GREMLIN Database
Q9HRF4 - Uncharacterized protein
UniProt: Q9HRF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (278)
Sequences: 175 (154)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L84_V3.9570.98
155_F159_G3.8360.98
159_G171_A3.4300.96
37_N71_Q3.1750.93
27_A282_D2.8190.88
37_N78_K2.5380.82
177_R255_W2.5300.82
57_F187_V2.4720.80
121_G256_T2.3710.77
242_H249_V2.3390.76
81_D85_R2.3020.75
267_A278_T2.2720.74
180_H183_A2.1590.70
73_N289_T2.1460.69
155_F172_F2.1380.69
269_D272_R2.0880.67
69_S134_Y2.0690.66
130_L277_V2.0560.66
68_D134_Y2.0480.66
247_I269_D2.0320.65
155_F171_A2.0230.65
241_F286_L2.0180.64
123_C143_C2.0000.64
68_D73_N1.9910.63
121_G130_L1.9860.63
93_F97_G1.9650.62
61_R65_G1.9610.62
32_F45_Q1.9210.60
97_G241_F1.9160.60
109_F235_D1.9090.60
38_E194_R1.8700.58
186_G238_V1.8660.58
218_Q240_A1.8170.56
71_Q168_V1.8010.55
167_E283_D1.7980.55
123_C126_C1.7920.55
57_F109_F1.7800.54
27_A252_T1.7610.54
31_A59_A1.7510.53
158_G219_Q1.7350.52
173_D177_R1.7320.52
141_V225_S1.7160.52
159_G163_R1.6730.50
57_F87_T1.6670.49
70_A134_Y1.6460.48
198_T270_P1.6290.48
59_A292_G1.6190.47
136_D233_L1.5860.46
154_A298_D1.5860.46
102_R159_G1.5830.46
163_R169_A1.5800.46
134_Y229_G1.5490.44
126_C143_C1.5460.44
102_R146_C1.5320.43
266_T297_V1.5220.43
120_T271_D1.5000.42
54_P288_V1.4990.42
198_T266_T1.4840.41
146_C159_G1.4560.40
28_A32_F1.4510.40
229_G255_W1.4270.39
134_Y238_V1.4150.39
60_L72_F1.4000.38
44_L193_G1.3970.38
44_L130_L1.3780.37
160_L181_C1.3760.37
89_D166_A1.3750.37
70_A73_N1.3720.37
41_I104_I1.3590.36
133_Q283_D1.3570.36
50_A127_G1.3550.36
155_F182_L1.3520.36
89_D282_D1.3500.36
175_R227_P1.3470.36
50_A257_L1.3270.35
55_V63_R1.3260.35
30_D271_D1.3190.35
100_V145_A1.3180.35
35_L94_Q1.3090.34
30_D33_A1.3060.34
23_D283_D1.3050.34
87_T247_I1.3010.34
42_D164_S1.3000.34
31_A102_R1.2970.34
183_A283_D1.2910.33
57_F88_D1.2850.33
47_L77_S1.2790.33
38_E109_F1.2760.33
44_L262_T1.2750.33
226_S283_D1.2520.32
86_S110_T1.2410.32
94_Q290_L1.2340.31
72_F103_A1.2280.31
70_A159_G1.2220.31
136_D228_V1.2180.31
57_F132_G1.2060.30
146_C171_A1.2040.30
120_T245_H1.2020.30
104_I228_V1.2020.30
83_F279_I1.2010.30
262_T265_T1.1980.30
38_E41_I1.1930.30
40_R74_Y1.1910.30
40_R75_H1.1910.30
63_R288_V1.1870.30
100_V103_A1.1870.30
108_T185_D1.1770.29
119_I145_A1.1710.29
67_R257_L1.1650.29
85_R114_S1.1610.29
41_I258_G1.1530.28
52_E82_H1.1510.28
155_F267_A1.1480.28
37_N86_S1.1430.28
249_V259_W1.1360.28
231_S244_D1.1360.28
185_D230_L1.1290.27
128_E145_A1.1220.27
116_S151_A1.1170.27
44_L258_G1.1160.27
100_V289_T1.1150.27
70_A171_A1.1120.27
37_N58_S1.1110.27
107_G136_D1.1080.27
81_D296_V1.0970.26
130_L163_R1.0930.26
113_V168_V1.0870.26
28_A36_G1.0850.26
71_Q167_E1.0800.26
101_V223_T1.0760.26
245_H283_D1.0750.26
130_L172_F1.0670.25
243_A250_T1.0640.25
172_F253_P1.0600.25
173_D239_V1.0570.25
122_T237_T1.0500.25
164_S178_H1.0500.25
228_V276_T1.0490.25
47_L72_F1.0370.24
96_A157_P1.0320.24
47_L83_F1.0320.24
108_T112_R1.0280.24
172_F196_T1.0250.24
72_F238_V1.0250.24
197_T271_D1.0230.24
88_D103_A1.0200.24
93_F99_K1.0150.24
199_L228_V1.0130.24
265_T285_S1.0110.23
99_K190_E1.0100.23
89_D290_L1.0070.23
62_K122_T1.0040.23
69_S255_W1.0030.23
44_L153_Y1.0010.23
232_L288_V0.9960.23
48_W159_G0.9960.23
49_R127_G0.9940.23
251_S290_L0.9900.23
85_R119_I0.9860.23
292_G295_S0.9850.23
78_K246_G0.9770.22
102_R190_E0.9740.22
46_A266_T0.9690.22
80_T176_I0.9690.22
134_Y274_R0.9680.22
119_I235_D0.9610.22
48_W184_A0.9590.22
120_T268_Y0.9540.22
57_F241_F0.9500.22
69_S73_N0.9480.22
59_A133_Q0.9410.21
94_Q158_G0.9410.21
245_H286_L0.9350.21
175_R261_V0.9330.21
103_A282_D0.9320.21
54_P259_W0.9240.21
182_L246_G0.9210.21
242_H245_H0.9180.21
105_L120_T0.9170.21
90_G97_G0.9160.21
193_G247_I0.9150.21
36_G244_D0.9140.21
86_S141_V0.9140.21
83_F158_G0.9130.21
129_T196_T0.9080.20
73_N109_F0.9060.20
167_E284_E0.9030.20
33_A88_D0.9030.20
114_S271_D0.8990.20
101_V227_P0.8940.20
135_A208_D0.8930.20
63_R112_R0.8920.20
159_G189_P0.8910.20
42_D170_A0.8900.20
109_F150_Y0.8890.20
44_L101_V0.8880.20
122_T283_D0.8880.20
102_R187_V0.8810.20
193_G238_V0.8760.19
88_D193_G0.8760.19
54_P103_A0.8750.19
68_D159_G0.8730.19
248_D251_S0.8730.19
62_K200_T0.8690.19
57_F70_A0.8640.19
35_L124_F0.8610.19
36_G276_T0.8610.19
58_S242_H0.8580.19
139_L164_S0.8540.19
87_T278_T0.8530.19
135_A197_T0.8530.19
110_T156_P0.8460.19
96_A136_D0.8460.19
267_A273_D0.8400.19
226_S257_L0.8340.18
140_S199_L0.8220.18
178_H187_V0.8190.18
236_A243_A0.8170.18
177_R228_V0.8150.18
246_G257_L0.8050.18
79_L220_C0.8040.18
188_C220_C0.8040.18
79_L188_C0.8040.18
191_C217_C0.8040.18
79_L191_C0.8040.18
191_C220_C0.8040.18
79_L217_C0.8040.18
188_C191_C0.8040.18
188_C217_C0.8040.18
217_C220_C0.8040.18
77_S195_M0.8030.18
51_P214_D0.8020.18
164_S167_E0.8010.18
28_A280_R0.8010.18
44_L106_A0.8000.17
43_I72_F0.7970.17
146_C165_D0.7960.17
73_N134_Y0.7940.17
63_R66_M0.7880.17
70_A115_L0.7880.17
147_A282_D0.7880.17
105_L240_A0.7840.17
45_Q175_R0.7830.17
48_W55_V0.7820.17
244_D251_S0.7810.17
57_F71_Q0.7810.17
71_Q179_L0.7800.17
111_D163_R0.7760.17
170_A292_G0.7750.17
235_D251_S0.7720.17
151_A249_V0.7720.17
165_D284_E0.7690.17
69_S94_Q0.7670.17
207_L260_C0.7630.17
56_S59_A0.7620.17
102_R192_G0.7550.16
206_R285_S0.7450.16
29_A55_V0.7440.16
55_V262_T0.7440.16
268_Y276_T0.7390.16
104_I125_A0.7360.16
113_V205_S0.7310.16
91_Y156_P0.7280.16
37_N271_D0.7230.16
102_R294_L0.7220.16
173_D255_W0.7190.16
137_E141_V0.7170.15
163_R171_A0.7160.15
249_V261_V0.7120.15
282_D293_S0.7120.15
121_G255_W0.7120.15
47_L60_L0.7120.15
196_T235_D0.7100.15
84_V290_L0.7100.15
68_D115_L0.7070.15
65_G295_S0.7060.15
161_R227_P0.7050.15
137_E173_D0.7040.15
33_A269_D0.7010.15
198_T268_Y0.7000.15
196_T218_Q0.6990.15
49_R196_T0.6960.15
183_A237_T0.6920.15
32_F173_D0.6890.15
96_A135_A0.6840.15
278_T283_D0.6830.15
192_G242_H0.6830.15
146_C294_L0.6820.15
126_C146_C0.6800.15
114_S270_P0.6760.15
39_T59_A0.6760.15
70_A176_I0.6720.14
147_A208_D0.6700.14
83_F295_S0.6650.14
35_L180_H0.6640.14
72_F75_H0.6630.14
169_A187_V0.6620.14
172_F261_V0.6610.14
141_V229_G0.6610.14
78_K174_Q0.6590.14
237_T242_H0.6590.14
89_D241_F0.6580.14
73_N84_V0.6570.14
204_D298_D0.6520.14
130_L258_G0.6500.14
283_D298_D0.6490.14
112_R124_F0.6470.14
72_F156_P0.6410.14
131_V216_T0.6410.14
61_R73_N0.6410.14
76_L238_V0.6390.14
93_F241_F0.6390.14
169_A177_R0.6370.14
70_A98_E0.6360.14
155_F163_R0.6350.14
59_A85_R0.6330.14
39_T102_R0.6320.14
93_F242_H0.6310.14
139_L187_V0.6300.14
35_L170_A0.6290.14
29_A288_V0.6270.14
92_E170_A0.6250.13
23_D34_L0.6240.13
165_D294_L0.6240.13
200_T214_D0.6220.13
123_C156_P0.6190.13
119_I250_T0.6180.13
284_E298_D0.6180.13
252_T275_A0.6160.13
114_S234_D0.6150.13
39_T269_D0.6150.13
28_A158_G0.6140.13
52_E56_S0.6140.13
56_S120_T0.6110.13
27_A116_S0.6040.13
46_A71_Q0.6020.13
36_G132_G0.6000.13
267_A272_R0.5980.13
72_F91_Y0.5980.13
63_R199_L0.5970.13
211_V275_A0.5970.13
80_T155_F0.5970.13
257_L281_L0.5930.13
270_P283_D0.5930.13
180_H292_G0.5920.13
43_I67_R0.5900.13
135_A211_V0.5900.13
42_D268_Y0.5880.13
255_W263_D0.5870.13
149_T287_T0.5860.13
104_I167_E0.5810.13
229_G259_W0.5810.13
59_A147_A0.5760.12
200_T284_E0.5730.12
49_R295_S0.5730.12
35_L174_Q0.5700.12
208_D227_P0.5690.12
69_S208_D0.5690.12
167_E205_S0.5640.12
163_R166_A0.5620.12
126_C156_P0.5620.12
99_K180_H0.5610.12
148_T205_S0.5590.12
175_R219_Q0.5590.12
53_R86_S0.5560.12
31_A120_T0.5560.12
132_G139_L0.5550.12
57_F107_G0.5530.12
141_V283_D0.5510.12
244_D285_S0.5500.12
177_R253_P0.5490.12
103_A110_T0.5480.12
63_R125_A0.5460.12
202_D205_S0.5460.12
230_L253_P0.5440.12
153_Y179_L0.5440.12
43_I279_I0.5430.12
87_T241_F0.5430.12
71_Q107_G0.5430.12
202_D251_S0.5420.12
47_L91_Y0.5360.12
169_A256_T0.5360.12
278_T293_S0.5350.12
36_G104_I0.5330.12
109_F159_G0.5310.12
211_V266_T0.5300.12
75_H191_C0.5300.12
75_H79_L0.5300.12
75_H188_C0.5300.12
74_Y79_L0.5300.12
74_Y191_C0.5300.12
75_H217_C0.5300.12
74_Y217_C0.5300.12
75_H220_C0.5300.12
74_Y220_C0.5300.12
74_Y188_C0.5300.12
86_S168_V0.5290.12
87_T118_P0.5280.12
32_F177_R0.5240.12
135_A245_H0.5240.12
37_N168_V0.5230.12
31_A127_G0.5230.12
159_G187_V0.5220.11
135_A164_S0.5210.11
95_Y235_D0.5160.11
249_V255_W0.5140.11
35_L109_F0.5130.11
56_S167_E0.5110.11
53_R129_T0.5100.11
129_T248_D0.5090.11
198_T248_D0.5080.11
296_V299_T0.5070.11
41_I296_V0.5060.11
143_C156_P0.5050.11
102_R169_A0.5050.11
28_A45_Q0.5040.11
228_V298_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y0uA 2 0.2848 98.3 0.908 Contact Map
2f2eA 4 0.4238 98.2 0.91 Contact Map
3f6vA 2 0.3013 98.2 0.911 Contact Map
4gcvA 3 0.4404 98 0.915 Contact Map
2fswA 2 0.3113 98 0.915 Contact Map
2kkoA 2 0.3411 97.9 0.916 Contact Map
3df8A 2 0.3377 97.9 0.917 Contact Map
2zkzA 2 0.2815 97.9 0.917 Contact Map
1r1tA 2 0.298 97.8 0.918 Contact Map
2hztA 2 0.2848 97.8 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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