GREMLIN Database
Q9HRF2 - Uncharacterized protein
UniProt: Q9HRF2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 494 (426)
Sequences: 18843 (14203)
Seq/√Len: 688.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K100_Q4.6811.00
157_A230_A3.9631.00
146_S219_Q3.3251.00
65_S301_G3.2631.00
367_V385_G3.1361.00
90_A326_G3.0811.00
362_Y365_P3.0471.00
128_E145_T3.0211.00
333_K336_R2.9341.00
262_R266_R2.9131.00
126_F129_D2.8541.00
128_E132_S2.7711.00
173_D176_T2.7661.00
150_V219_Q2.5331.00
85_G108_T2.5141.00
194_F199_W2.4751.00
187_L231_L2.4441.00
92_Y100_Q2.4411.00
145_T149_Q2.4311.00
258_L262_R2.4161.00
52_W196_I2.3361.00
59_D139_A2.2571.00
414_K464_W2.2441.00
52_W193_P2.2411.00
63_A143_P2.2151.00
26_K30_F2.2041.00
184_S232_A2.1771.00
321_V344_A2.1711.00
103_Y257_D2.1601.00
180_V235_V2.1151.00
143_P146_S2.1121.00
442_G445_G2.0881.00
342_R346_T2.0781.00
137_S294_D2.0721.00
379_A383_E2.0381.00
363_P390_R2.0181.00
160_G233_F2.0061.00
150_V222_A2.0031.00
154_G226_V1.9781.00
57_N60_A1.9731.00
387_Q444_A1.9591.00
364_E386_S1.9531.00
49_D225_T1.9411.00
299_A384_A1.9271.00
142_R146_S1.9191.00
92_Y97_K1.9141.00
380_Q383_E1.9041.00
36_V316_A1.8931.00
328_N336_R1.8881.00
219_Q223_I1.8751.00
58_T378_S1.8611.00
112_S163_V1.8451.00
216_L223_I1.8451.00
53_L221_A1.8351.00
196_I221_A1.8011.00
363_P386_S1.7851.00
52_W192_D1.7721.00
295_H380_Q1.7691.00
175_I179_L1.7591.00
92_Y95_A1.7461.00
194_F198_G1.7201.00
329_V412_A1.7041.00
132_S141_L1.7021.00
234_A238_A1.6991.00
257_D260_Y1.6931.00
150_V223_I1.6911.00
33_M37_I1.6701.00
360_Y390_R1.6601.00
153_L156_A1.6541.00
398_F455_V1.6391.00
180_V236_G1.6381.00
127_V145_T1.6371.00
341_A405_Y1.6201.00
324_M340_A1.6181.00
198_G215_R1.6161.00
32_A320_G1.6141.00
199_W215_R1.6111.00
338_A342_R1.6061.00
339_R343_L1.6021.00
186_V190_V1.6001.00
123_G152_A1.5901.00
364_E368_S1.5841.00
339_R342_R1.5811.00
88_L104_A1.5711.00
157_A233_F1.5601.00
348_L400_G1.5581.00
328_N333_K1.5521.00
129_D132_S1.5351.00
139_A294_D1.5171.00
193_P199_W1.5091.00
141_L145_T1.4961.00
329_V337_A1.4961.00
127_V149_Q1.4901.00
386_S390_R1.4871.00
356_G360_Y1.4851.00
192_D221_A1.4731.00
191_L224_A1.4721.00
414_K417_V1.4711.00
193_P197_F1.4621.00
365_P368_S1.4451.00
459_I463_A1.4451.00
341_A408_S1.4441.00
48_A189_I1.4401.00
100_Q103_Y1.4381.00
139_A142_R1.4381.00
391_Y448_L1.4351.00
441_L445_G1.4261.00
120_G156_A1.4241.00
164_F236_G1.4201.00
335_D339_R1.4161.00
150_V226_V1.4111.00
129_D133_V1.3941.00
128_E142_R1.3921.00
24_I324_M1.3911.00
132_S138_D1.3861.00
25_G343_L1.3781.00
98_D102_E1.3751.00
67_A148_M1.3751.00
131_L141_L1.3651.00
195_L199_W1.3621.00
190_V193_P1.3591.00
138_D142_R1.3581.00
368_S382_I1.3581.00
92_Y104_A1.3521.00
187_L191_L1.3461.00
463_A466_R1.3411.00
49_D188_N1.3411.00
463_A467_R1.3371.00
346_T350_G1.3371.00
179_L183_G1.3361.00
53_L64_I1.3281.00
99_E103_Y1.3251.00
238_A242_R1.3201.00
60_A143_P1.3151.00
190_V194_F1.3141.00
22_G26_K1.3131.00
41_F182_F1.3091.00
219_Q222_A1.3051.00
94_G330_G1.2961.00
365_P369_V1.2951.00
334_P338_A1.2851.00
383_E387_Q1.2831.00
91_Q95_A1.2731.00
93_T327_Q1.2681.00
360_Y393_A1.2611.00
462_Y466_R1.2581.00
417_V464_W1.2581.00
56_Y197_F1.2581.00
37_I178_M1.2521.00
58_T295_H1.2501.00
128_E141_L1.2381.00
124_Y149_Q1.2331.00
100_Q260_Y1.2291.00
429_I456_I1.2261.00
191_L227_F1.2251.00
93_T101_A1.2211.00
259_S262_R1.2191.00
348_L404_A1.2081.00
416_M420_A1.2061.00
445_G449_S1.2041.00
435_W439_G1.1991.00
55_Q372_G1.1921.00
180_V239_I1.1921.00
62_A298_A1.1911.00
195_L216_L1.1911.00
367_V382_I1.1881.00
424_I428_V1.1851.00
50_T305_R1.1831.00
357_L361_W1.1801.00
91_Q326_G1.1801.00
89_V170_G1.1761.00
25_G347_M1.1751.00
306_V366_I1.1721.00
441_L448_L1.1581.00
50_T61_L1.1521.00
107_Q261_L1.1511.00
91_Q413_G1.1411.00
296_I443_S1.1401.00
59_D143_P1.1371.00
464_W467_R1.1361.00
120_G124_Y1.1201.00
195_L227_F1.1191.00
384_A387_Q1.1151.00
188_N225_T1.1081.00
183_G235_V1.1071.00
59_D294_D1.1061.00
192_D224_A1.0991.00
63_A140_V1.0931.00
105_A167_L1.0921.00
318_A407_G1.0911.00
111_F261_L1.0911.00
341_A465_Y1.0851.00
131_L144_A1.0841.00
432_P436_A1.0801.00
325_T337_A1.0751.00
428_V432_P1.0751.00
64_I218_I1.0741.00
55_Q197_F1.0711.00
269_L273_I1.0701.00
112_S159_F1.0651.00
187_L228_S1.0611.00
303_G388_F1.0571.00
49_D192_D1.0571.00
193_P198_G1.0571.00
256_P261_L1.0551.00
193_P196_I1.0521.00
371_V381_V1.0451.00
295_H384_A1.0341.00
113_V160_G1.0321.00
287_F291_T1.0281.00
28_L344_A1.0281.00
420_A424_I1.0251.00
173_D177_P1.0241.00
402_A454_N1.0221.00
382_I385_G1.0171.00
102_E253_D1.0171.00
23_R26_K1.0151.00
195_L198_G1.0131.00
94_G331_A1.0111.00
343_L347_M1.0111.00
176_T239_I1.0101.00
172_G327_Q1.0081.00
124_Y128_E1.0021.00
350_G354_V1.0011.00
421_I461_A0.9981.00
250_N253_D0.9971.00
108_T264_L0.9921.00
372_G378_S0.9871.00
125_F129_D0.9871.00
104_A260_Y0.9861.00
198_G216_L0.9841.00
437_T441_L0.9841.00
434_A438_I0.9801.00
149_Q153_L0.9791.00
103_Y260_Y0.9761.00
127_V148_M0.9741.00
93_T171_Y0.9661.00
223_I226_V0.9611.00
247_V251_A0.9611.00
328_N340_A0.9561.00
91_Q329_V0.9481.00
405_Y465_Y0.9421.00
263_R266_R0.9421.00
364_E383_E0.9391.00
29_F33_M0.9381.00
182_F186_V0.9351.00
383_E386_S0.9321.00
107_Q256_P0.9271.00
391_Y444_A0.9261.00
106_S254_M0.9221.00
380_Q384_A0.9201.00
27_P30_F0.9191.00
299_A381_V0.9191.00
226_V230_A0.9171.00
164_F233_F0.9161.00
66_F136_A0.9161.00
93_T98_D0.9151.00
146_S149_Q0.9141.00
353_S357_L0.9141.00
398_F458_A0.9121.00
173_D239_I0.9031.00
199_W216_L0.9001.00
51_F54_G0.8961.00
354_V358_I0.8941.00
388_F443_S0.8911.00
306_V359_V0.8891.00
120_G153_L0.8881.00
363_P389_L0.8871.00
345_A401_I0.8861.00
114_L118_L0.8861.00
302_I370_F0.8851.00
191_L195_L0.8851.00
316_A320_G0.8831.00
125_F149_Q0.8801.00
192_D225_T0.8801.00
296_I384_A0.8801.00
360_Y364_E0.8791.00
235_V238_A0.8781.00
85_G89_V0.8781.00
325_T408_S0.8761.00
143_P218_I0.8751.00
153_L226_V0.8751.00
78_G159_F0.8751.00
409_F464_W0.8751.00
266_R416_M0.8711.00
231_L235_V0.8661.00
35_I319_R0.8661.00
46_N68_F0.8651.00
444_A448_L0.8641.00
299_A385_G0.8631.00
302_I385_G0.8601.00
127_V152_A0.8591.00
173_D243_G0.8581.00
337_A341_A0.8571.00
62_A140_V0.8561.00
391_Y451_A0.8511.00
337_A412_A0.8511.00
371_V378_S0.8471.00
71_V151_V0.8451.00
382_I386_S0.8421.00
273_I419_A0.8421.00
325_T411_G0.8411.00
31_L174_T0.8401.00
367_V386_S0.8391.00
188_N192_D0.8371.00
91_Q263_R0.8361.00
449_S453_S0.8361.00
354_V357_L0.8331.00
230_A234_A0.8311.00
122_I126_F0.8311.00
289_V443_S0.8291.00
361_W365_P0.8271.00
223_I227_F0.8261.00
401_I458_A0.8251.00
314_A352_L0.8231.00
48_A188_N0.8231.00
339_R346_T0.8221.00
48_A185_V0.8211.00
52_W197_F0.8211.00
379_A382_I0.8211.00
142_R145_T0.8201.00
328_N331_A0.8191.00
118_L122_I0.8181.00
179_L182_F0.8171.00
121_G125_F0.8151.00
59_D140_V0.8121.00
453_S457_G0.8111.00
56_Y215_R0.8091.00
429_I432_P0.8011.00
277_G423_V0.8001.00
161_F232_A0.8001.00
245_R248_E0.7971.00
168_M240_M0.7971.00
290_A297_V0.7941.00
260_Y263_R0.7901.00
336_R339_R0.7861.00
289_V446_I0.7821.00
237_L241_F0.7821.00
328_N337_A0.7821.00
300_Y447_W0.7781.00
108_T163_V0.7771.00
350_G353_S0.7761.00
164_F240_M0.7761.00
343_L346_T0.7751.00
90_A170_G0.7731.00
425_T457_G0.7731.00
317_I344_A0.7721.00
433_L452_V0.7711.00
89_V167_L0.7681.00
360_Y363_P0.7681.00
305_R370_F0.7681.00
288_I291_T0.7671.00
455_V459_I0.7671.00
276_T280_L0.7651.00
445_G448_L0.7601.00
28_L343_L0.7571.00
58_T381_V0.7571.00
138_D141_L0.7571.00
53_L196_I0.7511.00
140_V297_V0.7511.00
88_L267_I0.7451.00
124_Y127_V0.7451.00
110_T254_M0.7441.00
99_E253_D0.7411.00
41_F185_V0.7411.00
168_M176_T0.7401.00
110_T114_L0.7401.00
293_P296_I0.7401.00
178_M182_F0.7401.00
217_G220_G0.7381.00
378_S382_I0.7361.00
88_L92_Y0.7361.00
335_D342_R0.7341.00
288_I435_W0.7321.00
27_P324_M0.7291.00
349_F353_S0.7281.00
63_A218_I0.7281.00
54_G61_L0.7281.00
292_F438_I0.7271.00
362_Y366_I0.7261.00
188_N228_S0.7251.00
87_V91_Q0.7241.00
150_V153_L0.7221.00
344_A404_A0.7221.00
192_D196_I0.7211.00
346_T349_F0.7191.00
183_G187_L0.7191.00
25_G346_T0.7171.00
325_T341_A0.7131.00
169_R177_P0.7121.00
84_A268_G0.7121.00
77_L272_S0.7111.00
299_A388_F0.7111.00
307_F396_F0.7111.00
25_G29_F0.7081.00
99_E102_E0.7081.00
443_S447_W0.7061.00
238_A241_F0.7061.00
335_D338_A0.7051.00
216_L220_G0.7041.00
38_T181_M0.7041.00
128_E149_Q0.7041.00
103_Y106_S0.7031.00
448_L451_A0.7021.00
183_G231_L0.7021.00
131_L148_M0.7021.00
265_V269_L0.6991.00
106_S253_D0.6991.00
215_R219_Q0.6971.00
289_V300_Y0.6971.00
349_F400_G0.6961.00
59_D62_A0.6961.00
27_P327_Q0.6951.00
95_A330_G0.6941.00
291_T439_G0.6941.00
317_I351_V0.6891.00
353_S397_G0.6891.00
168_M236_G0.6881.00
247_V250_N0.6881.00
136_A290_A0.6861.00
146_S218_I0.6851.00
286_L290_A0.6841.00
153_L157_A0.6821.00
270_P419_A0.6821.00
438_I445_G0.6821.00
154_G157_A0.6821.00
284_L431_F0.6771.00
139_A143_P0.6771.00
102_E250_N0.6771.00
110_T256_P0.6751.00
437_T445_G0.6751.00
352_L400_G0.6751.00
53_L60_A0.6731.00
44_A48_A0.6731.00
45_Y225_T0.6701.00
417_V421_I0.6671.00
288_I438_I0.6671.00
407_G411_G0.6661.00
131_L145_T0.6641.00
51_F369_V0.6631.00
227_F230_A0.6621.00
126_F130_F0.6621.00
28_L320_G0.6601.00
147_Y192_D0.6591.00
118_L121_G0.6581.00
113_V117_L0.6571.00
216_L219_Q0.6561.00
242_R245_R0.6561.00
433_L437_T0.6531.00
176_T235_V0.6531.00
47_L309_V0.6511.00
51_F55_Q0.6491.00
263_R413_G0.6491.00
32_A316_A0.6481.00
121_G124_Y0.6471.00
436_A439_G0.6471.00
222_A226_V0.6471.00
241_F248_E0.6441.00
408_S412_A0.6441.00
288_I434_A0.6431.00
394_L397_G0.6431.00
361_W364_E0.6431.00
390_R394_L0.6411.00
100_Q104_A0.6401.00
148_M152_A0.6391.00
56_Y60_A0.6371.00
161_F233_F0.6371.00
140_V143_P0.6371.00
152_A155_L0.6371.00
405_Y461_A0.6341.00
334_P337_A0.6331.00
421_I460_I0.6321.00
103_Y107_Q0.6291.00
53_L218_I0.6271.00
268_G272_S0.6271.00
235_V239_I0.6271.00
313_P351_V0.6261.00
41_F44_A0.6261.00
295_H298_A0.6251.00
45_Y184_S0.6241.00
89_V101_A0.6231.00
40_L44_A0.6231.00
364_E382_I0.6231.00
63_A144_A0.6221.00
317_I348_L0.6221.00
267_I415_T0.6221.00
86_S166_A0.6221.00
48_A52_W0.6211.00
27_P336_R0.6181.00
351_V355_L0.6181.00
363_P367_V0.6171.00
87_V267_I0.6161.00
327_Q331_A0.6161.00
311_F399_I0.6161.00
87_V326_G0.6141.00
321_V325_T0.6131.00
329_V334_P0.6091.00
220_G224_A0.6081.00
259_S263_R0.6061.00
371_V379_A0.6031.00
58_T298_A0.6031.00
164_F237_L0.6001.00
117_L121_G0.5991.00
152_A156_A0.5981.00
60_A217_G0.5981.00
81_I272_S0.5971.00
61_L371_V0.5951.00
431_F435_W0.5941.00
429_I433_L0.5931.00
322_E410_R0.5931.00
197_F216_L0.5921.00
310_V355_L0.5901.00
269_L272_S0.5901.00
154_G229_R0.5891.00
60_A63_A0.5891.00
460_I463_A0.5881.00
45_Y229_R0.5881.00
149_Q219_Q0.5871.00
95_A332_G0.5851.00
195_L221_A0.5841.00
347_M350_G0.5841.00
61_L302_I0.5821.00
345_A349_F0.5821.00
182_F185_V0.5801.00
183_G186_V0.5781.00
314_A400_G0.5771.00
165_I169_R0.5771.00
187_L227_F0.5771.00
228_S231_L0.5751.00
430_R434_A0.5741.00
356_G397_G0.5741.00
23_R27_P0.5731.00
28_L32_A0.5731.00
349_F401_I0.5721.00
349_F397_G0.5711.00
405_Y462_Y0.5711.00
233_F237_L0.5691.00
44_A185_V0.5691.00
358_I362_Y0.5691.00
415_T419_A0.5681.00
157_A226_V0.5671.00
448_L452_V0.5651.00
80_G322_E0.5651.00
68_F72_F0.5641.00
97_K103_Y0.5631.00
127_V131_L0.5631.00
422_S425_T0.5621.00
116_S156_A0.5611.00
131_L136_A0.5611.00
187_L190_V0.5601.00
116_S152_A0.5601.00
80_G272_S0.5591.00
239_I243_G0.5581.00
141_L144_A0.5581.00
285_L446_I0.5581.00
62_A65_S0.5581.00
106_S251_A0.5571.00
342_R465_Y0.5541.00
371_V382_I0.5541.00
195_L223_I0.5521.00
299_A447_W0.5521.00
106_S110_T0.5521.00
307_F392_V0.5501.00
146_S150_V0.5491.00
156_A230_A0.5481.00
180_V232_A0.5481.00
161_F165_I0.5471.00
345_A405_Y0.5471.00
393_A397_G0.5471.00
24_I339_R0.5461.00
296_I299_A0.5461.00
140_V294_D0.5451.00
124_Y153_L0.5441.00
281_S426_L0.5411.00
66_F144_A0.5401.00
112_S116_S0.5401.00
324_M328_N0.5391.00
409_F414_K0.5361.00
456_I460_I0.5341.00
64_I147_Y0.5341.00
117_L120_G0.5321.00
292_F296_I0.5301.00
123_G127_V0.5301.00
438_I446_I0.5301.00
74_L155_L0.5301.00
430_R453_S0.5291.00
322_E407_G0.5291.00
425_T460_I0.5291.00
387_Q390_R0.5291.00
196_I224_A0.5271.00
147_Y221_A0.5261.00
402_A457_G0.5261.00
284_L287_F0.5251.00
113_V116_S0.5241.00
433_L436_A0.5241.00
116_S120_G0.5231.00
22_G25_G0.5231.00
166_A169_R0.5231.00
107_Q111_F0.5231.00
363_P393_A0.5231.00
224_A228_S0.5231.00
46_N151_V0.5231.00
405_Y458_A0.5231.00
51_F370_F0.5221.00
401_I462_Y0.5211.00
24_I343_L0.5211.00
48_A51_F0.5211.00
169_R174_T0.5201.00
451_A455_V0.5191.00
285_L434_A0.5191.00
295_H378_S0.5180.99
381_V385_G0.5180.99
134_V283_N0.5170.99
294_D298_A0.5160.99
124_Y152_A0.5160.99
56_Y193_P0.5160.99
246_G249_I0.5140.99
341_A345_A0.5130.99
188_N224_A0.5130.99
83_V319_R0.5130.99
288_I446_I0.5130.99
277_G419_A0.5130.99
432_P435_W0.5120.99
434_A446_I0.5120.99
295_H381_V0.5100.99
107_Q260_Y0.5090.99
145_T148_M0.5070.99
241_F244_T0.5060.99
303_G389_L0.5060.99
28_L347_M0.5060.99
89_V104_A0.5050.99
168_M171_Y0.5050.99
359_V366_I0.5030.99
168_M239_I0.5030.99
96_G331_A0.5030.99
288_I292_F0.5020.99
189_I193_P0.5020.99
393_A396_F0.5000.99
342_R345_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.913 100 0.334 Contact Map
4lz6A 1 0.8988 100 0.342 Contact Map
4humA 1 0.9211 100 0.344 Contact Map
3w4tA 1 0.8907 100 0.384 Contact Map
3wdoA 1 0.8239 96 0.921 Contact Map
4j05A 3 0.8158 95.6 0.923 Contact Map
1pw4A 1 0.836 94.8 0.927 Contact Map
4ikvA 1 0.8441 94.2 0.929 Contact Map
4w6vA 1 0.8016 93.8 0.93 Contact Map
4tphA 2 0.7733 93.4 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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