GREMLIN Database
Q9HRF8 - Uncharacterized protein
UniProt: Q9HRF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (253)
Sequences: 4245 (2883)
Seq/√Len: 181.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_G250_T5.2161.00
30_D228_R5.1471.00
29_A249_T3.9111.00
58_R93_A3.3231.00
230_V251_V3.3111.00
241_E245_R2.9791.00
212_P216_E2.8801.00
171_A192_V2.8691.00
249_T271_D2.5381.00
196_E202_S2.5191.00
76_D91_E2.4071.00
196_E204_D2.3701.00
113_S132_A2.2811.00
31_G222_L2.2641.00
56_G60_A2.2421.00
276_S279_D2.0781.00
56_G59_A2.0211.00
240_I250_T1.9521.00
275_D279_D1.9351.00
224_V229_C1.9321.00
55_D59_A1.8431.00
80_S84_G1.8411.00
254_L275_D1.7771.00
219_T229_C1.7231.00
46_L51_A1.7171.00
116_V126_L1.7041.00
176_R197_G1.7021.00
43_G181_A1.6841.00
76_D80_S1.6451.00
152_D155_T1.6221.00
34_F232_V1.6071.00
259_D262_A1.5991.00
231_M248_M1.5931.00
101_A170_L1.5891.00
101_A144_L1.5821.00
193_G196_E1.5691.00
42_V45_A1.5511.00
65_G221_L1.5501.00
215_V242_M1.5371.00
36_L66_F1.5261.00
148_D155_T1.5221.00
33_L67_L1.5081.00
47_V276_S1.4991.00
31_G224_V1.4861.00
258_T262_A1.4801.00
113_S141_D1.4741.00
254_L273_V1.4701.00
51_A55_D1.4671.00
244_N271_D1.4521.00
40_I66_F1.4481.00
112_E141_D1.4471.00
193_G197_G1.4231.00
36_L41_Y1.4231.00
258_T263_L1.4231.00
75_R99_S1.4151.00
170_L207_L1.4121.00
215_V231_M1.4081.00
32_V230_V1.4021.00
52_A278_S1.3741.00
119_E149_H1.3641.00
79_V91_E1.3611.00
251_V274_I1.3601.00
120_P124_E1.3581.00
102_A129_H1.3441.00
163_V195_I1.3431.00
211_S245_R1.3361.00
72_I147_M1.3181.00
216_E226_L1.3161.00
124_E127_A1.2991.00
108_A168_P1.2951.00
217_A220_D1.2911.00
161_N182_G1.2871.00
57_L62_V1.2761.00
169_F204_D1.2651.00
55_D88_P1.2511.00
79_V83_D1.2431.00
178_C187_D1.2421.00
30_D62_V1.2401.00
29_A230_V1.2381.00
90_D93_A1.2281.00
58_R64_V1.2141.00
73_E81_K1.2091.00
32_V62_V1.2021.00
74_R77_A1.2001.00
75_R125_E1.1981.00
77_A80_S1.1861.00
63_G93_A1.1851.00
254_L258_T1.1821.00
180_V185_V1.1741.00
40_I87_V1.1621.00
100_I214_A1.1561.00
80_S83_D1.1541.00
241_E268_V1.1541.00
34_F53_A1.1521.00
201_R204_D1.1511.00
52_A55_D1.1421.00
32_V57_L1.1411.00
254_L260_D1.1391.00
157_T161_N1.1271.00
114_V131_V1.1261.00
66_F89_A1.1201.00
103_S107_R1.1201.00
98_A102_A1.1201.00
40_I54_V1.1181.00
156_L194_A1.1161.00
79_V94_I1.1121.00
50_A87_V1.1081.00
106_A131_V1.0991.00
76_D124_E1.0951.00
51_A87_V1.0881.00
168_P205_R1.0831.00
31_G63_G1.0801.00
142_V168_P1.0801.00
260_D275_D1.0761.00
49_G52_A1.0681.00
161_N185_V1.0641.00
36_L39_T1.0611.00
274_I280_L1.0571.00
145_V192_V1.0571.00
260_D264_A1.0561.00
95_L217_A1.0521.00
215_V248_M1.0511.00
225_P228_R1.0501.00
109_H142_V1.0491.00
163_V199_T1.0441.00
33_L218_A1.0431.00
126_L144_L1.0411.00
34_F277_V1.0381.00
83_D91_E1.0371.00
235_R238_T1.0331.00
252_L258_T1.0271.00
263_L270_P1.0190.99
64_V93_A1.0150.99
65_G222_L1.0010.99
113_S139_R0.9890.99
71_A97_A0.9890.99
176_R193_G0.9880.99
218_A222_L0.9770.99
31_G229_C0.9750.99
68_S96_N0.9720.99
158_D162_A0.9700.99
157_T186_P0.9680.99
103_S217_A0.9670.99
107_R220_D0.9670.99
101_A207_L0.9660.99
235_R257_V0.9640.99
34_F64_V0.9590.99
244_N250_T0.9570.99
58_R88_P0.9560.99
117_V159_A0.9540.99
216_E220_D0.9540.99
157_T185_V0.9530.99
192_V206_V0.9490.99
78_F94_I0.9470.99
46_L85_L0.9450.99
39_T147_M0.9400.99
174_P206_V0.9350.99
95_L218_A0.9330.99
163_V166_G0.9300.99
104_Y207_L0.9240.99
115_F162_A0.9230.99
47_V50_A0.9210.99
249_T272_H0.9200.99
71_A146_S0.9160.99
205_R213_V0.9160.99
108_A205_R0.9120.99
176_R237_E0.9110.99
127_A133_T0.9090.99
50_A277_V0.9080.99
44_D81_K0.9070.99
123_F127_A0.8960.99
101_A172_T0.8940.99
65_G93_A0.8910.99
160_F198_A0.8870.99
78_F96_N0.8870.99
263_L273_V0.8860.99
83_D88_P0.8810.98
147_M151_F0.8810.98
67_L231_M0.8800.98
166_G201_R0.8780.98
41_Y85_L0.8770.98
39_T215_V0.8750.98
120_P123_F0.8750.98
140_A162_A0.8700.98
67_L214_A0.8690.98
45_A181_A0.8690.98
104_Y170_L0.8670.98
252_L273_V0.8640.98
230_V249_T0.8640.98
159_A195_I0.8620.98
77_A124_E0.8620.98
102_A106_A0.8600.98
49_G278_S0.8550.98
44_D84_G0.8500.98
95_L221_L0.8490.98
162_A167_T0.8450.98
81_K85_L0.8440.98
143_L159_A0.8420.98
237_E257_V0.8400.98
175_D238_T0.8330.98
41_Y66_F0.8280.98
171_A206_V0.8280.98
188_C192_V0.8280.98
154_D158_D0.8280.98
83_D89_A0.8210.98
114_V144_L0.8190.98
250_T271_D0.8170.98
190_S194_A0.8140.97
151_F156_L0.8120.97
145_V169_F0.8100.97
115_F159_A0.8060.97
63_G222_L0.8050.97
49_G276_S0.8050.97
240_I244_N0.7990.97
65_G95_L0.7980.97
219_T226_L0.7940.97
224_V228_R0.7910.97
190_S197_G0.7910.97
260_D263_L0.7870.97
27_E60_A0.7870.97
163_V167_T0.7850.97
145_V191_M0.7840.97
98_A101_A0.7820.97
66_F87_V0.7810.97
171_A188_C0.7770.97
265_A268_V0.7740.97
40_I277_V0.7670.96
54_V66_F0.7660.96
151_F191_M0.7640.96
270_P273_V0.7610.96
218_A242_M0.7570.96
125_E128_A0.7560.96
219_T248_M0.7550.96
109_H112_E0.7550.96
106_A129_H0.7540.96
102_A125_E0.7490.96
244_N268_V0.7450.96
39_T242_M0.7410.96
51_A86_G0.7410.96
217_A221_L0.7390.96
77_A121_P0.7360.95
116_V123_F0.7350.95
164_D167_T0.7340.95
99_S125_E0.7330.95
105_L144_L0.7320.95
124_E128_A0.7320.95
73_E78_F0.7280.95
97_A172_T0.7270.95
46_L87_V0.7260.95
105_L131_V0.7250.95
115_F143_L0.7150.95
36_L40_I0.7150.95
58_R90_D0.7130.95
42_V181_A0.7130.95
111_G132_A0.7110.94
253_V256_G0.7040.94
161_N164_D0.7030.94
231_M242_M0.7010.94
151_F194_A0.7000.94
97_A173_N0.7000.94
81_K84_G0.6990.94
48_P278_S0.6960.94
53_A64_V0.6920.94
39_T148_D0.6890.94
29_A271_D0.6850.93
44_D181_A0.6830.93
103_S129_H0.6820.93
118_G122_L0.6780.93
76_D128_A0.6750.93
174_P192_V0.6690.93
215_V243_G0.6670.92
140_A146_S0.6630.92
34_F40_I0.6630.92
121_P125_E0.6570.92
100_I217_A0.6570.92
89_A93_A0.6570.92
33_L214_A0.6570.92
163_V169_F0.6540.92
104_Y205_R0.6540.92
46_L86_G0.6530.92
29_A228_R0.6530.92
177_T235_R0.6520.92
167_T201_R0.6500.91
42_V47_V0.6500.91
151_F155_T0.6480.91
147_M191_M0.6450.91
215_V246_A0.6450.91
215_V218_A0.6440.91
103_S106_A0.6420.91
226_L248_M0.6420.91
33_L229_C0.6400.91
145_V171_A0.6360.91
41_Y82_L0.6360.91
219_T246_A0.6360.91
192_V204_D0.6350.90
36_L82_L0.6330.90
147_M178_C0.6320.90
175_D179_P0.6280.90
160_F195_I0.6270.90
58_R66_F0.6250.90
230_V272_H0.6240.90
111_G141_D0.6230.90
29_A32_V0.6210.89
236_I266_S0.6200.89
231_M243_G0.6180.89
50_A276_S0.6170.89
105_L126_L0.6150.89
68_S78_F0.6110.89
168_P201_R0.6110.89
123_F135_T0.6100.89
98_A122_L0.6060.88
36_L78_F0.6030.88
174_P196_E0.5990.88
119_E122_L0.5990.88
104_Y108_A0.5970.88
103_S221_L0.5930.87
52_A56_G0.5930.87
29_A251_V0.5910.87
39_T178_C0.5900.87
170_L205_R0.5890.87
70_K78_F0.5890.87
173_N188_C0.5850.87
54_V58_R0.5840.86
252_L255_S0.5840.86
254_L263_L0.5820.86
201_R205_R0.5780.86
123_F133_T0.5770.86
156_L195_I0.5730.85
112_E131_V0.5690.85
102_A131_V0.5670.85
174_P211_S0.5670.85
177_T257_V0.5640.84
53_A57_L0.5570.84
102_A126_L0.5570.84
216_E219_T0.5570.84
55_D58_R0.5560.84
34_F54_V0.5560.84
35_D38_G0.5560.84
114_V142_V0.5530.83
28_A249_T0.5500.83
113_S134_T0.5470.83
33_L248_M0.5470.83
36_L238_T0.5430.82
31_G65_G0.5410.82
212_P246_A0.5380.82
73_E77_A0.5360.81
50_A54_V0.5360.81
95_L100_I0.5350.81
240_I271_D0.5350.81
100_I103_S0.5330.81
253_V274_I0.5300.81
53_A278_S0.5290.81
100_I207_L0.5270.80
44_D85_L0.5270.80
122_L172_T0.5260.80
42_V187_D0.5250.80
242_M246_A0.5230.80
236_I240_I0.5210.80
112_E132_A0.5210.80
27_E62_V0.5210.80
134_T137_P0.5210.80
213_V216_E0.5200.79
29_A272_H0.5180.79
261_A264_A0.5170.79
163_V201_R0.5160.79
58_R61_G0.5130.79
195_I199_T0.5130.79
190_S198_A0.5120.78
237_E241_E0.5120.78
109_H168_P0.5090.78
65_G218_A0.5090.78
192_V196_E0.5060.78
139_R264_A0.5060.78
40_I46_L0.5040.77
236_I244_N0.5040.77
57_L61_G0.5030.77
251_V280_L0.5030.77
30_D229_C0.5020.77
70_K187_D0.5020.77
67_L100_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.8785 100 0.408 Contact Map
2ho4A 1 0.875 100 0.447 Contact Map
1zjjA 2 0.8889 100 0.47 Contact Map
4i9fA 2 0.9062 100 0.501 Contact Map
2oycA 2 0.9514 100 0.502 Contact Map
1vjrA 1 0.9028 100 0.533 Contact Map
3eprA 3 0.8993 100 0.542 Contact Map
3pdwA 1 0.8854 100 0.542 Contact Map
2hx1A 3 0.9201 100 0.554 Contact Map
1yv9A 2 0.8854 100 0.559 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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