Q9HRF8 - HALSA - GREMLIN Contacts

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Q9HRF8 - Uncharacterized protein

UniProt:	Q9HRF8	Sequences: MPCPSHRSGAGAALFAPPPRAAGVSDEAADGVLFDLDGTIYVGDALVPGAAAAVDGLRAAGVGVGFLSNKAIERRDAFVSKLDGLGVPADESAILNAASIAASYLARAHPGESVFVVGEPPLFEELAAHGVATTTDPGRADVLLVSMDHDFDYDTLTDAFNAVDEGTPFLATNPDRTCPVAGGEVPDCASMVGAIEGATGRSLDRVLGKPSPVAVEAATDLLGVPLARCVMVGDRIETDIEMGNRAGMTTVLVLSGVTDDAALAASDVEPDHVIDSVSDLDTVLPALP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (253)
Sequences:	4245 (2883)
Seq/√Len:	181.3

ECOLI - NAGD
BACSU - YUTF ARAL
HALSA - Q9HRF8 Q9HR34
SULSO - Q97W80

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
243_G	250_T	5.216	1.00
30_D	228_R	5.147	1.00
29_A	249_T	3.911	1.00
58_R	93_A	3.323	1.00
230_V	251_V	3.311	1.00
241_E	245_R	2.979	1.00
212_P	216_E	2.880	1.00
171_A	192_V	2.869	1.00
249_T	271_D	2.538	1.00
196_E	202_S	2.519	1.00
76_D	91_E	2.407	1.00
196_E	204_D	2.370	1.00
113_S	132_A	2.281	1.00
31_G	222_L	2.264	1.00
56_G	60_A	2.242	1.00
276_S	279_D	2.078	1.00
56_G	59_A	2.021	1.00
240_I	250_T	1.952	1.00
275_D	279_D	1.935	1.00
224_V	229_C	1.932	1.00
55_D	59_A	1.843	1.00
80_S	84_G	1.841	1.00
254_L	275_D	1.777	1.00
219_T	229_C	1.723	1.00
46_L	51_A	1.717	1.00
116_V	126_L	1.704	1.00
176_R	197_G	1.702	1.00
43_G	181_A	1.684	1.00
76_D	80_S	1.645	1.00
152_D	155_T	1.622	1.00
34_F	232_V	1.607	1.00
259_D	262_A	1.599	1.00
231_M	248_M	1.593	1.00
101_A	170_L	1.589	1.00
101_A	144_L	1.582	1.00
193_G	196_E	1.569	1.00
42_V	45_A	1.551	1.00
65_G	221_L	1.550	1.00
215_V	242_M	1.537	1.00
36_L	66_F	1.526	1.00
148_D	155_T	1.522	1.00
33_L	67_L	1.508	1.00
47_V	276_S	1.499	1.00
31_G	224_V	1.486	1.00
258_T	262_A	1.480	1.00
113_S	141_D	1.474	1.00
254_L	273_V	1.470	1.00
51_A	55_D	1.467	1.00
244_N	271_D	1.452	1.00
40_I	66_F	1.448	1.00
112_E	141_D	1.447	1.00
193_G	197_G	1.423	1.00
36_L	41_Y	1.423	1.00
258_T	263_L	1.423	1.00
75_R	99_S	1.415	1.00
170_L	207_L	1.412	1.00
215_V	231_M	1.408	1.00
32_V	230_V	1.402	1.00
52_A	278_S	1.374	1.00
119_E	149_H	1.364	1.00
79_V	91_E	1.361	1.00
251_V	274_I	1.360	1.00
120_P	124_E	1.358	1.00
102_A	129_H	1.344	1.00
163_V	195_I	1.343	1.00
211_S	245_R	1.336	1.00
72_I	147_M	1.318	1.00
216_E	226_L	1.316	1.00
124_E	127_A	1.299	1.00
108_A	168_P	1.295	1.00
217_A	220_D	1.291	1.00
161_N	182_G	1.287	1.00
57_L	62_V	1.276	1.00
169_F	204_D	1.265	1.00
55_D	88_P	1.251	1.00
79_V	83_D	1.243	1.00
178_C	187_D	1.242	1.00
30_D	62_V	1.240	1.00
29_A	230_V	1.238	1.00
90_D	93_A	1.228	1.00
58_R	64_V	1.214	1.00
73_E	81_K	1.209	1.00
32_V	62_V	1.202	1.00
74_R	77_A	1.200	1.00
75_R	125_E	1.198	1.00
77_A	80_S	1.186	1.00
63_G	93_A	1.185	1.00
254_L	258_T	1.182	1.00
180_V	185_V	1.174	1.00
40_I	87_V	1.162	1.00
100_I	214_A	1.156	1.00
80_S	83_D	1.154	1.00
241_E	268_V	1.154	1.00
34_F	53_A	1.152	1.00
201_R	204_D	1.151	1.00
52_A	55_D	1.142	1.00
32_V	57_L	1.141	1.00
254_L	260_D	1.139	1.00
157_T	161_N	1.127	1.00
114_V	131_V	1.126	1.00
66_F	89_A	1.120	1.00
103_S	107_R	1.120	1.00
98_A	102_A	1.120	1.00
40_I	54_V	1.118	1.00
156_L	194_A	1.116	1.00
79_V	94_I	1.112	1.00
50_A	87_V	1.108	1.00
106_A	131_V	1.099	1.00
76_D	124_E	1.095	1.00
51_A	87_V	1.088	1.00
168_P	205_R	1.083	1.00
31_G	63_G	1.080	1.00
142_V	168_P	1.080	1.00
260_D	275_D	1.076	1.00
49_G	52_A	1.068	1.00
161_N	185_V	1.064	1.00
36_L	39_T	1.061	1.00
274_I	280_L	1.057	1.00
145_V	192_V	1.057	1.00
260_D	264_A	1.056	1.00
95_L	217_A	1.052	1.00
215_V	248_M	1.051	1.00
225_P	228_R	1.050	1.00
109_H	142_V	1.049	1.00
163_V	199_T	1.044	1.00
33_L	218_A	1.043	1.00
126_L	144_L	1.041	1.00
34_F	277_V	1.038	1.00
83_D	91_E	1.037	1.00
235_R	238_T	1.033	1.00
252_L	258_T	1.027	1.00
263_L	270_P	1.019	0.99
64_V	93_A	1.015	0.99
65_G	222_L	1.001	0.99
113_S	139_R	0.989	0.99
71_A	97_A	0.989	0.99
176_R	193_G	0.988	0.99
218_A	222_L	0.977	0.99
31_G	229_C	0.975	0.99
68_S	96_N	0.972	0.99
158_D	162_A	0.970	0.99
157_T	186_P	0.968	0.99
103_S	217_A	0.967	0.99
107_R	220_D	0.967	0.99
101_A	207_L	0.966	0.99
235_R	257_V	0.964	0.99
34_F	64_V	0.959	0.99
244_N	250_T	0.957	0.99
58_R	88_P	0.956	0.99
117_V	159_A	0.954	0.99
216_E	220_D	0.954	0.99
157_T	185_V	0.953	0.99
192_V	206_V	0.949	0.99
78_F	94_I	0.947	0.99
46_L	85_L	0.945	0.99
39_T	147_M	0.940	0.99
174_P	206_V	0.935	0.99
95_L	218_A	0.933	0.99
163_V	166_G	0.930	0.99
104_Y	207_L	0.924	0.99
115_F	162_A	0.923	0.99
47_V	50_A	0.921	0.99
249_T	272_H	0.920	0.99
71_A	146_S	0.916	0.99
205_R	213_V	0.916	0.99
108_A	205_R	0.912	0.99
176_R	237_E	0.911	0.99
127_A	133_T	0.909	0.99
50_A	277_V	0.908	0.99
44_D	81_K	0.907	0.99
123_F	127_A	0.896	0.99
101_A	172_T	0.894	0.99
65_G	93_A	0.891	0.99
160_F	198_A	0.887	0.99
78_F	96_N	0.887	0.99
263_L	273_V	0.886	0.99
83_D	88_P	0.881	0.98
147_M	151_F	0.881	0.98
67_L	231_M	0.880	0.98
166_G	201_R	0.878	0.98
41_Y	85_L	0.877	0.98
39_T	215_V	0.875	0.98
120_P	123_F	0.875	0.98
140_A	162_A	0.870	0.98
67_L	214_A	0.869	0.98
45_A	181_A	0.869	0.98
104_Y	170_L	0.867	0.98
252_L	273_V	0.864	0.98
230_V	249_T	0.864	0.98
159_A	195_I	0.862	0.98
77_A	124_E	0.862	0.98
102_A	106_A	0.860	0.98
49_G	278_S	0.855	0.98
44_D	84_G	0.850	0.98
95_L	221_L	0.849	0.98
162_A	167_T	0.845	0.98
81_K	85_L	0.844	0.98
143_L	159_A	0.842	0.98
237_E	257_V	0.840	0.98
175_D	238_T	0.833	0.98
41_Y	66_F	0.828	0.98
171_A	206_V	0.828	0.98
188_C	192_V	0.828	0.98
154_D	158_D	0.828	0.98
83_D	89_A	0.821	0.98
114_V	144_L	0.819	0.98
250_T	271_D	0.817	0.98
190_S	194_A	0.814	0.97
151_F	156_L	0.812	0.97
145_V	169_F	0.810	0.97
115_F	159_A	0.806	0.97
63_G	222_L	0.805	0.97
49_G	276_S	0.805	0.97
240_I	244_N	0.799	0.97
65_G	95_L	0.798	0.97
219_T	226_L	0.794	0.97
224_V	228_R	0.791	0.97
190_S	197_G	0.791	0.97
260_D	263_L	0.787	0.97
27_E	60_A	0.787	0.97
163_V	167_T	0.785	0.97
145_V	191_M	0.784	0.97
98_A	101_A	0.782	0.97
66_F	87_V	0.781	0.97
171_A	188_C	0.777	0.97
265_A	268_V	0.774	0.97
40_I	277_V	0.767	0.96
54_V	66_F	0.766	0.96
151_F	191_M	0.764	0.96
270_P	273_V	0.761	0.96
218_A	242_M	0.757	0.96
125_E	128_A	0.756	0.96
219_T	248_M	0.755	0.96
109_H	112_E	0.755	0.96
106_A	129_H	0.754	0.96
102_A	125_E	0.749	0.96
244_N	268_V	0.745	0.96
39_T	242_M	0.741	0.96
51_A	86_G	0.741	0.96
217_A	221_L	0.739	0.96
77_A	121_P	0.736	0.95
116_V	123_F	0.735	0.95
164_D	167_T	0.734	0.95
99_S	125_E	0.733	0.95
105_L	144_L	0.732	0.95
124_E	128_A	0.732	0.95
73_E	78_F	0.728	0.95
97_A	172_T	0.727	0.95
46_L	87_V	0.726	0.95
105_L	131_V	0.725	0.95
115_F	143_L	0.715	0.95
36_L	40_I	0.715	0.95
58_R	90_D	0.713	0.95
42_V	181_A	0.713	0.95
111_G	132_A	0.711	0.94
253_V	256_G	0.704	0.94
161_N	164_D	0.703	0.94
231_M	242_M	0.701	0.94
151_F	194_A	0.700	0.94
97_A	173_N	0.700	0.94
81_K	84_G	0.699	0.94
48_P	278_S	0.696	0.94
53_A	64_V	0.692	0.94
39_T	148_D	0.689	0.94
29_A	271_D	0.685	0.93
44_D	181_A	0.683	0.93
103_S	129_H	0.682	0.93
118_G	122_L	0.678	0.93
76_D	128_A	0.675	0.93
174_P	192_V	0.669	0.93
215_V	243_G	0.667	0.92
140_A	146_S	0.663	0.92
34_F	40_I	0.663	0.92
121_P	125_E	0.657	0.92
100_I	217_A	0.657	0.92
89_A	93_A	0.657	0.92
33_L	214_A	0.657	0.92
163_V	169_F	0.654	0.92
104_Y	205_R	0.654	0.92
46_L	86_G	0.653	0.92
29_A	228_R	0.653	0.92
177_T	235_R	0.652	0.92
167_T	201_R	0.650	0.91
42_V	47_V	0.650	0.91
151_F	155_T	0.648	0.91
147_M	191_M	0.645	0.91
215_V	246_A	0.645	0.91
215_V	218_A	0.644	0.91
103_S	106_A	0.642	0.91
226_L	248_M	0.642	0.91
33_L	229_C	0.640	0.91
145_V	171_A	0.636	0.91
41_Y	82_L	0.636	0.91
219_T	246_A	0.636	0.91
192_V	204_D	0.635	0.90
36_L	82_L	0.633	0.90
147_M	178_C	0.632	0.90
175_D	179_P	0.628	0.90
160_F	195_I	0.627	0.90
58_R	66_F	0.625	0.90
230_V	272_H	0.624	0.90
111_G	141_D	0.623	0.90
29_A	32_V	0.621	0.89
236_I	266_S	0.620	0.89
231_M	243_G	0.618	0.89
50_A	276_S	0.617	0.89
105_L	126_L	0.615	0.89
68_S	78_F	0.611	0.89
168_P	201_R	0.611	0.89
123_F	135_T	0.610	0.89
98_A	122_L	0.606	0.88
36_L	78_F	0.603	0.88
174_P	196_E	0.599	0.88
119_E	122_L	0.599	0.88
104_Y	108_A	0.597	0.88
103_S	221_L	0.593	0.87
52_A	56_G	0.593	0.87
29_A	251_V	0.591	0.87
39_T	178_C	0.590	0.87
170_L	205_R	0.589	0.87
70_K	78_F	0.589	0.87
173_N	188_C	0.585	0.87
54_V	58_R	0.584	0.86
252_L	255_S	0.584	0.86
254_L	263_L	0.582	0.86
201_R	205_R	0.578	0.86
123_F	133_T	0.577	0.86
156_L	195_I	0.573	0.85
112_E	131_V	0.569	0.85
102_A	131_V	0.567	0.85
174_P	211_S	0.567	0.85
177_T	257_V	0.564	0.84
53_A	57_L	0.557	0.84
102_A	126_L	0.557	0.84
216_E	219_T	0.557	0.84
55_D	58_R	0.556	0.84
34_F	54_V	0.556	0.84
35_D	38_G	0.556	0.84
114_V	142_V	0.553	0.83
28_A	249_T	0.550	0.83
113_S	134_T	0.547	0.83
33_L	248_M	0.547	0.83
36_L	238_T	0.543	0.82
31_G	65_G	0.541	0.82
212_P	246_A	0.538	0.82
73_E	77_A	0.536	0.81
50_A	54_V	0.536	0.81
95_L	100_I	0.535	0.81
240_I	271_D	0.535	0.81
100_I	103_S	0.533	0.81
253_V	274_I	0.530	0.81
53_A	278_S	0.529	0.81
100_I	207_L	0.527	0.80
44_D	85_L	0.527	0.80
122_L	172_T	0.526	0.80
42_V	187_D	0.525	0.80
242_M	246_A	0.523	0.80
236_I	240_I	0.521	0.80
112_E	132_A	0.521	0.80
27_E	62_V	0.521	0.80
134_T	137_P	0.521	0.80
213_V	216_E	0.520	0.79
29_A	272_H	0.518	0.79
261_A	264_A	0.517	0.79
163_V	201_R	0.516	0.79
58_R	61_G	0.513	0.79
195_I	199_T	0.513	0.79
190_S	198_A	0.512	0.78
237_E	241_E	0.512	0.78
109_H	168_P	0.509	0.78
65_G	218_A	0.509	0.78
192_V	196_E	0.506	0.78
139_R	264_A	0.506	0.78
40_I	46_L	0.504	0.77
236_I	244_N	0.504	0.77
57_L	61_G	0.503	0.77
251_V	280_L	0.503	0.77
30_D	229_C	0.502	0.77
70_K	187_D	0.502	0.77
67_L	100_I	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kc2A	2	0.8785	100	0.408	Contact Map
2ho4A	1	0.875	100	0.447	Contact Map
1zjjA	2	0.8889	100	0.47	Contact Map
4i9fA	2	0.9062	100	0.501	Contact Map
2oycA	2	0.9514	100	0.502	Contact Map
1vjrA	1	0.9028	100	0.533	Contact Map
3eprA	3	0.8993	100	0.542	Contact Map
3pdwA	1	0.8854	100	0.542	Contact Map
2hx1A	3	0.9201	100	0.554	Contact Map
1yv9A	2	0.8854	100	0.559	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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