PGP - HALSA - GREMLIN Contacts

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PGP - Phosphoglycolate phosphatase

UniProt:	Q9HRF9	Sequences: MDTADPPLAVDIDGTLSRADRSIDGRVLDVLRGWDGPVVVATGKALPYAVALCQFAGIDERVIAENGGVAYVGDELLHFGDSRAVEQVAAAFEDAGHDIGWGDADLTNRWRETELAVSREQPLDVLSALAADHGLHVVDTGFAYHVKPESMSKGNALPAVAARLGVTAGDFVAVGDSANDVELFEAVGESYAVGNADDHAKGAAETVLSETHGDGFLAAVDRIRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	225 (218)
Sequences:	11862 (9687)
Seq/√Len:	656.1

ECOLI - YBHA MPGP YIGL COF YBJI SUPH YIDA
BACSU - YITU YCSE NTDB YWPJ YXEH YHAX YWTE YKRA
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
209_S	218_A	4.148	1.00
19_A	212_H	3.246	1.00
173_A	187_V	3.121	1.00
6_P	170_D	2.911	1.00
210_E	213_G	2.769	1.00
184_F	190_S	2.562	1.00
161_A	171_F	2.518	1.00
24_D	214_D	2.423	1.00
10_V	38_V	2.410	1.00
26_R	214_D	2.372	1.00
42_T	49_A	2.343	1.00
185_E	203_A	2.335	1.00
158_P	186_A	2.319	1.00
198_D	202_G	2.269	1.00
18_R	22_S	2.216	1.00
26_R	221_D	2.105	1.00
168_A	186_A	2.062	1.00
152_S	182_E	1.990	1.00
178_A	199_H	1.892	1.00
5_D	172_V	1.882	1.00
178_A	197_D	1.863	1.00
7_P	39_V	1.747	1.00
181_V	200_A	1.743	1.00
181_V	203_A	1.740	1.00
81_D	84_A	1.717	1.00
190_S	205_E	1.716	1.00
159_A	163_R	1.700	1.00
192_A	204_A	1.699	1.00
167_T	170_D	1.682	1.00
33_G	221_D	1.676	1.00
191_Y	219_A	1.669	1.00
9_A	157_L	1.662	1.00
25_G	29_D	1.640	1.00
173_A	183_L	1.620	1.00
154_G	186_A	1.615	1.00
33_G	36_G	1.596	1.00
189_E	205_E	1.590	1.00
31_L	38_V	1.583	1.00
189_E	206_T	1.578	1.00
28_L	55_F	1.577	1.00
209_S	213_G	1.575	1.00
159_A	162_A	1.574	1.00
9_A	41_A	1.571	1.00
206_T	219_A	1.529	1.00
155_N	158_P	1.527	1.00
198_D	201_K	1.505	1.00
72_V	75_E	1.499	1.00
157_L	183_L	1.499	1.00
158_P	162_A	1.494	1.00
127_S	131_A	1.483	1.00
5_D	170_D	1.477	1.00
37_P	164_L	1.474	1.00
12_I	17_S	1.455	1.00
82_S	86_E	1.396	1.00
10_V	174_V	1.393	1.00
35_D	59_D	1.383	1.00
29_D	33_G	1.382	1.00
24_D	27_V	1.365	1.00
84_A	87_Q	1.359	1.00
200_A	203_A	1.357	1.00
161_A	168_A	1.351	1.00
181_V	185_E	1.344	1.00
174_V	216_F	1.341	1.00
28_L	32_R	1.340	1.00
169_G	188_G	1.330	1.00
174_V	219_A	1.326	1.00
84_A	134_G	1.319	1.00
206_T	222_R	1.317	1.00
5_D	189_E	1.306	1.00
192_A	196_A	1.306	1.00
26_R	218_A	1.303	1.00
27_V	214_D	1.291	1.00
30_V	217_L	1.266	1.00
168_A	171_F	1.263	1.00
216_F	220_V	1.231	1.00
199_H	202_G	1.218	1.00
35_D	60_E	1.203	1.00
201_K	207_V	1.195	1.00
136_H	182_E	1.183	1.00
152_S	155_N	1.151	1.00
72_V	76_L	1.148	1.00
26_R	30_V	1.144	1.00
184_F	200_A	1.135	1.00
18_R	212_H	1.134	1.00
87_Q	133_H	1.128	1.00
39_V	160_V	1.125	1.00
191_Y	208_L	1.115	1.00
87_Q	134_G	1.114	1.00
30_V	221_D	1.110	1.00
173_A	184_F	1.108	1.00
194_G	210_E	1.099	1.00
7_P	166_V	1.095	1.00
63_I	156_A	1.093	1.00
122_P	125_V	1.074	1.00
217_L	221_D	1.070	1.00
171_F	187_V	1.066	1.00
177_S	197_D	1.063	1.00
84_A	135_L	1.061	1.00
8_L	220_V	1.058	1.00
91_A	95_A	1.055	1.00
70_A	159_A	1.050	1.00
219_A	222_R	1.040	1.00
208_L	219_A	1.037	1.00
161_A	186_A	1.036	1.00
32_R	36_G	1.036	1.00
208_L	215_G	1.036	1.00
8_L	34_W	1.034	1.00
32_R	35_D	1.029	1.00
160_V	164_L	1.020	1.00
68_G	151_M	1.012	1.00
128_A	131_A	1.010	1.00
9_A	39_V	1.005	1.00
191_Y	206_T	0.998	1.00
154_G	182_E	0.992	1.00
12_I	52_L	0.980	1.00
46_L	64_A	0.979	1.00
75_E	78_H	0.979	1.00
9_A	171_F	0.976	1.00
87_Q	90_A	0.975	1.00
61_R	164_L	0.972	1.00
196_A	201_K	0.971	1.00
158_P	168_A	0.967	1.00
172_V	191_Y	0.965	1.00
91_A	94_D	0.964	1.00
7_P	161_A	0.960	1.00
172_V	219_A	0.957	1.00
218_A	222_R	0.955	1.00
197_D	200_A	0.951	1.00
25_G	28_L	0.950	1.00
110_W	113_T	0.950	1.00
32_R	57_G	0.950	1.00
34_W	38_V	0.946	1.00
195_N	211_T	0.945	1.00
72_V	77_L	0.940	1.00
134_G	149_E	0.939	1.00
124_D	128_A	0.938	1.00
168_A	188_G	0.929	1.00
86_E	90_A	0.923	1.00
148_P	151_M	0.923	1.00
19_A	211_T	0.922	1.00
138_V	147_K	0.920	1.00
95_A	129_L	0.912	1.00
16_L	27_V	0.910	1.00
193_V	215_G	0.910	1.00
64_A	69_V	0.909	1.00
172_V	189_E	0.907	1.00
7_P	171_F	0.907	1.00
63_I	160_V	0.900	1.00
70_A	156_A	0.899	1.00
29_D	32_R	0.899	1.00
129_L	133_H	0.898	1.00
83_R	87_Q	0.898	1.00
187_V	190_S	0.897	1.00
124_D	127_S	0.897	1.00
136_H	150_S	0.895	1.00
209_S	215_G	0.886	1.00
124_D	139_D	0.884	1.00
125_V	128_A	0.884	1.00
10_V	216_F	0.884	1.00
41_A	63_I	0.874	1.00
192_A	200_A	0.857	1.00
27_V	217_L	0.850	1.00
157_L	187_V	0.848	1.00
178_A	181_V	0.843	1.00
194_G	201_K	0.842	1.00
90_A	94_D	0.841	1.00
45_A	65_E	0.839	1.00
46_L	71_Y	0.834	1.00
76_L	79_F	0.831	1.00
89_A	93_E	0.828	1.00
136_H	152_S	0.826	1.00
194_G	209_S	0.824	1.00
8_L	172_V	0.822	1.00
147_K	152_S	0.820	1.00
161_A	166_V	0.817	1.00
161_A	188_G	0.816	1.00
27_V	30_V	0.816	1.00
16_L	31_L	0.811	1.00
218_A	221_D	0.803	1.00
199_H	203_A	0.798	1.00
120_E	124_D	0.794	1.00
43_G	179_N	0.789	1.00
10_V	16_L	0.787	1.00
39_V	61_R	0.787	1.00
193_V	208_L	0.787	1.00
34_W	220_V	0.778	1.00
87_Q	91_A	0.773	1.00
91_A	133_H	0.772	1.00
137_V	146_V	0.768	1.00
171_F	186_A	0.768	1.00
26_R	217_L	0.767	1.00
125_V	129_L	0.767	1.00
64_A	71_Y	0.766	1.00
193_V	196_A	0.764	1.00
42_T	64_A	0.762	1.00
65_E	145_H	0.756	1.00
184_F	203_A	0.754	1.00
127_S	139_D	0.747	1.00
209_S	222_R	0.746	1.00
12_I	40_V	0.745	1.00
50_V	54_Q	0.744	1.00
155_N	159_A	0.739	1.00
194_G	213_G	0.738	1.00
151_M	155_N	0.736	1.00
61_R	160_V	0.733	1.00
188_G	205_E	0.733	1.00
171_F	188_G	0.733	1.00
30_V	33_G	0.724	1.00
91_A	129_L	0.721	1.00
46_L	50_V	0.720	1.00
80_G	148_P	0.719	1.00
157_L	173_A	0.718	1.00
71_Y	76_L	0.713	1.00
158_P	161_A	0.709	1.00
37_P	60_E	0.709	1.00
74_D	77_L	0.708	1.00
176_D	196_A	0.703	1.00
41_A	183_L	0.699	1.00
26_R	29_D	0.699	1.00
66_N	145_H	0.698	1.00
73_G	76_L	0.696	1.00
16_L	23_I	0.696	1.00
5_D	37_P	0.691	1.00
112_E	145_H	0.691	1.00
170_D	188_G	0.690	1.00
138_V	141_G	0.687	1.00
80_G	84_A	0.685	1.00
119_R	122_P	0.684	1.00
154_G	158_P	0.679	1.00
20_D	212_H	0.679	1.00
18_R	24_D	0.671	1.00
174_V	191_Y	0.669	1.00
8_L	174_V	0.667	1.00
206_T	218_A	0.667	1.00
208_L	218_A	0.666	1.00
92_F	115_L	0.666	1.00
94_D	129_L	0.664	1.00
108_N	111_R	0.664	1.00
123_L	127_S	0.662	1.00
27_V	31_L	0.654	1.00
129_L	132_D	0.654	1.00
61_R	72_V	0.650	1.00
109_R	112_E	0.640	1.00
190_S	204_A	0.640	1.00
206_T	209_S	0.640	1.00
68_G	148_P	0.638	1.00
182_E	185_E	0.638	1.00
107_T	113_T	0.637	1.00
107_T	110_W	0.636	1.00
99_I	102_G	0.635	1.00
196_A	200_A	0.634	1.00
7_P	160_V	0.634	1.00
73_G	77_L	0.627	1.00
40_V	49_A	0.624	1.00
106_L	110_W	0.624	1.00
95_A	125_V	0.619	1.00
12_I	16_L	0.615	1.00
118_S	122_P	0.615	1.00
85_V	89_A	0.614	1.00
49_A	62_V	0.611	1.00
49_A	64_A	0.609	1.00
128_A	132_D	0.608	1.00
200_A	204_A	0.603	1.00
176_D	193_V	0.601	1.00
136_H	149_E	0.600	1.00
18_R	211_T	0.598	1.00
93_E	99_I	0.596	1.00
97_H	103_D	0.591	1.00
109_R	113_T	0.589	1.00
137_V	144_Y	0.587	1.00
65_E	68_G	0.584	1.00
150_S	155_N	0.583	1.00
209_S	219_A	0.581	1.00
121_Q	124_D	0.581	1.00
184_F	204_A	0.580	1.00
174_V	208_L	0.580	1.00
23_I	27_V	0.577	1.00
82_S	109_R	0.577	1.00
12_I	49_A	0.575	1.00
106_L	109_R	0.575	1.00
30_V	34_W	0.574	1.00
83_R	86_E	0.571	1.00
112_E	115_L	0.571	1.00
16_L	211_T	0.570	1.00
193_V	211_T	0.569	1.00
141_G	177_S	0.568	1.00
53_C	62_V	0.567	1.00
7_P	37_P	0.567	1.00
14_G	193_V	0.566	1.00
16_L	40_V	0.566	1.00
23_I	28_L	0.565	1.00
61_R	73_G	0.564	1.00
16_L	216_F	0.561	1.00
195_N	201_K	0.557	1.00
190_S	200_A	0.554	1.00
5_D	8_L	0.554	1.00
178_A	200_A	0.554	1.00
17_S	211_T	0.554	1.00
65_E	69_V	0.553	1.00
70_A	160_V	0.552	1.00
195_N	210_E	0.551	1.00
39_V	60_E	0.549	1.00
62_V	73_G	0.544	1.00
37_P	61_R	0.542	1.00
189_E	219_A	0.541	1.00
214_D	217_L	0.538	1.00
45_A	48_Y	0.536	1.00
65_E	143_A	0.534	1.00
34_W	217_L	0.534	1.00
114_E	145_H	0.533	1.00
97_H	102_G	0.533	1.00
15_T	179_N	0.530	0.99
173_A	190_S	0.528	0.99
139_D	143_A	0.527	0.99
40_V	53_C	0.527	0.99
89_A	101_W	0.521	0.99
181_V	184_F	0.521	0.99
92_F	99_I	0.521	0.99
88_V	146_V	0.518	0.99
48_Y	143_A	0.517	0.99
192_A	203_A	0.515	0.99
63_I	70_A	0.507	0.99
29_D	221_D	0.507	0.99
69_V	104_A	0.505	0.99
91_A	130_A	0.505	0.99
121_Q	125_V	0.501	0.99
70_A	163_R	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nrwA	1	0.9778	100	0.238	Contact Map
1rkqA	1	0.9911	100	0.267	Contact Map
3pgvA	3	0.9822	100	0.271	Contact Map
4qjbA	1	0.9956	100	0.274	Contact Map
3l7yA	1	0.9733	100	0.275	Contact Map
1l6rA	2	0.9778	100	0.277	Contact Map
2b30A	2	0.9956	100	0.278	Contact Map
3fzqA	2	0.9822	100	0.287	Contact Map
1nf2A	4	0.9822	100	0.296	Contact Map
4dw8A	1	0.9778	100	0.299	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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