GREMLIN Database
PANE - Putative 2-dehydropantoate 2-reductase
UniProt: Q9HRF0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (297)
Sequences: 5094 (3972)
Seq/√Len: 230.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_E261_A4.4241.00
280_R290_R4.3731.00
279_A286_V3.9451.00
230_E282_H3.4571.00
4_V70_A2.9981.00
2_R25_A2.9281.00
16_G28_L2.9121.00
226_V286_V2.7991.00
219_A292_L2.7291.00
196_T254_S2.6931.00
276_V290_R2.5921.00
37_T41_E2.5301.00
278_R281_D2.4601.00
272_H289_I2.4141.00
149_R155_D2.3701.00
269_E297_R2.3511.00
257_R261_A2.1911.00
200_D261_A2.1721.00
72_L99_L2.1611.00
74_V99_L2.1501.00
47_V136_V2.1371.00
82_T102_Q2.1321.00
253_E257_R2.1281.00
230_E278_R2.1251.00
33_S37_T2.1101.00
286_V290_R2.0841.00
18_V21_G1.9011.00
218_R288_V1.8881.00
3_V164_A1.8861.00
149_R157_R1.8751.00
132_T138_R1.8511.00
34_E37_T1.8301.00
219_A288_V1.8291.00
36_L40_R1.8261.00
38_R42_D1.8261.00
202_D205_A1.8241.00
6_Q85_A1.8201.00
8_P28_L1.7991.00
83_A110_V1.7541.00
177_S180_R1.7351.00
144_E173_T1.7251.00
87_R114_H1.7181.00
183_W227_A1.6891.00
146_T175_T1.6441.00
3_V72_L1.6381.00
187_L223_G1.6321.00
190_V223_G1.6271.00
200_D257_R1.6201.00
21_G53_T1.6031.00
45_R52_T1.5941.00
90_G114_H1.5911.00
101_L123_G1.5901.00
24_T167_T1.5891.00
162_A166_S1.5851.00
93_C96_A1.5831.00
148_G178_P1.5781.00
189_N193_N1.5721.00
278_R282_H1.5501.00
285_A290_R1.5401.00
276_V286_V1.5021.00
197_A260_L1.4941.00
72_L161_V1.4801.00
268_V296_V1.4721.00
198_L295_L1.4681.00
13_S137_V1.4661.00
159_A163_A1.4521.00
48_Q139_H1.4381.00
121_L158_V1.4281.00
229_A284_I1.4201.00
30_G36_L1.4121.00
293_A297_R1.4061.00
272_H293_A1.4031.00
204_G250_A1.4021.00
175_T181_A1.3981.00
215_V291_T1.3861.00
266_T296_V1.3821.00
269_E293_A1.3771.00
240_E244_Q1.3391.00
45_R136_V1.3371.00
226_V275_V1.3321.00
276_V293_A1.3181.00
14_L129_A1.3141.00
213_E247_A1.3111.00
15_V101_L1.3111.00
194_A256_M1.3031.00
213_E217_E1.2991.00
227_A234_V1.2881.00
200_D299_A1.2871.00
82_T107_N1.2821.00
47_V138_R1.2811.00
125_T145_T1.2731.00
47_V52_T1.2671.00
106_G109_A1.2641.00
116_P119_T1.2631.00
87_R90_G1.2621.00
290_R294_D1.2611.00
279_A284_I1.2461.00
155_D159_A1.2341.00
269_E277_E1.2261.00
260_L266_T1.2251.00
158_V174_V1.2241.00
37_T40_R1.2161.00
217_E221_T1.2121.00
84_S87_R1.2111.00
97_M157_R1.2051.00
83_A113_E1.2031.00
35_H39_V1.2001.00
99_L123_G1.1991.00
98_V115_V1.1981.00
27_T70_A1.1981.00
30_G39_V1.1961.00
163_A166_S1.1721.00
5_V74_V1.1691.00
3_V24_T1.1621.00
83_A87_R1.1621.00
201_V205_A1.1571.00
108_A182_V1.1521.00
112_A117_A1.1471.00
4_V73_V1.1461.00
79_S270_S1.1431.00
84_S88_A1.1391.00
97_M121_L1.1381.00
291_T295_L1.1301.00
33_S36_L1.1291.00
4_V29_L1.1291.00
223_G275_V1.1181.00
219_A289_I1.1081.00
277_E281_D1.1031.00
100_T111_L1.0981.00
229_A282_H1.0961.00
11_L76_C1.0911.00
163_A167_T1.0881.00
286_V289_I1.0851.00
156_A159_A1.0721.00
274_A277_E1.0671.00
274_A278_R1.0671.00
133_E136_V1.0601.00
215_V288_V1.0581.00
45_R54_R1.0571.00
217_E239_V1.0571.00
72_L97_M1.0431.00
162_A174_V1.0401.00
105_L274_A1.0391.00
127_H139_H1.0361.00
13_S44_L1.0271.00
202_D251_S1.0171.00
193_N256_M1.0081.00
124_T182_V1.0081.00
288_V291_T1.0051.00
230_E281_D0.9981.00
97_M161_V0.9911.00
149_R152_G0.9881.00
25_A59_S0.9821.00
149_R158_V0.9811.00
116_P120_V0.9791.00
194_A272_H0.9791.00
195_A206_L0.9771.00
284_I287_P0.9721.00
244_Q247_A0.9681.00
40_R60_V0.9531.00
198_L299_A0.9501.00
166_S172_T0.9491.00
180_R184_E0.9421.00
185_K255_S0.9421.00
279_A285_A0.9411.00
130_A140_A0.9401.00
64_P67_V0.9361.00
130_A138_R0.9331.00
226_V279_A0.9331.00
191_G220_V0.9311.00
30_G33_S0.9301.00
103_N185_K0.9231.00
6_Q73_V0.9201.00
160_S163_A0.9101.00
244_Q248_R0.9000.99
11_L125_T0.8990.99
67_V70_A0.8970.99
200_D260_L0.8970.99
48_Q51_G0.8960.99
258_Q262_G0.8950.99
225_R228_E0.8940.99
210_P214_R0.8910.99
35_H134_P0.8910.99
147_I162_A0.8890.99
132_T136_V0.8890.99
69_D96_A0.8880.99
129_A137_V0.8870.99
196_T206_L0.8810.99
239_V243_R0.8740.99
82_T100_T0.8740.99
15_V125_T0.8730.99
146_T181_A0.8650.99
5_V26_V0.8610.99
199_A295_L0.8600.99
214_R218_R0.8560.99
63_D66_V0.8540.99
8_P16_G0.8540.99
35_H131_R0.8530.99
186_V271_L0.8490.99
81_D84_S0.8490.99
39_V135_G0.8490.99
240_E243_R0.8490.99
218_R290_R0.8480.99
130_A258_Q0.8440.99
86_A114_H0.8400.99
109_A113_E0.8400.99
78_K185_K0.8400.99
80_Y265_R0.8390.99
106_G274_A0.8380.99
87_R91_R0.8380.99
8_P13_S0.8360.99
2_R69_D0.8360.99
5_V16_G0.8340.99
74_V101_L0.8340.99
195_A216_L0.8330.99
280_R286_V0.8290.99
73_V98_V0.8280.99
27_T61_A0.8270.99
213_E243_R0.8250.99
123_G145_T0.8210.99
4_V92_Q0.8210.99
221_T225_R0.8200.99
78_K267_E0.8190.99
73_V93_C0.8150.99
291_T294_D0.8150.99
273_G277_E0.8130.99
273_G293_A0.8120.99
224_V228_E0.8100.99
14_L127_H0.8070.99
112_A150_Y0.8070.99
78_K259_D0.8070.99
42_D136_V0.8050.99
112_A116_P0.8050.99
2_R68_A0.8050.99
186_V275_V0.8040.99
108_A112_A0.8010.99
205_A208_E0.8000.99
9_G12_G0.7970.99
272_H275_V0.7960.99
203_N252_N0.7890.99
184_E235_S0.7880.99
36_L60_V0.7870.99
97_M119_T0.7850.99
249_T252_N0.7850.99
255_S259_D0.7840.99
17_G46_V0.7750.98
75_V98_V0.7740.98
156_A160_S0.7740.98
4_V27_T0.7720.98
269_E273_G0.7720.98
108_A122_V0.7680.98
225_R229_A0.7680.98
199_A215_V0.7670.98
79_S107_N0.7670.98
193_N255_S0.7630.98
221_T239_V0.7550.98
180_R232_V0.7520.98
100_T107_N0.7510.98
78_K255_S0.7490.98
128_G140_A0.7490.98
146_T173_T0.7480.98
259_D267_E0.7470.98
208_E250_A0.7440.98
214_R217_E0.7430.98
24_T164_A0.7410.98
207_V247_A0.7410.98
241_R244_Q0.7400.98
14_L139_H0.7380.98
46_V53_T0.7370.98
75_V100_T0.7350.98
111_L120_V0.7320.98
253_E258_Q0.7290.98
152_G155_D0.7290.98
295_L299_A0.7280.98
190_V289_I0.7270.98
277_E280_R0.7250.98
243_R247_A0.7230.98
242_A246_A0.7220.98
275_V289_I0.7200.97
15_V145_T0.7190.97
69_D95_G0.7170.97
85_A88_A0.7170.97
188_V192_I0.7170.97
218_R294_D0.7140.97
246_A249_T0.7100.97
193_N197_A0.7060.97
73_V96_A0.7060.97
220_V239_V0.7060.97
223_G226_V0.7050.97
187_L238_V0.7040.97
6_Q77_V0.7030.97
212_G298_L0.7030.97
18_V168_G0.7000.97
188_V245_V0.6990.97
15_V74_V0.6990.97
276_V289_I0.6970.97
47_V132_T0.6970.97
189_N271_L0.6950.97
192_I246_A0.6930.97
154_N159_A0.6910.97
238_V242_A0.6900.97
20_A28_L0.6880.97
228_E233_S0.6850.97
206_L246_A0.6840.97
192_I252_N0.6830.97
6_Q88_A0.6830.97
184_E241_R0.6780.96
121_L149_R0.6780.96
161_V165_F0.6750.96
192_I249_T0.6740.96
22_G168_G0.6730.96
42_D45_R0.6720.96
69_D94_D0.6720.96
194_A197_A0.6720.96
162_A172_T0.6710.96
102_Q107_N0.6660.96
86_A111_L0.6650.96
147_I172_T0.6650.96
106_G277_E0.6640.96
122_V150_Y0.6630.96
107_N111_L0.6610.96
39_V43_G0.6600.96
34_E38_R0.6600.96
179_Q230_E0.6590.96
204_G208_E0.6580.96
6_Q29_L0.6580.96
101_L125_T0.6570.96
70_A73_V0.6570.96
190_V271_L0.6540.96
122_V182_V0.6510.95
144_E171_E0.6500.95
217_E240_E0.6500.95
259_D264_A0.6500.95
85_A89_L0.6490.95
17_G20_A0.6460.95
209_C212_G0.6450.95
280_R285_A0.6440.95
53_T56_T0.6430.95
260_L299_A0.6420.95
225_R284_I0.6370.95
185_K193_N0.6360.95
78_K103_N0.6350.95
275_V279_A0.6340.95
75_V111_L0.6310.95
35_H38_R0.6260.94
35_H44_L0.6260.94
279_A287_P0.6260.94
230_E284_I0.6230.94
194_A292_L0.6210.94
36_L62_T0.6210.94
256_M259_D0.6210.94
55_V58_P0.6180.94
175_T178_P0.6140.94
215_V295_L0.6140.94
125_T143_G0.6140.94
103_N189_N0.6130.94
236_E240_E0.6120.94
235_S238_V0.6120.94
186_V189_N0.6080.93
239_V242_A0.6050.93
44_L48_Q0.6040.93
237_S240_E0.6030.93
202_D253_E0.6030.93
193_N258_Q0.6030.93
193_N271_L0.6020.93
272_H276_V0.6010.93
192_I203_N0.6000.93
185_K259_D0.6000.93
122_V178_P0.5970.93
77_V81_D0.5960.93
2_R71_D0.5950.93
192_I245_V0.5950.93
226_V284_I0.5950.93
99_L121_L0.5930.93
204_G251_S0.5930.93
166_S171_E0.5930.93
201_V206_L0.5890.92
15_V76_C0.5880.92
75_V85_A0.5860.92
15_V18_V0.5860.92
103_N255_S0.5840.92
81_D85_A0.5790.92
217_E243_R0.5770.92
203_N249_T0.5760.92
187_L224_V0.5760.92
256_M266_T0.5760.92
105_L186_V0.5740.91
31_H81_D0.5730.91
93_C118_D0.5730.91
124_T181_A0.5710.91
212_G215_V0.5700.91
128_G249_T0.5690.91
159_A162_A0.5640.91
38_R134_P0.5640.91
111_L115_V0.5610.90
199_A212_G0.5600.90
14_L143_G0.5600.90
179_Q182_V0.5560.90
197_A257_R0.5540.90
197_A266_T0.5530.90
150_Y179_Q0.5530.90
103_N267_E0.5490.90
159_A174_V0.5490.90
195_A219_A0.5490.90
77_V82_T0.5480.89
275_V286_V0.5460.89
13_S35_H0.5440.89
71_D95_G0.5440.89
101_L145_T0.5410.89
189_N255_S0.5400.89
14_L18_V0.5400.89
2_R27_T0.5400.89
238_V241_R0.5400.89
197_A256_M0.5390.89
8_P30_G0.5380.89
197_A201_V0.5370.88
157_R160_S0.5370.88
127_H143_G0.5340.88
185_K189_N0.5330.88
255_S267_E0.5330.88
225_R285_A0.5320.88
147_I165_F0.5310.88
109_A278_R0.5300.88
128_G252_N0.5290.88
194_A296_V0.5280.88
78_K193_N0.5270.88
22_G26_V0.5270.88
94_D118_D0.5260.87
48_Q52_T0.5250.87
19_L74_V0.5220.87
190_V219_A0.5210.87
147_I158_V0.5200.87
260_L296_V0.5190.87
19_L26_V0.5180.87
207_V246_A0.5180.87
268_V297_R0.5170.87
76_C101_L0.5170.87
40_R62_T0.5170.87
107_N182_V0.5160.86
131_R137_V0.5160.86
110_V113_E0.5140.86
160_S164_A0.5060.85
126_T144_E0.5060.85
237_S241_R0.5030.85
30_G35_H0.5010.85
141_G249_T0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wfiA 2 0.9967 100 0.318 Contact Map
2ew2A 2 0.9967 100 0.327 Contact Map
3egoA 2 0.9604 100 0.342 Contact Map
3hn2A 2 0.9901 100 0.344 Contact Map
3i83A 2 0.9901 100 0.345 Contact Map
3ghyA 2 0.9901 100 0.346 Contact Map
2qytA 1 0.9109 100 0.361 Contact Map
3hwrA 2 0.9703 100 0.366 Contact Map
4ol9A 2 0.9538 100 0.393 Contact Map
1ks9A 1 0.9439 100 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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