GREMLIN Database
Q9HRF3 - Uncharacterized protein
UniProt: Q9HRF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (179)
Sequences: 46342 (36864)
Seq/√Len: 2755.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K45_T3.9661.00
27_H36_R3.9641.00
22_S40_E3.5501.00
53_D57_E2.7431.00
24_L32_L2.3911.00
136_K154_D2.1641.00
54_T57_E2.1331.00
38_A48_V2.0871.00
26_E40_E2.0081.00
23_A40_E2.0051.00
14_A65_Y1.9771.00
19_A40_E1.9361.00
23_A32_L1.9261.00
23_A36_R1.8971.00
136_K140_S1.8841.00
12_A15_E1.8741.00
87_S188_S1.8631.00
81_A84_T1.8581.00
15_E19_A1.8501.00
13_E61_A1.8451.00
85_R141_H1.8001.00
35_K39_D1.7951.00
23_A27_H1.7941.00
140_S153_A1.7641.00
91_D184_R1.7611.00
140_S144_D1.6811.00
21_Y65_Y1.6631.00
14_A18_Q1.6521.00
44_S47_A1.6491.00
19_A22_S1.6441.00
20_T24_L1.5831.00
34_I49_H1.5651.00
17_M61_A1.5351.00
36_R39_D1.5321.00
34_I45_T1.5091.00
140_S143_I1.5041.00
22_S26_E1.4781.00
28_G32_L1.4411.00
61_A64_D1.4331.00
36_R40_E1.4211.00
60_A64_D1.4191.00
65_Y69_E1.4131.00
21_Y66_L1.4091.00
159_S163_I1.3971.00
33_T36_R1.3961.00
143_I150_A1.3891.00
60_A123_R1.3791.00
28_G31_D1.3751.00
52_Y61_A1.3591.00
21_Y62_F1.3341.00
64_D123_R1.3321.00
75_R134_M1.3181.00
20_T58_L1.3061.00
141_H145_E1.2981.00
11_E15_E1.2901.00
32_L37_I1.2761.00
18_Q65_Y1.2671.00
132_R158_R1.2651.00
47_A50_Y1.2651.00
13_E51_Y1.2421.00
34_I48_V1.2291.00
73_S92_E1.2051.00
11_E14_A1.2011.00
24_L29_Y1.1901.00
142_G147_A1.1851.00
45_T49_H1.1771.00
27_H31_D1.1761.00
84_T88_L1.1761.00
19_A23_A1.1731.00
105_V109_E1.1611.00
57_E61_A1.1491.00
132_R136_K1.1241.00
91_D188_S1.1191.00
48_V58_L1.1141.00
87_S91_D1.1141.00
142_G148_F1.1121.00
43_K47_A1.1081.00
17_M52_Y1.0861.00
152_D155_H1.0761.00
179_A182_A1.0741.00
19_A41_Y1.0721.00
143_I151_V1.0711.00
12_A51_Y1.0701.00
138_V142_G1.0661.00
56_E117_N1.0651.00
85_R138_V1.0631.00
47_A51_Y1.0541.00
83_E87_S1.0501.00
134_M137_S1.0481.00
88_L91_D1.0481.00
44_S50_Y1.0461.00
184_R188_S1.0411.00
185_R188_S1.0371.00
56_E60_A1.0371.00
105_V108_L1.0251.00
123_R126_Q1.0251.00
46_A50_Y1.0221.00
18_Q22_S1.0161.00
29_Y59_L1.0151.00
17_M62_F1.0051.00
27_H40_E1.0041.00
37_I58_L1.0041.00
49_H54_T1.0011.00
21_Y25_R0.9891.00
20_T62_F0.9851.00
22_S102_A0.9801.00
9_F50_Y0.9741.00
56_E119_P0.9681.00
64_D68_E0.9611.00
136_K153_A0.9541.00
57_E60_A0.9521.00
71_V130_Y0.9511.00
96_D100_N0.9411.00
143_I153_A0.9401.00
80_T88_L0.9391.00
129_E133_F0.9361.00
38_A45_T0.9311.00
137_S141_H0.9201.00
79_T85_R0.9161.00
71_V75_R0.9151.00
65_Y68_E0.9151.00
126_Q130_Y0.9151.00
84_T87_S0.9051.00
81_A147_A0.9031.00
61_A65_Y0.8971.00
104_S107_L0.8901.00
162_T166_G0.8881.00
73_S76_A0.8771.00
154_D158_R0.8751.00
82_P145_E0.8741.00
10_S14_A0.8721.00
137_S140_S0.8711.00
138_V141_H0.8671.00
66_L69_E0.8601.00
92_E95_V0.8551.00
171_S174_H0.8541.00
133_F137_S0.8501.00
136_K157_A0.8471.00
72_A76_A0.8371.00
122_E126_Q0.8311.00
91_D95_V0.8241.00
151_V156_V0.8181.00
88_L92_E0.8171.00
155_H182_A0.8151.00
132_R154_D0.8141.00
8_E11_E0.8131.00
155_H186_T0.8091.00
106_A110_M0.8021.00
39_D45_T0.7921.00
15_E41_Y0.7921.00
17_M65_Y0.7881.00
182_A186_T0.7871.00
125_Q128_D0.7841.00
12_A43_K0.7801.00
29_Y55_K0.7791.00
45_T50_Y0.7791.00
34_I55_K0.7781.00
25_R102_A0.7761.00
15_E18_Q0.7761.00
100_N103_L0.7751.00
130_Y134_M0.7731.00
107_L110_M0.7731.00
23_A26_E0.7691.00
141_H144_D0.7671.00
143_I146_G0.7641.00
9_F12_A0.7611.00
64_D127_N0.7601.00
68_E72_A0.7561.00
16_L48_V0.7551.00
27_H32_L0.7541.00
153_A157_A0.7451.00
121_R125_Q0.7431.00
80_T84_T0.7431.00
87_S185_R0.7421.00
123_R127_N0.7361.00
118_E122_E0.7301.00
118_E121_R0.7281.00
71_V134_M0.7131.00
79_T84_T0.7111.00
18_Q21_Y0.7111.00
133_F136_K0.7091.00
69_E72_A0.7091.00
155_H159_S0.7071.00
116_Y119_P0.7061.00
17_M21_Y0.6941.00
16_L41_Y0.6921.00
82_P142_G0.6881.00
155_H185_R0.6831.00
95_V180_L0.6811.00
72_A75_R0.6771.00
26_E36_R0.6711.00
12_A47_A0.6701.00
8_E12_A0.6661.00
181_A184_R0.6661.00
143_I148_F0.6651.00
130_Y133_F0.6631.00
180_L184_R0.6541.00
41_Y44_S0.6441.00
101_Q105_V0.6411.00
186_T189_E0.6351.00
95_V184_R0.6341.00
182_A185_R0.6331.00
64_D126_Q0.6291.00
170_R174_H0.6271.00
159_S162_T0.6261.00
181_A185_R0.6241.00
90_L160_L0.6231.00
91_D181_A0.6211.00
29_Y32_L0.6131.00
29_Y56_E0.6121.00
76_A92_E0.6121.00
87_S90_L0.6101.00
162_T165_D0.6061.00
35_K49_H0.6061.00
185_R189_E0.6041.00
102_A105_V0.6031.00
139_I143_I0.6031.00
125_Q129_E0.6001.00
34_I38_A0.5991.00
139_I160_L0.5991.00
178_S182_A0.5941.00
79_T88_L0.5901.00
104_S109_E0.5891.00
68_E127_N0.5861.00
139_I153_A0.5811.00
104_S108_L0.5801.00
81_A85_R0.5781.00
119_P122_E0.5741.00
16_L51_Y0.5701.00
24_L59_L0.5671.00
82_P147_A0.5661.00
180_L183_G0.5651.00
155_H158_R0.5641.00
91_D185_R0.5641.00
90_L93_L0.5631.00
144_D148_F0.5611.00
21_Y69_E0.5581.00
184_R187_A0.5571.00
140_S154_D0.5531.00
150_A153_A0.5501.00
98_Q180_L0.5491.00
9_F51_Y0.5441.00
20_T37_I0.5441.00
152_D156_V0.5401.00
12_A44_S0.5391.00
93_L97_P0.5391.00
41_Y45_T0.5371.00
106_A109_E0.5311.00
92_E96_D0.5311.00
127_N130_Y0.5301.00
165_D170_R0.5301.00
127_N131_T0.5251.00
82_P85_R0.5241.00
163_I166_G0.5231.00
35_K44_S0.5221.00
60_A119_P0.5201.00
116_Y120_F0.5161.00
165_D169_T0.5141.00
25_R105_V0.5131.00
69_E73_S0.5111.00
95_V99_P0.5111.00
38_A44_S0.5101.00
155_H189_E0.5081.00
122_E125_Q0.5071.00
128_D132_R0.5061.00
77_V80_T0.5031.00
10_S13_E0.5031.00
69_E100_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3crjA 2 0.9694 100 0.184 Contact Map
2xdnA 2 0.9796 100 0.186 Contact Map
2w53A 2 0.9388 100 0.2 Contact Map
4udsA 2 0.9388 100 0.205 Contact Map
2wuiA 2 0.9541 100 0.206 Contact Map
4kwaA 2 0.9643 100 0.21 Contact Map
2gfnA 2 0.9643 100 0.217 Contact Map
3lhqA 2 1 100 0.219 Contact Map
3lsjA 2 0.9745 100 0.219 Contact Map
4jykA 2 0.9694 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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