Q9HRF4 - HALSA - GREMLIN Contacts

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Q9HRF4 - Uncharacterized protein

UniProt:	Q9HRF4	Sequences: MSGSEQSPDPDTPQSASSATQDDDGLAAADAFALLGNETRIDILQALWRAPERPVSFSALRKRVGMRDSAQFNYHLSKLTDHFVRSTDDGYEFQYAGEKVVRAILAGTFTDRVSLSVPITGTCFACGETLVGQYADERLSVECAACATTYARYAFPPGGLRNRSDAEVAAAFDQRIRHLHCLAADGVCPECGGRMTTTLTPDDDSRLDLNVRVDHTCQQCQHTLSSPVGLSLLDDATVVAFHADHGIDVTSTPHWTLGWCVTDATTAYDPDRDRATVTIRLDDESLTVTLDGSLSVVDTTRA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	302 (278)
Sequences:	175 (154)
Seq/√Len:	9.2

HALSA - Q9HRF4 Q9HN68

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_L	84_V	3.957	0.98
155_F	159_G	3.836	0.98
159_G	171_A	3.430	0.96
37_N	71_Q	3.175	0.93
27_A	282_D	2.819	0.88
37_N	78_K	2.538	0.82
177_R	255_W	2.530	0.82
57_F	187_V	2.472	0.80
121_G	256_T	2.371	0.77
242_H	249_V	2.339	0.76
81_D	85_R	2.302	0.75
267_A	278_T	2.272	0.74
180_H	183_A	2.159	0.70
73_N	289_T	2.146	0.69
155_F	172_F	2.138	0.69
269_D	272_R	2.088	0.67
69_S	134_Y	2.069	0.66
130_L	277_V	2.056	0.66
68_D	134_Y	2.048	0.66
247_I	269_D	2.032	0.65
155_F	171_A	2.023	0.65
241_F	286_L	2.018	0.64
123_C	143_C	2.000	0.64
68_D	73_N	1.991	0.63
121_G	130_L	1.986	0.63
93_F	97_G	1.965	0.62
61_R	65_G	1.961	0.62
32_F	45_Q	1.921	0.60
97_G	241_F	1.916	0.60
109_F	235_D	1.909	0.60
38_E	194_R	1.870	0.58
186_G	238_V	1.866	0.58
218_Q	240_A	1.817	0.56
71_Q	168_V	1.801	0.55
167_E	283_D	1.798	0.55
123_C	126_C	1.792	0.55
57_F	109_F	1.780	0.54
27_A	252_T	1.761	0.54
31_A	59_A	1.751	0.53
158_G	219_Q	1.735	0.52
173_D	177_R	1.732	0.52
141_V	225_S	1.716	0.52
159_G	163_R	1.673	0.50
57_F	87_T	1.667	0.49
70_A	134_Y	1.646	0.48
198_T	270_P	1.629	0.48
59_A	292_G	1.619	0.47
136_D	233_L	1.586	0.46
154_A	298_D	1.586	0.46
102_R	159_G	1.583	0.46
163_R	169_A	1.580	0.46
134_Y	229_G	1.549	0.44
126_C	143_C	1.546	0.44
102_R	146_C	1.532	0.43
266_T	297_V	1.522	0.43
120_T	271_D	1.500	0.42
54_P	288_V	1.499	0.42
198_T	266_T	1.484	0.41
146_C	159_G	1.456	0.40
28_A	32_F	1.451	0.40
229_G	255_W	1.427	0.39
134_Y	238_V	1.415	0.39
60_L	72_F	1.400	0.38
44_L	193_G	1.397	0.38
44_L	130_L	1.378	0.37
160_L	181_C	1.376	0.37
89_D	166_A	1.375	0.37
70_A	73_N	1.372	0.37
41_I	104_I	1.359	0.36
133_Q	283_D	1.357	0.36
50_A	127_G	1.355	0.36
155_F	182_L	1.352	0.36
89_D	282_D	1.350	0.36
175_R	227_P	1.347	0.36
50_A	257_L	1.327	0.35
55_V	63_R	1.326	0.35
30_D	271_D	1.319	0.35
100_V	145_A	1.318	0.35
35_L	94_Q	1.309	0.34
30_D	33_A	1.306	0.34
23_D	283_D	1.305	0.34
87_T	247_I	1.301	0.34
42_D	164_S	1.300	0.34
31_A	102_R	1.297	0.34
183_A	283_D	1.291	0.33
57_F	88_D	1.285	0.33
47_L	77_S	1.279	0.33
38_E	109_F	1.276	0.33
44_L	262_T	1.275	0.33
226_S	283_D	1.252	0.32
86_S	110_T	1.241	0.32
94_Q	290_L	1.234	0.31
72_F	103_A	1.228	0.31
70_A	159_G	1.222	0.31
136_D	228_V	1.218	0.31
57_F	132_G	1.206	0.30
146_C	171_A	1.204	0.30
120_T	245_H	1.202	0.30
104_I	228_V	1.202	0.30
83_F	279_I	1.201	0.30
262_T	265_T	1.198	0.30
38_E	41_I	1.193	0.30
40_R	74_Y	1.191	0.30
40_R	75_H	1.191	0.30
63_R	288_V	1.187	0.30
100_V	103_A	1.187	0.30
108_T	185_D	1.177	0.29
119_I	145_A	1.171	0.29
67_R	257_L	1.165	0.29
85_R	114_S	1.161	0.29
41_I	258_G	1.153	0.28
52_E	82_H	1.151	0.28
155_F	267_A	1.148	0.28
37_N	86_S	1.143	0.28
249_V	259_W	1.136	0.28
231_S	244_D	1.136	0.28
185_D	230_L	1.129	0.27
128_E	145_A	1.122	0.27
116_S	151_A	1.117	0.27
44_L	258_G	1.116	0.27
100_V	289_T	1.115	0.27
70_A	171_A	1.112	0.27
37_N	58_S	1.111	0.27
107_G	136_D	1.108	0.27
81_D	296_V	1.097	0.26
130_L	163_R	1.093	0.26
113_V	168_V	1.087	0.26
28_A	36_G	1.085	0.26
71_Q	167_E	1.080	0.26
101_V	223_T	1.076	0.26
245_H	283_D	1.075	0.26
130_L	172_F	1.067	0.25
243_A	250_T	1.064	0.25
172_F	253_P	1.060	0.25
173_D	239_V	1.057	0.25
122_T	237_T	1.050	0.25
164_S	178_H	1.050	0.25
228_V	276_T	1.049	0.25
47_L	72_F	1.037	0.24
96_A	157_P	1.032	0.24
47_L	83_F	1.032	0.24
108_T	112_R	1.028	0.24
172_F	196_T	1.025	0.24
72_F	238_V	1.025	0.24
197_T	271_D	1.023	0.24
88_D	103_A	1.020	0.24
93_F	99_K	1.015	0.24
199_L	228_V	1.013	0.24
265_T	285_S	1.011	0.23
99_K	190_E	1.010	0.23
89_D	290_L	1.007	0.23
62_K	122_T	1.004	0.23
69_S	255_W	1.003	0.23
44_L	153_Y	1.001	0.23
232_L	288_V	0.996	0.23
48_W	159_G	0.996	0.23
49_R	127_G	0.994	0.23
251_S	290_L	0.990	0.23
85_R	119_I	0.986	0.23
292_G	295_S	0.985	0.23
78_K	246_G	0.977	0.22
102_R	190_E	0.974	0.22
46_A	266_T	0.969	0.22
80_T	176_I	0.969	0.22
134_Y	274_R	0.968	0.22
119_I	235_D	0.961	0.22
48_W	184_A	0.959	0.22
120_T	268_Y	0.954	0.22
57_F	241_F	0.950	0.22
69_S	73_N	0.948	0.22
59_A	133_Q	0.941	0.21
94_Q	158_G	0.941	0.21
245_H	286_L	0.935	0.21
175_R	261_V	0.933	0.21
103_A	282_D	0.932	0.21
54_P	259_W	0.924	0.21
182_L	246_G	0.921	0.21
242_H	245_H	0.918	0.21
105_L	120_T	0.917	0.21
90_G	97_G	0.916	0.21
193_G	247_I	0.915	0.21
36_G	244_D	0.914	0.21
86_S	141_V	0.914	0.21
83_F	158_G	0.913	0.21
129_T	196_T	0.908	0.20
73_N	109_F	0.906	0.20
167_E	284_E	0.903	0.20
33_A	88_D	0.903	0.20
114_S	271_D	0.899	0.20
101_V	227_P	0.894	0.20
135_A	208_D	0.893	0.20
63_R	112_R	0.892	0.20
159_G	189_P	0.891	0.20
42_D	170_A	0.890	0.20
109_F	150_Y	0.889	0.20
44_L	101_V	0.888	0.20
122_T	283_D	0.888	0.20
102_R	187_V	0.881	0.20
193_G	238_V	0.876	0.19
88_D	193_G	0.876	0.19
54_P	103_A	0.875	0.19
68_D	159_G	0.873	0.19
248_D	251_S	0.873	0.19
62_K	200_T	0.869	0.19
57_F	70_A	0.864	0.19
35_L	124_F	0.861	0.19
36_G	276_T	0.861	0.19
58_S	242_H	0.858	0.19
139_L	164_S	0.854	0.19
87_T	278_T	0.853	0.19
135_A	197_T	0.853	0.19
110_T	156_P	0.846	0.19
96_A	136_D	0.846	0.19
267_A	273_D	0.840	0.19
226_S	257_L	0.834	0.18
140_S	199_L	0.822	0.18
178_H	187_V	0.819	0.18
236_A	243_A	0.817	0.18
177_R	228_V	0.815	0.18
246_G	257_L	0.805	0.18
79_L	220_C	0.804	0.18
188_C	220_C	0.804	0.18
79_L	188_C	0.804	0.18
191_C	217_C	0.804	0.18
79_L	191_C	0.804	0.18
191_C	220_C	0.804	0.18
79_L	217_C	0.804	0.18
188_C	191_C	0.804	0.18
188_C	217_C	0.804	0.18
217_C	220_C	0.804	0.18
77_S	195_M	0.803	0.18
51_P	214_D	0.802	0.18
164_S	167_E	0.801	0.18
28_A	280_R	0.801	0.18
44_L	106_A	0.800	0.17
43_I	72_F	0.797	0.17
146_C	165_D	0.796	0.17
73_N	134_Y	0.794	0.17
63_R	66_M	0.788	0.17
70_A	115_L	0.788	0.17
147_A	282_D	0.788	0.17
105_L	240_A	0.784	0.17
45_Q	175_R	0.783	0.17
48_W	55_V	0.782	0.17
244_D	251_S	0.781	0.17
57_F	71_Q	0.781	0.17
71_Q	179_L	0.780	0.17
111_D	163_R	0.776	0.17
170_A	292_G	0.775	0.17
235_D	251_S	0.772	0.17
151_A	249_V	0.772	0.17
165_D	284_E	0.769	0.17
69_S	94_Q	0.767	0.17
207_L	260_C	0.763	0.17
56_S	59_A	0.762	0.17
102_R	192_G	0.755	0.16
206_R	285_S	0.745	0.16
29_A	55_V	0.744	0.16
55_V	262_T	0.744	0.16
268_Y	276_T	0.739	0.16
104_I	125_A	0.736	0.16
113_V	205_S	0.731	0.16
91_Y	156_P	0.728	0.16
37_N	271_D	0.723	0.16
102_R	294_L	0.722	0.16
173_D	255_W	0.719	0.16
137_E	141_V	0.717	0.15
163_R	171_A	0.716	0.15
249_V	261_V	0.712	0.15
282_D	293_S	0.712	0.15
121_G	255_W	0.712	0.15
47_L	60_L	0.712	0.15
196_T	235_D	0.710	0.15
84_V	290_L	0.710	0.15
68_D	115_L	0.707	0.15
65_G	295_S	0.706	0.15
161_R	227_P	0.705	0.15
137_E	173_D	0.704	0.15
33_A	269_D	0.701	0.15
198_T	268_Y	0.700	0.15
196_T	218_Q	0.699	0.15
49_R	196_T	0.696	0.15
183_A	237_T	0.692	0.15
32_F	173_D	0.689	0.15
96_A	135_A	0.684	0.15
278_T	283_D	0.683	0.15
192_G	242_H	0.683	0.15
146_C	294_L	0.682	0.15
126_C	146_C	0.680	0.15
114_S	270_P	0.676	0.15
39_T	59_A	0.676	0.15
70_A	176_I	0.672	0.14
147_A	208_D	0.670	0.14
83_F	295_S	0.665	0.14
35_L	180_H	0.664	0.14
72_F	75_H	0.663	0.14
169_A	187_V	0.662	0.14
172_F	261_V	0.661	0.14
141_V	229_G	0.661	0.14
78_K	174_Q	0.659	0.14
237_T	242_H	0.659	0.14
89_D	241_F	0.658	0.14
73_N	84_V	0.657	0.14
204_D	298_D	0.652	0.14
130_L	258_G	0.650	0.14
283_D	298_D	0.649	0.14
112_R	124_F	0.647	0.14
72_F	156_P	0.641	0.14
131_V	216_T	0.641	0.14
61_R	73_N	0.641	0.14
76_L	238_V	0.639	0.14
93_F	241_F	0.639	0.14
169_A	177_R	0.637	0.14
70_A	98_E	0.636	0.14
155_F	163_R	0.635	0.14
59_A	85_R	0.633	0.14
39_T	102_R	0.632	0.14
93_F	242_H	0.631	0.14
139_L	187_V	0.630	0.14
35_L	170_A	0.629	0.14
29_A	288_V	0.627	0.14
92_E	170_A	0.625	0.13
23_D	34_L	0.624	0.13
165_D	294_L	0.624	0.13
200_T	214_D	0.622	0.13
123_C	156_P	0.619	0.13
119_I	250_T	0.618	0.13
284_E	298_D	0.618	0.13
252_T	275_A	0.616	0.13
114_S	234_D	0.615	0.13
39_T	269_D	0.615	0.13
28_A	158_G	0.614	0.13
52_E	56_S	0.614	0.13
56_S	120_T	0.611	0.13
27_A	116_S	0.604	0.13
46_A	71_Q	0.602	0.13
36_G	132_G	0.600	0.13
267_A	272_R	0.598	0.13
72_F	91_Y	0.598	0.13
63_R	199_L	0.597	0.13
211_V	275_A	0.597	0.13
80_T	155_F	0.597	0.13
257_L	281_L	0.593	0.13
270_P	283_D	0.593	0.13
180_H	292_G	0.592	0.13
43_I	67_R	0.590	0.13
135_A	211_V	0.590	0.13
42_D	268_Y	0.588	0.13
255_W	263_D	0.587	0.13
149_T	287_T	0.586	0.13
104_I	167_E	0.581	0.13
229_G	259_W	0.581	0.13
59_A	147_A	0.576	0.12
200_T	284_E	0.573	0.12
49_R	295_S	0.573	0.12
35_L	174_Q	0.570	0.12
208_D	227_P	0.569	0.12
69_S	208_D	0.569	0.12
167_E	205_S	0.564	0.12
163_R	166_A	0.562	0.12
126_C	156_P	0.562	0.12
99_K	180_H	0.561	0.12
148_T	205_S	0.559	0.12
175_R	219_Q	0.559	0.12
53_R	86_S	0.556	0.12
31_A	120_T	0.556	0.12
132_G	139_L	0.555	0.12
57_F	107_G	0.553	0.12
141_V	283_D	0.551	0.12
244_D	285_S	0.550	0.12
177_R	253_P	0.549	0.12
103_A	110_T	0.548	0.12
63_R	125_A	0.546	0.12
202_D	205_S	0.546	0.12
230_L	253_P	0.544	0.12
153_Y	179_L	0.544	0.12
43_I	279_I	0.543	0.12
87_T	241_F	0.543	0.12
71_Q	107_G	0.543	0.12
202_D	251_S	0.542	0.12
47_L	91_Y	0.536	0.12
169_A	256_T	0.536	0.12
278_T	293_S	0.535	0.12
36_G	104_I	0.533	0.12
109_F	159_G	0.531	0.12
211_V	266_T	0.530	0.12
75_H	191_C	0.530	0.12
75_H	79_L	0.530	0.12
75_H	188_C	0.530	0.12
74_Y	79_L	0.530	0.12
74_Y	191_C	0.530	0.12
75_H	217_C	0.530	0.12
74_Y	217_C	0.530	0.12
75_H	220_C	0.530	0.12
74_Y	220_C	0.530	0.12
74_Y	188_C	0.530	0.12
86_S	168_V	0.529	0.12
87_T	118_P	0.528	0.12
32_F	177_R	0.524	0.12
135_A	245_H	0.524	0.12
37_N	168_V	0.523	0.12
31_A	127_G	0.523	0.12
159_G	187_V	0.522	0.11
135_A	164_S	0.521	0.11
95_Y	235_D	0.516	0.11
249_V	255_W	0.514	0.11
35_L	109_F	0.513	0.11
56_S	167_E	0.511	0.11
53_R	129_T	0.510	0.11
129_T	248_D	0.509	0.11
198_T	248_D	0.508	0.11
296_V	299_T	0.507	0.11
41_I	296_V	0.506	0.11
143_C	156_P	0.505	0.11
102_R	169_A	0.505	0.11
28_A	45_Q	0.504	0.11
228_V	298_D	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y0uA	2	0.2848	98.3	0.908	Contact Map
2f2eA	4	0.4238	98.2	0.91	Contact Map
3f6vA	2	0.3013	98.2	0.911	Contact Map
4gcvA	3	0.4404	98	0.915	Contact Map
2fswA	2	0.3113	98	0.915	Contact Map
2kkoA	2	0.3411	97.9	0.916	Contact Map
3df8A	2	0.3377	97.9	0.917	Contact Map
2zkzA	2	0.2815	97.9	0.917	Contact Map
1r1tA	2	0.298	97.8	0.918	Contact Map
2hztA	2	0.2848	97.8	0.918	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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