GREMLIN Database
Q9HRF7 - DNA damage-inducible protein
UniProt: Q9HRF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (425)
Sequences: 17650 (13244)
Seq/√Len: 642.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_E118_D4.6441.00
175_F233_V3.9461.00
164_D222_V3.4421.00
83_G310_I3.1341.00
376_V391_A3.1091.00
371_F374_Q3.0971.00
146_A163_A3.0701.00
108_S335_G3.0311.00
271_W275_T2.8451.00
146_A150_G2.8211.00
342_R345_T2.7961.00
191_D194_T2.7701.00
144_H147_A2.7571.00
103_T126_S2.5811.00
205_A234_V2.5651.00
168_V222_V2.5531.00
267_R271_W2.4811.00
163_A167_R2.4061.00
69_M214_I2.3941.00
77_A157_A2.3571.00
69_M211_G2.3191.00
420_D470_R2.3161.00
155_R303_Q2.3021.00
212_V217_L2.2961.00
110_R118_D2.2461.00
202_G235_V2.2431.00
161_F164_D2.2071.00
81_G161_F2.1851.00
43_R47_E2.1791.00
178_L236_T2.0991.00
393_T450_Y2.0841.00
351_R355_L2.0801.00
330_A353_I2.0731.00
198_L238_A2.0661.00
168_V225_G1.9781.00
121_Q266_V1.9771.00
160_A164_D1.9711.00
308_A390_I1.9701.00
172_G229_V1.9531.00
66_D228_T1.9521.00
386_P389_P1.9511.00
222_V226_L1.9511.00
372_A396_Y1.9241.00
448_G451_G1.9131.00
373_G392_V1.9031.00
70_V224_A1.8891.00
130_T181_I1.8841.00
304_P386_P1.8821.00
219_W226_L1.8771.00
75_G78_A1.8711.00
214_I224_A1.8681.00
53_I325_G1.8641.00
69_M210_N1.8341.00
212_V216_G1.8291.00
110_R115_E1.8041.00
150_G159_I1.7721.00
50_W54_L1.7651.00
337_E345_T1.7591.00
193_Y197_V1.7481.00
110_R113_A1.7401.00
145_P163_A1.7301.00
168_V226_L1.7081.00
237_T241_V1.7021.00
338_L418_T1.7001.00
171_F174_P1.6791.00
404_P461_C1.6761.00
333_L349_Y1.6721.00
350_G411_V1.6681.00
372_A392_V1.6661.00
198_L239_F1.6631.00
147_A150_G1.6591.00
369_C396_Y1.6501.00
266_V269_D1.6361.00
204_L208_G1.6281.00
49_A329_A1.6141.00
175_F236_T1.6121.00
348_A351_R1.6081.00
357_S406_G1.5991.00
106_L122_A1.5611.00
211_G215_F1.5551.00
159_I163_A1.5401.00
209_L227_G1.5391.00
65_A207_I1.5291.00
365_A369_C1.5271.00
156_Q160_A1.5211.00
157_A303_Q1.5201.00
157_A160_A1.5181.00
338_L346_A1.5131.00
347_A351_R1.5081.00
141_F170_A1.5071.00
373_G377_G1.5041.00
383_A389_P1.5001.00
210_N224_A1.4871.00
348_A352_E1.4861.00
145_P167_R1.4831.00
205_A209_L1.4821.00
420_D423_W1.4761.00
168_V229_V1.4731.00
42_A352_E1.4731.00
377_G388_V1.4721.00
337_E342_R1.4621.00
344_S348_A1.4541.00
182_G239_F1.4531.00
465_V469_L1.4501.00
149_I159_I1.4431.00
150_G156_Q1.4401.00
85_A166_L1.4391.00
138_A174_P1.4391.00
350_G414_A1.4381.00
374_Q377_G1.4371.00
76_S382_S1.4301.00
70_V82_V1.4261.00
146_A160_A1.4261.00
208_G211_G1.4101.00
241_V245_R1.4011.00
110_R122_A1.3941.00
41_R333_L1.3841.00
447_L451_G1.3841.00
389_P393_T1.3761.00
213_F219_W1.3731.00
116_I120_G1.3721.00
397_V454_L1.3591.00
197_V201_G1.3591.00
54_L196_M1.3581.00
39_E43_R1.3541.00
222_V225_G1.3481.00
66_D206_N1.3441.00
208_G212_V1.3421.00
392_V396_Y1.3401.00
118_D121_Q1.3381.00
374_Q378_V1.3351.00
117_A121_Q1.3311.00
355_L359_V1.3261.00
80_T307_A1.3151.00
213_F217_L1.3141.00
147_A151_L1.3101.00
382_S386_P1.3071.00
369_C399_A1.3041.00
111_F336_Q1.3031.00
423_W470_R1.2991.00
198_L242_G1.2981.00
109_Q113_A1.2921.00
111_F119_A1.2911.00
74_L78_A1.2821.00
209_L230_L1.2721.00
78_A161_F1.2691.00
58_G200_G1.2661.00
357_S410_T1.2611.00
366_G370_A1.2531.00
469_L472_R1.2521.00
109_Q335_G1.2461.00
315_V375_I1.2441.00
118_D269_D1.2421.00
146_A159_I1.2391.00
343_E347_A1.2361.00
67_V314_R1.2311.00
376_V388_V1.2261.00
383_A386_P1.2211.00
422_R426_Y1.2211.00
112_S339_G1.2191.00
451_G455_S1.2161.00
109_Q419_G1.2071.00
42_A356_Y1.2001.00
468_Y472_R1.1931.00
210_N227_G1.1901.00
268_D271_W1.1861.00
201_G238_A1.1791.00
76_S304_P1.1761.00
278_L282_G1.1731.00
77_A303_Q1.1691.00
81_G158_E1.1591.00
211_G216_G1.1511.00
149_I162_G1.1491.00
206_N228_T1.1471.00
72_A215_F1.1421.00
213_F230_L1.1331.00
125_S265_W1.1331.00
125_S270_C1.1291.00
138_A142_Y1.1291.00
82_V221_V1.1261.00
123_L185_A1.1241.00
67_V79_I1.1241.00
390_I393_T1.1221.00
107_V188_G1.1221.00
447_L454_L1.1201.00
72_A381_D1.1201.00
211_G214_I1.1181.00
142_Y167_R1.1111.00
334_V346_A1.1061.00
45_T353_I1.1021.00
77_A161_F1.0991.00
304_P390_I1.0991.00
129_L270_C1.0971.00
327_G413_G1.0951.00
430_V434_G1.0941.00
213_F216_G1.0841.00
426_Y430_V1.0811.00
388_V391_A1.0771.00
427_S467_N1.0731.00
259_S262_G1.0681.00
408_G460_T1.0671.00
194_T242_G1.0611.00
216_G219_W1.0601.00
350_G471_F1.0581.00
130_T177_G1.0581.00
359_V363_M1.0581.00
40_S43_R1.0551.00
305_V449_L1.0551.00
112_S340_Q1.0541.00
265_W270_C1.0521.00
191_D195_A1.0511.00
380_V383_A1.0481.00
312_V394_M1.0481.00
205_A231_S1.0451.00
167_R171_F1.0411.00
131_V178_L1.0411.00
411_V471_F1.0361.00
415_L470_R1.0271.00
386_P390_I1.0251.00
352_E356_Y1.0181.00
66_D210_N1.0161.00
120_G262_G1.0071.00
272_D275_T0.9951.00
46_A50_W0.9941.00
380_V387_S0.9941.00
296_A300_L0.9901.00
434_G437_P0.9841.00
226_L229_V0.9801.00
63_S86_G0.9781.00
143_S147_A0.9771.00
126_S273_I0.9771.00
111_F189_A0.9751.00
190_D336_Q0.9731.00
121_Q269_D0.9691.00
337_E349_Y0.9691.00
200_G204_L0.9661.00
111_F116_I0.9651.00
122_A269_D0.9631.00
182_G236_T0.9631.00
397_V450_Y0.9601.00
389_P392_V0.9561.00
138_A171_F0.9551.00
325_G329_A0.9481.00
373_G389_P0.9481.00
315_V368_V0.9431.00
435_A462_V0.9381.00
44_R47_E0.9321.00
145_P166_L0.9321.00
394_M449_L0.9311.00
109_Q338_L0.9291.00
84_Y154_D0.9281.00
376_V392_V0.9251.00
363_M367_V0.9181.00
96_G177_G0.9171.00
362_V366_G0.9171.00
404_P464_A0.9141.00
143_S167_R0.9131.00
52_R328_L0.9111.00
128_A265_W0.9101.00
210_N228_T0.9091.00
459_E463_P0.9031.00
68_A71_G0.9031.00
308_A387_S0.9021.00
164_D167_R0.9001.00
229_V233_V0.8991.00
233_V237_T0.8991.00
354_T407_I0.8961.00
309_Y453_Y0.8961.00
132_A136_P0.8931.00
238_A241_V0.8871.00
369_C373_G0.8841.00
346_A350_G0.8831.00
438_L458_S0.8811.00
255_P259_S0.8791.00
69_M215_F0.8771.00
65_A206_N0.8771.00
311_I379_F0.8771.00
161_F221_V0.8731.00
334_V417_A0.8721.00
89_W169_V0.8721.00
156_Q159_I0.8711.00
124_R263_A0.8681.00
65_A203_A0.8651.00
171_F229_V0.8591.00
286_V429_A0.8531.00
191_D242_G0.8531.00
450_Y454_L0.8511.00
186_L243_L0.8481.00
363_M366_G0.8471.00
346_A418_T0.8451.00
179_N235_V0.8451.00
245_R248_L0.8451.00
370_A374_Q0.8441.00
48_L192_A0.8431.00
209_L213_F0.8431.00
206_N210_N0.8411.00
282_G425_F0.8391.00
388_V392_V0.8381.00
103_T107_V0.8381.00
196_M200_G0.8371.00
308_A391_A0.8361.00
182_G243_L0.8331.00
305_V390_I0.8321.00
455_S459_E0.8311.00
191_D246_G0.8301.00
334_V414_A0.8291.00
201_G205_A0.8281.00
136_P140_L0.8271.00
142_Y146_A0.8271.00
298_M449_L0.8251.00
298_M452_I0.8251.00
323_G361_Y0.8201.00
348_A355_L0.8181.00
197_V200_G0.8171.00
345_T348_A0.8171.00
58_G203_A0.8151.00
80_T158_E0.8151.00
314_R379_F0.8131.00
299_S306_A0.8121.00
140_L144_H0.8101.00
344_S351_R0.8091.00
109_Q272_D0.8091.00
139_V143_S0.8061.00
234_V238_A0.8061.00
337_E340_Q0.8061.00
226_L230_L0.8061.00
70_V214_I0.8061.00
145_P170_A0.8001.00
44_R333_L0.7981.00
297_F300_L0.7951.00
275_T422_R0.7921.00
76_S387_S0.7881.00
431_G463_P0.7881.00
107_V185_A0.7881.00
128_A263_A0.7861.00
407_I464_A0.7861.00
186_L194_T0.7861.00
186_L239_F0.7831.00
77_A158_E0.7821.00
106_L276_I0.7821.00
326_F353_I0.7821.00
206_N231_S0.7811.00
353_I410_T0.7811.00
44_R336_Q0.7801.00
160_A163_A0.7801.00
108_S188_G0.7761.00
45_T352_E0.7751.00
255_P258_V0.7741.00
126_S181_I0.7731.00
168_V171_F0.7721.00
311_I391_A0.7681.00
269_D272_D0.7671.00
440_Y443_A0.7651.00
113_A339_G0.7631.00
461_C465_V0.7631.00
42_A46_A0.7631.00
187_I195_A0.7621.00
58_G61_S0.7621.00
128_A132_A0.7601.00
62_K228_T0.7601.00
352_E355_L0.7591.00
95_I281_V0.7561.00
358_V362_V0.7521.00
210_N214_I0.7491.00
272_D419_G0.7491.00
337_E346_A0.7481.00
68_A378_V0.7481.00
164_D221_V0.7461.00
400_A403_I0.7441.00
359_V362_V0.7411.00
355_L358_V0.7391.00
49_A325_G0.7391.00
442_G446_P0.7391.00
149_I166_L0.7361.00
362_V403_I0.7351.00
241_V244_S0.7341.00
81_G221_V0.7341.00
117_A262_G0.7311.00
240_V244_S0.7301.00
411_V467_N0.7291.00
42_A355_L0.7271.00
120_G259_S0.7261.00
158_E306_A0.7241.00
106_L110_R0.7241.00
55_T199_R0.7231.00
308_A394_M0.7191.00
274_V278_L0.7171.00
225_G229_V0.7161.00
201_G234_V0.7161.00
397_V457_F0.7141.00
64_A318_I0.7141.00
297_F439_V0.7131.00
61_S65_A0.7121.00
71_G79_I0.7111.00
157_A161_F0.7111.00
454_L457_F0.7101.00
68_A72_A0.7051.00
423_W427_S0.7031.00
134_T174_P0.7011.00
326_F360_M0.7001.00
170_A173_V0.7001.00
371_F375_I0.7001.00
45_T329_A0.6991.00
285_S289_L0.6981.00
194_T238_A0.6981.00
105_A109_Q0.6961.00
334_V350_G0.6961.00
373_G388_V0.6951.00
326_F357_S0.6931.00
358_V406_G0.6911.00
136_P139_V0.6881.00
144_H148_L0.6871.00
451_G454_L0.6871.00
166_L170_A0.6861.00
372_A376_V0.6841.00
107_V119_A0.6831.00
171_F175_F0.6821.00
301_F305_V0.6821.00
81_G162_G0.6811.00
77_A80_T0.6811.00
57_I61_S0.6801.00
344_S347_A0.6801.00
297_F440_Y0.6781.00
70_V221_V0.6781.00
372_A395_V0.6771.00
441_L444_T0.6771.00
449_L453_Y0.6761.00
139_V142_Y0.6751.00
276_I421_T0.6731.00
205_A230_L0.6711.00
298_M309_Y0.6701.00
219_W222_V0.6701.00
369_C372_A0.6701.00
277_G281_V0.6701.00
65_A69_M0.6671.00
304_P307_A0.6651.00
124_R262_G0.6651.00
294_L452_I0.6611.00
167_R222_V0.6601.00
299_S302_G0.6601.00
62_K202_G0.6591.00
118_D122_A0.6591.00
213_F224_A0.6571.00
330_A334_V0.6571.00
200_G203_A0.6531.00
230_L233_V0.6521.00
172_G232_N0.6521.00
78_A220_G0.6521.00
396_Y400_A0.6501.00
165_Y210_N0.6481.00
172_G175_F0.6481.00
360_M364_F0.6471.00
302_G305_V0.6471.00
231_S234_V0.6451.00
158_E161_F0.6451.00
413_G417_A0.6421.00
279_P425_F0.6421.00
343_E346_A0.6391.00
159_I162_G0.6391.00
361_Y406_G0.6381.00
117_A120_G0.6361.00
370_A373_G0.6351.00
121_Q124_R0.6321.00
98_G281_V0.6321.00
358_V407_I0.6321.00
121_Q125_S0.6301.00
70_V78_A0.6271.00
115_E121_Q0.6271.00
383_A388_V0.6231.00
387_S391_A0.6211.00
466_V469_L0.6201.00
170_A174_P0.6171.00
411_V468_Y0.6171.00
142_Y171_F0.6161.00
320_N405_Q0.6151.00
338_L343_E0.6151.00
294_L439_V0.6141.00
336_Q340_Q0.6121.00
278_L281_V0.6121.00
322_P360_M0.6121.00
79_I311_I0.6121.00
154_D299_S0.6111.00
105_A276_I0.6091.00
319_M364_F0.6091.00
399_A403_I0.6081.00
367_V371_F0.6081.00
238_A242_G0.6071.00
305_V308_A0.6061.00
380_V388_V0.6061.00
331_S416_D0.6051.00
134_T138_A0.6051.00
183_S187_I0.6041.00
268_D272_D0.6041.00
74_L221_V0.6041.00
213_F226_L0.6031.00
441_L445_T0.6021.00
308_A453_Y0.6011.00
70_V74_L0.6011.00
356_Y359_V0.6001.00
436_L440_Y0.6001.00
135_L139_V0.5991.00
215_F219_W0.5991.00
146_A167_R0.5981.00
182_G240_V0.5961.00
104_I184_R0.5951.00
295_L299_S0.5941.00
113_A341_G0.5941.00
61_S203_A0.5931.00
62_K232_N0.5931.00
316_F402_V0.5901.00
354_T358_V0.5881.00
354_T411_V0.5881.00
179_N236_T0.5871.00
86_G90_G0.5861.00
206_N227_G0.5851.00
164_D168_V0.5851.00
134_T170_A0.5841.00
427_S466_V0.5841.00
105_A335_G0.5841.00
79_I380_V0.5811.00
213_F218_G0.5811.00
407_I468_Y0.5801.00
201_G204_L0.5781.00
442_G445_T0.5771.00
414_A418_T0.5771.00
131_V135_L0.5761.00
435_A459_E0.5721.00
149_I163_A0.5711.00
290_A432_M0.5711.00
431_G466_V0.5711.00
41_R352_E0.5701.00
242_G246_G0.5701.00
323_G406_G0.5691.00
441_L446_P0.5691.00
165_Y224_A0.5681.00
92_A173_V0.5671.00
454_L458_S0.5661.00
430_V466_V0.5661.00
40_S44_R0.5651.00
80_T83_G0.5651.00
401_A457_F0.5641.00
135_L138_A0.5631.00
69_M227_G0.5621.00
436_L439_V0.5611.00
149_I154_D0.5591.00
78_A81_G0.5591.00
207_I211_G0.5591.00
142_Y145_P0.5591.00
94_S97_G0.5581.00
187_I192_A0.5581.00
41_R348_A0.5571.00
44_R345_T0.5571.00
125_S269_D0.5551.00
317_G320_N0.5551.00
316_F398_A0.5551.00
223_G227_G0.5541.00
297_F301_F0.5531.00
198_L235_V0.5531.00
350_G354_T0.5521.00
76_S307_A0.5511.00
205_A208_G0.5501.00
365_A403_I0.5501.00
99_L133_A0.5501.00
421_T425_F0.5501.00
154_D159_I0.5501.00
244_S248_L0.5501.00
415_L420_D0.5481.00
114_D340_Q0.5461.00
52_R325_G0.5461.00
175_F229_V0.5461.00
227_G231_S0.5451.00
101_A328_L0.5441.00
158_E162_G0.5441.00
46_A356_Y0.5431.00
297_F452_I0.5421.00
163_A166_L0.5421.00
411_V464_A0.5411.00
312_V395_V0.5401.00
428_R431_G0.5401.00
174_P233_V0.5401.00
155_R159_I0.5401.00
270_C274_V0.5391.00
65_A68_A0.5391.00
408_G463_P0.5391.00
39_E47_E0.5391.00
141_F145_P0.5381.00
301_F448_G0.5381.00
39_E42_A0.5360.99
358_V403_I0.5360.99
107_V122_A0.5360.99
457_F461_C0.5360.99
45_T356_Y0.5350.99
99_L281_V0.5330.99
194_T246_G0.5310.99
138_A170_A0.5310.99
148_L151_L0.5300.99
220_G223_G0.5300.99
52_R192_A0.5300.99
399_A402_V0.5290.99
142_Y170_A0.5290.99
236_T240_V0.5290.99
102_G277_G0.5290.99
84_Y306_A0.5290.99
135_L174_P0.5280.99
41_R349_Y0.5270.99
179_N183_S0.5270.99
308_A312_V0.5260.99
286_V425_F0.5250.99
152_L292_F0.5240.99
230_L234_V0.5240.99
124_R128_A0.5240.99
45_T49_A0.5240.99
443_A446_P0.5240.99
331_S413_G0.5240.99
219_W223_G0.5230.99
158_E303_Q0.5220.99
351_R471_F0.5210.99
377_G381_D0.5200.99
258_V262_G0.5190.99
119_A123_L0.5190.99
140_L143_S0.5180.99
244_S247_R0.5170.99
138_A143_S0.5170.99
63_S169_V0.5170.99
465_V468_Y0.5160.99
84_Y162_G0.5120.99
368_V375_I0.5120.99
42_A348_A0.5110.99
284_N324_W0.5090.99
462_V466_V0.5070.99
75_G161_F0.5070.99
215_F218_G0.5040.99
369_C400_A0.5040.99
293_P436_L0.5030.99
320_N409_A0.5030.99
153_T156_Q0.5010.99
393_T396_Y0.5000.99
186_L242_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9182 100 0.377 Contact Map
4lz6A 1 0.908 100 0.388 Contact Map
4humA 1 0.9223 100 0.389 Contact Map
3w4tA 1 0.8998 100 0.437 Contact Map
4ikvA 1 0.8466 64.9 0.954 Contact Map
4j05A 3 0.7832 60.5 0.955 Contact Map
4xnjA 1 0.4601 57.3 0.956 Contact Map
1pw4A 1 0.4479 51.9 0.957 Contact Map
3wdoA 1 0.8037 44.2 0.959 Contact Map
4zw9A 1 0.863 38.4 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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