D0.5560.85
120_V146_A0.5550.85
148_D152_P0.5540.85
181_A185_A0.5520.84
46_F207_V0.5510.84
9_I168_A0.5510.84
54_S129_V0.5470.84
163_A211_E0.5440.83
185_A189_V0.5430.83
86_T112_E0.5420.83
163_A185_A0.5390.83
59_V129_V0.5370.83
85_L100_L0.5370.83
73_M76_V0.5360.83
201_G218_A0.5340.82
7_T11_A0.5300.82
46_F209_L0.5280.82
27_M99_F0.5280.82
136_K211_E0.5280.82
138_R142_A0.5270.82
49_V215_V0.5270.82
144_E199_A0.5250.81
38_T65_G0.5250.81
118_D121_T0.5230.81
50_L155_L0.5210.81
182_A187_A0.5200.81
153_G217_A0.5190.81
207_V213_I0.5170.80
205_A217_A0.5170.80
124_E149_V0.5160.80
27_M66_F0.5130.80
28_A32_E0.5120.80
143_F156_I0.5110.80
60_F146_A0.5100.79
158_A214_A0.5100.79
59_V85_L0.5070.79
166_V186_T0.5060.79
151_A155_L0.5020.78
192_Y196_V0.5000.78
16_G193_V0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tr6A 2 0.9134 100 0.447 Contact Map
3dr5A 2 0.9134 100 0.472 Contact Map
3tosA 5 0.8528 100 0.474 Contact Map
1suiA 2 0.9307 100 0.485 Contact Map
3cbgA 2 0.9091 100 0.49 Contact Map
3c3yA 2 0.9307 100 0.491 Contact Map
4ymhA 2 0.974 100 0.495 Contact Map
2hnkA 2 0.9177 100 0.504 Contact Map
2gpyA 2 0.8009 100 0.504 Contact Map
3ntvA 2 0.9048 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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