GREMLIN Database
Q9HRF6 - Probable peptidase
UniProt: Q9HRF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (343)
Sequences: 11044 (8094)
Seq/√Len: 437.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_R357_E4.9831.00
325_V353_A4.3181.00
271_V351_V3.2671.00
146_L350_V3.0851.00
252_A340_E2.5711.00
258_E262_D2.4791.00
158_A189_H2.4251.00
250_P253_F2.3971.00
162_D185_R2.3821.00
252_A255_T2.3761.00
259_V291_A2.3741.00
151_R154_G2.3711.00
278_G320_D2.3381.00
184_D188_A2.3191.00
266_A287_V2.3171.00
29_P308_D2.2941.00
276_S279_A2.2731.00
140_R324_D2.2431.00
181_F184_D2.2381.00
149_L328_V2.2101.00
20_A105_L2.2011.00
174_T217_E2.1891.00
265_R269_D2.1711.00
204_P216_R2.1511.00
251_A255_T2.1441.00
270_A283_A2.1381.00
281_D285_R2.0821.00
267_A284_A2.0681.00
286_R290_D2.0631.00
116_Q119_R2.0371.00
305_V348_L2.0311.00
16_R52_A2.0091.00
103_R126_T1.9631.00
59_V93_V1.9321.00
150_R154_G1.9261.00
148_A233_D1.9231.00
219_Q222_D1.8681.00
218_I245_F1.8231.00
256_V341_F1.8091.00
89_V92_A1.8021.00
35_S48_L1.7891.00
266_A269_D1.7841.00
183_A187_A1.7361.00
287_V291_A1.7361.00
185_R188_A1.7171.00
176_H215_A1.7141.00
352_T357_E1.7121.00
254_R258_E1.7031.00
216_R222_D1.6991.00
276_S322_K1.6981.00
256_V343_V1.6881.00
262_D266_A1.6791.00
282_A286_R1.6761.00
14_T17_D1.6591.00
185_R189_H1.6571.00
103_R128_G1.6431.00
262_D291_A1.6321.00
331_I349_V1.6221.00
223_P253_F1.6151.00
244_V249_P1.6121.00
174_T177_E1.5631.00
268_V349_V1.5601.00
260_V343_V1.5571.00
261_R265_R1.5551.00
288_I335_V1.5431.00
272_E275_V1.5371.00
180_D184_D1.5241.00
324_D327_M1.4951.00
202_S216_R1.4191.00
11_C34_L1.4181.00
200_A224_V1.4051.00
6_S10_D1.4031.00
223_P244_V1.4031.00
8_T12_Q1.4021.00
162_D189_H1.4001.00
350_V359_L1.3981.00
171_I220_R1.3971.00
195_S236_P1.3951.00
267_A280_V1.3921.00
139_V327_M1.3911.00
14_T18_A1.3911.00
178_L218_I1.3891.00
143_D147_D1.3861.00
275_V279_A1.3661.00
181_F185_R1.3611.00
67_Q71_E1.3591.00
147_D151_R1.3571.00
231_V236_P1.3521.00
264_H268_V1.3511.00
330_S348_L1.3441.00
263_A287_V1.3311.00
227_D238_D1.3181.00
273_P325_V1.2921.00
20_A25_L1.2841.00
61_P64_Y1.2791.00
21_A102_G1.2701.00
262_D290_D1.2671.00
256_V337_R1.2621.00
284_A301_T1.2591.00
251_A254_R1.2551.00
9_R13_R1.2471.00
7_R142_D1.2451.00
168_A181_F1.2211.00
155_A191_G1.2201.00
238_D346_E1.2171.00
177_E188_A1.2161.00
278_G282_A1.2071.00
55_E76_D1.2061.00
202_S218_I1.2041.00
266_A283_A1.1861.00
32_Y234_R1.1861.00
149_L153_G1.1831.00
255_T291_A1.1821.00
289_A294_G1.1811.00
178_L224_V1.1801.00
115_T119_R1.1791.00
323_L351_V1.1771.00
279_A282_A1.1751.00
12_Q51_P1.1711.00
151_R232_V1.1691.00
154_G158_A1.1671.00
20_A128_G1.1601.00
181_F188_A1.1591.00
161_A167_G1.1581.00
144_A148_A1.1551.00
264_H347_D1.1531.00
257_H345_I1.1461.00
262_D287_V1.1451.00
323_L329_F1.1451.00
20_A23_A1.1431.00
93_V96_D1.1371.00
112_A115_T1.1351.00
13_R17_D1.1311.00
22_G25_L1.1301.00
160_M239_Q1.1291.00
271_V280_V1.1281.00
65_E69_A1.1261.00
140_R327_M1.1261.00
47_V50_V1.1171.00
268_V358_P1.1151.00
112_A116_Q1.1101.00
173_M177_E1.1101.00
30_N107_D1.1081.00
155_A234_R1.1061.00
179_A183_A1.1011.00
255_T259_V1.0961.00
173_M181_F1.0951.00
34_L137_L1.0941.00
162_D188_A1.0851.00
153_G157_D1.0841.00
216_R219_Q1.0791.00
201_G211_H1.0781.00
136_S324_D1.0771.00
227_D346_E1.0721.00
22_G49_V1.0661.00
223_P242_T1.0641.00
92_A96_D1.0591.00
21_A103_R1.0561.00
10_D13_R1.0531.00
270_A275_V1.0511.00
337_R340_E1.0491.00
130_A133_V1.0481.00
156_A239_Q1.0451.00
11_C23_A1.0411.00
157_D361_D1.0361.00
255_T258_E1.0361.00
203_G222_D1.0351.00
259_V288_I1.0341.00
147_D150_R1.0331.00
271_V331_I1.0331.00
349_V358_P1.0311.00
326_G350_V1.0301.00
268_V331_I1.0291.00
15_L20_A1.0241.00
14_T136_S1.0231.00
266_A270_A1.0221.00
169_D172_G1.0211.00
267_A283_A1.0181.00
183_A194_V1.0181.00
91_R95_A1.0171.00
105_L130_A1.0161.00
328_V350_V1.0151.00
85_D88_A1.0141.00
191_G230_T1.0131.00
144_A147_D1.0101.00
108_P116_Q1.0051.00
352_T355_S1.0031.00
10_D137_L0.9981.00
150_R350_V0.9981.00
205_N216_R0.9921.00
275_V283_A0.9911.00
162_D181_F0.9901.00
176_H180_D0.9851.00
259_V287_V0.9841.00
252_A337_R0.9801.00
202_S222_D0.9761.00
170_A173_M0.9721.00
283_A286_R0.9711.00
194_V198_V0.9691.00
22_G51_P0.9651.00
281_D301_T0.9621.00
259_V262_D0.9591.00
197_D212_T0.9581.00
329_F351_V0.9541.00
77_I80_Y0.9501.00
57_A78_R0.9501.00
316_V319_S0.9491.00
280_V283_A0.9481.00
153_G348_L0.9481.00
8_T56_P0.9471.00
263_A288_I0.9451.00
278_G318_D0.9451.00
25_L34_L0.9381.00
226_C243_V0.9361.00
31_L48_L0.9351.00
273_P352_T0.9301.00
183_A198_V0.9301.00
24_V49_V0.9271.00
224_V245_F0.9271.00
25_L134_L0.9261.00
205_N211_H0.9261.00
51_P56_P0.9251.00
287_V290_D0.9251.00
201_G206_G0.9211.00
159_A185_R0.9191.00
151_R233_D0.9161.00
349_V356_C0.9161.00
305_V328_V0.9141.00
116_Q120_D0.9101.00
160_M243_V0.9091.00
136_S321_R0.9061.00
286_R289_A0.9031.00
321_R324_D0.9011.00
271_V356_C0.8991.00
11_C50_V0.8981.00
12_Q50_V0.8931.00
12_Q52_A0.8911.00
206_G225_V0.8881.00
34_L134_L0.8871.00
93_V97_R0.8861.00
275_V280_V0.8861.00
151_R155_A0.8851.00
12_Q56_P0.8811.00
178_L200_A0.8761.00
252_A256_V0.8761.00
148_A151_R0.8741.00
271_V349_V0.8741.00
143_D352_T0.8701.00
30_N135_G0.8701.00
182_I186_L0.8681.00
113_Q117_L0.8671.00
21_A52_A0.8661.00
270_A280_V0.8641.00
156_A237_S0.8611.00
8_T50_V0.8581.00
13_R16_R0.8551.00
283_A287_V0.8551.00
277_A323_L0.8551.00
204_P339_G0.8551.00
111_W114_F0.8491.00
258_E261_R0.8461.00
280_V323_L0.8441.00
153_G360_T0.8431.00
169_D178_L0.8341.00
32_Y307_L0.8341.00
350_V357_E0.8281.00
261_R345_I0.8281.00
9_R12_Q0.8271.00
268_V356_C0.8211.00
15_L22_G0.8201.00
85_D89_V0.8181.00
267_A331_I0.8171.00
154_G157_D0.8171.00
79_T82_D0.8171.00
158_A161_A0.8161.00
155_A232_V0.8111.00
244_V253_F0.8111.00
284_A297_F0.8101.00
205_N208_K0.8071.00
276_S320_D0.8071.00
83_S86_P0.8061.00
257_H261_R0.8051.00
33_Y137_L0.8051.00
273_P353_A0.8041.00
146_L150_R0.8021.00
58_F68_L0.8011.00
12_Q15_L0.8001.00
315_I329_F0.7941.00
157_D161_A0.7901.00
57_A93_V0.7901.00
304_G313_P0.7901.00
92_A95_A0.7861.00
117_L121_T0.7851.00
208_K211_H0.7831.00
133_V136_S0.7791.00
304_G311_E0.7781.00
288_I293_Y0.7761.00
173_M178_L0.7761.00
6_S9_R0.7751.00
256_V293_Y0.7721.00
23_A130_A0.7711.00
266_A284_A0.7711.00
10_D14_T0.7701.00
159_A186_L0.7681.00
256_V259_V0.7681.00
155_A189_H0.7641.00
101_D104_L0.7631.00
175_E205_N0.7611.00
163_V226_C0.7611.00
51_P57_A0.7601.00
89_V93_V0.7561.00
110_M114_F0.7551.00
221_G248_D0.7511.00
145_E235_Y0.7511.00
180_D187_A0.7481.00
12_Q16_R0.7451.00
273_P324_D0.7431.00
270_A273_P0.7431.00
249_P254_R0.7431.00
168_A171_I0.7411.00
139_V324_D0.7361.00
106_V112_A0.7331.00
69_A72_T0.7331.00
76_D79_T0.7321.00
110_M115_T0.7311.00
111_W115_T0.7301.00
202_S245_F0.7301.00
139_V321_R0.7291.00
241_R347_D0.7281.00
332_E346_E0.7271.00
162_D168_A0.7271.00
263_A267_A0.7261.00
167_G171_I0.7261.00
263_A283_A0.7251.00
108_P129_L0.7241.00
51_P55_E0.7231.00
171_I245_F0.7221.00
153_G237_S0.7211.00
166_L243_V0.7191.00
273_P351_V0.7161.00
78_R82_D0.7161.00
279_A283_A0.7141.00
26_F29_P0.7141.00
351_V356_C0.7121.00
296_A338_P0.7111.00
182_I226_C0.7091.00
163_V178_L0.7091.00
196_F229_G0.7071.00
186_L230_T0.7051.00
22_G104_L0.7041.00
285_R297_F0.7021.00
272_E356_C0.7021.00
182_I228_F0.6991.00
177_E180_D0.6991.00
72_T76_D0.6991.00
14_T133_V0.6981.00
227_D332_E0.6981.00
337_R341_F0.6971.00
19_G103_R0.6941.00
148_A232_V0.6931.00
192_T233_D0.6921.00
221_G245_F0.6911.00
206_G223_P0.6901.00
184_D187_A0.6891.00
209_P299_H0.6891.00
220_R248_D0.6891.00
336_Y344_R0.6881.00
194_V197_D0.6871.00
200_A226_C0.6861.00
321_R327_M0.6861.00
319_S322_K0.6861.00
206_G209_P0.6851.00
117_L120_D0.6841.00
305_V330_S0.6811.00
266_A286_R0.6801.00
35_S56_P0.6781.00
249_P253_F0.6761.00
30_N134_L0.6761.00
11_C137_L0.6741.00
55_E83_S0.6731.00
352_T356_C0.6711.00
75_D80_Y0.6701.00
153_G359_L0.6691.00
280_V301_T0.6691.00
14_T137_L0.6661.00
159_A182_I0.6661.00
78_R81_T0.6651.00
252_A341_F0.6621.00
299_H310_H0.6601.00
162_D167_G0.6601.00
72_T75_D0.6591.00
238_D303_H0.6591.00
29_P307_L0.6571.00
163_V181_F0.6571.00
264_H331_I0.6551.00
325_V352_T0.6551.00
303_H346_E0.6551.00
160_M228_F0.6540.99
236_P309_V0.6520.99
88_A121_T0.6510.99
156_A159_A0.6490.99
28_S31_L0.6480.99
21_A25_L0.6470.99
230_T237_S0.6420.99
267_A301_T0.6400.99
141_K145_E0.6400.99
31_L42_S0.6370.99
169_D243_V0.6360.99
206_G342_G0.6360.99
238_D332_E0.6350.99
174_T215_A0.6340.99
86_P89_V0.6330.99
267_A270_A0.6320.99
314_F318_D0.6300.99
322_K325_V0.6290.99
222_D253_F0.6280.99
160_M163_V0.6280.99
273_P356_C0.6280.99
153_G239_Q0.6240.99
143_D326_G0.6230.99
32_Y38_D0.6220.99
265_R268_V0.6190.99
60_A65_E0.6180.99
62_A298_V0.6170.99
253_F340_E0.6160.99
336_Y342_G0.6150.99
274_G324_D0.6140.99
30_N33_Y0.6090.99
272_E354_D0.6090.99
210_H310_H0.6060.99
146_L328_V0.6050.99
179_A213_H0.6050.99
250_P340_E0.6020.99
206_G341_F0.6010.99
262_D265_R0.6010.99
282_A289_A0.6010.99
75_D79_T0.6000.99
136_S139_V0.6000.99
156_A228_F0.5990.99
259_V293_Y0.5940.99
47_V51_P0.5940.99
223_P249_P0.5900.99
24_V47_V0.5850.99
178_L226_C0.5840.99
259_V335_V0.5790.99
358_P361_D0.5790.99
288_I294_G0.5780.99
277_A319_S0.5780.99
155_A230_T0.5760.99
85_D93_V0.5760.99
106_V127_W0.5750.99
282_A317_A0.5730.99
263_A284_A0.5720.99
334_G344_R0.5710.99
12_Q53_D0.5700.99
152_A156_A0.5650.99
328_V348_L0.5630.99
273_P355_S0.5630.99
91_R121_T0.5620.98
202_S219_Q0.5610.98
147_D154_G0.5610.98
143_D325_V0.5580.98
37_F67_Q0.5560.98
256_V335_V0.5560.98
259_V263_A0.5550.98
64_Y67_Q0.5540.98
244_V250_P0.5540.98
271_V323_L0.5520.98
298_V338_P0.5520.98
73_W77_I0.5510.98
50_V53_D0.5500.98
102_G126_T0.5490.98
263_A266_A0.5480.98
22_G101_D0.5480.98
15_L23_A0.5460.98
167_G172_G0.5460.98
239_Q348_L0.5380.98
348_L360_T0.5370.98
158_A185_R0.5360.98
135_G312_A0.5360.98
204_P207_A0.5350.98
177_E217_E0.5340.98
248_D254_R0.5320.98
206_G244_V0.5300.98
114_F117_L0.5300.98
354_D357_E0.5290.98
253_F341_F0.5290.98
205_N215_A0.5280.98
274_G322_K0.5280.98
227_D303_H0.5250.98
166_L181_F0.5250.98
278_G319_S0.5240.98
88_A91_R0.5230.98
285_R289_A0.5230.98
284_A287_V0.5220.98
171_I219_Q0.5210.98
183_A193_G0.5200.98
334_G342_G0.5160.97
303_H332_E0.5130.97
288_I297_F0.5120.97
288_I291_A0.5120.97
153_G156_A0.5090.97
18_A130_A0.5090.97
240_T346_E0.5080.97
275_V351_V0.5080.97
158_A162_D0.5080.97
300_R314_F0.5070.97
281_D297_F0.5050.97
163_V182_I0.5030.97
239_Q360_T0.5030.97
111_W117_L0.5020.97
87_S90_V0.5010.97
83_S89_V0.5010.97
15_L18_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fkcA 2 0.9864 100 0.123 Contact Map
1wn1A 2 0.9593 100 0.137 Contact Map
4r60A 2 0.9837 100 0.139 Contact Map
3q6dA 1 0.9593 100 0.139 Contact Map
4egeA 2 0.9783 100 0.148 Contact Map
1wy2A 2 0.9512 100 0.149 Contact Map
2zsgA 2 0.9566 100 0.15 Contact Map
1kp0A 2 0.8726 100 0.182 Contact Map
1chmA 2 0.9756 100 0.19 Contact Map
3ig4A 4 0.9756 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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