GREMLIN Database
PGP - Phosphoglycolate phosphatase
UniProt: Q9HRF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (218)
Sequences: 11862 (9687)
Seq/√Len: 656.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_S218_A4.1481.00
19_A212_H3.2461.00
173_A187_V3.1211.00
6_P170_D2.9111.00
210_E213_G2.7691.00
184_F190_S2.5621.00
161_A171_F2.5181.00
24_D214_D2.4231.00
10_V38_V2.4101.00
26_R214_D2.3721.00
42_T49_A2.3431.00
185_E203_A2.3351.00
158_P186_A2.3191.00
198_D202_G2.2691.00
18_R22_S2.2161.00
26_R221_D2.1051.00
168_A186_A2.0621.00
152_S182_E1.9901.00
178_A199_H1.8921.00
5_D172_V1.8821.00
178_A197_D1.8631.00
7_P39_V1.7471.00
181_V200_A1.7431.00
181_V203_A1.7401.00
81_D84_A1.7171.00
190_S205_E1.7161.00
159_A163_R1.7001.00
192_A204_A1.6991.00
167_T170_D1.6821.00
33_G221_D1.6761.00
191_Y219_A1.6691.00
9_A157_L1.6621.00
25_G29_D1.6401.00
173_A183_L1.6201.00
154_G186_A1.6151.00
33_G36_G1.5961.00
189_E205_E1.5901.00
31_L38_V1.5831.00
189_E206_T1.5781.00
28_L55_F1.5771.00
209_S213_G1.5751.00
159_A162_A1.5741.00
9_A41_A1.5711.00
206_T219_A1.5291.00
155_N158_P1.5271.00
198_D201_K1.5051.00
72_V75_E1.4991.00
157_L183_L1.4991.00
158_P162_A1.4941.00
127_S131_A1.4831.00
5_D170_D1.4771.00
37_P164_L1.4741.00
12_I17_S1.4551.00
82_S86_E1.3961.00
10_V174_V1.3931.00
35_D59_D1.3831.00
29_D33_G1.3821.00
24_D27_V1.3651.00
84_A87_Q1.3591.00
200_A203_A1.3571.00
161_A168_A1.3511.00
181_V185_E1.3441.00
174_V216_F1.3411.00
28_L32_R1.3401.00
169_G188_G1.3301.00
174_V219_A1.3261.00
84_A134_G1.3191.00
206_T222_R1.3171.00
5_D189_E1.3061.00
192_A196_A1.3061.00
26_R218_A1.3031.00
27_V214_D1.2911.00
30_V217_L1.2661.00
168_A171_F1.2631.00
216_F220_V1.2311.00
199_H202_G1.2181.00
35_D60_E1.2031.00
201_K207_V1.1951.00
136_H182_E1.1831.00
152_S155_N1.1511.00
72_V76_L1.1481.00
26_R30_V1.1441.00
184_F200_A1.1351.00
18_R212_H1.1341.00
87_Q133_H1.1281.00
39_V160_V1.1251.00
191_Y208_L1.1151.00
87_Q134_G1.1141.00
30_V221_D1.1101.00
173_A184_F1.1081.00
194_G210_E1.0991.00
7_P166_V1.0951.00
63_I156_A1.0931.00
122_P125_V1.0741.00
217_L221_D1.0701.00
171_F187_V1.0661.00
177_S197_D1.0631.00
84_A135_L1.0611.00
8_L220_V1.0581.00
91_A95_A1.0551.00
70_A159_A1.0501.00
219_A222_R1.0401.00
208_L219_A1.0371.00
161_A186_A1.0361.00
32_R36_G1.0361.00
208_L215_G1.0361.00
8_L34_W1.0341.00
32_R35_D1.0291.00
160_V164_L1.0201.00
68_G151_M1.0121.00
128_A131_A1.0101.00
9_A39_V1.0051.00
191_Y206_T0.9981.00
154_G182_E0.9921.00
12_I52_L0.9801.00
46_L64_A0.9791.00
75_E78_H0.9791.00
9_A171_F0.9761.00
87_Q90_A0.9751.00
61_R164_L0.9721.00
196_A201_K0.9711.00
158_P168_A0.9671.00
172_V191_Y0.9651.00
91_A94_D0.9641.00
7_P161_A0.9601.00
172_V219_A0.9571.00
218_A222_R0.9551.00
197_D200_A0.9511.00
25_G28_L0.9501.00
110_W113_T0.9501.00
32_R57_G0.9501.00
34_W38_V0.9461.00
195_N211_T0.9451.00
72_V77_L0.9401.00
134_G149_E0.9391.00
124_D128_A0.9381.00
168_A188_G0.9291.00
86_E90_A0.9231.00
148_P151_M0.9231.00
19_A211_T0.9221.00
138_V147_K0.9201.00
95_A129_L0.9121.00
16_L27_V0.9101.00
193_V215_G0.9101.00
64_A69_V0.9091.00
172_V189_E0.9071.00
7_P171_F0.9071.00
63_I160_V0.9001.00
70_A156_A0.8991.00
29_D32_R0.8991.00
129_L133_H0.8981.00
83_R87_Q0.8981.00
187_V190_S0.8971.00
124_D127_S0.8971.00
136_H150_S0.8951.00
209_S215_G0.8861.00
124_D139_D0.8841.00
125_V128_A0.8841.00
10_V216_F0.8841.00
41_A63_I0.8741.00
192_A200_A0.8571.00
27_V217_L0.8501.00
157_L187_V0.8481.00
178_A181_V0.8431.00
194_G201_K0.8421.00
90_A94_D0.8411.00
45_A65_E0.8391.00
46_L71_Y0.8341.00
76_L79_F0.8311.00
89_A93_E0.8281.00
136_H152_S0.8261.00
194_G209_S0.8241.00
8_L172_V0.8221.00
147_K152_S0.8201.00
161_A166_V0.8171.00
161_A188_G0.8161.00
27_V30_V0.8161.00
16_L31_L0.8111.00
218_A221_D0.8031.00
199_H203_A0.7981.00
120_E124_D0.7941.00
43_G179_N0.7891.00
10_V16_L0.7871.00
39_V61_R0.7871.00
193_V208_L0.7871.00
34_W220_V0.7781.00
87_Q91_A0.7731.00
91_A133_H0.7721.00
137_V146_V0.7681.00
171_F186_A0.7681.00
26_R217_L0.7671.00
125_V129_L0.7671.00
64_A71_Y0.7661.00
193_V196_A0.7641.00
42_T64_A0.7621.00
65_E145_H0.7561.00
184_F203_A0.7541.00
127_S139_D0.7471.00
209_S222_R0.7461.00
12_I40_V0.7451.00
50_V54_Q0.7441.00
155_N159_A0.7391.00
194_G213_G0.7381.00
151_M155_N0.7361.00
61_R160_V0.7331.00
188_G205_E0.7331.00
171_F188_G0.7331.00
30_V33_G0.7241.00
91_A129_L0.7211.00
46_L50_V0.7201.00
80_G148_P0.7191.00
157_L173_A0.7181.00
71_Y76_L0.7131.00
158_P161_A0.7091.00
37_P60_E0.7091.00
74_D77_L0.7081.00
176_D196_A0.7031.00
41_A183_L0.6991.00
26_R29_D0.6991.00
66_N145_H0.6981.00
73_G76_L0.6961.00
16_L23_I0.6961.00
5_D37_P0.6911.00
112_E145_H0.6911.00
170_D188_G0.6901.00
138_V141_G0.6871.00
80_G84_A0.6851.00
119_R122_P0.6841.00
154_G158_P0.6791.00
20_D212_H0.6791.00
18_R24_D0.6711.00
174_V191_Y0.6691.00
8_L174_V0.6671.00
206_T218_A0.6671.00
208_L218_A0.6661.00
92_F115_L0.6661.00
94_D129_L0.6641.00
108_N111_R0.6641.00
123_L127_S0.6621.00
27_V31_L0.6541.00
129_L132_D0.6541.00
61_R72_V0.6501.00
109_R112_E0.6401.00
190_S204_A0.6401.00
206_T209_S0.6401.00
68_G148_P0.6381.00
182_E185_E0.6381.00
107_T113_T0.6371.00
107_T110_W0.6361.00
99_I102_G0.6351.00
196_A200_A0.6341.00
7_P160_V0.6341.00
73_G77_L0.6271.00
40_V49_A0.6241.00
106_L110_W0.6241.00
95_A125_V0.6191.00
12_I16_L0.6151.00
118_S122_P0.6151.00
85_V89_A0.6141.00
49_A62_V0.6111.00
49_A64_A0.6091.00
128_A132_D0.6081.00
200_A204_A0.6031.00
176_D193_V0.6011.00
136_H149_E0.6001.00
18_R211_T0.5981.00
93_E99_I0.5961.00
97_H103_D0.5911.00
109_R113_T0.5891.00
137_V144_Y0.5871.00
65_E68_G0.5841.00
150_S155_N0.5831.00
209_S219_A0.5811.00
121_Q124_D0.5811.00
184_F204_A0.5801.00
174_V208_L0.5801.00
23_I27_V0.5771.00
82_S109_R0.5771.00
12_I49_A0.5751.00
106_L109_R0.5751.00
30_V34_W0.5741.00
83_R86_E0.5711.00
112_E115_L0.5711.00
16_L211_T0.5701.00
193_V211_T0.5691.00
141_G177_S0.5681.00
53_C62_V0.5671.00
7_P37_P0.5671.00
14_G193_V0.5661.00
16_L40_V0.5661.00
23_I28_L0.5651.00
61_R73_G0.5641.00
16_L216_F0.5611.00
195_N201_K0.5571.00
190_S200_A0.5541.00
5_D8_L0.5541.00
178_A200_A0.5541.00
17_S211_T0.5541.00
65_E69_V0.5531.00
70_A160_V0.5521.00
195_N210_E0.5511.00
39_V60_E0.5491.00
62_V73_G0.5441.00
37_P61_R0.5421.00
189_E219_A0.5411.00
214_D217_L0.5381.00
45_A48_Y0.5361.00
65_E143_A0.5341.00
34_W217_L0.5341.00
114_E145_H0.5331.00
97_H102_G0.5331.00
15_T179_N0.5300.99
173_A190_S0.5280.99
139_D143_A0.5270.99
40_V53_C0.5270.99
89_A101_W0.5210.99
181_V184_F0.5210.99
92_F99_I0.5210.99
88_V146_V0.5180.99
48_Y143_A0.5170.99
192_A203_A0.5150.99
63_I70_A0.5070.99
29_D221_D0.5070.99
69_V104_A0.5050.99
91_A130_A0.5050.99
121_Q125_V0.5010.99
70_A163_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.9778 100 0.238 Contact Map
1rkqA 1 0.9911 100 0.267 Contact Map
3pgvA 3 0.9822 100 0.271 Contact Map
4qjbA 1 0.9956 100 0.274 Contact Map
3l7yA 1 0.9733 100 0.275 Contact Map
1l6rA 2 0.9778 100 0.277 Contact Map
2b30A 2 0.9956 100 0.278 Contact Map
3fzqA 2 0.9822 100 0.287 Contact Map
1nf2A 4 0.9822 100 0.296 Contact Map
4dw8A 1 0.9778 100 0.299 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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