GREMLIN Database
THIC - Phosphomethylpyrimidine synthase
UniProt: Q9HRG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (419)
Sequences: 1236 (400)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D148_K3.8221.00
377_N390_Q3.7511.00
62_T355_A3.3841.00
247_T251_W3.2991.00
55_I60_F3.2641.00
378_R381_D3.2391.00
247_T259_V3.1410.99
34_A40_A3.1170.99
143_I205_E3.0710.99
293_V350_A2.9980.99
84_L95_V2.9920.99
271_R275_D2.9900.99
176_T418_M2.9780.99
339_D388_R2.9750.99
20_V55_I2.8650.99
176_T227_S2.8140.99
35_V42_I2.7390.98
15_D18_R2.7280.98
146_V199_L2.7110.98
210_L217_I2.6850.98
29_E32_R2.6480.98
143_I206_L2.5720.98
208_E253_H2.5360.97
150_A215_V2.5180.97
26_R31_V2.5150.97
109_T152_Q2.4550.97
147_E151_K2.4390.97
13_V32_R2.4020.96
105_D126_E2.3900.96
309_A320_L2.3410.96
366_A378_R2.3390.96
6_Q211_Q2.2990.95
178_I187_S2.2050.94
274_V315_A2.1930.94
18_R22_D2.1750.94
76_D79_D2.1670.93
14_T17_M2.1590.93
66_A341_M2.1540.93
20_V42_I2.1370.93
267_M310_T2.1350.93
345_R363_W2.1090.92
349_H364_D2.1050.92
39_H58_R2.1040.92
28_P32_R2.0990.92
147_E212_A2.0880.92
23_R52_D2.0860.92
211_Q253_H2.0830.92
30_V34_A2.0760.92
296_I363_W2.0690.92
31_V40_A2.0550.91
248_R282_D2.0420.91
39_H283_G2.0040.90
298_P304_T2.0030.90
121_T154_V1.9810.90
204_D249_R1.9680.90
159_L217_I1.9460.89
267_M311_E1.9280.89
232_S273_N1.9260.89
82_E334_A1.9130.88
103_N106_G1.9090.88
146_V206_L1.9020.88
82_E85_H1.8290.86
211_Q254_G1.7990.85
31_V34_A1.7750.84
4_Q17_M1.7650.84
361_R365_D1.7580.83
40_A60_F1.7530.83
175_T365_D1.7380.83
150_A157_M1.7280.82
251_W282_D1.7090.82
391_A395_Q1.6860.81
34_A39_H1.6830.81
268_D356_G1.6580.79
88_V116_P1.6510.79
18_R28_P1.6340.78
175_T229_A1.6180.78
207_C217_I1.6130.78
5_L41_V1.6100.77
6_Q254_G1.6100.77
369_E373_N1.5990.77
305_S323_V1.5860.76
259_V277_Q1.5760.76
195_E201_T1.5750.76
165_A194_G1.5550.75
200_Y245_E1.5530.75
159_L206_L1.5510.75
269_Q279_E1.5510.75
277_Q286_F1.5380.74
62_T357_K1.5310.74
4_Q14_T1.5230.73
44_A51_L1.5220.73
322_Y337_V1.5130.73
240_L286_F1.4980.72
175_T227_S1.4970.72
13_V28_P1.4920.72
232_S286_F1.4880.71
370_A378_R1.4880.71
273_N286_F1.4870.71
67_N158_T1.4710.71
219_L243_L1.4650.70
277_Q281_C1.4510.69
94_T118_P1.4490.69
338_R342_A1.4480.69
10_D254_G1.4440.69
33_E37_D1.4400.69
202_H205_E1.4110.67
68_I84_L1.4110.67
85_H114_N1.4080.67
42_I55_I1.4020.67
378_R382_L1.3910.66
366_A382_L1.3820.66
41_V216_T1.3820.66
66_A87_A1.3670.65
139_P202_H1.3470.64
147_E205_E1.3450.63
242_T245_E1.3430.63
5_L251_W1.3420.63
43_P56_I1.3360.63
209_I215_V1.3240.62
227_S368_S1.3230.62
228_V353_V1.3210.62
375_D378_R1.3150.62
313_A351_G1.3140.62
41_V258_M1.3110.61
368_S418_M1.3110.61
84_L115_S1.3090.61
309_A344_Y1.2960.60
139_P201_T1.2920.60
89_H387_E1.2860.60
8_A14_T1.2820.60
81_L84_L1.2800.60
31_V35_V1.2710.59
396_T409_S1.2670.59
271_R315_A1.2590.58
102_E107_I1.2570.58
278_Q318_A1.2560.58
17_M31_V1.2530.58
112_I149_Q1.2530.58
87_A341_M1.2510.58
59_D318_A1.2440.57
338_R388_R1.2370.57
251_W259_V1.2340.57
167_H242_T1.2330.57
268_D361_R1.2290.56
274_V317_A1.2230.56
232_S237_F1.2150.55
7_H12_T1.2040.55
203_Y219_L1.2040.55
365_D369_E1.2010.55
207_C253_H1.2000.54
207_C255_V1.1970.54
104_L107_I1.1880.54
142_L146_V1.1870.54
58_R283_G1.1840.53
20_V35_V1.1830.53
156_Y319_M1.1810.53
105_D152_Q1.1790.53
294_T297_A1.1750.53
359_G362_D1.1730.53
126_E130_R1.1630.52
166_E196_Q1.1590.52
30_V40_A1.1580.52
251_W284_A1.1570.52
26_R30_V1.1530.51
237_F276_R1.1520.51
149_Q157_M1.1430.51
66_A95_V1.1390.51
170_L238_A1.1360.50
335_E339_D1.1320.50
56_I118_P1.1220.50
115_S119_V1.1200.49
221_D225_P1.1150.49
303_I343_A1.1080.49
65_N71_S1.1060.48
64_V341_M1.1020.48
314_R355_A1.0990.48
88_V115_S1.0940.48
140_D143_I1.0930.48
176_T368_S1.0930.48
5_L247_T1.0930.48
165_A190_M1.0920.48
19_R52_D1.0880.47
288_V312_A1.0850.47
166_E169_P1.0850.47
17_M32_R1.0780.47
47_H213_H1.0690.46
122_V289_L1.0680.46
388_R391_A1.0660.46
205_E212_A1.0660.46
249_R253_H1.0660.46
231_A269_Q1.0610.46
68_I95_V1.0550.45
168_L190_M1.0540.45
108_R152_Q1.0510.45
270_I311_E1.0500.45
86_T90_Y1.0460.45
419_R423_D1.0460.45
305_S344_Y1.0410.44
146_V157_M1.0400.44
140_D205_E1.0340.44
64_V119_V1.0290.44
139_P143_I1.0280.44
90_Y341_M1.0260.43
119_V268_D1.0260.43
320_L344_Y1.0240.43
406_R422_Q1.0220.43
65_N260_E1.0200.43
296_I349_H1.0180.43
342_A345_R1.0170.43
65_N122_V1.0130.43
276_R286_F1.0110.42
54_M93_D1.0080.42
292_L305_S1.0060.42
62_T352_D1.0010.42
184_S417_S1.0010.42
296_I364_D0.9960.42
366_A369_E0.9960.42
17_M42_I0.9940.41
4_Q214_D0.9930.41
49_D113_D0.9920.41
35_V41_V0.9910.41
61_A345_R0.9900.41
207_C210_L0.9880.41
35_V55_I0.9840.41
377_N381_D0.9810.41
281_C286_F0.9810.41
311_E315_A0.9780.40
406_R419_R0.9770.40
93_D345_R0.9630.39
260_E289_L0.9590.39
220_G260_E0.9580.39
59_D278_Q0.9570.39
122_V260_E0.9560.39
48_H53_P0.9540.39
90_Y338_R0.9520.39
88_V117_V0.9510.39
266_P269_Q0.9450.38
330_G396_T0.9400.38
111_N119_V0.9390.38
247_T282_D0.9380.38
65_N289_L0.9350.38
217_I259_V0.9330.38
241_D280_V0.9300.37
234_D248_R0.9290.37
250_A257_A0.9290.37
142_L199_L0.9270.37
8_A36_A0.9270.37
162_G243_L0.9170.37
239_E291_P0.9160.37
187_S421_D0.9130.36
8_A17_M0.9120.36
93_D184_S0.9080.36
387_E391_A0.9060.36
149_Q152_Q0.9030.36
41_V251_W0.9010.36
17_M36_A0.9010.36
137_I193_H0.9000.36
240_L277_Q0.8990.36
319_M344_Y0.8980.36
111_N351_G0.8970.36
71_S220_G0.8910.35
31_V60_F0.8890.35
85_H89_H0.8870.35
144_D147_E0.8870.35
166_E238_A0.8830.35
220_G289_L0.8830.35
162_G219_L0.8750.34
170_L245_E0.8730.34
398_P407_F0.8720.34
198_P312_A0.8700.34
54_M118_P0.8700.34
297_A346_I0.8700.34
146_V159_L0.8700.34
159_L199_L0.8670.34
110_A113_D0.8620.33
330_G392_F0.8580.33
181_R289_L0.8560.33
388_R392_F0.8530.33
241_D276_R0.8490.33
158_T287_Y0.8490.33
383_A386_P0.8490.33
247_T350_A0.8480.33
144_D148_K0.8460.33
333_D395_Q0.8460.33
37_D283_G0.8450.33
409_S425_R0.8450.33
19_R22_D0.8440.32
172_D282_D0.8400.32
62_T314_R0.8350.32
294_T364_D0.8350.32
65_N220_G0.8330.32
267_M270_I0.8320.32
13_V29_E0.8300.32
64_V254_G0.8300.32
71_S260_E0.8290.32
272_A275_D0.8280.32
161_A217_I0.8270.32
240_L273_N0.8250.31
175_T368_S0.8240.31
122_V287_Y0.8220.31
232_S269_Q0.8190.31
40_A59_D0.8150.31
187_S425_R0.8140.31
243_L259_V0.8110.31
137_I141_L0.8070.30
170_L241_D0.8010.30
163_V222_G0.8000.30
161_A269_Q0.8000.30
91_G337_V0.7990.30
393_H406_R0.7970.30
94_T319_M0.7960.30
71_S289_L0.7960.30
163_V167_H0.7910.30
40_A55_I0.7860.29
139_P205_E0.7850.29
67_N220_G0.7810.29
157_M210_L0.7810.29
97_D221_D0.7800.29
240_L276_R0.7790.29
77_I106_G0.7780.29
177_G185_I0.7740.29
141_L149_Q0.7720.29
68_I134_V0.7720.29
5_L254_G0.7700.28
140_D194_G0.7690.28
97_D225_P0.7670.28
71_S122_V0.7630.28
66_A84_L0.7610.28
158_T289_L0.7610.28
175_T369_E0.7610.28
142_L145_V0.7610.28
67_N178_I0.7600.28
380_F389_A0.7600.28
122_V220_G0.7600.28
227_S351_G0.7560.28
200_Y203_Y0.7470.27
273_N287_Y0.7460.27
168_L379_Q0.7460.27
159_L164_L0.7440.27
309_A367_L0.7430.27
86_T334_A0.7410.27
158_T231_A0.7400.27
146_V161_A0.7390.27
157_M215_V0.7390.27
236_Q288_V0.7360.27
34_A59_D0.7350.27
363_W384_L0.7330.27
393_H409_S0.7320.27
268_D275_D0.7310.26
339_D343_A0.7300.26
384_L387_E0.7270.26
23_R54_M0.7240.26
70_N100_T0.7240.26
121_T223_L0.7230.26
33_E212_A0.7230.26
169_P320_L0.7180.26
81_L115_S0.7180.26
376_W410_M0.7140.26
184_S420_I0.7120.26
152_Q213_H0.7110.25
65_N70_N0.7090.25
158_T221_D0.7090.25
203_Y217_I0.7080.25
143_I147_E0.7070.25
149_Q177_G0.7070.25
311_E314_R0.7050.25
172_D234_D0.7040.25
37_D58_R0.7040.25
330_G379_Q0.7030.25
14_T42_I0.7010.25
304_T323_V0.6950.25
8_A32_R0.6940.25
181_R260_E0.6930.25
150_A209_I0.6920.25
392_F396_T0.6900.24
170_L242_T0.6880.24
9_R254_G0.6860.24
54_M94_T0.6840.24
393_H407_F0.6840.24
89_H345_R0.6840.24
170_L234_D0.6830.24
62_T359_G0.6820.24
252_D267_M0.6810.24
159_L210_L0.6790.24
27_D30_V0.6790.24
208_E211_Q0.6770.24
236_Q240_L0.6730.24
393_H396_T0.6720.24
78_D85_H0.6670.23
158_T178_I0.6650.23
116_P155_D0.6640.23
307_I310_T0.6630.23
48_H51_L0.6600.23
81_L85_H0.6600.23
18_R296_I0.6590.23
4_Q8_A0.6570.23
95_V117_V0.6530.23
109_T113_D0.6520.23
101_G185_I0.6510.23
163_V205_E0.6490.23
127_A314_R0.6490.23
78_D110_A0.6470.22
109_T334_A0.6460.22
305_S406_R0.6460.22
56_I390_Q0.6440.22
157_M164_L0.6440.22
86_T89_H0.6430.22
155_D216_T0.6420.22
238_A367_L0.6420.22
122_V181_R0.6420.22
203_Y243_L0.6410.22
131_V141_L0.6400.22
32_R36_A0.6390.22
215_V381_D0.6380.22
205_E208_E0.6380.22
354_A382_L0.6360.22
228_V368_S0.6350.22
204_D253_H0.6340.22
121_T145_V0.6340.22
298_P367_L0.6330.22
384_L389_A0.6290.22
170_L235_A0.6290.22
34_A58_R0.6280.22
310_T314_R0.6270.22
135_T192_E0.6240.21
158_T181_R0.6230.21
334_A341_M0.6220.21
362_D366_A0.6220.21
243_L284_A0.6180.21
346_I384_L0.6170.21
374_F407_F0.6150.21
130_R193_H0.6120.21
6_Q10_D0.6110.21
311_E342_A0.6100.21
107_I111_N0.6100.21
143_I202_H0.6090.21
244_G281_C0.6080.21
70_N331_L0.6080.21
13_V17_M0.6070.21
97_D121_T0.6070.21
342_A346_I0.6060.21
244_G284_A0.6050.21
296_I345_R0.6050.21
115_S184_S0.6050.21
126_E379_Q0.6020.21
4_Q274_V0.6020.21
135_T185_I0.6010.20
237_F240_L0.6000.20
43_P216_T0.6000.20
100_T420_I0.6000.20
162_G206_L0.5980.20
100_T222_G0.5980.20
96_M289_L0.5970.20
128_V231_A0.5970.20
15_D32_R0.5970.20
260_E287_Y0.5970.20
363_W382_L0.5960.20
56_I124_I0.5950.20
12_T355_A0.5940.20
88_V114_N0.5940.20
176_T186_L0.5930.20
94_T156_Y0.5930.20
65_N331_L0.5920.20
201_T205_E0.5910.20
16_A19_R0.5900.20
203_Y250_A0.5900.20
72_D333_D0.5890.20
232_S276_R0.5880.20
181_R287_Y0.5880.20
143_I222_G0.5880.20
269_Q272_A0.5870.20
104_L424_A0.5870.20
142_L198_P0.5860.20
185_I368_S0.5860.20
110_A114_N0.5850.20
7_H10_D0.5850.20
210_L255_V0.5830.20
45_N155_D0.5830.20
25_G358_P0.5820.20
247_T351_G0.5820.20
374_F418_M0.5820.20
10_D252_D0.5800.20
274_V288_V0.5790.20
157_M206_L0.5790.20
80_E83_K0.5780.20
225_P312_A0.5780.20
100_T220_G0.5780.20
135_T177_G0.5760.19
43_P54_M0.5750.19
167_H245_E0.5750.19
45_N48_H0.5740.19
122_V331_L0.5700.19
133_D136_D0.5700.19
96_M120_G0.5700.19
97_D288_V0.5690.19
265_V276_R0.5680.19
272_A279_E0.5680.19
60_F313_A0.5680.19
50_A64_V0.5670.19
161_A288_V0.5670.19
231_A287_Y0.5670.19
67_N71_S0.5660.19
255_V280_V0.5660.19
97_D154_V0.5640.19
78_D82_E0.5640.19
236_Q322_Y0.5630.19
92_A122_V0.5630.19
32_R395_Q0.5630.19
158_T162_G0.5620.19
203_Y259_V0.5610.19
162_G376_W0.5610.19
386_P389_A0.5600.19
65_N287_Y0.5590.19
64_V90_Y0.5590.19
274_V278_Q0.5590.19
112_I119_V0.5580.19
120_G262_P0.5570.19
5_L35_V0.5570.19
222_G284_A0.5570.19
162_G222_G0.5570.19
58_R62_T0.5540.19
267_M315_A0.5540.19
178_I220_G0.5540.19
309_A319_M0.5540.19
70_N104_L0.5540.19
177_G187_S0.5520.19
3_T6_Q0.5520.19
15_D335_E0.5520.19
101_G126_E0.5520.19
100_T187_S0.5520.19
56_I112_I0.5520.19
405_A409_S0.5520.19
126_E177_G0.5510.18
421_D425_R0.5510.18
198_P288_V0.5500.18
298_P329_L0.5500.18
100_T181_R0.5490.18
140_D206_L0.5470.18
367_L383_A0.5460.18
91_G409_S0.5460.18
148_K152_Q0.5460.18
86_T341_M0.5450.18
19_R23_R0.5450.18
66_A92_A0.5450.18
162_G273_N0.5450.18
97_D320_L0.5450.18
97_D349_H0.5440.18
159_L190_M0.5440.18
35_V259_V0.5420.18
154_V228_V0.5420.18
315_A378_R0.5420.18
394_D397_L0.5410.18
143_I258_M0.5400.18
243_L291_P0.5400.18
49_D213_H0.5400.18
234_D241_D0.5400.18
234_D245_E0.5400.18
247_T277_Q0.5390.18
312_A375_D0.5380.18
210_L215_V0.5370.18
46_H214_D0.5370.18
390_Q394_D0.5350.18
231_A266_P0.5350.18
67_N122_V0.5350.18
373_N422_Q0.5350.18
194_G345_R0.5350.18
359_G369_E0.5350.18
8_A11_G0.5340.18
27_D33_E0.5320.18
227_S379_Q0.5320.18
267_M356_G0.5320.18
105_D109_T0.5320.18
58_R278_Q0.5310.18
97_D309_A0.5310.18
81_L114_N0.5310.18
22_D61_A0.5310.18
120_G289_L0.5310.18
139_P195_E0.5300.18
241_D278_Q0.5290.18
138_T141_L0.5280.18
76_D409_S0.5270.18
135_T188_Q0.5270.18
126_E145_V0.5270.18
259_V396_T0.5270.18
128_V259_V0.5260.18
94_T155_D0.5240.17
66_A90_Y0.5240.17
145_V339_D0.5240.17
163_V223_L0.5230.17
335_E387_E0.5220.17
177_G372_Y0.5200.17
189_W193_H0.5190.17
342_A388_R0.5190.17
363_W368_S0.5180.17
85_H217_I0.5170.17
247_T257_A0.5170.17
345_R386_P0.5160.17
204_D217_I0.5140.17
122_V158_T0.5130.17
65_N181_R0.5120.17
164_L235_A0.5120.17
198_P375_D0.5120.17
297_A304_T0.5120.17
156_Y278_Q0.5110.17
213_H353_V0.5100.17
54_M117_V0.5100.17
107_I177_G0.5100.17
206_L217_I0.5090.17
5_L9_R0.5070.17
41_V319_M0.5060.17
33_E252_D0.5060.17
6_Q253_H0.5050.17
181_R231_A0.5050.17
12_T49_D0.5050.17
67_N260_E0.5050.17
240_L323_V0.5040.17
61_A310_T0.5040.17
64_V173_D0.5040.17
140_D151_K0.5030.17
186_L206_L0.5030.17
313_A393_H0.5030.17
381_D390_Q0.5020.17
58_R355_A0.5010.17
143_I198_P0.5010.17
243_L356_G0.5010.17
161_A203_Y0.5010.17
228_V384_L0.5000.17
211_Q217_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epoA 2 0.8193 100 0.025 Contact Map
4s28A 2 0.9139 100 0.035 Contact Map
1w8sA 4 0.4832 93.1 0.975 Contact Map
4djdD 1 0.5084 92.2 0.976 Contact Map
2dqwA 2 0.4643 91.1 0.977 Contact Map
3f4wA 2 0.4265 90.1 0.977 Contact Map
1aj0A 1 0.5063 88.8 0.978 Contact Map
4cq8A 1 0.5231 87.8 0.978 Contact Map
2h9aB 1 0.4958 86.3 0.979 Contact Map
2y5sA 2 0.4937 85.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.